BR112014032254B1 - Processo para a preparação de uma composição, aparelho, e, uso de um aparelho - Google Patents

Processo para a preparação de uma composição, aparelho, e, uso de um aparelho Download PDF

Info

Publication number
BR112014032254B1
BR112014032254B1 BR112014032254-6A BR112014032254A BR112014032254B1 BR 112014032254 B1 BR112014032254 B1 BR 112014032254B1 BR 112014032254 A BR112014032254 A BR 112014032254A BR 112014032254 B1 BR112014032254 B1 BR 112014032254B1
Authority
BR
Brazil
Prior art keywords
gas
inlet
microbubbles
protein
protein solution
Prior art date
Application number
BR112014032254-6A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112014032254A2 (pt
Inventor
Ole Johannes Tokerud
Svein Kvaale
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of BR112014032254A2 publication Critical patent/BR112014032254A2/pt
Publication of BR112014032254B1 publication Critical patent/BR112014032254B1/pt

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/248—Reactors comprising multiple separated flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00076—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements inside the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24—Stationary reactors without moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Accessories For Mixers (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • General Preparation And Processing Of Foods (AREA)
BR112014032254-6A 2012-06-26 2013-06-25 Processo para a preparação de uma composição, aparelho, e, uso de um aparelho BR112014032254B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12173606 2012-06-26
EP12173606.0 2012-06-26
PCT/EP2013/063218 WO2014001297A2 (en) 2012-06-26 2013-06-25 Preparation of composition comprising gas microbubbles

Publications (2)

Publication Number Publication Date
BR112014032254A2 BR112014032254A2 (pt) 2017-06-27
BR112014032254B1 true BR112014032254B1 (pt) 2022-11-01

Family

ID=48699026

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014032254-6A BR112014032254B1 (pt) 2012-06-26 2013-06-25 Processo para a preparação de uma composição, aparelho, e, uso de um aparelho

Country Status (14)

Country Link
US (1) US10350314B2 (https=)
EP (1) EP2864033B1 (https=)
JP (1) JP6420761B2 (https=)
KR (1) KR102139393B1 (https=)
CN (1) CN104519989B (https=)
AU (2) AU2013283409B2 (https=)
BR (1) BR112014032254B1 (https=)
CA (1) CA2876950C (https=)
DK (1) DK2864033T3 (https=)
ES (1) ES2571481T3 (https=)
IN (1) IN2014DN10714A (https=)
MX (1) MX354719B (https=)
RU (1) RU2640078C2 (https=)
WO (1) WO2014001297A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014DN10714A (https=) 2012-06-26 2015-09-04 Ge Healthcare As
NL2014178B1 (en) * 2015-01-22 2017-01-05 Tide Microfluidics B V System and method for controlled manufacturing of mono-disperse microbubbles.
US11317888B2 (en) 2016-10-11 2022-05-03 Thomas Jefferson University Non-invasive method for pressure measurement
JP7220567B2 (ja) * 2017-02-10 2023-02-10 キリンホールディングス株式会社 スパージャー及び培養装置
CN112808187B (zh) * 2021-01-19 2023-05-30 浙江省林业科学研究院 一种生产气泡胶囊菌剂的自动化设备及方法
US12345068B2 (en) 2021-11-19 2025-07-01 Sundance Spas, Inc. Self-maintaining hot tub or spa

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US20080063603A1 (en) 1990-04-02 2008-03-13 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
HU218018B (hu) 1991-09-17 2000-05-28 Sonus Pharmaceuticals Inc. Gázos ultrahang-kontrasztanyag és eljárás ultrahang kontrasztanyaghoz megfelelő gázok kiválasztására
AU722742B2 (en) * 1993-07-02 2000-08-10 Molecular Biosystems, Inc. Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
WO1995001187A1 (en) 1993-07-02 1995-01-12 Molecular Biosystems, Inc. Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
JPH0747251A (ja) 1993-08-06 1995-02-21 Toho Asechiren Kk 混合ガス発生方法
US5370955A (en) 1993-09-27 1994-12-06 Xerox Corporation Electrophotographic elements with arylamine polycondensation polymers
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
PL319600A1 (en) 1994-09-29 1997-08-18 Andaris Ltd Spray-dried microparticles as therapeutic carriers
ATE238072T1 (de) 1996-02-19 2003-05-15 Amersham Health As Verbesserungen an (oder im bezug auf) kontrastmittel
US5976501A (en) 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
TR199901544T2 (xx) * 1996-10-21 1999-09-21 Nycomed Imaging As Kontrast ajanlar�ndaki veya kontrast ajanlar�yla ilgili geli�meler.
JP3693276B2 (ja) 1998-09-17 2005-09-07 東京瓦斯株式会社 温度差を有する気液を配管上で混合するための装置
AR035779A1 (es) 2001-02-06 2004-07-14 Genetics Inst Llc Polipeptidos de fusion derivados de glicoproteina ib alfa de plaqueta y metodos de uso de los mismos
JP4350058B2 (ja) * 2004-11-09 2009-10-21 株式会社デンソー 冷媒用二重管
DE102005052973B4 (de) * 2004-11-09 2014-11-20 Denso Corporation Doppelwandiges Rohr und Herstellungsverfahren dafür
DE102005020727A1 (de) 2005-05-04 2006-11-09 Dr.Ing.H.C. F. Porsche Ag Stranggepresstes Mehrkammerrohr, insbesondere für einen Wärmeübertrager
CN101130094A (zh) * 2007-09-06 2008-02-27 上海新兴医药股份有限公司 一种超声造影剂及其制备方法
CN101507908B (zh) 2009-04-09 2010-12-01 北京化工大学 微通道套管式装置及其应用
IN2014DN10714A (https=) 2012-06-26 2015-09-04 Ge Healthcare As

Also Published As

Publication number Publication date
CA2876950C (en) 2020-09-22
DK2864033T3 (en) 2016-05-17
KR102139393B1 (ko) 2020-07-29
US10350314B2 (en) 2019-07-16
AU2013283409B2 (en) 2017-06-08
BR112014032254A2 (pt) 2017-06-27
CA2876950A1 (en) 2014-01-03
RU2014150473A (ru) 2016-08-20
JP6420761B2 (ja) 2018-11-07
WO2014001297A2 (en) 2014-01-03
EP2864033B1 (en) 2016-04-06
JP2015524792A (ja) 2015-08-27
US20150250904A1 (en) 2015-09-10
EP2864033A2 (en) 2015-04-29
CN104519989B (zh) 2016-10-26
WO2014001297A3 (en) 2014-10-02
RU2640078C2 (ru) 2017-12-26
ES2571481T3 (es) 2016-05-25
KR20150024420A (ko) 2015-03-06
AU2017216553A1 (en) 2017-09-07
CN104519989A (zh) 2015-04-15
HK1209381A1 (en) 2016-04-01
AU2017216553B2 (en) 2019-06-27
AU2013283409A1 (en) 2015-01-22
MX354719B (es) 2018-03-16
MX2014015717A (es) 2015-08-05
IN2014DN10714A (https=) 2015-09-04

Similar Documents

Publication Publication Date Title
AU2017216553B2 (en) Preparation of composition comprising gas microbubbles
Sheeran et al. Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography
Zhang et al. CO 2 foam properties and the stabilizing mechanism of sodium bis (2-ethylhexyl) sulfosuccinate and hydrophobic nanoparticle mixtures
Freitas et al. Continuous contact-and contamination-free ultrasonic emulsification—a useful tool for pharmaceutical development and production
Yildirim et al. Stable encapsulation of air in mesoporous silica nanoparticles: fluorocarbon‐free nanoscale ultrasound contrast agents
KR100218642B1 (ko) 열변성된 단백질로부터 캡슐화된 마이크로스피어의 제조방법
CN112210087B (zh) 一种水包水Pickering乳液及其制备方法
Gao et al. Crystallization methods for preparation of nanocrystals for drug delivery system
CN104353088A (zh) 一种脂质气泡的制备方法
Chen et al. Engineering the echogenic properties of microfluidic microbubbles using mixtures of recombinant protein and amphiphilic copolymers
CN103846067A (zh) 一种粒径和形貌均可控的磁性异性Janus微球及其制备方法和所用的微流体控制装置
Bhutto et al. Polyelectrolyte nanocomplex from sodium caseinate and chitosan as potential vehicles for oil encapsulation by flash nanoprecipitation
CN114307708B (zh) 一种连续制备载药纳米乳的方法
Akiyama et al. Fabrication of PEGylated liposome in microfluidic flow process using supercritical CO2
Seo et al. Direct incorporation of lipophilic nanoparticles into monodisperse perfluorocarbon nanodroplets via solvent dissolution from microfluidic-generated precursor microdroplets
HK1209381B (en) Preparation of composition comprising gas microbubbles
CN105816440A (zh) 一种明胶微球的制备方法
JP5072057B2 (ja) 微小流路構造体を用いたマイクロカプセルの製造方法
Polachini et al. Production of Pickering Emulsions Stabilized by Protein Microgels
Huang et al. Microfluidic Methods for Generation of Submicron Droplets: A Review. Micromachines 2023, 14, 638
YUYAMA et al. Fabrication of Cyanoacrylate Hollow Particles using Microbubble Generation Technique
CN101108166A (zh) 定量纳米气雾剂及其制备方法
JP2001342108A (ja) 乳化組成物
Ma et al. Stable Small Composite Microbubbles Decorated with Magnetite Nanoparticles–A Synergistic Effect between Surfactant Molecules and Nanoparticles
CN113995734A (zh) 一种离心乳化技术制备药物复合物的方法

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/06/2013, OBSERVADAS AS CONDICOES LEGAIS