CN104351572A - Dog food for preventing dog viral hepatitis and preparation method of dog food - Google Patents
Dog food for preventing dog viral hepatitis and preparation method of dog food Download PDFInfo
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Abstract
The invention discloses dog food for preventing dog viral hepatitis and a preparation method of the dog food for preventing dog viral hepatitis. The dog food is prepared from the following raw materials: corn, dehydrated chicken, dehydrated duck, dehydrated lean pork, dehydrated chicken liver, mung bean, Chinese yam, carrots, hawthorn fruits, linseeds, cooked egg yolk, soybean oil, lutein extract and salt. The dog food disclosed by the invention has the beneficial effect that traditional Chinese additives contained in the dog food are mainly used for clearing away heat and toxic materials, cooling livers and purging intense heat, and secondarily used for protecting livers, benefiting gallbladder, and replenishing qi to invigorate spleen, has the advantages of being good in curative effect, quick to become effective, free of toxic and side effects when being used for preventing and treating the dog viral hepatitis. The traditional Chinese medicine additives in the dog food disclosed by the invention interact and co-act with other raw materials, so that not only can nutrient needs of sick dogs be met, but also the immunity and the recoverability of sick dogs can be improved.
Description
Technical field
The present invention relates to a kind of dog grain, particularly relate to a kind of dog grain for preventing canine virus hepatitis and preparation method thereof.
Background technology
Canine viral hepatitis is a kind of hot height sexually transmitted disease, except dog infects, also have the carnivorous order animal such as ermine, fox, wolf, bear all can infection morbidity, with Early manifestation diphasic fever, acute coryza and bronchitis subsequently, catarrhal pneumonia, serious gastroenteritis and muscular tremor be feature.This disease all can occur throughout the year, and the dog at various age all can fall ill, particularly weanling pup, and the incidence of infection and fatal rate are very high, and provisions dog industry causes massive losses.
Cause of disease Adenovirus canine infectious hepatitis virus, diameter 75 ~ 80mm, has capsid, containing distrand DNA.This viral optimal pH 7.0, all can survive under PH3-9 condition.Virus can be survived the several years at-70 DEG C, can preserve for a long time after freeze-drying.To heat and drying responsive, in 56 DEG C of 15min or 60 DEG C 3 ~ 5min deactivation.3% formalin, 5% carbon acid solution and 3% caustic soda etc. have good disinfective action to this disease.Have tolerance to EC, can resist 95% alcohol reach 24h in room temperature, therefore when treating, syringe and syringe needle only can not rely on alcohol disinfecting.
Canine viral hepatitis clinical symptoms have the following aspects: sick dog body temperature raises 40 ~ 41 DEG C, and down in spirits, anorexia, bend over, happiness drink cold water, has vomiting, mouth stream mucus, coughing of having is breathed heavily, is suffered from diarrhoea, and with mucus in ight soil, bloody flux appears in severe one, stomachache, later turn round and look at abdomen, eye conjunctiva is pale, indivedual dog opacity of the cornea, there is oedema under some jaws, then feed through to inside four limbs, under abdomen.At this moment accelerated breathing is shown as, palpitating speed, 115 times/min.There is xanthochromia in visual mucous membrane, some appearance are stained with blood, some appearance albuminuria, the jaundice of some urines, and some gums have blood cake, tonsillotome acute inflammation enlargement, and hemorrhage rear blood clotting time extends.Cut open inspection change: cut the dog that dies of illness open, be found to be subcutaneous dropsy, there is a large amount of hydrops in abdominal cavity, is mixed with blood, and mesenterium has slight xanthochromia, has Fibrin exudation thing above.The visible serous coat bleed bottom of stomach and intestine, gall-bladder and barrier film, mesenterium, lymph node are hemorrhage, hepatomegaly, what have has red ecchymosis, and gall-bladder has tip-like hemorrhage, thicken oedema, whole gall-bladder is dark red, and mucous membrane of gallbladder has fibrin calm, has single cases to occur nervous symptoms, be overexcited, spasm, paralysis, the later stage occur stupor.Have two to occur mixed infecting (canine distemper) and bacillary scabies secondary infections, make to face examine show complicated.
The method mainly western medicine of current treatment canine viral hepatitis, vein inputs 5% glucose saline 250 ~ 500ml, and add Vc20ml, VK5ml, 400,000 × 4, penicillin (calculating by the dog of 20kg), what occur oedema adds diuretics furosemide 2ml, 1 time/d, be used in conjunction 3 times, serum can be used at the initial stage of a disease to treat, but once there are obvious clinical symptoms, even if use heavy dose of hyper-immune serum to be also difficult to result for the treatment of.Although there is the Chinese medicine for the treatment of canine viral hepatitis at present, its result for the treatment of is unsatisfactory.
Summary of the invention
In order to solve the deficiencies in the prior art part, provide a kind of containing good, the instant effect of prevention effect, the prescription type dog grain being used for the treatment of canine viral hepatitis of Chinese medicine additive that has no side effect and preparation method thereof.
In order to realize foregoing invention object, the invention provides a kind of dog grain for preventing canine virus hepatitis, it is characterized in that, described dog grain comprises following raw material: corn, dehydrated chicken, dehydration duck, dehydration thin pork, dehydration chicken gizzard, mung bean, Chinese yam, carrot, hawthorn, linseed, the egg yolk boiled, soybean oil, lutein extract and salt.
Described dog grain is made up of the raw material of following parts by weight: corn 25-51 weight portion, dehydrated chicken 48-79 weight portion, dehydration duck 32-58 weight portion, dehydration thin pork 27-49 weight portion, dehydration chicken gizzard 15-30 weight portion, mung bean 11-19 weight portion, Chinese yam 22-31 weight portion, carrot 8-20 weight portion, hawthorn 5-15 weight portion, linseed 5-13 weight portion, the egg yolk 10-26 weight portion boiled, soybean oil 3-7 weight portion, lutein extract 1-5 weight portion and salt 2-6 weight portion.
Described dog grain is preferably made up of the raw material of following parts by weight: corn 38 weight portion, dehydrated chicken 63 weight portion, dehydration duck 45 weight portion, dehydration thin pork 38 weight portion, dehydration chicken gizzard 22 weight portion, mung bean 15 weight portion, Chinese yam 27 weight portion, carrot 14 weight portion, hawthorn 10 weight portion, linseed 9 weight portion, egg yolk 18 weight portion boiled, soybean oil 5 weight portion, lutein extract 3 weight portion and salt 4 weight portion.
Preferably, described dog grain also comprises Chinese medicine additive, described dog grain is made up of the raw material of following parts by weight: corn 25-51 weight portion, dehydrated chicken 48-79 weight portion, dehydration duck 32-58 weight portion, dehydration thin pork 27-49 weight portion, dehydration chicken gizzard 15-30 weight portion, mung bean 11-19 weight portion, Chinese yam 22-31 weight portion, carrot 8-20 weight portion, hawthorn 5-15 weight portion, linseed 5-13 weight portion, the egg yolk 10-26 weight portion boiled, soybean oil 3-7 weight portion, lutein extract 1-5 weight portion, salt 2-6 weight portion and Chinese medicine additive 2-7 weight portion.
Described dog grain can also be made up of the raw material of following parts by weight: corn 30-45 weight portion, dehydrated chicken 55-68 weight portion, dehydration duck 40-50 weight portion, dehydration thin pork 33-41 weight portion, dehydration chicken gizzard 18-25 weight portion, mung bean 13-17 weight portion, Chinese yam 25-28 weight portion, carrot 12-17 weight portion, hawthorn 8-12 weight portion, linseed 8-10 weight portion, the egg yolk 15-21 weight portion boiled, soybean oil 4-6 weight portion, lutein extract 2-5 weight portion, salt 3-6 weight portion and Chinese medicine additive 3-7 weight portion.
Described dog grain can also be made up of the raw material of following parts by weight: corn 38 weight portion, dehydrated chicken 63 weight portion, dehydration duck 45 weight portion, dehydration thin pork 38 weight portion, dehydration chicken gizzard 22 weight portion, mung bean 15 weight portion, Chinese yam 27 weight portion, carrot 14 weight portion, hawthorn 10 weight portion, linseed 9 weight portion, egg yolk 18 weight portion boiled, soybean oil 5 weight portion, lutein extract 3 weight portion, salt 4 weight portion and Chinese medicine additive 5 weight portion.
Described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: root of large-flowered skullcap 20-30 weight portion, Chinese aloe leaf 14-25 weight portion, sophora bud 8-17 weight portion, evodia rutaecarpa 12-23 weight portion, felwort 10-20 weight portion, cape jasmine 10-15 weight portion, Galium verum 10-17 weight portion, hypericum japonicum 15-25 weight portion, Radix Angelicae Sinensis 20-30 weight portion, India Canna Rhizome 10-18 weight portion, glossy ganoderma 10-20 weight portion, radix pseudostellariae 10-15 weight portion, unpleasant swallowwort herb 10-20 weight portion, cassia seed 12-18 weight portion, Horseweed Herb 10-20 weight portion, root bark of white mulberry 10-19 weight portion, dried immature fruit of citron orange 18-25 weight portion, swertia mileensis 8-16 weight portion, Rhizoma Sparganii 3-10 weight portion, the fragrant 5-12 weight portion of bodhi, red sage root 10-20 weight portion, pine needle 5-16 weight portion and Radix Glycyrrhizae 8-15 weight portion.
Described Chinese medicine additive can also be made up of the raw medicinal material of following parts by weight: the root of large-flowered skullcap 25 weight portion, Chinese aloe leaf 19 weight portion, the sophora bud 12 weight portion, evodia rutaecarpa 17 weight portion, felwort 15 weight portion, cape jasmine 12 weight portion, Galium verum 13 weight portion, hypericum japonicum 19 weight portion, Radix Angelicae Sinensis 25 weight portion, India Canna Rhizome 14 weight portion, glossy ganoderma 15 weight portion, radix pseudostellariae 13 weight portion, unpleasant swallowwort herb 15 weight portion, cassia seed 15 weight portion, Horseweed Herb 15 weight portion, the root bark of white mulberry 13 weight portion, the dried immature fruit of citron orange 22 weight portion, swertia mileensis 12 weight portion, Rhizoma Sparganii 6 weight portion, fragrant 8 weight portions of bodhi, the red sage root 15 weight portion, pine needle 10 weight portion and Radix Glycyrrhizae 11 weight portion.
Described Chinese medicine additive can be made up of the raw medicinal material of following parts by weight again: the root of large-flowered skullcap 30 weight portion, Chinese aloe leaf 14 weight portion, the sophora bud 17 weight portion, evodia rutaecarpa 23 weight portion, felwort 10 weight portion, cape jasmine 10 weight portion, Galium verum 17 weight portion, hypericum japonicum 15 weight portion, Radix Angelicae Sinensis 30 weight portion, India Canna Rhizome 18 weight portion, glossy ganoderma 20 weight portion, radix pseudostellariae 10 weight portion, unpleasant swallowwort herb 20 weight portion, cassia seed 12 weight portion, Horseweed Herb 20 weight portion, the root bark of white mulberry 10 weight portion, the dried immature fruit of citron orange 18 weight portion, swertia mileensis 8 weight portion, Rhizoma Sparganii 3 weight portion, fragrant 5 weight portions of bodhi, the red sage root 10 weight portion, pine needle 16 weight portion and Radix Glycyrrhizae 8 weight portion.
The preparation method of described Chinese medicine additive is:
The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains Chinese medicine additive.
In order to better realize foregoing invention object, the invention provides a kind of preparation method of the dog grain for preventing canine virus hepatitis, preparation method is:
Step one, to take mixing after Chinese yam, carrot, hawthorn and the egg yolk chopping of boiling by described parts by weight, put into the baking oven of 50 DEG C, smoke 30-40 minute, obtain mixture A;
Step 2, after by corn, dehydrated chicken, dehydration duck, dehydration pork, dehydration, chicken gizzard, mung bean and linseed mix with the mixture A that step one obtains, be placed in micronizer and pulverize 1 ~ 2 hour, sieve, obtain 300 order ~ 400 object micropowders; Wherein, corn, dehydrated chicken, dehydration duck, dehydration pork, dehydration chicken gizzard, mung bean are the raw material of the oven dry after shortening.
Step 3, micropowders is mixed with soybean oil, lutein extract, salt, Chinese medicine additive after, be placed in granulator granulation, 40-60 minute smoked by the baking oven putting into 40 DEG C subsequently, then cools under room temperature, sterilization, packs.
The invention has the beneficial effects as follows: the Chinese medicine additive that dog grain of the present invention contains, based on clearing heat and detoxicating, cool liver purging intense heat, with hepatic cholagogic, to replenish qi to invigorate the spleen be auxiliary, the advantages such as control canine viral hepatitis has good effect, instant effect, have no side effect, Chinese medicine additive in dog grain of the present invention and his raw material interact, acting in conjunction, can not only meet the nutritional need of ill dog, and improves ill dog immunity and recovery capability.
Detailed description of the invention
The invention provides a kind of dog grain being used for the treatment of dog virus hepatitis, its Chinese medicine additive comprised comprises following raw medicinal material: the root of large-flowered skullcap, Chinese aloe leaf, the sophora bud, evodia rutaecarpa, felwort, cape jasmine, Galium verum, hypericum japonicum, Radix Angelicae Sinensis, India Canna Rhizome, glossy ganoderma, radix pseudostellariae, unpleasant swallowwort herb, cassia seed, Horseweed Herb, the root bark of white mulberry, the dried immature fruit of citron orange, swertia mileensis, Rhizoma Sparganii, bodhi perfume, the red sage root, pine needle and Radix Glycyrrhizae, wherein, the root of large-flowered skullcap, Chinese aloe leaf, the sophora bud, evodia rutaecarpa, felwort, cape jasmine, Galium verum is clearing heat and detoxicating, cool liver purging intense heat, Radix Angelicae Sinensis, India Canna Rhizome hepatic cholagogic, glossy ganoderma, radix pseudostellariae, unpleasant swallowwort herb replenishes qi to invigorate the spleen, stir-baked CAULIS BANBUSAE in teaniam with ginger juice, cassia seed, Horseweed Herb, root bark of white mulberry inducing diuresis for treating strangurtia, the dried immature fruit of citron orange, swertia mileensis cholagogic toxin expelling, the red sage root, Rhizoma Sparganii, bodhi is fragrant, the red sage root is invigorated blood circulation and is assaulted fortified position, pine needle, Radix Glycyrrhizae adjusts regulating the function of middle-JIAO, because of very violent when its virus hepatitis is sent out, therefore to get rid of evils as wanting, heresy is gone just from peace, play clearing heat and detoxicating altogether, cool liver purging intense heat, inducing diuresis for treating strangurtia, cholagogic toxin expelling, to invigorate blood circulation the effect of assaulting fortified position.
Wherein, the pharmacology of above-mentioned raw materials medicinal material is as follows:
The root of large-flowered skullcap: have heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swell the diseases such as furuncle sore.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: bitter is so eliminating dampness; Cold sensation of the genitalia is so victory warm, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines are out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestine profit and water from by, source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood room, make us obstructed through closing, damp and hot solution, then Ying Qi clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head then stays knot, and is that the carbuncle stain that swells is also rotten: fiery ulcer person, also, cool blood heat extraction, then self-healing also for internal heat blood trouble.
Chinese aloe leaf: bitter; Puckery; Cold in nature.Return liver; Large intestine channel.Function cures mainly: purging intense heat; Removing toxic substances; Stagnation resolvation; Desinsection.Argument is red; Constipation; Gonorrhoea; Hematuria; Pediatric epilepsy scared; Infantile malnutrition due to digestive disturbances or intestinalparasites; Burn and scald; Women's amenorrhoea; Hemorrhoid; Scabies; Carbuncle furuncle poison; Traumatic injury.
The sophora bud: bitter, is slightly cold.Return liver, large intestine channel.Function cures mainly: cooling blood and hemostasis, clearing liver-fire.For having blood in stool, hemorrhoid blood, bloody flux, uterine bleeding, spit blood, bleeding from five sense organs or subcutaneous tissue, the hot hot eyes of liver, has a headache dizzy.
Evodia rutaecarpa: pungent, bitter, heat.Return liver, spleen, stomach, kidney channel.Function cures mainly: eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For jueyin headache, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal distention, vomiting acid regurgitation, Diarrhoea, controls aphtha outward; Hypertension.
Felwort: bitter, cold.Return liver, gallbladder channel.Function cures mainly: heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire.For jaundice with damp-heat pathogen, swelling of vulva pruritus vulvae, under band, Qiang Zhong, eczema itch, hot eyes, deaf, hypochondriac pain, bitter taste, convulsion.
Cape jasmine: bitter, cold.The thoughts of returning home, lung, tri-jiao channel.Function cures mainly: fruit: purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.Vexed for pyreticosis, jaundice urine is red, blood strangury and dry pain, and blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles; Control bruise pain outward.Root: purging intense heat and detonicating, clearing heat and promoting diuresis, cool the blood dissipate blood stasis.For catarrhal jaundice, traumatic injury, acute toothache.
Galium verum: bitter, sweet, temperature.Function cures mainly: removing toxic substances, and dampness removing is antipruritic.For acute urticaria, paddy-field dermatitis, phlebitis, carbuncle furuncle furunculosis.
Hypericum japonicum: sweet, micro-hardship is cool.Function cures mainly: clearing heat and promoting diuresis, removing toxicity for detumescence, blood stasis removing analgesic.For hepatitis, early-phase hepatocirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Sore furuncle poison is controlled in external application, herpes zoster, venomous snake bite, traumatic injury.
Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, the spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, and menstruction regulating and pain relieving relaxes bowel.Sallow for the deficiency of blood, dizzy palpitaition, irregular menstruation, through closing dysmenorrhoea, asthenia cold abdominalgia, the dry constipation of intestines, arthralgia due to wind-dampness, injury from falling down, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine activating blood to promote menstruation.For through closing dysmenorrhoea, arthralgia due to wind-dampness, injury from falling down.
India Canna Rhizome: taste is sweet; Micro-hardship; Puckery; Cool in nature.The thoughts of returning home; Small intestine; Liver Channel.Function cures mainly: clearing heat and detoxicating; Menstruation regulating; Li Shui.Main irregular menstruation; Under band; Jaundice; Dysentery; Sore swollen toxin.
Glossy ganoderma: property is sweet, flat.The thoughts of returning home, lung, liver, kidney channel.Cure mainly consumptive disease, cough, asthma, insomnia, indigestion, malignant tumour etc.Animal pharmacology shows experiment: glossy ganoderma has inhibitory action to nervous system, and the circulatory system has step-down and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, protects liver in addition, improves immunologic function, antibacterially waits effect.
Radix pseudostellariae: sweet, micro-hardship is flat.Return spleen, lung channel.Function cures mainly: replenish qi to invigorate the spleen, promoting production of body fluid and nourishing the lung.Tired for insufficiency of the spleen body, poor appetite, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Unpleasant swallowwort herb: bitter; Micro-pungent; Property is put down.Return lung channel.Function cures mainly: clearing heat and cooling blood; Cholagogic; Removing toxic substances.Main fever due to yin deficiency; Consumptive disease is coughed for a long time; Spitting of blood; The distending pain in hypochondrium; To vomit evil; Rush down dysentery; Postpartum dysphoria; Scrofula; Nameless sores or boils; Snakeworm; Mad dog is bitten.
Cassia seed: sweet, bitter, salty, is slightly cold.Return liver, large intestine channel.Function cures mainly: removing heat to brighten vision, relaxes bowel.For the puckery pain of hot eyes, the many tear of photophobia, have a headache dizzy, order is secretly failed to understand, constipation.
Horseweed Herb: micro-hardship, pungent, cool.Function cures mainly: clearing heat and promoting diuresis, eliminating stasis to subdue swelling.Enteritis, dysentery, catarrhal jaundice, cholecystitis; Psoriasis is controlled in external application, traumatic injury, sore furuncle poison, treating rheumatic ostealgia, traumatism and bleeding; Fresh leaf is smash juice and is controlled tympanitis, eye conjunctivitis.
The root bark of white mulberry: sweet; Pungent; Cold in nature.Return lung; The spleen channel.Function cures mainly: removing heat from lung and relieving asthma; Inducing diuresis for removing edema.Main lung heat breathes heavily phlegm; Water drink stops lung; Turgor breathes heavily urgency; Oedema; Beriberi; Difficult urination.
The dried immature fruit of citron orange: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: relieving stagnant Qi disappears long-pending, loose ruffian of reducing phlegm.Stop in stagnant, the full distending pain of ruffian, heavy after rushing down dysentery, suffer from constipation, the stagnant vapour lock obstruction of qi in the chest of phlegm, accumulation of pathogens in chest; Gastroptosis, prolapse of the anus, the prolapse of uterus.
Swertia mileensis: bitter; Cold in nature.Return liver; Courage; Urinary bladder channel.Function cures mainly: clearing heat and detoxicating; Dampness removing removing jaundice.Main jaundice with damp-heat pathogen; Heat drenches puckery pain; Damp-heat dysentery; Leukorrhea with reddish discharge; Influenza; Malaria is generated heat; Acute gastritis; Acute laryngopharyngitis; Acute tonsillitis.External application can control acute conjunctivitis; Allergic dermatitis.
Rhizoma Sparganii: pungent, bitter, flat.Return liver, the spleen channel.Function cures mainly: broken blood gas, disappear long-pending pain relieving.For abdominal mass lump in the abdomen, hemostasis through closing, dyspepsia distending pain.
Bodhi is fragrant: another name: Tibet throatroot.Source: the rose family
bodhi is fragrantgeum urbanum L., with all herbal medicine.Habitats distribution: Tibet.Pungent, sweet, flat.Function cures mainly: enriching yin and nourishing kidney, flat liver improving eyesight, swelling and pain relieving.Cure cold, dizziness headache, hypertension, anaemia, chronic enterogastritis, irregular menstruation, mastitis, the diseases such as sore.
The red sage root: bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Pine needle: bitter; Warm in nature.The thoughts of returning home; The spleen channel.Function cures mainly: dispel pathogenic wind and remove dampness; Killing parasites to relieve itshing; Blood-promoting and mind-easing.Main air wets impotence numbness; Beriberi; Wet sore; Tinea; Rubella itch; Traumatic injury; Neurasthenia; Chronic nephritis; High blood pressure.Preventing encephalitis, influenza.
Radix Glycyrrhizae: sweet, property put down, enter 12 warps, have clearing heat and detoxicating, be in harmonious proportion the property of medicine, the effect of expelling phlegm and arresting coughing, and can invigorating the spleen and in, relieving spasm to stop pain, is mainly used in weakness of the spleen and the stomach abdominal distension and anorexia, weak; Contraction pain in abdomen being alleviated, relax the strong and toxicity of some drugs, alleviate medicine to the toxic and side effect of body or to GI stimulation, tonifying Qi neutralization can be played by adding Radix Glycyrrhizae, be in harmonious proportion the effect of each component.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
Embodiments provide a kind of Chinese medicine additive being used for the treatment of canine viral hepatitis, be made up of the raw medicinal material of following parts by weight: the root of large-flowered skullcap 30 weight portion, Chinese aloe leaf 14 weight portion, the sophora bud 17 weight portion, evodia rutaecarpa 23 weight portion, felwort 10 weight portion, cape jasmine 10 weight portion, Galium verum 17 weight portion, hypericum japonicum 15 weight portion, Radix Angelicae Sinensis 30 weight portion, India Canna Rhizome 18 weight portion, glossy ganoderma 20 weight portion, radix pseudostellariae 10 weight portion, unpleasant swallowwort herb 20 weight portion, cassia seed 12 weight portion, Horseweed Herb 20 weight portion, the root bark of white mulberry 10 weight portion, the dried immature fruit of citron orange 18 weight portion, swertia mileensis 8 weight portion, Rhizoma Sparganii 3 weight portion, fragrant 5 weight portions of bodhi, the red sage root 10 weight portion, pine needle 16 weight portion and Radix Glycyrrhizae 8 weight portion.
Its preparation method is:
The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, adds hot reflux 2 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1.5 times to be again the ethanol of 90%, to add hot reflux 2 hours that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders;
3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, obtains Chinese medicine additive.
Embodiment 2 dog grain
Embodiments provide a kind of dog grain for preventing canine virus hepatitis, described dog grain is made up of the raw material of following parts by weight: corn 38 weight portion, dehydrated chicken 63 weight portion, dehydration duck 45 weight portion, dehydration thin pork 38 weight portion, dehydration chicken gizzard 22 weight portion, mung bean 15 weight portion, Chinese yam 27 weight portion, carrot 14 weight portion, hawthorn 10 weight portion, linseed 9 weight portion, egg yolk 18 weight portion boiled, soybean oil 5 weight portion, lutein extract 3 weight portion, salt 4 weight portion and Chinese medicine additive 5 weight portion.
Wherein, Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the root of large-flowered skullcap 30 weight portion, Chinese aloe leaf 14 weight portion, the sophora bud 17 weight portion, evodia rutaecarpa 23 weight portion, felwort 10 weight portion, cape jasmine 10 weight portion, Galium verum 17 weight portion, hypericum japonicum 15 weight portion, Radix Angelicae Sinensis 30 weight portion, India Canna Rhizome 18 weight portion, glossy ganoderma 20 weight portion, radix pseudostellariae 10 weight portion, unpleasant swallowwort herb 20 weight portion, cassia seed 12 weight portion, Horseweed Herb 20 weight portion, the root bark of white mulberry 10 weight portion, the dried immature fruit of citron orange 18 weight portion, swertia mileensis 8 weight portion, Rhizoma Sparganii 3 weight portion, fragrant 5 weight portions of bodhi, the red sage root 10 weight portion, pine needle 16 weight portion and Radix Glycyrrhizae 8 weight portion,
The preparation method of Chinese medicine additive is:
The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, adds hot reflux 2 hours, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1.5 times to be again the ethanol of 90%, to add hot reflux 2 hours that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1.5 hours, pulverize, sieve, obtain 350 object micropowders;
3rd step, adds the starch relative to its quality 3 times in the micropowders obtained by second step, mixing, obtains Chinese medicine additive.
The preparation method of dog grain is:
Step one, to take mixing after Chinese yam, carrot, hawthorn and the egg yolk chopping of boiling by described parts by weight, put into the baking oven of 50 DEG C, smoke 35 minutes, obtain mixture A;
Step 2, after chicken gizzard, mung bean and linseed mix with the mixture A that step one obtains by corn, dehydrated chicken, dehydration duck, dehydration pork, dehydration, to be placed in micronizer pulverizing 2 hours, to sieve, obtain 400 object micropowders;
Step 3, micropowders is mixed with soybean oil, lutein extract, salt, Chinese medicine additive after, be placed in granulator granulation, the baking oven putting into 40 DEG C subsequently smokes 50 minutes, then cools under room temperature, sterilization, packs.
Toxicity test
(1) acute toxicity test
Application NIH mouse 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mouse is divided into two groups at random, often organizes 20, i.e. control group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 2 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), control group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll.Experimental result shows: compare with control group, and after administration, mouse has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.
(2) long term toxicity test
The Chinese medicine additive of the embodiment of the present invention 2 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mouse, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat of Chinese medicine additive of the present invention to mouse all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine additive of the present invention is little to toxicity after mouse long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
(3) cumulative toxicity test
Select 20 healthy mices, female, each 10 of hero, with the Chinese medicine additive of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.
Contrast test
Using Shandong, three animal doctor's outpatient services are as Experimental Base, with the dog suffering from virus hepatitis coming to go to a doctor during in July ,-2013 in August, 2010, choose wherein 350 ill dogs as experimental subjects, ill dog is weanling pup, 210 ill dogs are divided into three treatment groups, be respectively embodiment group 1, embodiment group 2 and control group, adopt different methods of treatments respectively, often organize 70, the equal no difference of science of statistics in aspect such as age, body weight, the state of an illness of the ill dog of each treatment group, has comparativity.
When above-mentioned ill dog comes medical, all there is following symptom in various degree: body temperature is increased to 40 DEG C, down in spirits, anorexia, coughing of having is breathed heavily, is suffered from diarrhoea, indivedual dog opacity of the cornea, there is the symptoms such as oedema, all through blood test and histological examination, be diagnosed as virus hepatitis.
The ill dog of embodiment group 1 uses the Chinese medicine additive of the embodiment of the present invention 1 to treat, and every day three times, each 30g, can dissolve to gavage or directly admix in dog grain and feed, continuously treatment 3-7 days; The ill dog of embodiment group 2 uses the dog grain of the embodiment of the present invention 2 to treat, and feeds, use 3-7 days continuously according to normal feed mode; The ill dog of control group uses antitoxin clever freeze drying powder injection to treat, and adds proper amount of sugar, saline IV, every day twice, traditional dog grain of feeding by the dosage of 1/10 kg body weight, continuously treatment 3-7 days.
Each group of ill dog is after treatment, body temperature, appetite, spirit etc. all recover normal for curing, and normally, it is effective that appetite, spirit etc. are recovered normally substantially to temperature recovery, body temperature is persistent, poor appetite, One's spirits are drooping, before and after treatment, symptom does not take a turn for the better even dead for invalid.Each treatment group treatment results is as shown in table 1.
The each treatment group of table 1 ill dog result for the treatment of table of comparisons example
As can be seen from the data of table 1, the ill dog cure rate using the Chinese medicine additive of the embodiment of the present invention 1 and the dog grain of embodiment 2 to carry out treating and be efficiently obviously better than conventional medicament, and Chinese medicine additive of the present invention safely, have no side effect.
Model case
The domesticated dog about 250 that in October, 2012, Liaocheng of Shandong Province villager raised, wherein more than 90 pup occurs that body temperature is increased to 40 DEG C, down in spirits, the symptom of anorexia, occur dead pup after several days, cut open inspection and find dead pup subcutaneous dropsy, there is hydrops in abdominal cavity, mesenterium has xanthochromia, stomach and intestine and the visible serous coat bleed bottom of gall-bladder.Carry out blood examination to ill dog, visible number of white blood cells reduces, and neutrophil and LNC reduce relatively more serious, get disease dog lymph node endothelial cell and do histological examination, have oval inclusion body in visible cell core.Pup is diagnosed as virus hepatitis, random selecting 40 pups are also divided into two groups, use the Chinese medicine additive of the embodiment of the present invention 1 and the dog grain of embodiment 2 to treat respectively, the ill dog of embodiment group 1 uses the powder of the embodiment of the present invention 1 to treat, every day three times, each 30g, can dissolve to gavage or directly admix in dog grain and feed, continuously treatment 5 days (the change of illness state cut-off treatment according to ill dog), after 7 days, 35 ill dogs are all fully recovered, and 5 ill dogs are almost recovered; The ill dog of embodiment group 2 uses the dog grain of the embodiment of the present invention 2 to treat, and feeds according to normal feed mode, continuously treatment 5 days (the change of illness state cut-off treatment according to ill dog), and after 7 days, 39 ill dogs are all fully recovered, and 1 ill dog is almost recovered.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. for the dog grain of preventing canine virus hepatitis, it is characterized in that, described dog grain comprises following raw material: corn, dehydrated chicken, dehydration duck, dehydration thin pork, dehydration chicken gizzard, mung bean, Chinese yam, carrot, hawthorn, linseed, the egg yolk boiled, soybean oil, lutein extract and salt.
2. the dog grain for preventing canine virus hepatitis according to claim 1, it is characterized in that, described dog grain also comprises Chinese medicine additive, described dog grain is made up of the raw material of following parts by weight: corn 25-51 weight portion, dehydrated chicken 48-79 weight portion, dehydration duck 32-58 weight portion, dehydration thin pork 27-49 weight portion, dehydration chicken gizzard 15-30 weight portion, mung bean 11-19 weight portion, Chinese yam 22-31 weight portion, carrot 8-20 weight portion, hawthorn 5-15 weight portion, linseed 5-13 weight portion, the egg yolk 10-26 weight portion boiled, soybean oil 3-7 weight portion, lutein extract 1-5 weight portion, salt 2-6 weight portion and Chinese medicine additive 2-7 weight portion.
3. the dog grain for preventing canine virus hepatitis according to claim 1 and 2, it is characterized in that, described dog grain is made up of the raw material of following parts by weight: corn 30-45 weight portion, dehydrated chicken 55-68 weight portion, dehydration duck 40-50 weight portion, dehydration thin pork 33-41 weight portion, dehydration chicken gizzard 18-25 weight portion, mung bean 13-17 weight portion, Chinese yam 25-28 weight portion, carrot 12-17 weight portion, hawthorn 8-12 weight portion, linseed 8-10 weight portion, the egg yolk 15-21 weight portion boiled, soybean oil 4-6 weight portion, lutein extract 2-5 weight portion, salt 3-6 weight portion and Chinese medicine additive 3-7 weight portion.
4. the dog grain for preventing canine virus hepatitis according to any one of claim 1-3, it is characterized in that, described dog grain is made up of the raw material of following parts by weight: corn 38 weight portion, dehydrated chicken 63 weight portion, dehydration duck 45 weight portion, dehydration thin pork 38 weight portion, dehydration chicken gizzard 22 weight portion, mung bean 15 weight portion, Chinese yam 27 weight portion, carrot 14 weight portion, hawthorn 10 weight portion, linseed 9 weight portion, egg yolk 18 weight portion boiled, soybean oil 5 weight portion, lutein extract 3 weight portion, salt 4 weight portion and Chinese medicine additive 5 weight portion.
5. the dog grain for preventing canine virus hepatitis according to any one of claim 1-4, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: root of large-flowered skullcap 20-30 weight portion, Chinese aloe leaf 14-25 weight portion, sophora bud 8-17 weight portion, evodia rutaecarpa 12-23 weight portion, felwort 10-20 weight portion, cape jasmine 10-15 weight portion, Galium verum 10-17 weight portion, hypericum japonicum 15-25 weight portion, Radix Angelicae Sinensis 20-30 weight portion, India Canna Rhizome 10-18 weight portion, glossy ganoderma 10-20 weight portion, radix pseudostellariae 10-15 weight portion, unpleasant swallowwort herb 10-20 weight portion, cassia seed 12-18 weight portion, Horseweed Herb 10-20 weight portion, root bark of white mulberry 10-19 weight portion, dried immature fruit of citron orange 18-25 weight portion, swertia mileensis 8-16 weight portion, Rhizoma Sparganii 3-10 weight portion, the fragrant 5-12 weight portion of bodhi, red sage root 10-20 weight portion, pine needle 5-16 weight portion and Radix Glycyrrhizae 8-15 weight portion.
6. the dog grain for preventing canine virus hepatitis according to any one of claim 1-5, it is characterized in that, described Chinese medicine additive is made up of the raw medicinal material of following parts by weight: the root of large-flowered skullcap 25 weight portion, Chinese aloe leaf 19 weight portion, the sophora bud 12 weight portion, evodia rutaecarpa 17 weight portion, felwort 15 weight portion, cape jasmine 12 weight portion, Galium verum 13 weight portion, hypericum japonicum 19 weight portion, Radix Angelicae Sinensis 25 weight portion, India Canna Rhizome 14 weight portion, glossy ganoderma 15 weight portion, radix pseudostellariae 13 weight portion, unpleasant swallowwort herb 15 weight portion, cassia seed 15 weight portion, Horseweed Herb 15 weight portion, the root bark of white mulberry 13 weight portion, the dried immature fruit of citron orange 22 weight portion, swertia mileensis 12 weight portion, Rhizoma Sparganii 6 weight portion, fragrant 8 weight portions of bodhi, the red sage root 15 weight portion, pine needle 10 weight portion and Radix Glycyrrhizae 11 weight portion.
7. the dog grain for preventing canine virus hepatitis according to any one of claim 1-6, is characterized in that, the preparation method of described Chinese medicine additive is:
The first step, mixes in proportion by each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, adds hot reflux 1 ~ 3 hour, extracts, and filters acquisition first extract; Filter the dregs of a decoction obtained to add relative to the determining alcohol of described dregs of a decoction quality 1 ~ 2 times to be again the ethanol of 85 ~ 95%, to add hot reflux 1 ~ 3 hour that acquisition second extract is filtered in extraction; First extract and the second extract are merged, reduced pressure concentration removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in micronizer and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains Chinese medicine additive.
8. the preparation method of the dog grain for preventing canine virus hepatitis according to any one of claim 1-7, is characterized in that, the preparation method of described dog grain is:
Step one, to take mixing after Chinese yam, carrot, hawthorn and the egg yolk chopping of boiling by described parts by weight, put into the baking oven of 50 DEG C, smoke 30-40 minute, obtain mixture A;
Step 2, after by corn, dehydrated chicken, dehydration duck, dehydration pork, dehydration, chicken gizzard, mung bean and linseed mix with the mixture A that step one obtains, be placed in micronizer and pulverize 1 ~ 2 hour, sieve, obtain 300 order ~ 400 object micropowders;
Step 3, micropowders is mixed with soybean oil, lutein extract, salt, Chinese medicine additive after, be placed in granulator granulation, 40-60 minute smoked by the baking oven putting into 40 DEG C subsequently, then cools under room temperature, sterilization, packs.
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| CN201410706878.7A CN104351572A (en) | 2014-12-01 | 2014-12-01 | Dog food for preventing dog viral hepatitis and preparation method of dog food |
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| CN201410706878.7A CN104351572A (en) | 2014-12-01 | 2014-12-01 | Dog food for preventing dog viral hepatitis and preparation method of dog food |
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| CN108294185A (en) * | 2018-01-30 | 2018-07-20 | 华兴宠物食品有限公司 | A kind of dog food and preparation method thereof for preventing canine virus hepatitis |
| CN108576452A (en) * | 2018-04-04 | 2018-09-28 | 华兴宠物食品有限公司 | A kind of health care dog food for preventing puppy rickets |
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Application publication date: 20150218 |