CN103989894A - Lozenge capable of improving anoxia endurance, and preparation method and application thereof - Google Patents
Lozenge capable of improving anoxia endurance, and preparation method and application thereof Download PDFInfo
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- CN103989894A CN103989894A CN201410268795.4A CN201410268795A CN103989894A CN 103989894 A CN103989894 A CN 103989894A CN 201410268795 A CN201410268795 A CN 201410268795A CN 103989894 A CN103989894 A CN 103989894A
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Abstract
The invention discloses a lozenge capable of improving anoxia endurance. The lozenge comprises 10 to 30 parts of iris confuse, 20 to 40 parts of lousewort root, 15 to 25 parts of pratia nummularia, 10 to 30 parts of caltrop, 10 to 30 parts of tofieldia thibetica, and 10 to 30 parts of stickyhair pearleverlasting herb. The invention also discloses a preparation method of the lozenge. The preparation method comprises the following steps: decocting with water; concentrating; precipitating with alcohol; spray-drying; crushing the obtained particles into dry extract powder; adding auxiliary materials; then preparing into the lozenge. The invention also discloses application of the lozenge in preparation of a medicine for improving anoxia endurance.
Description
Technical field
The present invention relates to Chinese medicine preparation technical field, be specifically related to a kind of buccal tablet that improves anoxia endurance and its preparation method and application.
Background technology
The each organ of human body all needs oxygen, and each organ has not commensurability demand for oxygen, such as brain oxygen consumption be human body oxygen consumption total amount 25%, heart 18%, these two is the organ that oxygen consumption is maximum.When in the situation that oxygen supply amount or utilization rate reduce, organ will anoxia, and anoxia will cause various chronic diseases (anoxia is the source of ten thousand diseases), and acute anoxia will cause and suffocate and dead certainly.Refer to and reduced the demand of organ to oxygen and improve anoxia endurance, but each organ can normally be worked again simultaneously.Clinical practice is a lot of in improving medicine and the tonic of anoxia endurance, but these kind toxic and side effects are larger, and is inconvenient to take, and up to now, people are finding a kind of Chinese medicine of the raising anoxia endurance of making simple, taking convenience.
Summary of the invention
Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of buccal tablet that improves anoxia endurance.
Technical scheme: the object of the invention is to realize by following scheme:
Improve a buccal tablet for anoxia endurance, it is extracted and is prepared by the crude drug of following parts by weight: demutation grass 10-30 part, Gaster caprae seu Ovis ginseng 20-40 part, Herba pratiae begonifoliae 15-25 part, Fructus Tribuli 10-30 part, Rhizoma Bergeniae purpurascentis 10-30 part and Herba Clematidis Meyenianae 10-30 part.
The buccal tablet of described raising anoxia endurance, it is extracted and is prepared by the crude drug of following parts by weight: 20 parts of 20 parts of demutation grass, 30 parts of Gaster caprae seu Ovis ginsengs, 20 parts of Herba pratiae begonifoliaes, 20 parts of Fructus Tribulis, 20 parts of Rhizoma Bergeniae purpurascentis and Herba Clematidis Meyenianaes.
The buccal tablet of described raising anoxia endurance, preparation process is: get demutation grass, Gaster caprae seu Ovis ginseng, Herba pratiae begonifoliae, Fructus Tribuli, Rhizoma Bergeniae purpurascentis and Herba Clematidis Meyenianae medical material merge, decoct with water twice, each amount of water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, while being concentrated into 65 DEG C, relative density is 1.10, add ethanol, stir, make containing alcohol amount by volume percentage calculation reach 65%, leave standstill, filter, when filtrate decompression is concentrated into 65 DEG C, relative density is 1.20 and reclaims ethanol and obtain concentrated solution, spraying is dry, spraying drying condition is: inlet temperature is 100 DEG C, leaving air temp is 70 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 5ml/s, add sucrose, granulate, tabletting, make buccal tablet.
The buccal tablet of described raising anoxia endurance improves the application in anoxia endurance medicine in preparation.
In the present invention, demutation grass is Liliaceae demutation grass Tofieldia divergens Bur.et Franch.[Tofieldia yunnanensis Franch.], with all herbal medicine, the root that Gaster caprae seu Ovis ginseng is goatweed Radix Scrophulariae, Herba pratiae begonifoliae is campanulaceae Herba pratiae begonifoliae platymiscium Herba pratiae begonifoliae Pratia mummularia A.Brown et Aschers., herb, Fructus Tribuli is the dry mature fruit of zygophyllaceae plant Fructus Tribuli Tribulus terrestris L., Rhizoma Bergeniae purpurascentis is the dry rhizome of saxifragaceae plant Rhizoma Seu Herba Bergeniae Bergenia purpurascens (Hook.f.etThoms) Engl, Herba Clematidis Meyenianae is the fragrant blue or green herb in feverfew Kunming.
Beneficial effect:
From theory of Chinese medical science, demutation grass in we, Gaster caprae seu Ovis ginseng invigorate vital energy and yang are that monarch drug, Herba pratiae begonifoliae, Fructus Tribuli blood circulation promoting and blood stasis dispelling are ministerial drug, promote the anti-hypoxia tolerance ability of monarch drug, Rhizoma Bergeniae purpurascentis and Herba Clematidis Meyenianae promoting flow of QI and blood; Eliminating stasis to stop pain is adjuvant, and all medicines are harmonious, and plays altogether QI invigorating, invigorates blood circulation, supporing yang effect, for improving anoxia endurance.Formulation of the present invention is reasonable, and compatibility is rigorous.Consist of Chinese crude drug, have no side effect, low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1:
Get demutation grass 20g, Gaster caprae seu Ovis ginseng 30g, Herba pratiae begonifoliae 20g, Fructus Tribuli 20g, Rhizoma Bergeniae purpurascentis 20g and Herba Clematidis Meyenianae 20g merge, decoct with water twice, each amount of water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, while being concentrated into 65 DEG C, relative density is 1.10, add ethanol, stir, make containing alcohol amount by volume percentage calculation reach 65%, leave standstill, filter, when filtrate decompression is concentrated into 65 DEG C, relative density is 1.20 and reclaims ethanol and obtain concentrated solution, spraying is dry, spraying drying condition is: inlet temperature is 100 DEG C, leaving air temp is 70 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 5ml/s, add sucrose, granulate, tabletting, make buccal tablet.
Embodiment 2: the pharmacodynamic study that improves anoxia endurance
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: press the preparation method preparation of above-described embodiment 1, obtain 100, every 1g, containing crude drug 1.3g.
Dosage: according to " the dose,equivalent ratio table of converting by surface between humans and animals ", every day, 70 kilograms of people's consumption was 130g, every day, the consumption of every 20g mice was 130*0.0026=0.338g, because every buccal tablet 1g is 1.3g containing crude drug amount, the consumption that is every mice is 0.26g, therefore determine low dose of every gavage 0.26g tablet, middle dosage and high dose be gavage 0.52g and 1.04g respectively.
Positive drug gold day board heart source cellulose capsule, Xiamen Goldensun Technology Co., Ltd., No. 0249th, hygienic food and health number (1999), lot number: 20110423.Specification: every dress 0.5g.Patient uses general each 2, every day 2 times, i.e. and people's consumption per day 2g, being equivalent to every 20g mice consumption is 2*0.0026=0.0052g, calculates by per kilogram mice, positive drug group gives gold day board heart source cellulose capsule 0.26g/kg.
Instrument and reagent: 250mL ground wide mouthed bottle, operating scissors, 1mL syringe, stopwatch, vaseline, sodica calx.
Normal pressure anoxia enduring experiment: select 50 of healthy mices, separate at random 10 as normal group, all the other 40 mices, be divided at random 4 groups: high dose group, middle dosage group, low dose group, positive drug gold day board heart source cellulose capsule group, wherein 3 dosage groups, a gold day board heart source cellulose capsule groups are pressed above-mentioned dosage gastric infusion, normal group is to the water of 0.2ml, every morning 1 time, 30d continuously, last is tested by tested material and, after 1 hour, mice is put into respectively to the 250mL ground wide mouthed bottle (every bottle of mice) that fills 5g sodica calx; Smear bottleneck with vaseline, cover tightly, make it air tight; The immediate record time, taking respiratory arrest as index, record mice because of the anoxia death time.
The impact ((X scholar D) of the present invention on the mice normobaric hypoxia time-to-live
* with relatively p<0.05 of normal group; * and normal group be p<0.01 relatively
The normobaric hypoxia time-to-live of of the present invention group of mice is significantly longer than normal group, and has significant difference, illustrates that the present invention has raising anoxia endurance, and compared with positive drug, the time-to-live is long, illustrates that improving anoxia endurance effect is better than positive drug.
Claims (4)
1. one kind is improved the buccal tablet of anoxia endurance, it is characterized in that, it is extracted and is prepared by the crude drug of following parts by weight: demutation grass 10-30 part, Gaster caprae seu Ovis ginseng 20-40 part, Herba pratiae begonifoliae 15-25 part, Fructus Tribuli 10-30 part, Rhizoma Bergeniae purpurascentis 10-30 part and Herba Clematidis Meyenianae 10-30 part.
2. improve as claimed in claim 1 the buccal tablet of anoxia endurance, it is characterized in that, it is extracted and is prepared by the crude drug of following parts by weight: 20 parts of 20 parts of demutation grass, 30 parts of Gaster caprae seu Ovis ginsengs, 20 parts of Herba pratiae begonifoliaes, 20 parts of Fructus Tribulis, 20 parts of Rhizoma Bergeniae purpurascentis and Herba Clematidis Meyenianaes.
3. improve as claimed in claim 1 the buccal tablet of anoxia endurance, it is characterized in that, preparation process is: get demutation grass, Gaster caprae seu Ovis ginseng, Herba pratiae begonifoliae, Fructus Tribuli, Rhizoma Bergeniae purpurascentis and Herba Clematidis Meyenianae medical material merge, decoct with water twice, each amount of water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, while being concentrated into 65 DEG C, relative density is 1.10, add ethanol, stir, make containing alcohol amount by volume percentage calculation reach 65%, leave standstill, filter, when filtrate decompression is concentrated into 65 DEG C, relative density is 1.20 and reclaims ethanol and obtain concentrated solution, spraying is dry, spraying drying condition is: inlet temperature is 100 DEG C, leaving air temp is 70 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 5ml/s, add sucrose, granulate, tabletting, make buccal tablet.
4. the buccal tablet that improves as claimed in claim 1 anoxia endurance improves the application in anoxia endurance medicine in preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410268795.4A CN103989894A (en) | 2014-06-16 | 2014-06-16 | Lozenge capable of improving anoxia endurance, and preparation method and application thereof |
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| CN201410268795.4A CN103989894A (en) | 2014-06-16 | 2014-06-16 | Lozenge capable of improving anoxia endurance, and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398754A (en) * | 2014-11-07 | 2015-03-11 | 朱海燕 | Traditional Chinese medicine composition capable of improving hypoxia endurance, preparation method and applications thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398754A (en) * | 2014-11-07 | 2015-03-11 | 朱海燕 | Traditional Chinese medicine composition capable of improving hypoxia endurance, preparation method and applications thereof |
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Application publication date: 20140820 |