CN104306176A - Quaternary ammonium salt type antibacterial hand washing solution - Google Patents
Quaternary ammonium salt type antibacterial hand washing solution Download PDFInfo
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- CN104306176A CN104306176A CN201410489787.2A CN201410489787A CN104306176A CN 104306176 A CN104306176 A CN 104306176A CN 201410489787 A CN201410489787 A CN 201410489787A CN 104306176 A CN104306176 A CN 104306176A
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Abstract
The present invention discloses a quaternary ammonium salt type antibacterial hand washing solution, which comprises, by weight, 0.4-0.8% of sodium lauryl polyoxyethylene ether sulfate, 1-2% of a quaternary ammonium salt, 15-25% of cocamidopropyl betaine, 0.1-0.2% of MES (AESS), 1-2% of coconut oil diethanolamide, 0.05-0.15% of a preservative, 0.1-0.5% of essence, and the balance of distilled water, wherein the pH value is 6.5-7.0. According to the quaternary ammonium salt type antibacterial hand washing solution, the anionic surfactant and the cationic surfactant can stably exist in the compounding system, and the solubility is good when the use amount of the one surfactant is more than the use amount of the other surfactant, such that the coagulation is not easily produced. The quaternary ammonium salt type antibacterial hand washing solution has characteristics of good stability, high escherichia coli killing rate, high staphylococcus aureus killing rate, and foaming property achieving the market level.
Description
Technical field
The present invention relates to a kind of quaternary anti-bacterial hand lotion.
Background technology
In November, 1999, ancestral's silk released first bottle of handwashing liquid in China, but finally led to the failure because not meeting consumption demand, and within 2000, the blue moon draws the former lesson, and consumer demand finds breach.At sars period, the requirement of people to handwashing liquid is more and more higher, and the development of handwashing liquid has developed into antibacterial effect from common stain release type, low stimulation, the features such as environmental sound.The blue moon of the common on the market anti-bacterial hand lotion of current China, drip dew, Wei Lushi, Safeguard, the central material mainly as antimicrobial component is α-phenylphenol, PCMX, DMG gram bacteria factor, PCMX respectively, and at the exigent hospital operating room of anti-microbial property is then the bromo geramine disinfectant solution of comparatively hindering hands.Commercially extremely rare as the handwashing liquid of antimicrobial component using quaternary ammonium salt at present, and traditional antibacterial is generally chlorine class, phenol compound, although they have good antibacterial effect, it also can not be ignored the harm of human body and environment.In January, 2014, Liu He pointed out that in Environmental science and technology article the material containing phenyl ring can reduce the degradation capability of microorganism to a greater extent, this means handwashing liquid used by people after just extended stationary periods in the Nature, be difficult to degraded, even can the original degradation capability of destroy microorganisms self, thus cause secondary pollution.
Also correlational study is had to carry out natural plant essence as antimicrobial component in recent years, as: Flos Lonicerae, tea tree oil, the Chinese herbal medicine classes such as Aloe, but still perplex everybody at cost and in the problem to these extracted form natural plant explained hereafter, and also traditional extracted form natural plant generally will use a large amount of organic solvents, as methanol, acetone, diethyl ether etc., not only cost is high for this, and also affects to environment, is therefore finally also extensively promoted.Therefore, the trend of present handwashing liquid is: clean effect is good, safety, and low stimulation, has antibacterial ability, environment amenable, the Novel hand-washing liquid of low cost.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of environmentally friendly, the quaternary anti-bacterial hand lotion of good anti-bacterial effect
To achieve these goals, the present invention adopts following technical scheme:
A kind of quaternary anti-bacterial hand lotion, is made up of the component of following percetage by weight:
Alkylpolyoxyethylene sodium sulfate 0.4-0.8%, quaternary ammonium salt 1-2%, cocamido propyl betaine 15-25%, alcohol ether mono sulfosuccinates 0.1-0.2%, coconut oil diethanol amide 1-2%, antiseptic 0.05-0.15%, essence 0.1-0.5%, pH is 6.5 ~ 7.0, distilled water surplus.
The component composition of preferred percetage by weight: alkylpolyoxyethylene sodium sulfate 0.667%, quaternary ammonium salt 1.333%, cocamido propyl betaine 20%, alcohol ether mono sulfosuccinates 0.15%, coconut oil diethanol amide 1.5%, antiseptic 0.1%, essence 0.1%-0.5%, pH is 6.5 ~ 7.0, distilled water surplus.
In above-mentioned quaternary anti-bacterial hand lotion, described antiseptic is antiseptic DMDMH, adopts citric acid adjust ph.
In above-mentioned quaternary anti-bacterial hand lotion, described quaternary ammonium salt is dodecyl methyl dihydroxy ethyl ammonium bromide, tetradecylmethyl dihydroxy ethyl ammonium bromide or cetyl methyl dihydroxy ethyl ammonium bromide.Be preferably dodecyl methyl dihydroxy ethyl ammonium bromide.
Compared with prior art, the present invention has following beneficial effect: the cationic and anionic surfactant of handwashing liquid of the present invention can stable existence in compound system, and when amount ratio the opposing party of a wherein side is many, dissolubility is better, not easily coagulation occurs.This handwashing liquid good stability, high to the sterilizing rate of escherichia coli and staphylococcus aureus, the foam performance of product reaches market level.
Detailed description of the invention
R12, R14, R16 refer to dodecyl methyl dihydroxy ethyl ammonium bromide, tetradecylmethyl dihydroxy ethyl ammonium bromide, cetyl methyl dihydroxy ethyl ammonium bromide.
Embodiment 1:(percetage by weight)
Alkylpolyoxyethylene sodium sulfate 0.667%, quaternary ammonium salt 1.333%, cocamido propyl betaine 20%, alcohol ether mono sulfosuccinates 0.15%, coconut oil diethanol amide 1.5%, antiseptic DMDMH 0.1%, essence 0.2%, distilled water surplus.By each component mixing and stirring, be 6.5 with Fructus Citri Limoniae acid for adjusting pH, adding water soluble pigment regulates appearance color and get final product.
Embodiment 2:(percetage by weight)
Tetradecylmethyl dihydroxy ethyl ammonium bromide 0.667%, quaternary ammonium salt 1.333%, cocamido propyl betaine 20%, alcohol ether mono sulfosuccinates 0.15%, coconut oil diethanol amide 1.5%, antiseptic DMDMH0.1%, essence 0.2%, distilled water surplus.By each component mixing and stirring, be 6.5 with Fructus Citri Limoniae acid for adjusting pH, adding water soluble pigment regulates appearance color and get final product.
Embodiment 3:(percetage by weight)
Cetyl methyl dihydroxy ethyl ammonium bromide 0.667%, quaternary ammonium salt 1.333%, cocamido propyl betaine 20%, alcohol ether mono sulfosuccinates 0.15%, coconut oil diethanol amide 1.5%, antiseptic DMDMH0.1%, essence 0.2%, distilled water surplus.By each component mixing and stirring, be 6.5 with Fructus Citri Limoniae acid for adjusting pH, adding water soluble pigment regulates appearance color and get final product.
Embodiment 4: performance test
Handwashing liquid microbiological indicator and method of testing:
With reference to the extraordinary handwashing liquid standard of GB GB19877.1-2005 and QB2654-2004 handwashing liquid industry standard, the project measuring handwashing liquid microbiological indicator is needed to have: total plate count, sterilizing rate, bacteriostasis rate, excrement colibacillus group.The operation of sterilizing rate determination experiment is carried out with reference to standard GB/T 15979-2002, specific as follows:
After test organisms 24h slant culture, take a small amount of strain with inoculating loop, be then placed in the sterilized test tube that normal saline is housed, bacteria suspension is made in abundant concussion, and (concentration controls at 1X10
4~ 9X10
4cuf/mL).Get in the test tube that 3.5mL bacteria suspension joins containing 3.5mL antibacterial, abundant mixing, suitably dilute after 2min, get wherein 2-3 dilution factor, draw 0.5mL respectively, be placed in two culture dishs, cultivate with the Nutrient agar of 40-45 DEG C, rotate culture dish and make it fully shake up, after agar solidification, be down flat plate, and be placed in 35 ± 2 DEG C of incubators cultivation 48h, do viable bacteria colony counting.
Test repetition 3 times, is calculated as follows sterilizing rate:
X＝(A-B)/A?X100％
X in formula: sterilizing rate %
A: blank sample average colony number
B: test sample average colony number
Evaluation criterion: sterilization Shuai≤90% is antimicrobial form handwashing liquid, sterilization Shuai≤50% is antibacterial type handwashing liquid.
Foaming characteristic is tested: consider that experiment test sample is more, if tested by Roche foam meter method, operate cumbersome, and frothing capacity is not necessary test index in the GB of handwashing liquid, it just reflects the power of the detergency of this detergent by the frothing capacity of detergent, so this problem adopts general test method---graduated cylinder method is measured qualitatively.Operational approach is as follows:
Take the color comparison tube that liquid 1g to be measured is placed in 50mL specification, add hard water to 10g, at every turn with identical dynamics, shake half a minute up and down, record foam elemental height, after static 5min, record now foam height, experiment repeats 2-3 time and calculating mean value.
Embodiment 1 is carried out properties test, and result is as shown in table 1 below:
The performance test results of table 1, embodiment 1
Embodiment 2 is carried out properties test, and result is as shown in table 2 below:
The performance test results of table 2, embodiment 2
Embodiment 3 is carried out properties test, and result is as shown in table 3 below:
The performance test results of table 3, embodiment 3
The sterilization Orthogonal experiment results of embodiment 1-3 is as shown in table 4 below:
The sterilization Orthogonal experiment results of table 4, embodiment 1-3
From upper table 4, the antibacterial effect of the handwashing liquid of embodiment 1 is best.
Claims (6)
1. a quaternary anti-bacterial hand lotion, is characterized in that being made up of the component of following percetage by weight:
Alkylpolyoxyethylene sodium sulfate 0.4-0.8%, quaternary ammonium salt 1-2 %, cocamido propyl betaine 15-25%, alcohol ether mono sulfosuccinates 0.1-0.2%, coconut oil diethanol amide 1-2%, antiseptic 0.05-0.15%, essence 0.1-0.5%, pH are 6.5 ~ 7.0, distilled water surplus.
2. quaternary anti-bacterial hand lotion as claimed in claim 1, is characterized in that, be made up of the component of following percetage by weight:
Alkylpolyoxyethylene sodium sulfate 0.667%, quaternary ammonium salt 1.333%, cocamido propyl betaine 20%, alcohol ether mono sulfosuccinates 0.15%, coconut oil diethanol amide 1.5%, antiseptic 0.1%, essence 0.1%-0.5%, pH are 6.5 ~ 7.0, distilled water surplus.
3. quaternary anti-bacterial hand lotion as claimed in claim 1, it is characterized in that, described antiseptic is antiseptic DMDMH.
4. quaternary anti-bacterial hand lotion as claimed in claim 1, is characterized in that, adopts citric acid adjust ph.
5. quaternary anti-bacterial hand lotion as claimed in claim 1, it is characterized in that, described quaternary ammonium salt is dodecyl methyl dihydroxy ethyl ammonium bromide, tetradecylmethyl dihydroxy ethyl ammonium bromide or cetyl methyl dihydroxy ethyl ammonium bromide.
6. quaternary anti-bacterial hand lotion as claimed in claim 5, it is characterized in that, described quaternary ammonium salt is dodecyl methyl dihydroxy ethyl ammonium bromide.
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| CN106497698A (en) * | 2016-09-09 | 2017-03-15 | 拉芳家化股份有限公司 | A kind of antimicrobial laundry liquid of zwitterion compounding |
| CN106511427A (en) * | 2016-12-27 | 2017-03-22 | 四川默森药业有限公司 | Composition for skin mucous membrane disinfection and preparation method of composition |
| CN106566665A (en) * | 2016-10-14 | 2017-04-19 | 拉芳家化股份有限公司 | Zwitterion-compounded antibacterial detergent |
| CN107385904A (en) * | 2017-07-11 | 2017-11-24 | 广州大学 | A kind of antimicrobial organosilane emulsion and preparation method and application |
| CN108728261A (en) * | 2018-05-15 | 2018-11-02 | 贝德氏（上海）健康科技股份有限公司 | A kind of environmental protecting physical bacteriostatic lotion and application thereof |
| CN109602630A (en) * | 2019-01-24 | 2019-04-12 | 四川工商职业技术学院 | A kind of antibacterial skin-whitening liquid soap |
| CN109998955A (en) * | 2019-04-15 | 2019-07-12 | 陕西师范大学 | A kind of camellia bacteriostatic hand sanitizer and preparation method thereof |
| CN111163637A (en) * | 2017-08-01 | 2020-05-15 | 纳诺全球公司 | Alkyl dimethyl organosilane quaternary ammonium salt in durable system and method |
| CN113491268A (en) * | 2021-05-31 | 2021-10-12 | 山东消博士消毒科技股份有限公司 | Low-temperature hydrogen peroxide disinfectant and preparation method thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106497698B (en) * | 2016-09-09 | 2019-06-07 | 拉芳家化股份有限公司 | A kind of antimicrobial laundry liquid of zwitterion compounding |
| CN106497698A (en) * | 2016-09-09 | 2017-03-15 | 拉芳家化股份有限公司 | A kind of antimicrobial laundry liquid of zwitterion compounding |
| CN106566665A (en) * | 2016-10-14 | 2017-04-19 | 拉芳家化股份有限公司 | Zwitterion-compounded antibacterial detergent |
| CN106511427A (en) * | 2016-12-27 | 2017-03-22 | 四川默森药业有限公司 | Composition for skin mucous membrane disinfection and preparation method of composition |
| CN107385904A (en) * | 2017-07-11 | 2017-11-24 | 广州大学 | A kind of antimicrobial organosilane emulsion and preparation method and application |
| CN107385904B (en) * | 2017-07-11 | 2019-09-17 | 广州大学 | A kind of antimicrobial organosilane lotion and the preparation method and application thereof |
| CN111163637A (en) * | 2017-08-01 | 2020-05-15 | 纳诺全球公司 | Alkyl dimethyl organosilane quaternary ammonium salt in durable system and method |
| CN108728261A (en) * | 2018-05-15 | 2018-11-02 | 贝德氏（上海）健康科技股份有限公司 | A kind of environmental protecting physical bacteriostatic lotion and application thereof |
| CN108728261B (en) * | 2018-05-15 | 2020-09-08 | 贝德氏（上海）健康科技股份有限公司 | Environment-friendly physical bacteriostatic lotion and application thereof |
| CN109602630A (en) * | 2019-01-24 | 2019-04-12 | 四川工商职业技术学院 | A kind of antibacterial skin-whitening liquid soap |
| CN109602630B (en) * | 2019-01-24 | 2021-12-07 | 四川工商职业技术学院 | Antibacterial whitening hand sanitizer |
| CN109998955A (en) * | 2019-04-15 | 2019-07-12 | 陕西师范大学 | A kind of camellia bacteriostatic hand sanitizer and preparation method thereof |
| CN109998955B (en) * | 2019-04-15 | 2022-02-15 | 陕西师范大学 | Camellia bacteriostatic hand sanitizer and preparation method thereof |
| CN113491268A (en) * | 2021-05-31 | 2021-10-12 | 山东消博士消毒科技股份有限公司 | Low-temperature hydrogen peroxide disinfectant and preparation method thereof |
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Effective date of registration: 20190626 Address after: 223000 Airport Industrial Park No. 19, Huaigao Town, Huaiyin District, Huaian City, Jiangsu Province Patentee after: Jiangsu Drucker Biotechnology Co., Ltd. Address before: 510006 No. 230, West Ring Road, University Town, Panyu District, Guangzhou City, Guangdong Province Patentee before: Guangzhou University |