CN104306353A - 一种维生素d3微胶囊粉的制备工艺及装置 - Google Patents
一种维生素d3微胶囊粉的制备工艺及装置 Download PDFInfo
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- CN104306353A CN104306353A CN201410618488.4A CN201410618488A CN104306353A CN 104306353 A CN104306353 A CN 104306353A CN 201410618488 A CN201410618488 A CN 201410618488A CN 104306353 A CN104306353 A CN 104306353A
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- 239000000843 powder Substances 0.000 title claims abstract description 60
- 239000003094 microcapsule Substances 0.000 title claims abstract description 41
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title claims abstract description 32
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 title claims abstract description 32
- 235000005282 vitamin D3 Nutrition 0.000 title claims abstract description 32
- 239000011647 vitamin D3 Substances 0.000 title claims abstract description 32
- 229940021056 vitamin d3 Drugs 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 229920002472 Starch Polymers 0.000 claims abstract description 130
- 235000019698 starch Nutrition 0.000 claims abstract description 130
- 239000008107 starch Substances 0.000 claims abstract description 130
- 238000001035 drying Methods 0.000 claims abstract description 33
- 229920000881 Modified starch Polymers 0.000 claims abstract description 23
- 239000004368 Modified starch Substances 0.000 claims abstract description 23
- 235000019426 modified starch Nutrition 0.000 claims abstract description 23
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 17
- 229930006000 Sucrose Natural products 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 15
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 15
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 3
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 3
- 239000007921 spray Substances 0.000 claims description 69
- 239000000463 material Substances 0.000 claims description 60
- 230000001804 emulsifying effect Effects 0.000 claims description 32
- 239000002245 particle Substances 0.000 claims description 28
- 238000005516 engineering process Methods 0.000 claims description 27
- 238000012216 screening Methods 0.000 claims description 21
- 239000004531 microgranule Substances 0.000 claims description 20
- 238000011084 recovery Methods 0.000 claims description 18
- 238000007599 discharging Methods 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 17
- 239000006199 nebulizer Substances 0.000 claims description 14
- 238000005469 granulation Methods 0.000 claims description 12
- 230000003179 granulation Effects 0.000 claims description 12
- 238000005276 aerator Methods 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 11
- 239000000839 emulsion Substances 0.000 claims description 10
- 239000008213 purified water Substances 0.000 claims description 10
- 210000000582 semen Anatomy 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 9
- -1 octenyl succinate anhydride Chemical class 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 16
- 238000004064 recycling Methods 0.000 abstract description 4
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 3
- 239000003921 oil Substances 0.000 abstract 2
- 235000019198 oils Nutrition 0.000 abstract 2
- 235000005687 corn oil Nutrition 0.000 abstract 1
- 239000002285 corn oil Substances 0.000 abstract 1
- 235000020238 sunflower seed Nutrition 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 16
- 239000011248 coating agent Substances 0.000 description 10
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- 229920000159 gelatin Polymers 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 108010010803 Gelatin Proteins 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 235000011852 gelatine desserts Nutrition 0.000 description 6
- 230000008901 benefit Effects 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 235000021050 feed intake Nutrition 0.000 description 3
- 229910052785 arsenic Inorganic materials 0.000 description 2
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 2
- 229910052793 cadmium Inorganic materials 0.000 description 2
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
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- 239000011257 shell material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 238000001548 drop coating Methods 0.000 description 1
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- 239000012535 impurity Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
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- 238000004062 sedimentation Methods 0.000 description 1
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- 150000003384 small molecules Chemical class 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017063102A1 (zh) * | 2015-10-12 | 2017-04-20 | 浙江医药股份有限公司新昌制药厂 | 一种脂溶性营养素微胶囊微粒的造粒成型干燥方法 |
CN107649071A (zh) * | 2017-08-31 | 2018-02-02 | 南京仰常健康管理有限公司 | 一种低聚果糖造粒装置及其应用 |
CN109351295A (zh) * | 2018-10-17 | 2019-02-19 | 嘉必优生物技术(武汉)股份有限公司 | 一种微胶囊造粒分级系统及微胶囊制备方法 |
CN109674062A (zh) * | 2019-02-01 | 2019-04-26 | 浙江花园营养科技有限公司 | 一种稳定性维生素d3纳米冻干粉的制备方法 |
CN109699986A (zh) * | 2018-12-29 | 2019-05-03 | 明富(上海)健康科技有限公司 | 一种工业化生产油脂包埋酸味剂颗粒的设备及其生产方法 |
CN111780495A (zh) * | 2020-05-29 | 2020-10-16 | 浙江工业大学 | 一种连续生产维生素d3微胶囊粉的闭路循环工艺 |
CN112274494A (zh) * | 2019-07-24 | 2021-01-29 | 重庆桑禾动物药业有限公司 | 一种新型高稳定性维生素d3微囊分散剂的制备 |
CN113996239A (zh) * | 2021-10-26 | 2022-02-01 | 山东邹平农药有限公司 | 一种水分散粒剂生产线 |
CN114392672A (zh) * | 2022-01-07 | 2022-04-26 | 浙江威仕生物科技有限公司 | 一种饲料级维生素d3微胶囊用的生产设备及其生产方法 |
Citations (5)
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CN101536993A (zh) * | 2009-04-21 | 2009-09-23 | 浙江花园生物高科股份有限公司 | 维生素d3微胶囊及其制备方法 |
CN102389095A (zh) * | 2011-10-14 | 2012-03-28 | 天津科技大学 | 低温流态化涂覆造粒制备酸味剂—油脂微胶囊系统及方法 |
WO2013150384A1 (en) * | 2012-04-04 | 2013-10-10 | Pronova Biopharma Norge As | Compositions comprising omega-3 fatty acids and vitamin d for psoriasis, and methods and uses thereof |
WO2013150386A2 (en) * | 2012-04-04 | 2013-10-10 | Pronova Biopharma Norge As | Compositions comprising omega-3 fatty acids and vitamin d for acne vulgaris and/or eczema, and methods and uses thereof |
CN203711011U (zh) * | 2014-01-24 | 2014-07-16 | 清华大学深圳研究生院 | 相变储能微胶囊制备装置 |
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2014
- 2014-11-06 CN CN201410618488.4A patent/CN104306353B/zh active Active
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CN101536993A (zh) * | 2009-04-21 | 2009-09-23 | 浙江花园生物高科股份有限公司 | 维生素d3微胶囊及其制备方法 |
CN102389095A (zh) * | 2011-10-14 | 2012-03-28 | 天津科技大学 | 低温流态化涂覆造粒制备酸味剂—油脂微胶囊系统及方法 |
WO2013150384A1 (en) * | 2012-04-04 | 2013-10-10 | Pronova Biopharma Norge As | Compositions comprising omega-3 fatty acids and vitamin d for psoriasis, and methods and uses thereof |
WO2013150386A2 (en) * | 2012-04-04 | 2013-10-10 | Pronova Biopharma Norge As | Compositions comprising omega-3 fatty acids and vitamin d for acne vulgaris and/or eczema, and methods and uses thereof |
CN203711011U (zh) * | 2014-01-24 | 2014-07-16 | 清华大学深圳研究生院 | 相变储能微胶囊制备装置 |
Non-Patent Citations (1)
Title |
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张彩菊等: "饲用维生素D3微胶囊型粉末的研制", 《饲料工业》 * |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US10821412B2 (en) * | 2015-10-12 | 2020-11-03 | Zhejiang Madicine Co., Ltd. Xinchang Pharmaceutical Factory | Method for granulating, forming, and drying fat soluble nutrient microcapsule particles |
WO2017063102A1 (zh) * | 2015-10-12 | 2017-04-20 | 浙江医药股份有限公司新昌制药厂 | 一种脂溶性营养素微胶囊微粒的造粒成型干燥方法 |
EP3363532A4 (en) * | 2015-10-12 | 2019-05-08 | Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory | METHOD FOR GRANULATING, FORMING AND DRYING FAT-SOLUBLE NUTRIENT MICRO-CAPSULE PARTICLES |
US20190193042A1 (en) * | 2015-10-12 | 2019-06-27 | Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory | Method For Granulating, Forming, And Drying Fat Soluble Nutrient Microcapsule Particles |
CN107649071A (zh) * | 2017-08-31 | 2018-02-02 | 南京仰常健康管理有限公司 | 一种低聚果糖造粒装置及其应用 |
CN109351295A (zh) * | 2018-10-17 | 2019-02-19 | 嘉必优生物技术(武汉)股份有限公司 | 一种微胶囊造粒分级系统及微胶囊制备方法 |
CN109699986A (zh) * | 2018-12-29 | 2019-05-03 | 明富(上海)健康科技有限公司 | 一种工业化生产油脂包埋酸味剂颗粒的设备及其生产方法 |
CN109699986B (zh) * | 2018-12-29 | 2022-08-26 | 明富(上海)健康科技有限公司 | 一种工业化生产油脂包埋酸味剂颗粒的设备及其生产方法 |
CN109674062A (zh) * | 2019-02-01 | 2019-04-26 | 浙江花园营养科技有限公司 | 一种稳定性维生素d3纳米冻干粉的制备方法 |
CN112274494A (zh) * | 2019-07-24 | 2021-01-29 | 重庆桑禾动物药业有限公司 | 一种新型高稳定性维生素d3微囊分散剂的制备 |
CN111780495B (zh) * | 2020-05-29 | 2022-03-25 | 浙江工业大学 | 一种连续生产维生素d3微胶囊粉的闭路循环工艺 |
CN111780495A (zh) * | 2020-05-29 | 2020-10-16 | 浙江工业大学 | 一种连续生产维生素d3微胶囊粉的闭路循环工艺 |
CN113996239A (zh) * | 2021-10-26 | 2022-02-01 | 山东邹平农药有限公司 | 一种水分散粒剂生产线 |
CN114392672A (zh) * | 2022-01-07 | 2022-04-26 | 浙江威仕生物科技有限公司 | 一种饲料级维生素d3微胶囊用的生产设备及其生产方法 |
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Denomination of invention: Preparation process and device of vitamin D3 microcapsule powder Effective date of registration: 20220427 Granted publication date: 20170301 Pledgee: Ji'nan rural commercial bank Limited by Share Ltd. high tech branch Pledgor: Douyuanhe (Shandong) food and Beverage Co.,Ltd. Registration number: Y2022980004695 |
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Denomination of invention: Preparation process and device of vitamin D3 microcapsule powder Effective date of registration: 20230224 Granted publication date: 20170301 Pledgee: Ji'nan rural commercial bank Limited by Share Ltd. high tech branch Pledgor: Douyuanhe (Shandong) food and Beverage Co.,Ltd. Registration number: Y2023980033211 |