CN104334179A - 含有高温下萃取的鹿角萃取物的医药组合物及健康功能食品 - Google Patents
含有高温下萃取的鹿角萃取物的医药组合物及健康功能食品 Download PDFInfo
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KR1020120062548A KR101445648B1 (ko) | 2012-06-12 | 2012-06-12 | 고온에서 추출된 녹각추출물을 포함하는 약학 조성물 및 건강기능식품 |
KR10-2012-0062548 | 2012-06-12 | ||
PCT/KR2013/003800 WO2013187602A1 (ko) | 2012-06-12 | 2013-05-02 | 고온에서 추출된 녹각추출물을 포함하는 약학 조성물 및 건강기능식품 |
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CN1569034A (zh) * | 2003-07-22 | 2005-01-26 | 肖劲夫 | 用于治疗骨质疏松症的健骨中药制剂及其制造方法 |
KR20110049437A (ko) * | 2009-11-05 | 2011-05-12 | 허만복 | 녹용 엑기스가 첨가된 고추장의 제조방법 |
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KR20030031272A (ko) * | 2001-10-13 | 2003-04-21 | 신석균 | 양면이 다른 양면매직테이프 |
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CN1569034A (zh) * | 2003-07-22 | 2005-01-26 | 肖劲夫 | 用于治疗骨质疏松症的健骨中药制剂及其制造方法 |
KR20110049437A (ko) * | 2009-11-05 | 2011-05-12 | 허만복 | 녹용 엑기스가 첨가된 고추장의 제조방법 |
Non-Patent Citations (5)
Title |
---|
于文影: "鹿角脱盘多肽的制备及其生物活性的研究", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
傅香九: "鹿角胶工艺改进与质量", 《中成药研究》 * |
姜仲良: "中药鹿角炮制工艺研究", 《中成药研究》 * |
郭振纲等: "《中医临床药对新编》", 31 August 2002, 云南科技出版社 * |
项平等: "《中医进补全书》", 31 October 2001, 上海中医药大学出版社 * |
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KR20130138968A (ko) | 2013-12-20 |
JP6063038B2 (ja) | 2017-01-18 |
WO2013187602A1 (ko) | 2013-12-19 |
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