CN1044116C - 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途 - Google Patents

用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途 Download PDF

Info

Publication number
CN1044116C
CN1044116C CN94194304A CN94194304A CN1044116C CN 1044116 C CN1044116 C CN 1044116C CN 94194304 A CN94194304 A CN 94194304A CN 94194304 A CN94194304 A CN 94194304A CN 1044116 C CN1044116 C CN 1044116C
Authority
CN
China
Prior art keywords
compound
chloro
acid
reaction
milliliters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94194304A
Other languages
English (en)
Chinese (zh)
Other versions
CN1136311A (zh
Inventor
R·L·哈里森
G·库
S·B·梅克兰茨
C·R·多尔顿
D·M·斯坦莫里克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of CN1136311A publication Critical patent/CN1136311A/zh
Application granted granted Critical
Publication of CN1044116C publication Critical patent/CN1044116C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN94194304A 1993-11-29 1994-11-03 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途 Expired - Fee Related CN1044116C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15901493A 1993-11-29 1993-11-29
US159014 1993-11-29

Publications (2)

Publication Number Publication Date
CN1136311A CN1136311A (zh) 1996-11-20
CN1044116C true CN1044116C (zh) 1999-07-14

Family

ID=22570705

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94194304A Expired - Fee Related CN1044116C (zh) 1993-11-29 1994-11-03 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途

Country Status (21)

Country Link
US (1) US5684017A (cg-RX-API-DMAC7.html)
EP (1) EP0731791B1 (cg-RX-API-DMAC7.html)
JP (1) JPH09506345A (cg-RX-API-DMAC7.html)
KR (1) KR100340375B1 (cg-RX-API-DMAC7.html)
CN (1) CN1044116C (cg-RX-API-DMAC7.html)
AT (1) ATE177083T1 (cg-RX-API-DMAC7.html)
AU (1) AU683114B2 (cg-RX-API-DMAC7.html)
CA (1) CA2175458C (cg-RX-API-DMAC7.html)
DE (1) DE69416859T2 (cg-RX-API-DMAC7.html)
DK (1) DK0731791T3 (cg-RX-API-DMAC7.html)
ES (1) ES2131297T3 (cg-RX-API-DMAC7.html)
FI (1) FI109901B (cg-RX-API-DMAC7.html)
GR (1) GR3029827T3 (cg-RX-API-DMAC7.html)
HU (1) HU219565B (cg-RX-API-DMAC7.html)
IL (1) IL111776A (cg-RX-API-DMAC7.html)
NO (1) NO306211B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ276577A (cg-RX-API-DMAC7.html)
PT (1) PT731791E (cg-RX-API-DMAC7.html)
TW (1) TW279161B (cg-RX-API-DMAC7.html)
WO (1) WO1995014669A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA949303B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
DE19705133A1 (de) * 1997-02-11 1998-08-13 Hoechst Ag Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN1302206A (zh) * 1997-10-17 2001-07-04 阿温蒂斯药物制品公司 喹啉衍生物的治疗用途
DE19858253A1 (de) * 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
NO345566B1 (no) 2001-06-26 2021-04-19 Amgen Inc OPGL bindende antistoff, farmasøytisk sammensetning samt anvendelse derav
EP1406621A2 (en) * 2001-06-26 2004-04-14 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
AU2003299971A1 (en) 2002-12-30 2004-07-29 Amgen Inc. Combination therapy with co-stimulatory factors
KR100687522B1 (ko) * 2005-05-28 2007-02-27 한국화학연구원 2,2-디메틸-3-에스테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 pge2 활성에 관련된 염증질환 치료제
CN104447489B (zh) * 2014-12-29 2017-01-11 南京工业大学 3,4-二芳基马来酰亚胺衍生物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015565A1 (en) * 1991-02-27 1992-09-17 Merrell Dow Pharmaceuticals Inc. Nmda antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US3921636A (en) * 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
GB8719102D0 (en) * 1987-08-12 1987-09-16 Merck Sharp & Dohme Therapeutic agents
HU222819B1 (hu) * 1993-11-29 2003-11-28 Merrell Pharmaceuticals Inc. IL-1 hatást gátló (benzolszulfonil-imino)-kromén-származékok és alkalmazásuk

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015565A1 (en) * 1991-02-27 1992-09-17 Merrell Dow Pharmaceuticals Inc. Nmda antagonists

Also Published As

Publication number Publication date
PT731791E (pt) 2000-11-30
CA2175458A1 (en) 1995-06-01
JPH09506345A (ja) 1997-06-24
NO306211B1 (no) 1999-10-04
NZ276577A (en) 1997-11-24
KR960706476A (ko) 1996-12-09
IL111776A (en) 1999-06-20
IL111776A0 (en) 1995-01-24
HU219565B (hu) 2001-05-28
EP0731791B1 (en) 1999-03-03
ATE177083T1 (de) 1999-03-15
ZA949303B (en) 1995-08-07
AU683114B2 (en) 1997-10-30
CN1136311A (zh) 1996-11-20
FI962235A0 (fi) 1996-05-28
FI109901B (fi) 2002-10-31
DE69416859T2 (de) 1999-08-05
ES2131297T3 (es) 1999-07-16
DE69416859D1 (de) 1999-04-08
US5684017A (en) 1997-11-04
NO962155L (no) 1996-05-28
GR3029827T3 (en) 1999-06-30
AU1087995A (en) 1995-06-13
FI962235L (fi) 1996-05-28
KR100340375B1 (ko) 2002-11-13
DK0731791T3 (da) 1999-09-27
HU9601435D0 (en) 1996-07-29
EP0731791A1 (en) 1996-09-18
TW279161B (cg-RX-API-DMAC7.html) 1996-06-21
NO962155D0 (no) 1996-05-28
CA2175458C (en) 1999-03-02
WO1995014669A1 (en) 1995-06-01
HUT76273A (en) 1997-07-28

Similar Documents

Publication Publication Date Title
CN1044116C (zh) 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途
CN100339374C (zh) 调节雌激素受体的化合物和方法
CN1093759C (zh) 蛋白激酶c抑制剂
US5491153A (en) 3-amidoindolyl derivative
JP5676769B2 (ja) Ａｈｒ活性化因子としての１，２‐ジヒドロ‐４‐ヒドロキシ‐２‐オキソ‐キノリン‐３‐カルボキシアニリド
CZ20033529A3 (cs) Nové deriváty indolu s afinitou k receptoru 5-HT6
CN1726191A (zh) 用作纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代的吲哚氧代－乙酰氨基乙酸衍生物
CN1228775A (zh) 作为时间生物学药物的苯并呋喃和苯并吡喃
CN1708495A (zh) 杂环化合物及以其为有效成分的抗肿瘤药
EA019702B1 (ru) Замещенные производные индазола и азаиндазола в качестве модуляторов гамма-секретазы
CN1795187A (zh) 新型ido抑制剂及其使用方法
KR0178281B1 (ko) 3-인돌릴 티오아세테이트 유도체 및 이를 함유하는 약제학적 조성물
CN87104099A (zh) 抗变态反应和消炎药剂
CN1045596C (zh) 杂环苯磺酰亚胺衍生物的药物用途，该类新化合物及其药物组合物
CN115677762B (zh) 一种苯磺酰氨基膦酸酯衍生物及其制备方法、应用
CN1051302C (zh) 3－(吲哚－3－基)丙烯酸衍生物及其用作nmda拮抗剂
US20040162276A1 (en) Indazole or indole derivatives, and use thereof in human medicine and more particularly in oncology
CN1307563A (zh) N－苯基－n′－苯丙基哌嗪衍生物及其制备方法
CN1671708A (zh) 新的环烷二酮衍生物、它们的制备方法和它们的药物应用
CN1053448C (zh) 用作抗增殖药物及garft抑制剂的化合物
CN1049497A (zh) 取代的苯甲酰脲化合物或它们的盐、它们的制备方法及含有该类物质的抗肿瘤组合物
CN1047076A (zh) 苯乙醇胺衍生物的制备
CN1110485C (zh) 1－芳基磺酰基、芳基(硫代)羰基－哒嗪子基衍生物及其制法
HK1030946A (en) O-substituted hydroxycoumaranone derivatives as antitumor and antimetastatic agents
CN1019390B (zh) 戊二酰亚胺抗焦虑及抗高血压化合物的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee