CN104367588B - 地塞米松果胶锌复合凝胶口服结肠定位释药微丸 - Google Patents
地塞米松果胶锌复合凝胶口服结肠定位释药微丸 Download PDFInfo
- Publication number
- CN104367588B CN104367588B CN201410702399.8A CN201410702399A CN104367588B CN 104367588 B CN104367588 B CN 104367588B CN 201410702399 A CN201410702399 A CN 201410702399A CN 104367588 B CN104367588 B CN 104367588B
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- Prior art keywords
- dexamethasone
- pectin
- solution
- zinc
- micropill
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410702399.8A CN104367588B (zh) | 2014-11-29 | 2014-11-29 | 地塞米松果胶锌复合凝胶口服结肠定位释药微丸 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410702399.8A CN104367588B (zh) | 2014-11-29 | 2014-11-29 | 地塞米松果胶锌复合凝胶口服结肠定位释药微丸 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104367588A CN104367588A (zh) | 2015-02-25 |
CN104367588B true CN104367588B (zh) | 2017-02-22 |
Family
ID=52546949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410702399.8A Expired - Fee Related CN104367588B (zh) | 2014-11-29 | 2014-11-29 | 地塞米松果胶锌复合凝胶口服结肠定位释药微丸 |
Country Status (1)
Country | Link |
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CN (1) | CN104367588B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109806238A (zh) * | 2019-03-18 | 2019-05-28 | 徐州生物工程职业技术学院 | 一种吲哚美辛结肠释药微丸的制备方法 |
CN111450049B (zh) * | 2020-05-11 | 2021-06-25 | 中国药科大学 | 一种具有结肠特异性递送的微米水凝胶制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0888778A1 (en) * | 1997-07-03 | 1999-01-07 | Samyang Corporation | Colon selective drug delivery system and compositions comprising said system |
CN102579363A (zh) * | 2012-03-02 | 2012-07-18 | 北京科信必成医药科技发展有限公司 | 一种结肠定位释药的微丸及其制备方法 |
CN102940888A (zh) * | 2012-11-12 | 2013-02-27 | 天津科技大学 | 一种含有卵磷脂的果胶结肠靶向给药方法 |
-
2014
- 2014-11-29 CN CN201410702399.8A patent/CN104367588B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0888778A1 (en) * | 1997-07-03 | 1999-01-07 | Samyang Corporation | Colon selective drug delivery system and compositions comprising said system |
CN102579363A (zh) * | 2012-03-02 | 2012-07-18 | 北京科信必成医药科技发展有限公司 | 一种结肠定位释药的微丸及其制备方法 |
CN102940888A (zh) * | 2012-11-12 | 2013-02-27 | 天津科技大学 | 一种含有卵磷脂的果胶结肠靶向给药方法 |
Non-Patent Citations (6)
Title |
---|
口服结肠靶向制剂中辅料的应用;胡万杨;《中国实验方剂学杂志》;20100831;第16卷(第10期);210-212 * |
果胶基口服结肠靶向给药系统的研究进展;刘健;《现代化工》;20110228;第31卷(第2期);25-27 * |
结肠定位给药系统研究概况;梁桂贤;《国外医药》;19991231;第20卷(第4期);全文 * |
酶控渗透泵型结肠定位微丸的制备及体外释放度考察;杨志欣;《中国现代应用药学》;20110531;第28卷(第5期);451 * |
酶触型苦参碱结肠靶向微丸的研制;侯伟娜;《河北医科大学学位论文》;20110415;7 * |
高效液相色谱法测定地塞米松果胶凝胶微丸的药物含量;邢洋;《中国药物与临床》;20130228;第13卷(第2期);177-178 * |
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Publication number | Publication date |
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CN104367588A (zh) | 2015-02-25 |
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Application publication date: 20150225 Assignee: Shanxi Medical University Asset Management Co., Ltd Assignor: Shanxi Medial University Contract record no.: X2019980000611 Denomination of invention: Dexamethasone, pectin and zinc combined gel oral colon-specific drug delivery pellet Granted publication date: 20170222 License type: Common License Record date: 20191115 |
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Assignee: Shanxi Medical University Asset Management Co.,Ltd. Assignor: SHANXI MEDICAL University Contract record no.: X2019980000611 Date of cancellation: 20210422 |
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