CN104350054B - 作为选择性细胞周期蛋白依赖性激酶抑制剂的吡唑并三嗪衍生物 - Google Patents
作为选择性细胞周期蛋白依赖性激酶抑制剂的吡唑并三嗪衍生物 Download PDFInfo
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- CN104350054B CN104350054B CN201380011917.5A CN201380011917A CN104350054B CN 104350054 B CN104350054 B CN 104350054B CN 201380011917 A CN201380011917 A CN 201380011917A CN 104350054 B CN104350054 B CN 104350054B
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- isopropyl
- pyrazolo
- triazin
- benzyl
- amine
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- 0 CC([C@](C)(C(*)N*)N)NC(*)N Chemical compound CC([C@](C)(C(*)N*)N)NC(*)N 0.000 description 17
- LZMATGARSSLFMQ-UHFFFAOYSA-N CC(C)NC(N)=O Chemical compound CC(C)NC(N)=O LZMATGARSSLFMQ-UHFFFAOYSA-N 0.000 description 1
- ODSNLAHWJMQSAD-UHFFFAOYSA-N CC(C)c(cn[n]1c(O)n2)c1nc2S(C)(=O)=O Chemical compound CC(C)c(cn[n]1c(O)n2)c1nc2S(C)(=O)=O ODSNLAHWJMQSAD-UHFFFAOYSA-N 0.000 description 1
- MTGOAOABFUSGKF-UHFFFAOYSA-N CC(C)c(cn[n]1c(O)n2)c1nc2SC Chemical compound CC(C)c(cn[n]1c(O)n2)c1nc2SC MTGOAOABFUSGKF-UHFFFAOYSA-N 0.000 description 1
- WIWOHHCKWSXYFI-YSTIKXIDSA-N CC(C/C=C/[U])c(cn[n]1c(NCc2ccccc2OC(C)=O)n2)c1nc2O[C@H]1CNCCC1 Chemical compound CC(C/C=C/[U])c(cn[n]1c(NCc2ccccc2OC(C)=O)n2)c1nc2O[C@H]1CNCCC1 WIWOHHCKWSXYFI-YSTIKXIDSA-N 0.000 description 1
- DCOXUCLYBHCTQD-UHFFFAOYSA-N CC1=C(N)OC1(CCN)N Chemical compound CC1=C(N)OC1(CCN)N DCOXUCLYBHCTQD-UHFFFAOYSA-N 0.000 description 1
- PTFQJJDAHUWEAF-BZZOAKBMSA-N CCO/C(/C(C)NC(NCc1ccccc1-[n]1nccc1)[n]1ncc(C(C)C)c1C)=N\C Chemical compound CCO/C(/C(C)NC(NCc1ccccc1-[n]1nccc1)[n]1ncc(C(C)C)c1C)=N\C PTFQJJDAHUWEAF-BZZOAKBMSA-N 0.000 description 1
- FJCZWCURAHLMAT-UHFFFAOYSA-N CCOC(c1nc2c(C(C)C)cn[n]2c(NCc(cccc2)c2-[n]2nccc2)n1)=N Chemical compound CCOC(c1nc2c(C(C)C)cn[n]2c(NCc(cccc2)c2-[n]2nccc2)n1)=N FJCZWCURAHLMAT-UHFFFAOYSA-N 0.000 description 1
- YFDBEDSVQOAWSJ-UHFFFAOYSA-N CCOC(c1nc2c(C(C)C)cn[n]2c(NCc(cccc2)c2-[n]2nccc2)n1)=O Chemical compound CCOC(c1nc2c(C(C)C)cn[n]2c(NCc(cccc2)c2-[n]2nccc2)n1)=O YFDBEDSVQOAWSJ-UHFFFAOYSA-N 0.000 description 1
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D487/04—Ortho-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12157751.4A EP2634190A1 (en) | 2012-03-01 | 2012-03-01 | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| EP12157751.4 | 2012-03-01 | ||
| PCT/EP2013/054224 WO2013128028A1 (en) | 2012-03-01 | 2013-03-01 | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104350054A CN104350054A (zh) | 2015-02-11 |
| CN104350054B true CN104350054B (zh) | 2017-06-13 |
Family
ID=47757629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380011917.5A Active CN104350054B (zh) | 2012-03-01 | 2013-03-01 | 作为选择性细胞周期蛋白依赖性激酶抑制剂的吡唑并三嗪衍生物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9567345B2 (https=) |
| EP (2) | EP2634190A1 (https=) |
| JP (1) | JP6182549B2 (https=) |
| KR (1) | KR101821452B1 (https=) |
| CN (1) | CN104350054B (https=) |
| AU (1) | AU2013224848B2 (https=) |
| BR (1) | BR112014021189B1 (https=) |
| CA (1) | CA2865946C (https=) |
| DK (1) | DK2820020T3 (https=) |
| ES (1) | ES2583231T3 (https=) |
| HU (1) | HUE029264T2 (https=) |
| IL (1) | IL234183A (https=) |
| MX (1) | MX347359B (https=) |
| RU (1) | RU2645347C2 (https=) |
| SG (1) | SG11201405129RA (https=) |
| WO (1) | WO2013128028A1 (https=) |
| ZA (1) | ZA201406078B (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| CN110229142A (zh) | 2014-04-04 | 2019-09-13 | 希洛斯医药品股份有限公司 | 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂 |
| EP3129371B1 (en) * | 2014-04-05 | 2020-07-29 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| CA2966164C (en) | 2014-10-31 | 2023-10-17 | Ube Industries, Ltd. | Substituted dihydropyrrolopyrazole compound |
| ES2899196T3 (es) * | 2015-03-09 | 2022-03-10 | Aurigene Discovery Tech Ltd | Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK |
| MX394157B (es) | 2015-06-15 | 2025-03-24 | Ube Corp | Derivado de dihidropirrolopirazol sustituido. |
| AU2016284638B2 (en) * | 2015-06-24 | 2020-01-23 | Curovir Ab | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
| KR102480965B1 (ko) | 2016-09-13 | 2022-12-26 | 알레간 인코포레이티드 | 안정화된 비단백질 클로스트리듐 독소 조성물 |
| CN106432249B (zh) * | 2016-09-30 | 2018-12-04 | 陕西科技大学 | 一类吡咯并[2，1-f][1，2，4]三嗪母核化合物的合成及其医药用途 |
| EP3664806B1 (en) | 2017-08-09 | 2025-04-30 | Sanford Burnham Prebys Medical Discovery Institute | 3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE-5-CARBOXILIC ACID DERIVATIVES AS APELIN (APJ) RECEPTOR AGONISTS FOR THE TREATMENT OF CARDIOVASCULAR, METABOLIC, CNS, OR INFECTIOUS DISEASES OR DISORDERS |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| CA3088347A1 (en) * | 2018-01-17 | 2019-07-25 | Glaxosmithkline Intellectual Property Development Limited | Pi4kiii.beta. inhibitors |
| US12606561B2 (en) | 2018-04-11 | 2026-04-21 | Qurient Co., Ltd. | Substituted pyrazolo[1,5-a][1,3,5]triazines as CDK inhibitors |
| KR20200141487A (ko) * | 2018-04-11 | 2020-12-18 | 주식회사 큐리언트 | 사이클린 의존성 키나아제의 선택적 억제제로서의 피라졸로-트리아진 및/또는 피라졸로피리미딘 유도체 |
| BR112020020645A2 (pt) * | 2018-04-11 | 2021-01-12 | Qurient Co., Ltd. | Derivados farmaceuticamente aceitáveis de pirazol-triazina e/ou pirazol-pirimidina |
| US11517568B2 (en) | 2018-09-12 | 2022-12-06 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| US11364234B2 (en) | 2018-09-12 | 2022-06-21 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| CR20210287A (es) | 2018-11-01 | 2022-02-15 | Syros Pharmaceuticals Inc | Inhibidores de cinasa 7 dependiente de ciclina (cdk7) |
| EP3885347B1 (en) | 2018-11-14 | 2023-11-22 | UBE Corporation | Dihydropyrrolopyrazole derivative |
| CN110101703B (zh) * | 2019-05-06 | 2021-06-11 | 暨南大学 | Cdk7抑制剂在制备溃疡性结肠炎或结肠癌药物的应用 |
| RU2713152C1 (ru) * | 2019-08-30 | 2020-02-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения хронической аллергической крапивницы на фоне описторхоза |
| TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| GB201918541D0 (en) | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| CN110950871B (zh) * | 2019-12-25 | 2022-05-17 | 陕西师范大学 | 2-取代-4-芳氨基吡唑并三嗪衍生物及制备抗肿瘤药物的应用 |
| CN116964061A (zh) * | 2020-12-21 | 2023-10-27 | 詹森药业有限公司 | 作为细胞周期蛋白依赖性激酶7（cdk7）抑制剂的三环嘧啶 |
| US20250281495A1 (en) * | 2021-02-25 | 2025-09-11 | Icahn School Of Medicine At Mount Sinai | Methods for inhibiting inflammation and progression of atherosclerotic plaques and cardiovascular events in patients with cerebro- and cardio-vascular disease |
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| CA2865946C (en) | 2020-01-21 |
| HUE029264T2 (en) | 2017-02-28 |
| CN104350054A (zh) | 2015-02-11 |
| ZA201406078B (en) | 2016-08-31 |
| EP2820020A1 (en) | 2015-01-07 |
| US20150018329A1 (en) | 2015-01-15 |
| MX2014010494A (es) | 2015-04-08 |
| EP2820020B1 (en) | 2016-04-06 |
| KR101821452B1 (ko) | 2018-01-23 |
| SG11201405129RA (en) | 2014-09-26 |
| EP2634190A1 (en) | 2013-09-04 |
| JP6182549B2 (ja) | 2017-08-16 |
| CA2865946A1 (en) | 2013-09-06 |
| IL234183A (en) | 2016-11-30 |
| BR112014021189B1 (pt) | 2022-08-16 |
| KR20140131994A (ko) | 2014-11-14 |
| DK2820020T3 (en) | 2016-07-04 |
| RU2014139705A (ru) | 2016-04-20 |
| WO2013128028A8 (en) | 2014-10-02 |
| MX347359B (es) | 2017-04-06 |
| AU2013224848B2 (en) | 2017-06-29 |
| BR112014021189A2 (https=) | 2017-06-20 |
| ES2583231T3 (es) | 2016-09-19 |
| JP2015511952A (ja) | 2015-04-23 |
| AU2013224848A1 (en) | 2014-08-28 |
| US9567345B2 (en) | 2017-02-14 |
| HK1206014A1 (en) | 2015-12-31 |
| WO2013128028A1 (en) | 2013-09-06 |
| RU2645347C2 (ru) | 2018-02-21 |
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