CN104487051B - 用于脊椎施用的可注射过饱和对乙酰氨基酚溶液 - Google Patents

用于脊椎施用的可注射过饱和对乙酰氨基酚溶液 Download PDF

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Publication number
CN104487051B
CN104487051B CN201380034500.0A CN201380034500A CN104487051B CN 104487051 B CN104487051 B CN 104487051B CN 201380034500 A CN201380034500 A CN 201380034500A CN 104487051 B CN104487051 B CN 104487051B
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CN
China
Prior art keywords
acetaminophen
solution
supersaturated
aqueous solution
local anesthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380034500.0A
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English (en)
Chinese (zh)
Other versions
CN104487051A (zh
Inventor
奥古斯托·米提蒂利
伊丽莎白·多纳蒂
尼古拉·卡龙佐罗
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Sintetica SA
Original Assignee
Sintetica SA
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Publication of CN104487051A publication Critical patent/CN104487051A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380034500.0A 2012-06-29 2013-06-27 用于脊椎施用的可注射过饱和对乙酰氨基酚溶液 Expired - Fee Related CN104487051B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001154A ITMI20121154A1 (it) 2012-06-29 2012-06-29 Soluzione iniettabile di acetaminofene per la somministrazione spinale
ITMI2012A001154 2012-06-29
PCT/IB2013/055277 WO2014002042A1 (en) 2012-06-29 2013-06-27 Injectable supersaturated acetaminophen solution for spinal administration

Publications (2)

Publication Number Publication Date
CN104487051A CN104487051A (zh) 2015-04-01
CN104487051B true CN104487051B (zh) 2017-12-12

Family

ID=46690603

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380034500.0A Expired - Fee Related CN104487051B (zh) 2012-06-29 2013-06-27 用于脊椎施用的可注射过饱和对乙酰氨基酚溶液

Country Status (44)

Country Link
US (2) US11344517B2 (enExample)
EP (1) EP2874602B1 (enExample)
JP (1) JP5876620B2 (enExample)
KR (1) KR102118227B1 (enExample)
CN (1) CN104487051B (enExample)
AP (1) AP2014008152A0 (enExample)
AR (1) AR091633A1 (enExample)
AU (1) AU2013282753B2 (enExample)
BR (1) BR112014032818B1 (enExample)
CA (1) CA2876801C (enExample)
CL (1) CL2014003536A1 (enExample)
CO (1) CO7240357A2 (enExample)
CR (1) CR20150036A (enExample)
CU (1) CU20140150A7 (enExample)
CY (1) CY1117691T1 (enExample)
DK (1) DK2874602T3 (enExample)
DO (1) DOP2014000302A (enExample)
EA (1) EA028909B1 (enExample)
EC (1) ECSP15000500A (enExample)
ES (1) ES2578012T3 (enExample)
GE (1) GEP201706689B (enExample)
HR (1) HRP20160706T1 (enExample)
HU (1) HUE029431T2 (enExample)
IL (1) IL236423A (enExample)
IT (1) ITMI20121154A1 (enExample)
MA (1) MA37811B1 (enExample)
MD (1) MD4537C1 (enExample)
ME (1) ME02431B (enExample)
MX (1) MX369264B (enExample)
MY (1) MY169251A (enExample)
NI (1) NI201400147A (enExample)
NZ (1) NZ703829A (enExample)
PE (1) PE20150331A1 (enExample)
PH (1) PH12015500178B1 (enExample)
PL (1) PL2874602T3 (enExample)
PT (1) PT2874602T (enExample)
RS (1) RS54844B1 (enExample)
SG (2) SG10201704482YA (enExample)
SI (1) SI2874602T1 (enExample)
SM (1) SMT201600248B (enExample)
TN (1) TN2014000526A1 (enExample)
UA (1) UA117101C2 (enExample)
WO (1) WO2014002042A1 (enExample)
ZA (1) ZA201409478B (enExample)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072080A2 (de) * 2001-03-13 2002-09-19 Fresenius Kabi De Gmbh Lagerstabile fertiginfusionslösungen des paracetamols
EP1752139A1 (de) * 2005-08-05 2007-02-14 TheraSelect GmbH Stabile, flüssige Formulierung von Paracetamol

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427728T2 (de) * 1993-04-14 2002-05-08 Nippon Sanso Corp., Tokio/Tokyo Vorrichtung zur herabsetzung vom gelöstem sauerstoff
US6171298B1 (en) * 1996-05-03 2001-01-09 Situs Corporation Intravesical infuser
FR2751875B1 (fr) 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
FR2809619B1 (fr) 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
US20050203175A1 (en) * 2001-12-18 2005-09-15 Ioulia Tseti Parenteral composition of paracetamol
FR2851164B1 (fr) 2003-02-14 2005-04-22 Xuan Tho Nguyen Formulation liquide injectable de paracetamol
AU2006346318B2 (en) * 2006-07-18 2011-02-10 Genfarma Laboratorio S.L. Injectable liquid paracetamol formulation
CN101015542A (zh) * 2007-02-13 2007-08-15 天津生机集团有限公司 家畜用复方对乙酰氨基酚注射液及其制备方法
MD3528G2 (ro) * 2007-09-28 2008-11-30 Сергей ШАНДРУ Metodă de anestezie spinală continuă la pacienţii în etate
CA2705733C (en) * 2007-11-13 2015-02-03 Cadence Pharmaceuticals Reduced dose intravenous acetaminophen
EP2307056B1 (en) 2008-01-17 2021-12-15 Pharmis Biofarmacêutica, LDA Stabilized aqueous formulation containing paracetamol
WO2009143558A1 (en) 2008-05-26 2009-12-03 Silphion Pty Limited Injectable formulations
EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
JP2013006770A (ja) 2009-10-09 2013-01-10 Ssp Co Ltd アセトアミノフェン含有経口液剤
BR112012031928B1 (pt) * 2010-06-30 2021-08-31 Troikaa Pharmaceuticals Ltd Composições farmacêuticas as quais incluem paracetamol e processo para preparação do mesmo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072080A2 (de) * 2001-03-13 2002-09-19 Fresenius Kabi De Gmbh Lagerstabile fertiginfusionslösungen des paracetamols
EP1752139A1 (de) * 2005-08-05 2007-02-14 TheraSelect GmbH Stabile, flüssige Formulierung von Paracetamol

Also Published As

Publication number Publication date
MA37811A1 (fr) 2016-10-31
MX2014015402A (es) 2015-06-17
HRP20160706T1 (hr) 2016-08-12
EP2874602B1 (en) 2016-03-30
MY169251A (en) 2019-03-19
US20150148379A1 (en) 2015-05-28
AP2014008152A0 (en) 2014-12-31
US11344517B2 (en) 2022-05-31
PH12015500178B1 (en) 2021-08-04
NI201400147A (es) 2015-04-13
EA201500065A1 (ru) 2015-10-30
CY1117691T1 (el) 2017-05-17
MD4537B1 (ro) 2017-12-31
NZ703829A (en) 2016-06-24
CN104487051A (zh) 2015-04-01
ME02431B (me) 2016-09-20
WO2014002042A1 (en) 2014-01-03
JP2015522004A (ja) 2015-08-03
MD20140138A2 (ro) 2015-06-30
PL2874602T3 (pl) 2016-10-31
AU2013282753B2 (en) 2017-03-02
ECSP15000500A (es) 2015-11-30
KR102118227B1 (ko) 2020-06-03
SG10201704482YA (en) 2017-07-28
US20160128955A1 (en) 2016-05-12
DK2874602T3 (en) 2016-07-04
ITMI20121154A1 (it) 2013-12-30
RS54844B1 (sr) 2016-10-31
SI2874602T1 (sl) 2016-09-30
CO7240357A2 (es) 2015-04-17
PT2874602T (pt) 2016-07-13
AR091633A1 (es) 2015-02-18
SG11201408479WA (en) 2015-01-29
MA37811B1 (fr) 2017-07-31
UA117101C2 (uk) 2018-06-25
IL236423A0 (en) 2015-02-26
SMT201600248B (it) 2016-08-31
DOP2014000302A (es) 2015-03-15
MX369264B (es) 2019-11-04
HUE029431T2 (en) 2017-03-28
BR112014032818B1 (pt) 2022-06-14
IL236423A (en) 2017-07-31
CU20140150A7 (es) 2015-10-27
PE20150331A1 (es) 2015-03-07
PH12015500178A1 (en) 2015-04-06
AU2013282753A1 (en) 2015-02-05
EP2874602A1 (en) 2015-05-27
EA028909B1 (ru) 2018-01-31
KR20150027160A (ko) 2015-03-11
CR20150036A (es) 2015-03-13
TN2014000526A1 (en) 2016-03-30
JP5876620B2 (ja) 2016-03-02
ES2578012T3 (es) 2016-07-20
MD4537C1 (ro) 2018-07-31
BR112014032818A2 (pt) 2017-06-27
CA2876801A1 (en) 2014-01-03
CA2876801C (en) 2020-11-03
CL2014003536A1 (es) 2015-05-08
ZA201409478B (en) 2016-01-27
GEP201706689B (en) 2017-06-26

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