CN104507500A - 流感中和药剂 - Google Patents

流感中和药剂 Download PDF

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Publication number
CN104507500A
CN104507500A CN201380024604.3A CN201380024604A CN104507500A CN 104507500 A CN104507500 A CN 104507500A CN 201380024604 A CN201380024604 A CN 201380024604A CN 104507500 A CN104507500 A CN 104507500A
Authority
CN
China
Prior art keywords
antibody
seq
binding
influenza
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380024604.3A
Other languages
English (en)
Chinese (zh)
Inventor
S·拉居拉姆
维斯瓦纳坦·萨西赛哈兰
文卡塔拉曼·桑达拉拉詹
拉姆·萨西赛哈兰
维迪亚·苏布拉马尼亚安
卡纳安·塔拉卡拉曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to CN201811019451.4A priority Critical patent/CN109265541A/zh
Publication of CN104507500A publication Critical patent/CN104507500A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380024604.3A 2012-05-10 2013-03-14 流感中和药剂 Pending CN104507500A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811019451.4A CN109265541A (zh) 2012-05-10 2013-03-14 流感中和药剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261645453P 2012-05-10 2012-05-10
US61/645,453 2012-05-10
PCT/US2013/031704 WO2013169377A1 (en) 2012-05-10 2013-03-14 Agents for influenza neutralization

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811019451.4A Division CN109265541A (zh) 2012-05-10 2013-03-14 流感中和药剂

Publications (1)

Publication Number Publication Date
CN104507500A true CN104507500A (zh) 2015-04-08

Family

ID=49548780

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380024604.3A Pending CN104507500A (zh) 2012-05-10 2013-03-14 流感中和药剂
CN201811019451.4A Pending CN109265541A (zh) 2012-05-10 2013-03-14 流感中和药剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201811019451.4A Pending CN109265541A (zh) 2012-05-10 2013-03-14 流感中和药剂

Country Status (14)

Country Link
US (4) US9683030B2 (https=)
EP (2) EP2846833A4 (https=)
JP (2) JP6431477B2 (https=)
KR (1) KR102122618B1 (https=)
CN (2) CN104507500A (https=)
AU (2) AU2013260123A1 (https=)
BR (1) BR112014027991A2 (https=)
CA (1) CA2871160C (https=)
CL (1) CL2014003052A1 (https=)
HK (1) HK1207970A1 (https=)
IL (1) IL235237A0 (https=)
MX (1) MX378749B (https=)
SG (2) SG11201406769RA (https=)
WO (1) WO2013169377A1 (https=)

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SG11201406769RA (en) 2012-05-10 2014-11-27 Massachusetts Inst Technology Agents for influenza neutralization
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
MY186585A (en) 2015-02-05 2021-07-28 Janssen Vaccines & Prevention Bv Binding molecules directed against influenza hemagglutinin and uses thereof
EP3294753A1 (en) * 2015-05-11 2018-03-21 Janssen Vaccines & Prevention B.V. Influenza virus neutralizing peptidomimetic compounds
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
KR101887876B1 (ko) 2016-08-18 2018-08-13 한국과학기술연구원 H5형 조류독감 바이러스에 특이적으로 결합하는 핵산 압타머 및 이를 이용하는 h5형 조류독감 바이러스의 검출방법
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2021119467A1 (en) 2019-12-11 2021-06-17 Visterra, Inc. Compositions and methods for treating and preventing influenza

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CN102164613A (zh) * 2008-07-25 2011-08-24 生物医学研究所 中和抗甲型流感病毒抗体及其用途
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Also Published As

Publication number Publication date
KR102122618B1 (ko) 2020-06-29
CA2871160C (en) 2023-03-14
CN109265541A (zh) 2019-01-25
IL235237A0 (en) 2014-12-31
EP3492101A3 (en) 2019-10-23
JP2015517492A (ja) 2015-06-22
AU2018202468B2 (en) 2020-04-16
US9683030B2 (en) 2017-06-20
EP2846833A4 (en) 2016-01-06
MX2014013678A (es) 2015-02-04
SG10201807059QA (en) 2018-09-27
US20130302348A1 (en) 2013-11-14
AU2013260123A1 (en) 2014-11-13
US9982037B2 (en) 2018-05-29
WO2013169377A1 (en) 2013-11-14
US20170306003A1 (en) 2017-10-26
BR112014027991A2 (pt) 2017-07-18
HK1207970A1 (en) 2016-02-19
US10538578B2 (en) 2020-01-21
KR20150008180A (ko) 2015-01-21
AU2018202468A1 (en) 2018-04-26
MX378749B (es) 2025-03-10
US10947300B2 (en) 2021-03-16
EP3492101A2 (en) 2019-06-05
EP2846833A1 (en) 2015-03-18
US20200123234A1 (en) 2020-04-23
US20190062407A1 (en) 2019-02-28
JP6431477B2 (ja) 2018-12-05
JP2018118991A (ja) 2018-08-02
CL2014003052A1 (es) 2015-06-26
CA2871160A1 (en) 2013-11-14
SG11201406769RA (en) 2014-11-27

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Application publication date: 20150408