CN104430411A - Sterilization composition - Google Patents
Sterilization composition Download PDFInfo
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- CN104430411A CN104430411A CN201410575827.5A CN201410575827A CN104430411A CN 104430411 A CN104430411 A CN 104430411A CN 201410575827 A CN201410575827 A CN 201410575827A CN 104430411 A CN104430411 A CN 104430411A
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- thifluzamide
- chlorobenzene ether
- rice
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- acid amides
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Abstract
The invention belongs to the technical field of pesticides and relates to a sterilization composition. The sterilization composition is characterized in that active ingredients of the sterilization composition include chlorobenzene ester amide and thifluzamide. The composition can be made into a suspending agent and is remarkable in synergistic effect and safe and harmless to crops.
Description
Technical field
The invention belongs to technical field of pesticide, contain the bactericidal composition with synergistic effect of thifluzamide and chlorobenzene ether acid amides specifically.
Background technology
Thifluzamide (Thifluzamide) is novel low toxicity, efficient, wide-spectrum bactericide, belong to thiazole amide bactericide, thifluzamide is succinate dehydrogenase inhibitor, its mechanism of action is by suppressing succinate dehydrogenase in germ tricarbonic acid cycle, cause thalline dead, there is strong Uptake and translocation and long lasting effect.Show all there is good control efficiency to rice sheath blight disease, wheat sharp eyespot through field control effectiveness test result.This composition shows paddy rice, wheat through field efficacy experiment, has no poisoning and occurs.
Chlorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, has extraordinary effect to the banded sclerotial blight that the crop such as paddy rice, wheat is common, and active ingredient is novel, non-resistant.
Rice sheath blight disease, also known as moire disease, is one of Major Diseases in current Rice Production.All there is generation in paddy rice producing region, causes harm seriously in South Rice Region of China, and the not plump paddy making paddy rice not ear or to ear is more, causes Rice Yield Loss Caused.Paddy rice main producing region banded sclerotial blight medicament is reused in a large number all the time, improves Disease Resistance, causes rice sheath blight disease seriously to occur year after year.
Summary of the invention
The object of this invention is to provide and a kind ofly there is synergistic effect and the bactericidal composition of safety and environmental protection, for the water prevention rice sheath blight, compared with existing pesticide control, realize improving drug effect, decreasing pollution, the object that reduces costs.Be specifically related to the complex preparation of thifluzamide and chlorobenzene ether acid amides.
Utilizing above-mentioned bactericidal composition, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, is suspending agent.
In above-mentioned bactericidal composition, the weight ratio of thifluzamide and chlorobenzene ether acid amides is 1:50-100:1.
Above-mentioned bactericidal composition has following characteristics: the 1. advanced environmental protection of formulation, and environmental pollution is little; 2. bactericidal action is strong, not easily develops immunity to drugs; 3. two kinds of compositions are composite, have synergistic effect; 4. active ingredient is advanced, non-resistant.
First applicant uses these two kinds of compositions to carry out indoor biometrics test, test method and result as follows:
First, after analyzing the action character of two kinds of active ingredients, the raw object surveyed is decided to be Rhizoctonia solani Kuhn by us, and this bacterium can cause rice sheath blight disease.
The test method of indoor biometrics is with reference to NY/T1156.6-2006: adopt growth rate method to measure medicament to the inhibitory action of rice sheath blight disease bacteria growing.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the former medicine of 96% thifluzamide and the former medicine of 95% chlorobenzene ether acid amides with methyl alcohol to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of identical amount methyl alcohol for blank for four times; With card punch (Φ 5mm) the picking Rhizoctonia solani Kuhn cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be placed in the interior cultivation of constant incubator of 25 DEG C, cultivate and within 6 days, adopt right-angled intersection method to measure colony diameter afterwards, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when co-toxicity coefficient CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Table 1 thifluzamide, chlorobenzene ether acid amides and different ratio thereof are to the measurement result of rice sheath blight disease co-toxicity coefficient
Analyze above-mentioned data, when thifluzamide and chlorobenzene ether acid amides are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of rice sheath blight disease is had to the synergistic effect of different proportion.Visible, the complex preparation of thifluzamide and chlorobenzene ether acid amides can become the favourable agents of the water prevention rice sheath blight.
Tested by indoor biometrics, checking thifluzamide and chlorobenzene ether acid amides two kinds of active ingredients composite after, have good synergistic effect, below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 35.7% thifluzamide chlorobenzene ether amide suspending agents
Example two, 20.8% thifluzamide chlorobenzene ether amide suspending agents
Example three, 11% thifluzamide chlorobenzene ether amide suspending agents
Example four, 18% thifluzamide chlorobenzene ether amide suspending agents
Example five, 20% thifluzamide chlorobenzene ether amide suspending agents
Example six, 30% thifluzamide chlorobenzene ether amide suspending agents
Example seven, 22% thifluzamide chlorobenzene ether amide suspending agents
Example eight, 26% thifluzamide chlorobenzene ether amide suspending agents
Example nine, 30.6% thifluzamide chlorobenzene ether amide suspending agents
Example ten, 40.4% thifluzamide chlorobenzene ether amide suspending agents
Select above example to carry out the field trial of the water prevention rice sheath blight, determine the effect of the formula water prevention rice sheath blight; Simultaneously by the Contrast on effect with thifluzamide and chlorobenzene ether acid amides single dose, verify composite after synergistic effect.Concrete test method is with reference to GB/T17980.20-2000.20% thifluzamide chlorobenzene ether amide suspending agents and other preparation do the field control effectiveness test of the water prevention rice sheath blight, carry out comparative trial with 24% thifluzamide suspending agent and 24% chlorobenzene ether amide suspending agents single dose simultaneously.Test site is rice district, Hongze County, Huai'an, Jiangsu Province, time is on August 15th, 2014, test each process four repetition, community randomized arrangement, each plot area is 25m2, adopts back-pack electric compression sprayer, dispenser was sunny calm for the same day, the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
| Date | Weather | With or without special weather situation |
| 8-15 | 22-28 DEG C fine | Nothing |
| 8-16 | 20-30 DEG C fine | Nothing |
| 8-17 | 21-31 DEG C cloudy | Nothing |
| 8-18 | 22-31 DEG C cloudy | Nothing |
| 8-19 | 20-29 DEG C fine | Nothing |
| 8-20 | 25-32 DEG C fine | Nothing |
| 8-21 | 22-30 DEG C cloudy | Nothing |
| 8-22 | 24-31 DEG C cloudy | Nothing |
| 8-23 | 25-34 DEG C fine | Nothing |
| 8-24 | 22-31 DEG C fine | Nothing |
| 8-25 | 22-30 DEG C cloudy | Nothing |
| 8-26 | 20-33 DEG C of the moon | Nothing |
| 8-27 | 18-32 DEG C cloudy | Nothing |
| 8-28 | 25-31 DEG C cloudy | Nothing |
| 8-29 | 25-32 DEG C fine | Nothing |
Investigation method is: often according to rice leaf sheath and blade damage symptom grading, in units of strain, every community diagonal 5 sampling, and often some investigation is connected 5 clumps, totally 25 clumps, records total strain number, diseased plant number and sick progression.Investigation in 7th day after dispenser, dispenser 2 times, investigates each community disease and refers to altogether, calculates preventive effect, and carries out the new multipole difference analysis of Deng Kenshi.
0 grade: complete stool is anosis;
1 grade: quaterfoil and following leaf sheath thereof, blade morbidity (taking sword-like leave as first leaf);
3 grades: Three-blade and following leaf sheath thereof, blade is fallen ill;
5 grades: second blade and following leaf sheath thereof, blade is fallen ill;
7 grades: sword-like leave and following leaf sheath thereof, blade is fallen ill;
9 grades: complete stool falls ill, withered ahead of time.
Table 320% thifluzamide chlorobenzene ether amide suspending agents and different agents are to the preventive effect of rice sheath blight disease
As can be seen from above-mentioned data, thifluzamide and chlorobenzene ether acid amides complex preparation after first time medicine 7 days preventive effects all more than 71%, and the preventive effect of 24% thifluzamide suspending agent is 51.40%, the preventive effect of 24% chlorobenzene ether amide suspending agents is 49.77%, visible, after two kinds of active ingredients are composite, there is good synergistic effect.And after last medicine 7 days, all complex preparations have all exceeded 78% to the preventive effect of rice sheath blight disease.Compared with after first time medicine 7 days, preventive effect is higher.In summary, complex preparation can well improve drug effect, extends the lasting period, alleviates the amount of labour of peasant, have very high practicality.
Claims (2)
1. a bactericidal composition, is characterized in that: active component is made up of thifluzamide and chlorobenzene ether acid amides, and the weight ratio of described thifluzamide and chlorobenzene ether acid amides is 1:50 ~ 100:1.
2. composition according to claim 1, is characterized in that: make suspending agent by active component and auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410575827.5A CN104430411A (en) | 2014-10-25 | 2014-10-25 | Sterilization composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410575827.5A CN104430411A (en) | 2014-10-25 | 2014-10-25 | Sterilization composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104430411A true CN104430411A (en) | 2015-03-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410575827.5A Pending CN104430411A (en) | 2014-10-25 | 2014-10-25 | Sterilization composition |
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| CN (1) | CN104430411A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
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- 2014-10-25 CN CN201410575827.5A patent/CN104430411A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
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Application publication date: 20150325 |