CN104324139A - 一种治疗干眼症的药物组合物 - Google Patents
一种治疗干眼症的药物组合物 Download PDFInfo
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- CN104324139A CN104324139A CN201410625308.5A CN201410625308A CN104324139A CN 104324139 A CN104324139 A CN 104324139A CN 201410625308 A CN201410625308 A CN 201410625308A CN 104324139 A CN104324139 A CN 104324139A
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Abstract
Description
组别 | 病例数 | 治疗前 | 治疗后 |
治疗组 | 96 | 4.24±1.65 | 8.19±1.33¥ |
对照组 | 96 | 4.37±1.48 | 5.61±1.68 |
组别 | 病例数 | 治疗前 | 治疗后 |
治疗组 | 96 | 3.98±1.24 | 7.10±1.41#& |
对照组 | 96 | 4.01±1.19 | 5.24±1.26 |
组别 | 病例数 | 治疗前 | 治疗后 |
治疗组 | 96 | 6.13±2.12 | 3.05±1.34*$ |
对照组 | 96 | 6.25±1.88 | 4.63±1.67 |
组别 | 病例数 | 显效(显效率) | 有效(有效率) | 无效(无效率) | 总有效率 |
治疗组 | 96 | 69(71.88%) | 26 | 1 | 98.96% |
对照组 | 96 | 45(46.88%) | 15 | 36 | 62.50% |
Claims (7)
Priority Applications (1)
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CN201410625308.5A CN104324139B (zh) | 2014-11-07 | 2014-11-07 | 一种治疗干眼症的药物组合物 |
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Application Number | Priority Date | Filing Date | Title |
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CN201410625308.5A CN104324139B (zh) | 2014-11-07 | 2014-11-07 | 一种治疗干眼症的药物组合物 |
Publications (2)
Publication Number | Publication Date |
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CN104324139A true CN104324139A (zh) | 2015-02-04 |
CN104324139B CN104324139B (zh) | 2017-03-01 |
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CN201410625308.5A Expired - Fee Related CN104324139B (zh) | 2014-11-07 | 2014-11-07 | 一种治疗干眼症的药物组合物 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105148118A (zh) * | 2015-09-30 | 2015-12-16 | 张晰 | 一种治疗干眼症的中药组合物药剂及其制备方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007211007A (ja) * | 2006-01-13 | 2007-08-23 | Taisho Pharmaceut Co Ltd | O/w型エマルション水性点眼剤 |
CN102210821A (zh) * | 2011-05-15 | 2011-10-12 | 王春兰 | 一种治疗干眼症的中药 |
CN102302686A (zh) * | 2011-07-22 | 2012-01-04 | 陈超 | 一种治疗干眼症的药剂 |
CN102973842A (zh) * | 2012-12-04 | 2013-03-20 | 王亚明 | 一种治疗干眼症的中药熏洗液 |
CN103007014A (zh) * | 2012-11-21 | 2013-04-03 | 邱丽萍 | 一种用于治疗干眼症的中药组合物及制备方法 |
CN103751278A (zh) * | 2013-12-27 | 2014-04-30 | 湖南中医药大学 | 一种密蒙花颗粒剂及其制备方法 |
CN104116774A (zh) * | 2014-08-04 | 2014-10-29 | 毕宏生 | 一种红景天提取物、提取方法和其在治疗/预防眼科病症中的用途及制品 |
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2014
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Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007211007A (ja) * | 2006-01-13 | 2007-08-23 | Taisho Pharmaceut Co Ltd | O/w型エマルション水性点眼剤 |
CN102210821A (zh) * | 2011-05-15 | 2011-10-12 | 王春兰 | 一种治疗干眼症的中药 |
CN102302686A (zh) * | 2011-07-22 | 2012-01-04 | 陈超 | 一种治疗干眼症的药剂 |
CN103007014A (zh) * | 2012-11-21 | 2013-04-03 | 邱丽萍 | 一种用于治疗干眼症的中药组合物及制备方法 |
CN102973842A (zh) * | 2012-12-04 | 2013-03-20 | 王亚明 | 一种治疗干眼症的中药熏洗液 |
CN103751278A (zh) * | 2013-12-27 | 2014-04-30 | 湖南中医药大学 | 一种密蒙花颗粒剂及其制备方法 |
CN104116774A (zh) * | 2014-08-04 | 2014-10-29 | 毕宏生 | 一种红景天提取物、提取方法和其在治疗/预防眼科病症中的用途及制品 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105148118A (zh) * | 2015-09-30 | 2015-12-16 | 张晰 | 一种治疗干眼症的中药组合物药剂及其制备方法 |
CN105148118B (zh) * | 2015-09-30 | 2018-11-02 | 张晰 | 一种治疗干眼症的中药组合物药剂及其制备方法 |
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