CN104418941B - 万古霉素衍生物、制备方法及其应用 - Google Patents

万古霉素衍生物、制备方法及其应用 Download PDF

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Publication number
CN104418941B
CN104418941B CN201310361577.0A CN201310361577A CN104418941B CN 104418941 B CN104418941 B CN 104418941B CN 201310361577 A CN201310361577 A CN 201310361577A CN 104418941 B CN104418941 B CN 104418941B
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CN
China
Prior art keywords
alkyl
vancomycin
amino
coor
aryl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201310361577.0A
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English (en)
Chinese (zh)
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CN104418941A (zh
Inventor
葛敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACESYS PHARMATECH Ltd
Original Assignee
ACESYS PHARMATECH Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201711062456.0A priority Critical patent/CN107759672A/zh
Application filed by ACESYS PHARMATECH Ltd filed Critical ACESYS PHARMATECH Ltd
Priority to CN201310361577.0A priority patent/CN104418941B/zh
Priority to AU2014311148A priority patent/AU2014311148B2/en
Priority to KR1020167006849A priority patent/KR20160043094A/ko
Priority to US14/912,573 priority patent/US9828413B2/en
Priority to MX2016002190A priority patent/MX2016002190A/es
Priority to SG11201601127TA priority patent/SG11201601127TA/en
Priority to CA2921080A priority patent/CA2921080A1/en
Priority to EP14838314.4A priority patent/EP3037431A4/en
Priority to PCT/CN2014/075905 priority patent/WO2015024389A1/zh
Priority to JP2016535311A priority patent/JP6452698B2/ja
Priority to BR112016003491A priority patent/BR112016003491A2/pt
Priority to EA201690396A priority patent/EA029855B1/ru
Priority to NZ717098A priority patent/NZ717098A/en
Publication of CN104418941A publication Critical patent/CN104418941A/zh
Priority to IL244140A priority patent/IL244140A0/en
Priority to ZA2016/01343A priority patent/ZA201601343B/en
Application granted granted Critical
Publication of CN104418941B publication Critical patent/CN104418941B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201310361577.0A 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用 Expired - Fee Related CN104418941B (zh)

Priority Applications (16)

Application Number Priority Date Filing Date Title
CN201310361577.0A CN104418941B (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用
CN201711062456.0A CN107759672A (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用
BR112016003491A BR112016003491A2 (pt) 2013-08-19 2014-04-22 derivado de vancomicina e processo de preparação para aplicação deste
US14/912,573 US9828413B2 (en) 2013-08-19 2014-04-22 Vancomycin derivative, and preparation method and application thereof
MX2016002190A MX2016002190A (es) 2013-08-19 2014-04-22 Derivado de vancomicina, y procedimiento de preparacion y aplicacion del mismo.
SG11201601127TA SG11201601127TA (en) 2013-08-19 2014-04-22 Vancomycin derivative, and preparation method and application thereof
CA2921080A CA2921080A1 (en) 2013-08-19 2014-04-22 Vancomycin derivative, and preparation process and application thereof
EP14838314.4A EP3037431A4 (en) 2013-08-19 2014-04-22 Vancomycin derivative, and preparation method and application thereof
AU2014311148A AU2014311148B2 (en) 2013-08-19 2014-04-22 Vancomycin derivative, and preparation method and application thereof
JP2016535311A JP6452698B2 (ja) 2013-08-19 2014-04-22 バンコマイシン誘導体、その製造方法及び応用
KR1020167006849A KR20160043094A (ko) 2013-08-19 2014-04-22 반코마이신 유도체 및 그 제조 방법과 용도
EA201690396A EA029855B1 (ru) 2013-08-19 2014-04-22 Производное ванкомицина, способ его получения и его применение
NZ717098A NZ717098A (en) 2013-08-19 2014-04-22 Vancomycin derivative, and preparation method and application thereof
PCT/CN2014/075905 WO2015024389A1 (zh) 2013-08-19 2014-04-22 万古霉素衍生物、制备方法及其应用
IL244140A IL244140A0 (en) 2013-08-19 2016-02-15 Vancomycin derivative, method for its preparation and use
ZA2016/01343A ZA201601343B (en) 2013-08-19 2016-02-26 Vancomycin derivative, and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310361577.0A CN104418941B (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201711062456.0A Division CN107759672A (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用

Publications (2)

Publication Number Publication Date
CN104418941A CN104418941A (zh) 2015-03-18
CN104418941B true CN104418941B (zh) 2017-11-07

Family

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Family Applications (2)

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CN201310361577.0A Expired - Fee Related CN104418941B (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用
CN201711062456.0A Pending CN107759672A (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201711062456.0A Pending CN107759672A (zh) 2013-08-19 2013-08-19 万古霉素衍生物、制备方法及其应用

Country Status (15)

Country Link
US (1) US9828413B2 (enExample)
EP (1) EP3037431A4 (enExample)
JP (1) JP6452698B2 (enExample)
KR (1) KR20160043094A (enExample)
CN (2) CN104418941B (enExample)
AU (1) AU2014311148B2 (enExample)
BR (1) BR112016003491A2 (enExample)
CA (1) CA2921080A1 (enExample)
EA (1) EA029855B1 (enExample)
IL (1) IL244140A0 (enExample)
MX (1) MX2016002190A (enExample)
NZ (1) NZ717098A (enExample)
SG (1) SG11201601127TA (enExample)
WO (1) WO2015024389A1 (enExample)
ZA (1) ZA201601343B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105985412A (zh) * 2015-02-28 2016-10-05 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用
CN107365359B (zh) * 2017-07-17 2021-06-04 昆明理工大学 一种万古霉素手性功能单体合成方法
CN107759671A (zh) * 2017-09-11 2018-03-06 昆明理工大学 水相中合成万古霉素手性功能单体的方法
USD922342S1 (en) 2018-10-05 2021-06-15 Samsung Electronics Co., Ltd. Television receiver
USD906992S1 (en) 2018-12-13 2021-01-05 Samsung Electronics Co., Ltd. Television receiver
CN112079902B (zh) * 2019-06-12 2025-05-06 迪普深合医药研发(上海)有限公司 万古霉素衍生物、其中间体、制备方法、组合物及用途
EP4069712A4 (en) * 2019-12-04 2024-03-13 University of Massachusetts COMPOSITIONS AND METHODS FOR ON-DEMAND RELEASE OF ANTIMICROBIAL AGENTS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1052483A (zh) * 1989-12-13 1991-06-26 伊莱利利公司 糖肽衍生物的改进及有关的糖肽衍生物
WO1996030401A1 (en) * 1995-03-24 1996-10-03 Eli Lilly And Company Glycopeptide antibiotic derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2145609C1 (ru) * 1994-01-28 2000-02-20 Эли Лилли Энд Компани Производные гликопептида или их соли, способ получения, фармацевтическая композиция
EP1095058A4 (en) 1998-07-14 2003-07-16 Univ Princeton GLYCOPEPTIDANTIBIOTICS, COMBINATIONAL LIBRARIES OF GLYCOPEPTIDANTIBIOTICS AND METHOD FOR THEIR PRODUCTION
GB0026924D0 (en) 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
TWI233932B (en) 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
US8193312B2 (en) 2004-01-28 2012-06-05 The Regents Of The University Of California Bone morphogenic protein binding peptide
US8778874B2 (en) * 2004-11-29 2014-07-15 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
CN104418941B (zh) * 2013-08-19 2017-11-07 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1052483A (zh) * 1989-12-13 1991-06-26 伊莱利利公司 糖肽衍生物的改进及有关的糖肽衍生物
WO1996030401A1 (en) * 1995-03-24 1996-10-03 Eli Lilly And Company Glycopeptide antibiotic derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis of analogues of the 2-O-alkyl glycerate part of the moenomycins;Uwe Eichelberger，et al.，;《Tetrahedron》;20021203;第58卷;第545-559页 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用

Also Published As

Publication number Publication date
AU2014311148B2 (en) 2017-07-13
US20160200768A1 (en) 2016-07-14
EP3037431A1 (en) 2016-06-29
EP3037431A4 (en) 2017-04-19
EA201690396A1 (ru) 2016-06-30
AU2014311148A1 (en) 2016-03-10
MX2016002190A (es) 2016-11-25
IL244140A0 (en) 2016-04-21
NZ717098A (en) 2017-06-30
CA2921080A1 (en) 2015-02-26
US9828413B2 (en) 2017-11-28
KR20160043094A (ko) 2016-04-20
CN107759672A (zh) 2018-03-06
JP6452698B2 (ja) 2019-01-16
BR112016003491A2 (pt) 2017-09-12
ZA201601343B (en) 2017-05-31
WO2015024389A1 (zh) 2015-02-26
EA029855B1 (ru) 2018-05-31
JP2016528262A (ja) 2016-09-15
SG11201601127TA (en) 2016-03-30
CN104418941A (zh) 2015-03-18

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C06 Publication
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SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: ACESYS PHARMATECH (NANJING) CO., LTD.

Free format text: FORMER OWNER: NANJING YOUJIE PHARMACEUTICAL TECHNOLOGY CO., LTD.

Effective date: 20150812

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20150812

Address after: 24, building 5, block B, Nanjing science and Technology Plaza, No. 210009, new exemplary Road, Jiangsu, Nanjing

Applicant after: ACESYS PHARMATECH Ltd.

Address before: 24, building 5, block B, Nanjing science and Technology Plaza, No. 210009, new exemplary Road, Jiangsu, Nanjing

Applicant before: ACESYS PHARMATECH Ltd.

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20171107

Termination date: 20210819