CN104398754A - Traditional Chinese medicine composition capable of improving hypoxia endurance, preparation method and applications thereof - Google Patents

Traditional Chinese medicine composition capable of improving hypoxia endurance, preparation method and applications thereof Download PDF

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CN104398754A
CN104398754A CN201410626501.0A CN201410626501A CN104398754A CN 104398754 A CN104398754 A CN 104398754A CN 201410626501 A CN201410626501 A CN 201410626501A CN 104398754 A CN104398754 A CN 104398754A
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朱海燕
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a traditional Chinese medicine composition capable of improving the hypoxia endurance. The composition comprises tripterospermum, negundo chastetree branchlet, beechey fig root, treebine stem, etc. The dosage form can be particles, tablets, or capsules. The invention also discloses a preparation method of the composition. The preparation method comprises the following steps: decocting the raw materials mentioned above in water, condensing the decoction, performing alcohol precipitation, carrying out spray drying, grinding the obtained particles to obtain dried extract powder, and adding auxiliary materials so as to obtain the target preparation. The invention also discloses an application of the composition in preparation of drugs for improving the hypoxia endurance.

Description

A kind of Chinese medicine composition improving anoxia endurance and its preparation method and application
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition improving anoxia endurance and its preparation method and application.
Background technology
Be applied at present and improve the medicine of anoxia endurance and tonic is a lot, but these kind toxic and side effects are comparatively large, and be inconvenient to take, up to now, people are finding a kind of Chinese medicine making the raising anoxia endurance of simple, taking convenience.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation improving anoxia endurance.
Technical scheme: the object of the invention is by following scheme realize:
Have the Chinese medicine composition improving anoxia endurance, it is prepared by the raw material of following parts by weight: Herba Tripterospermi 10 parts, Ramulus viticis negundo 12 parts, Radix Fici beecheyanae 8 parts, Cissus pteroclada Hayata 14 parts, Rubus sieboldi Blume. 12 parts, Radix scirpi triangulati 10 parts, Herba Girardiniae Palmatae 16 parts, Herba Brediae Amoenae 8 parts, Radix Bauhiniae Hupehanae 12 parts, Radix Elaeagni 14 parts, Herba Wahlenbergiae 16 parts, Radix Lysionoti Serrati 12 parts, Cortex Lespedezae Buergeri 14 parts, Herba Houttuyniae 8 parts, Rhizoma dispori flaventis 10 parts.
Described a kind of Chinese medicine composition with raising anoxia endurance, preparation method comprises the steps: that getting above-mentioned medical material merges, decoct with water twice, collecting decoction, concentrated, add ethanol precipitate with ethanol, leave standstill, filter, filtrate reduced in volume, spraying dry, adds adjuvant and makes capsule, tablet, granule.
The above-mentioned preparation method with the Chinese medicine composition of anti-fatigue effect, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, and second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
The above-mentioned preparation method with the Chinese medicine composition of anti-fatigue effect, described spray drying condition is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Described have the application of raising anoxia endurance Chinese medicine composition in preparation raising anoxia endurance medicine.
Above-mentioned Herba Tripterospermi is the herb of Gentianaceae Tripterospermum plant Tripterospermum affine Tripterospermum affine (Wall.) H.Smith.The four seasons can adopt.Clean, dry.Heat-clearing and toxic substances removing, cough-relieving is stopped blooding.For bronchitis, hemoptysis of pulmonary tuberculosis, pneumonia, lung abscess, nephritis, urinary system infection; Furuncle furuncle and phyma is controlled in external, mastitis, traumatic hemorrhage.
Ramulus viticis negundo is the branch of Verbenaceae five-leaved chaste tree, expelling pathogenic wind from the body surface, subduing swelling and detoxicating.
Radix Fici beecheyanae is the root of moraceae plants Fructus Fici Beecheyanae.Invigorating the spleen and replenishing QI, invigorating the spleen for eliminating dampness, bone and muscle strengthening, detumescence, promoting blood circulation and detoxication.Control the middle deficiency of vital energy weak, QI and blood is on the decline, and extremity are aching and limp, stiffness of the muscle and joint, amenorrhea, galactostasis."
Cissus pteroclada Hayata is Vitaceae Cissus plant Cissus pteroclada Hayata Cissus pteroclada Hayata, is used as medicine with rattan.The whole year can adopt, and dries.Wind-damp dispelling, relax meridians.For rheumatic arthralgia, joint distending pain, lumbar muscle strain, grain contracture.
Rubus sieboldi Blume. is the Herb of the rosaceous plant hot pillar certain kind of berries.Latin name: Rubus sieboldi Blume., hemostasis, invigorates blood circulation, pain relieving, antipyretic diuresis.
Radix scirpi triangulati is the root of sedge water hair flower, and Classification system Scirpus triangulatus Roxb., has heat clearing away, diuresis.Control heat symptom-complex toothache, stranguria, the effects such as leucorrhea.
Herba Girardiniae Palmatae is herb or the root of contrayerva Herba Girardiniae Palmatae.Expelling pathogenic wind from the body surface, promoting the circulation of QI expectorant, Qinghuo Jiedu.Control the cough due to common cold, abundant expectoration uncomfortable in chest, skin is itched, sore.
Herba Brediae Amoenae is herb and the root of Melastomateae plants Herba Brediae Amoenae.Expelling wind and removing dampness, promoting blood flow to regulate menstruation.
Radix Bauhiniae Hupehanae is pulse family bauhinia bauhinia hupehana Craib Bauhinia hupehana Craib, is used as medicine with root.Wild product are uprooted autumn; Cultivation product are in cultivation after 3,4 years, and autumn uproots, and dries.Clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.For preventing and treating dysentery, painful and swollen testis, eczema scrotum.
Radix Elaeagni is the root of Elaeangnaceae plant Fructus Elaeagni, has cough-relieving, stops blooding, dispels the wind, dampness removing, removing food stagnancy are stagnant, effect of throat.
Herba Wahlenbergiae is root or the whole herb with root of Campanulaceae Herba Wahlenbergiae.Latin name: Wahlenbergia marginata (Thunb.) A.DC., tonify deficiency, induces sweat.Control deficient impairment caused by overstrain, hemoptysis, epistaxis, spontaneous perspiration, night sweat, women leucorrhea, the cough due to common cold, stomachache, dysentery, knife injury.
Radix Lysionoti Serrati is the root of Gesneriaceae Herba Scindapsi Officinalis.Removing heat from blood, hemostasis, cough-relieving, dampness removing.Control hemoptysis, rheumatalgia.
Cortex Lespedezae Buergeri is the peel of stem of bean kind of plant greenery Caulis Seu Folium Lespedezae Bicoloris.Latin is called Lespedeza buergeri Miq., expelling wind and removing dampness.
Herba Houttuyniae is Compositae Dichrocephala plant Herba Houttuyniae Dichrocephala auriculata (Thunb.) Druce, with all herbal medicine.Promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.For menoxenia, sprain and swell and ache; Venom is controlled in external, furunculosis.
Rhizoma dispori flaventis is rhizome and the root of liliaceous plant cantonese fairy bells.In the summer, gather between the autumn.Nourishing the lung to arrest cough, spleen invigorating removing food stagnancy.Control deficient cough with asthma, sputum mixed with blood, discharging fresh blood stool, food stagnation distension.
Beneficial effect: the present invention is for improving anoxia endurance.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, preparation embodiment: get Herba Tripterospermi 10g, Ramulus viticis negundo 12g, Radix Fici beecheyanae 8g, Cissus pteroclada Hayata 14g, Rubus sieboldi Blume. 12g, Radix scirpi triangulati 10g, Herba Girardiniae Palmatae 16g, Herba Brediae Amoenae 8g, Radix Bauhiniae Hupehanae 12g, Radix Elaeagni 14g, Herba Wahlenbergiae 16g, Radix Lysionoti Serrati 12g, Cortex Lespedezae Buergeri 14g, Herba Houttuyniae 8g, Rhizoma dispori flaventis 10g medical material, mixing, decoct with water twice, first time adds water as 8 times amount of medical material weight, decoct 1.5h, second time adds water as 6 times amount of medical material weight, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.10 (65 DEG C), it is spray-dried that (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), be ground into dry extract, then add suitable dextrin, with appropriate 80% ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 70 DEG C of dryings, 60 order granulate, obtain granule.
Get Herba Tripterospermi 10g, Ramulus viticis negundo 12g, Radix Fici beecheyanae 8g, Cissus pteroclada Hayata 14g, Rubus sieboldi Blume. 12g, Radix scirpi triangulati 10g, Herba Girardiniae Palmatae 16g, Herba Brediae Amoenae 8g, Radix Bauhiniae Hupehanae 12g, Radix Elaeagni 14g, Herba Wahlenbergiae 16g, Radix Lysionoti Serrati 12g, Cortex Lespedezae Buergeri 14g, Herba Houttuyniae 8g, Rhizoma dispori flaventis 10g medical material, mixing, decoct with water twice, add water as 10 times amount of medical material weight time, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5/s.), be ground into dry extract, then add starch, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, bag fat clothing, subpackage, outer package, censorship is qualified, obtains finished product.
Get Herba Tripterospermi 10g, Ramulus viticis negundo 12g, Radix Fici beecheyanae 8g, Cissus pteroclada Hayata 14g, Rubus sieboldi Blume. 12g, Radix scirpi triangulati 10g, Herba Girardiniae Palmatae 16g, Herba Brediae Amoenae 8g, Radix Bauhiniae Hupehanae 12g, Radix Elaeagni 14g, Herba Wahlenbergiae 16g, Radix Lysionoti Serrati 12g, Cortex Lespedezae Buergeri 14g, Herba Houttuyniae 8g, Rhizoma dispori flaventis 10g medical material, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 7.5/s.), be ground into dry extract, cross No. 6 sieves, reinstall No. 1 capsule finished product.
2, the pharmacodynamic study of anoxia endurance is improved
2.1 laboratory animals: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
2.2 Experimental agents: prepare by the preparation method of above-mentioned granule embodiment, specification: 10g/ bag (being equivalent to containing crude drug 15g)
Dosage: by Mice Body restatement, low dosage, middle dosage and high dose gavage amount are respectively 10g crude drug amount/kg, 20g crude drug amount/kg and 40g crude drug amount/kg.
Positive drug gold day board heart source cellulose capsule, Xiamen Goldensun Technology Co., Ltd., No. 0249th, hygienic food and health number (1999), lot number: 20130223.Specification: every dress 0.5g.Patient uses generally each 2, every day 2 times, i.e. people's consumption per day 2g, and being equivalent to every 20g mice consumption is 2*0.0026=0.0052g, calculates by per kilogram mice, and namely positive drug group gives gold day board heart source cellulose capsule 0.26g/kg.
2.3 instruments and reagent: 250mL ground wide mouthed bottle, operating scissors, 1mL syringe, stopwatch, vaseline, sodica calx.
2.4 oxygen deficit tolerance experiments: select healthy mice 50, separate 10 at random as normal group, all the other 40 mices, be divided into 4 groups at random: high dose group, middle dosage group, low dose group, positive drug gold day board heart source cellulose capsule group, wherein 3 dosage groups, gold day board heart source cellulose capsule groups press above-mentioned dosage gastric infusion, normal group is to the water of 0.2ml, every morning 1 time, continuous 30d, last gave experiment tested material after 1 hour, mice was put into respectively the 250mL ground wide mouthed bottle (every bottle of mice) filling 5g sodica calx; Smear bottleneck with vaseline, cover tightly, make it air tight; The immediate record time take respiratory arrest as index, and record mice is the death time because of anoxia.
The present invention is on the impact ((X scholar D) of mice normobaric hypoxia time-to-live
* p<0.05 is compared with normal group; * compares p<0.01 with normal group
2.5 conclusions: the normobaric hypoxia time-to-live of of the present invention group of mice is significantly longer than normal group, and has significant difference, illustrate that the present invention has raising anoxia endurance, compared with positive drug, the time-to-live is long, illustrates that improving anoxia endurance effect is better than positive drug.

Claims (3)

1. one kind has the Chinese medicine composition improving anoxia endurance, it is characterized in that, it is prepared by the raw material of following parts by weight: Herba Tripterospermi 10 parts, Ramulus viticis negundo 12 parts, Radix Fici beecheyanae 8 parts, Cissus pteroclada Hayata 14 parts, Rubus sieboldi Blume. 12 parts, Radix scirpi triangulati 10 parts, Herba Girardiniae Palmatae 16 parts, Herba Brediae Amoenae 8 parts, Radix Bauhiniae Hupehanae 12 parts, Radix Elaeagni 14 parts, Herba Wahlenbergiae 16 parts, Radix Lysionoti Serrati 12 parts, Cortex Lespedezae Buergeri 14 parts, Herba Houttuyniae 8 parts, Rhizoma dispori flaventis 10 parts.
2. a kind of as claimed in claim 1 have the Chinese medicine composition improving anoxia endurance, it is characterized in that, preparation method comprises the steps: that getting above-mentioned medical material merges, and decocts with water twice, collecting decoction, concentrated, add ethanol precipitate with ethanol, leave standstill, filter, filtrate reduced in volume, spraying dry, adds adjuvant and makes capsule, tablet, granule.
3. have as claimed in claim 1 and improve the application of anoxia endurance Chinese medicine composition in raising anoxia endurance medicine.
CN201410626501.0A 2014-11-07 2014-11-07 Traditional Chinese medicine composition capable of improving hypoxia endurance, preparation method and applications thereof Withdrawn CN104398754A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102266452A (en) * 2011-07-18 2011-12-07 南京苏美瑞医药科技有限公司 Chinese medicinal composition for enhancing anoxia endurance and preparation method and application thereof
CN102614281A (en) * 2012-04-23 2012-08-01 卞毓平 Chinese medicinal composition for improving anoxia endurance and preparation method and application thereof
CN102935130B (en) * 2012-12-08 2014-03-19 新乡医学院 Traditional Chinese medicine composition for improving anoxia endurance as well as preparation method and application thereof
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Application publication date: 20150311