CN104363774A - 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法 - Google Patents

番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法 Download PDF

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Publication number
CN104363774A
CN104363774A CN201380031408.9A CN201380031408A CN104363774A CN 104363774 A CN104363774 A CN 104363774A CN 201380031408 A CN201380031408 A CN 201380031408A CN 104363774 A CN104363774 A CN 104363774A
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extract
tomato
composition
tomato extract
active fraction
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CN201380031408.9A
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Chinese (zh)
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A·K·杜塔罗伊
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Universitetet i Oslo
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Universitetet i Oslo
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Priority to CN201710610558.5A priority Critical patent/CN107397830A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Cardiology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
CN201380031408.9A 2012-04-23 2013-04-22 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法 Withdrawn CN104363774A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710610558.5A CN107397830A (zh) 2012-04-23 2013-04-22 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636813P 2012-04-23 2012-04-23
US61/636,813 2012-04-23
PCT/US2013/037524 WO2013163057A1 (en) 2012-04-23 2013-04-22 Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract

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CN201710610558.5A Division CN107397830A (zh) 2012-04-23 2013-04-22 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法

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CN104363774A true CN104363774A (zh) 2015-02-18

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CN201710610558.5A Pending CN107397830A (zh) 2012-04-23 2013-04-22 番茄提取物用作抗高血压剂的用途以及制造水溶性无糖番茄提取物的方法

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US (3) US20150132371A1 (enExample)
EP (1) EP2844083B1 (enExample)
JP (5) JP2015515493A (enExample)
CN (2) CN104363774A (enExample)
AU (1) AU2013252637B2 (enExample)
CA (1) CA2881555C (enExample)
DK (1) DK2844083T3 (enExample)
ES (1) ES2692158T3 (enExample)
IN (1) IN2014MN02392A (enExample)
NZ (1) NZ630482A (enExample)
PL (1) PL2844083T3 (enExample)
PT (1) PT2844083T (enExample)
TR (1) TR201815457T4 (enExample)
WO (1) WO2013163057A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110638902A (zh) * 2019-09-30 2020-01-03 白冬平 番茄提取物在制备降血压药物中的应用及其降血压组合物
WO2020077747A1 (zh) * 2018-10-17 2020-04-23 汤臣倍健股份有限公司 一种具有辅助降血压功效的组合物及保健食品

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GB0819959D0 (en) * 2008-10-31 2008-12-10 Provexis Natural Products Ltd Fruit extracts
PL2844083T3 (pl) 2012-04-23 2018-12-31 University Of Oslo Zastosowanie ekstraktu pomidorowego jako środka przeciwdziałającego nadciśnieniu i proces do sporządzania rozpuszczalnego w wodzie ekstraktu pomidorowego bez cukru
GB201223365D0 (en) 2012-12-24 2013-02-06 Provexis Natural Products Ltd Compositions
MX2019005054A (es) 2016-11-02 2019-06-20 Provexis Natural Products Ltd Extracto de jitomate soluble en agua protege contra los efectos adversos de la contaminacion del aire.
TW202034936A (zh) * 2019-02-15 2020-10-01 國立大學法人信州大學 具有降低血壓的作用之源自茄子的組成物
DE102020001722A1 (de) 2020-03-14 2021-09-16 DÖHLER GmbH Verfahren zur Herstellung eines aromabeladenen Gases, aromabeladenes Gas und Verwendung des aromabeladenen Gases
WO2022238727A1 (en) * 2021-05-08 2022-11-17 Momand Hossay Methods for preparing white heirloom tomato-based compositions for skin lightening via enhanced glutathione, and associated compositions thereof
CN114617920B (zh) * 2022-04-11 2023-10-13 汤臣倍健股份有限公司 一种具有改善记忆力功能的水溶性番茄提取物及其应用
GB202208323D0 (en) * 2022-06-07 2022-07-20 Provexis Natural Products Ltd Compostions

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH099892A (ja) * 1995-07-01 1997-01-14 Kagome Co Ltd トマト由来の食品組成物
WO2010049707A2 (en) * 2008-10-31 2010-05-06 Provexis Natural Products Limited Fruit extracts
JP2011144147A (ja) * 2010-01-18 2011-07-28 Kikkoman Corp 抗ストレス作用を有するｇａｂａ高含有トマト由来組成物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020077747A1 (zh) * 2018-10-17 2020-04-23 汤臣倍健股份有限公司 一种具有辅助降血压功效的组合物及保健食品
CN110638902A (zh) * 2019-09-30 2020-01-03 白冬平 番茄提取物在制备降血压药物中的应用及其降血压组合物

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WO2013163057A1 (en) 2013-10-31
DK2844083T3 (en) 2018-11-12
US20180271926A1 (en) 2018-09-27
NZ630482A (en) 2016-11-25
AU2013252637A1 (en) 2014-12-04
ES2692158T3 (es) 2018-11-30
US10864241B2 (en) 2020-12-15
CN107397830A (zh) 2017-11-28
EP2844083B1 (en) 2018-07-25
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JP2025010139A (ja) 2025-01-20
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CA2881555C (en) 2021-10-19
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IN2014MN02392A (enExample) 2015-08-21
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US20210236578A1 (en) 2021-08-05
JP2023009053A (ja) 2023-01-19
PT2844083T (pt) 2018-11-12
JP2015515493A (ja) 2015-05-28
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EP2844083A1 (en) 2015-03-11
JP2021008474A (ja) 2021-01-28

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