SG11201405129RA - Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors - Google Patents
Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitorsInfo
- Publication number
- SG11201405129RA SG11201405129RA SG11201405129RA SG11201405129RA SG11201405129RA SG 11201405129R A SG11201405129R A SG 11201405129RA SG 11201405129R A SG11201405129R A SG 11201405129RA SG 11201405129R A SG11201405129R A SG 11201405129RA SG 11201405129R A SG11201405129R A SG 11201405129RA
- Authority
- SG
- Singapore
- Prior art keywords
- inhinitors
- pyrazolo
- dependent kinase
- triazine derivatives
- selective cyclin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12157751.4A EP2634190A1 (en) | 2012-03-01 | 2012-03-01 | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| PCT/EP2013/054224 WO2013128028A1 (en) | 2012-03-01 | 2013-03-01 | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201405129RA true SG11201405129RA (en) | 2014-09-26 |
Family
ID=47757629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201405129RA SG11201405129RA (en) | 2012-03-01 | 2013-03-01 | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9567345B2 (en) |
| EP (2) | EP2634190A1 (en) |
| JP (1) | JP6182549B2 (en) |
| KR (1) | KR101821452B1 (en) |
| CN (1) | CN104350054B (en) |
| AU (1) | AU2013224848B2 (en) |
| BR (1) | BR112014021189B1 (en) |
| CA (1) | CA2865946C (en) |
| DK (1) | DK2820020T3 (en) |
| ES (1) | ES2583231T3 (en) |
| HK (1) | HK1206014A1 (en) |
| HU (1) | HUE029264T2 (en) |
| IL (1) | IL234183A (en) |
| MX (1) | MX347359B (en) |
| RU (1) | RU2645347C2 (en) |
| SG (1) | SG11201405129RA (en) |
| WO (1) | WO2013128028A1 (en) |
| ZA (1) | ZA201406078B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (en) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| SG11201608242XA (en) | 2014-04-04 | 2016-10-28 | Syros Pharmaceuticals Inc | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| EP3129371B1 (en) * | 2014-04-05 | 2020-07-29 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| WO2016068287A1 (en) | 2014-10-31 | 2016-05-06 | 宇部興産株式会社 | Substituted dihydropyrrolopyrazole compound |
| EP3268000B1 (en) * | 2015-03-09 | 2021-08-04 | Aurigene Discovery Technologies Limited | Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors |
| RU2765718C1 (en) | 2015-06-15 | 2022-02-02 | Убе Индастриз, Лтд. | Substituted dihydropyrrolopyrazole derivative |
| BR112017026061B1 (en) * | 2015-06-24 | 2023-03-28 | Curovir Ab | COMPOUND, PHARMACEUTICAL COMPOSITION, AND, USE OF A COMPOUND |
| ES2755815T3 (en) | 2016-09-13 | 2020-04-23 | Allergan Inc | Stabilized non-protein Clostridium toxin compositions |
| CN106432249B (en) * | 2016-09-30 | 2018-12-04 | 陕西科技大学 | The synthesis of a kind of pyrrolo- [2,1-f] [1,2,4] triazine parent nucleus compound and its medical usage |
| EP3664806A4 (en) | 2017-08-09 | 2021-04-07 | Sanford Burnham Prebys Medical Discovery Institute | Apelin receptor agonists and methods of use thereof |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| UY38051A (en) | 2018-01-17 | 2019-08-30 | Glaxosmithkline Ip Dev Ltd | PI4KIIIß INHIBITORS |
| CA3095426A1 (en) * | 2018-04-11 | 2019-10-17 | Qurient Co., Ltd. | Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives |
| US11945822B2 (en) * | 2018-04-11 | 2024-04-02 | Qurient Co., Ltd. | Pyrazolo-triazine and/or pyrazolo-pxrimidine derivatives as selective inhibitor of cyclin dependent kinase |
| CA3112443A1 (en) | 2018-09-12 | 2020-03-19 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| US11517568B2 (en) | 2018-09-12 | 2022-12-06 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| EP3885347B1 (en) | 2018-11-14 | 2023-11-22 | UBE Corporation | Dihydropyrrolopyrazole derivative |
| CN110101703B (en) * | 2019-05-06 | 2021-06-11 | 暨南大学 | Application of CDK7 inhibitor in preparation of medicine for treating ulcerative colitis or colon cancer |
| RU2713152C1 (en) * | 2019-08-30 | 2020-02-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Method of treating chronic allergic urticaria accompanying opisthorchiasis |
| TW202146416A (en) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | Pyrazolotriazines |
| GB201918541D0 (en) * | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| CN110950871B (en) * | 2019-12-25 | 2022-05-17 | 陕西师范大学 | 2-substituted-4-arylamino pyrazolotriazine derivative and application thereof in preparing antitumor drugs |
| US20240109912A1 (en) * | 2020-12-21 | 2024-04-04 | Janssen Pharmaceutica Nv | Tricyclic pyrimidines as cyclin-dependent kinase 7 (cdk7) inhibitors |
| EP4305040A1 (en) * | 2021-03-09 | 2024-01-17 | JANSSEN Pharmaceutica NV | Tricyclic pyridines as cyclin-dependent kinase 7 (cdk7) inhibitors |
| WO2022266418A1 (en) * | 2021-06-17 | 2022-12-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Triazine inhibitors of cyclin-dependent kinases |
| WO2023001061A1 (en) * | 2021-07-17 | 2023-01-26 | Jingrui Biopharma Co., Ltd. | Cdk7 selective inhibitors as anticancer agents |
| WO2023006789A1 (en) | 2021-07-29 | 2023-02-02 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
| WO2023094310A1 (en) * | 2021-11-23 | 2023-06-01 | Origenis Gmbh | Pyrazolotriazine derivatives useful as cdk9 inhibitors |
| CN114181217B (en) * | 2022-01-10 | 2022-12-27 | 陕西师范大学 | Pyrazolo [1,5-a ] [1,3,5] triazine derivative and salt thereof and application of derivative and salt thereof in preparation of anti-cancer drugs |
| WO2023175173A1 (en) * | 2022-03-18 | 2023-09-21 | Qurient Co., Ltd. | Cdk7 inhibitors for antiviral treatment |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US615968A (en) | 1898-12-13 | Apparatus for treating ores | ||
| DK1150982T3 (en) * | 1999-02-01 | 2005-12-27 | Cv Therapeutics Inc | Purine inhibitors of cylin-dependent kinase 2 and 1kB alpha |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| TW200536536A (en) * | 2004-02-25 | 2005-11-16 | Schering Corp | Pyrazolotriazines as kinase inhibitors |
| CZ302122B6 (en) * | 2009-01-28 | 2010-10-20 | Univerzita Palackého v Olomouci | Substituted derivatives of 6-(2-aminobenzylamino)purine, their use as well as a medicament and compositions in which said derivatives are comprised |
| FR2943058B1 (en) * | 2009-03-11 | 2011-06-03 | Centre Nat Rech Scient | DERIVATIVES OF PYRAZOLO® 1,5-A! -1,3,5-TRIAZINES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS. |
| CZ302711B6 (en) * | 2009-06-03 | 2011-09-14 | Univerzita Palackého v Olomouci | Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and pharmaceutical compositions comprising thereof |
-
2012
- 2012-03-01 EP EP12157751.4A patent/EP2634190A1/en not_active Withdrawn
-
2013
- 2013-03-01 JP JP2014559259A patent/JP6182549B2/en active Active
- 2013-03-01 MX MX2014010494A patent/MX347359B/en active IP Right Grant
- 2013-03-01 US US14/381,146 patent/US9567345B2/en active Active
- 2013-03-01 AU AU2013224848A patent/AU2013224848B2/en active Active
- 2013-03-01 RU RU2014139705A patent/RU2645347C2/en active
- 2013-03-01 CA CA2865946A patent/CA2865946C/en active Active
- 2013-03-01 WO PCT/EP2013/054224 patent/WO2013128028A1/en active Application Filing
- 2013-03-01 HU HUE13707008A patent/HUE029264T2/en unknown
- 2013-03-01 CN CN201380011917.5A patent/CN104350054B/en active Active
- 2013-03-01 BR BR112014021189-2A patent/BR112014021189B1/en active IP Right Grant
- 2013-03-01 KR KR1020147027812A patent/KR101821452B1/en active IP Right Grant
- 2013-03-01 DK DK13707008.2T patent/DK2820020T3/en active
- 2013-03-01 ES ES13707008.2T patent/ES2583231T3/en active Active
- 2013-03-01 EP EP13707008.2A patent/EP2820020B1/en active Active
- 2013-03-01 SG SG11201405129RA patent/SG11201405129RA/en unknown
-
2014
- 2014-08-19 ZA ZA2014/06078A patent/ZA201406078B/en unknown
- 2014-08-19 IL IL234183A patent/IL234183A/en active IP Right Grant
-
2015
- 2015-07-07 HK HK15106476.3A patent/HK1206014A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013224848A1 (en) | 2014-08-28 |
| EP2820020B1 (en) | 2016-04-06 |
| US20150018329A1 (en) | 2015-01-15 |
| CA2865946C (en) | 2020-01-21 |
| HK1206014A1 (en) | 2015-12-31 |
| ES2583231T3 (en) | 2016-09-19 |
| ZA201406078B (en) | 2016-08-31 |
| IL234183A (en) | 2016-11-30 |
| EP2820020A1 (en) | 2015-01-07 |
| MX2014010494A (en) | 2015-04-08 |
| DK2820020T3 (en) | 2016-07-04 |
| BR112014021189B1 (en) | 2022-08-16 |
| CA2865946A1 (en) | 2013-09-06 |
| KR20140131994A (en) | 2014-11-14 |
| JP6182549B2 (en) | 2017-08-16 |
| JP2015511952A (en) | 2015-04-23 |
| CN104350054A (en) | 2015-02-11 |
| WO2013128028A1 (en) | 2013-09-06 |
| BR112014021189A2 (en) | 2017-06-20 |
| WO2013128028A8 (en) | 2014-10-02 |
| KR101821452B1 (en) | 2018-01-23 |
| MX347359B (en) | 2017-04-06 |
| EP2634190A1 (en) | 2013-09-04 |
| CN104350054B (en) | 2017-06-13 |
| US9567345B2 (en) | 2017-02-14 |
| AU2013224848B2 (en) | 2017-06-29 |
| HUE029264T2 (en) | 2017-02-28 |
| RU2014139705A (en) | 2016-04-20 |
| RU2645347C2 (en) | 2018-02-21 |
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