CN106726662A - A kind of high-efficiency sterilization hands washing liquid - Google Patents
A kind of high-efficiency sterilization hands washing liquid Download PDFInfo
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- CN106726662A CN106726662A CN201611084313.5A CN201611084313A CN106726662A CN 106726662 A CN106726662 A CN 106726662A CN 201611084313 A CN201611084313 A CN 201611084313A CN 106726662 A CN106726662 A CN 106726662A
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- washing liquid
- efficiency sterilization
- liquid according
- hands washing
- acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of high-efficiency sterilization hands washing liquid, including surfactant, chelating agent, NMF, thickener, bactericidal activity composition, compound MannolideA and α mangostin is contained in bactericidal activity composition.Contain compound MannolideA and α mangostin in the bactericidal activity composition of hand cleanser of the invention, sterilization is gentle and bactericidal effect is good.
Description
Technical field
The present invention relates to a kind of high-efficiency sterilization hands washing liquid.
Background technology
The both hands of people will contact many germy articles daily, and so-called illness finds its way in by the mouth, refers to just that people eat
Germy dirt, it is sick so as to cause.So hygienic habit that is most simple when washing one's hands, needing most, when perfumed soap is washed one's hands
Traditional hand-washing article, it is cheap and easy to use, but if in public, people inevitably use
Other people used perfumed soaps, can so make many people feel under the weather, because most people is all uncomfortable to use other people used things
Product, and hand cleanser avoids the problem, and most product functions on the market are single, it is impossible to meet the extensive market demand.
MannolideA isolates three kinds of new diterpene-kind compounds for cephalotaxus plant, finds with new complete
Carbon skeleton, is published in Mannolides A-C with an Intact Diterpenoid Skeleton Providing
Insights on the Biosynthesis of Antitumor Cephalotaxus Troponoids, Org.Lett.,
2016,18(8),1880–1883。
It is found by the applicant that MannolideA is prepared under certain proportion with α-mangostin as bactericidal activity composition washing
Hand liquid has effect sterilized well.
The content of the invention
For the problem that above-mentioned prior art is present, the present invention provides a kind of high-efficiency sterilization hands washing liquid, bacterium is suppressed very well
Effect.To achieve these goals, the technical solution adopted by the present invention is：Live on a kind of high-efficiency sterilization hands washing liquid, including surface
Property agent, chelating agent, NMF, thickener, bactericidal activity composition, compound is contained in bactericidal activity composition
MannolideA, described MannolideA chemical structural formulas are as follows：
Also contain α-mangostin in described bactericidal activity composition.
In described bactericidal activity composition, the ratio between MannolideA and α-mangostin parts by weight are 1:1-20:1.
Surfactant 5%-20%, chelating agent 0.2%-1%, NMF 1%-10%, thickener 0.5%-10%, kill
Bacterium active compound 0.5%-3%, addition qs pH adjuster adjust pH value to 7, and 100% is complemented to deionized water.
Described surfactant is lauryl sulfosuccinic acid monoester disodium, lauryl sodium sulfate, dodecyl sulphur
Sour ammonium, AEO sulfosuccinic acid monoesters disodium, Coconut Fatty Acid Monoethanolamide sulfosuccinic acid monoesters disodium, ten
Dialkyl group ether sulfate, dodecyl ether sulfate ammonium, 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium, single Tryfac 5573, dodecyl
Glycine betaine, Cocoamidopropyl betaine, lauryl amidopropyl betaine, dodecanamide propyl amine oxide, dodecyl two
It is several in methyl oxidation amine.
Wherein chelating agent is ethylenediamine tetra-acetic acid, disodium ethylene diamine tetraacetate or tetrasodium ethylenediamine tetraacetate.
NMF is one or more in glycerine, propane diols, 1,3-butylene glycol, sorbierite, polyethylene glycol.
Thickener is fatty monoethanol amide, fatty acid distribution of coconut oil diglycollic amide, card ripple, xanthan gum, carboxymethyl
The double stearates of sodium cellulosate, Macrogol 6000, hydroxyethyl cellulose, polyvinylpyrrolidone, sodium alginate, acrylic acid are common
One or more in polymers, sodium chloride.PH adjusting agent is citric acid, sodium citrate, disodium hydrogen phosphate, potassium dihydrogen phosphate, boron
One or more in sand, boric acid.
Its preparation method of the present invention is specially：Deionized water is weighed by above-mentioned percentage by weight, chelating agent and moisturizing is added
Agent, stirs, and is subsequently adding surfactant and thickener, is heated to 70-80 DEG C and dissolves and stir, and is subsequently adding profit
Skin agent, stirs, and is then cooled to 45 DEG C, adds bactericidal activity composition, dissolves and stirs, and finally uses pH adjusting agent
Regulation system pH value is obtained final product for 7.
Contain compound MannolideA and α-mangostin in the bactericidal activity composition of hand cleanser of the invention, it is sterilized
It is gentle and bactericidal effect is good, particularly in 8-10:Under 1 ratio, its synergy is notable, with extremely strong bactericidal effect,
Reduce hand cleanser usage amount.
Specific embodiment
α-mangostin, No. CAS：6147-11-1.
The preparation method of compound MannolideA involved in the present invention is referring to document：
Mannolides A–C with an Intact Diterpenoid Skeleton Providing Insights
On the Biosynthesis of Antitumor Cephalotaxus Troponoids, Org.Lett., 2016,18
(8),1880–1883。
Ratio of the present invention is weight ratio.
Its preparation method of the present invention is specially：Deionized water is weighed by above-mentioned percentage by weight, chelating agent and moisturizing is added
Agent, stirs, and is subsequently adding surfactant and thickener, is heated to 70-80 DEG C and dissolves and stir, and is subsequently adding profit
Skin agent, stirs, and is then cooled to 45 DEG C, adds bactericidal activity composition, dissolves and stirs, and finally uses pH adjusting agent
Regulation system pH value is obtained final product for 7.
Embodiment 1
Lauryl sulfosuccinic acid monoester disodium 10%, ethylenediamine tetra-acetic acid 0.5%, glycerine 1%, sodium alginate 2%, kill
Bacterium active compound 1%, balance deionized water, pH adjusting agent is citric acid.
Embodiment 2
Dodecyl ether sulfate 12%, disodium ethylene diamine tetraacetate 0.8%, propane diols 4%, fatty acid distribution of coconut oil diethyl
Alkylolamides 6%, bactericidal activity composition 0.5%, balance deionized water, pH adjusting agent is citric acid.
Embodiment 3
Dodecanamide propyl amine oxide %, disodium ethylene diamine tetraacetate 0.5%, propane diols 1%-10%, xanthan gum 4%,
Bactericidal activity composition 1%, balance deionized water, pH adjusting agent is citric acid.
BA：
Experiment is with the Ministry of Public Health《Disinfection technology standard》(2002 editions) is guidance,
Experimental subjects
With embodiment 1 for standard prepares hand cleanser, the MannolideA and α of different proportion in fungicide active ingredient-fall to twist with the fingers
Sub- element, blank group is free from the hand cleanser of active sterilization component.
It is prepared by bacteria suspension：
Test organisms：Staphylococcus aureus ATCC6538, Escherichia coli 8099.
It is prepared by bacteria suspension：The nutrient agar inclined-plane fresh cultured thing in the generation of strain the 5th is taken, is added with 5mL dilutions
Inclined-plane, washes lower lawn, and shake mixing.
Bacteriostatic test operating procedure
Bacteria suspension will be tested with PBS liquid to dilute, it is desirable to which concentration is:0.1mL drops are taken in control sample liquid (PBS) 5.0mL, is returned
It is 1 × 10 to receive bacterium number4~9 × 104cfu/mL；
Test specimen Sterile standard hard water is diluted to the concentration of regulation；
Draw test specimen stoste or its dilution 5mL is put into sterilizing test tubes, 20 DEG C of constant temperature 5min；
Experiment bacterium solution 0.1mL is drawn to be added in the test tube containing 5mL samples, it is rapid to mix, and timing immediately；
After effect to setting time, the mixed liquor 0.1mL of test organisms and sample is taken, be added to containing 5mL sterilized PBS's
In test tube, mix；
After placing 10min, sample liquid (or after making appropriate dilution, taking the wherein 2-3 dilution of dilution factor) 1mL is drawn, put
In in sterilizing plates, each sample liquid or dilution are inoculated with two sterilizing plates.With cool to 40-45 DEG C of nutrient agar
(bacterium) or (sabouraud's agar saccharomycete) 15mL is poured into, and rotates plate, makes its full and uniform, is overturn after agar solidification
Plate, after (35 scholar 2) DEG C culture 48h (bacterium) or 72h (saccharomycete), does viable bacteria colony counting；
Test specimen is replaced with PBS, while operated by above step, as control sample；
Experiment in triplicate, seeks its average value.
Evaluation criterion：
Bacteriostasis rate >=50%~90%, product has bacteriostasis, bacteriostasis rate >=90%, and product has stronger bacteriostasis.
5. antibacterial result：
A is MannolideA, and B is α-mangostin,
Each group sterilizing rate,
| Fungicide active ingredient | Staphylococcus aureus (%) | Escherichia coli (%) |
| A:B(20：1) | 52.4 | 50.7 |
| A:B(15：1) | 51.7 | 53.6 |
| A:B(13：1) | 50.6 | 51.5 |
| A:B(10：1) | 99.7 | 99.2 |
| A:B(8：1) | 99.1 | 99.8 |
| A:B(5：1) | 49.3 | 49.7 |
| A:B(2：1) | 51.7 | 50.6 |
| A:B(1：1) | 47.9 | 54.2 |
| A:B(1：2) | 50.3 | 52.6 |
| A:B(1：5) | 46.8 | 48.7 |
| A:B(1：10) | 45.6 | 49.3 |
| A | 48.2 | 50.2 |
| B | 44.6 | 47.3 |
| Blank | 13.7 | 14.5 |
Above-mentioned result of the test is visible, single MannolideA and α-mangostin as Fungicidal active substance, with one
Fixed bactericidal activity, but effect is not very significantly, to mix as ratio, in 8-10:There is surprising collaboration to make in the case of 1
With, bactericidal effect significantly, other ratio group effects are not notable, with but one group of difference is little, it is seen that MannolideA and α-fall to twist with the fingers
Sub- element is in 8-10:There is good bactericidal activity in the case of 1 in hand cleanser carrier prepared by embodiment 1.
Claims (10)
1. a kind of high-efficiency sterilization hands washing liquid, including surfactant, chelating agent, NMF, thickener, bactericidal activity composition,
Characterized in that, containing compound MannolideA in bactericidal activity composition, described MannolideA chemical structural formulas are such as
Under：
。
2. a kind of high-efficiency sterilization hands washing liquid according to claim 1, in described bactericidal activity composition also containing α-fall
Spill element.
3. a kind of high-efficiency sterilization hands washing liquid according to claim 2, in described bactericidal activity composition, MannolideA
It is 1 with the ratio between α-mangostin parts by weight:1-20:1.
4. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that surfactant 5%-20%, chela
Mixture 0.2%-1%, NMF 1%-10%, thickener 0.5%-10%, deionized water dissolubility moisturizing fat 0.1%-6%, kill
Bacterium active compound 0.5%-3%, addition qs pH adjuster adjust pH value to 7, and 100% is complemented to deionized water.
5. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that described surfactant is bay
Base sulfosuccinic acid monoester disodium, lauryl sodium sulfate, ammonium lauryl sulfate, AEO sulfosuccinic acid
Monoesters disodium, Coconut Fatty Acid Monoethanolamide sulfosuccinic acid monoesters disodium, dodecyl ether sulfate, dodecyl alcohol ether sulphur
Sour ammonium, 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium, single Tryfac 5573, empgen BB, Cocoamidopropyl betaine, lauryl
It is several in amido propyl betaine, dodecanamide propyl amine oxide, DDAO.
6. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that wherein chelating agent is ethylenediamine tetrem
Acid, disodium ethylene diamine tetraacetate or tetrasodium ethylenediamine tetraacetate.
7. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that NMF is glycerine, propane diols, fourth
Between one or more in glycol, sorbierite, polyethylene glycol.
8. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that thickener is fatty acid distribution of coconut oil list second
The double stearic acid of alkylolamides, fatty acid distribution of coconut oil diglycollic amide, card ripple, xanthan gum, sodium carboxymethylcellulose, Macrogol 6000
One or more in ester, hydroxyethyl cellulose, polyvinylpyrrolidone, sodium alginate, acrylic copolymer, sodium chloride.
9. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that pH adjusting agent is citric acid, lemon
One or more in sour sodium, disodium hydrogen phosphate, potassium dihydrogen phosphate, borax, boric acid.
10. a kind of high-efficiency sterilization hands washing liquid according to claim 1, it is characterised in that its preparation method is specially：By upper
State percentage by weight and weigh deionized water, add chelating agent and NMF, stir, be subsequently adding surfactant and thickening
Agent, is heated to 70-80 DEG C and dissolves and stir, and is subsequently adding emollient, stirs, and is then cooled to 45 DEG C, and addition is killed
Bacterium active compound, dissolves and stirs, and is finally obtained final product for 7 with pH adjusting agent regulation system pH value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611084313.5A CN106726662A (en) | 2016-11-30 | 2016-11-30 | A kind of high-efficiency sterilization hands washing liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611084313.5A CN106726662A (en) | 2016-11-30 | 2016-11-30 | A kind of high-efficiency sterilization hands washing liquid |
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| Publication Number | Publication Date |
|---|---|
| CN106726662A true CN106726662A (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611084313.5A Pending CN106726662A (en) | 2016-11-30 | 2016-11-30 | A kind of high-efficiency sterilization hands washing liquid |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743423A (en) * | 2018-08-23 | 2018-11-06 | 安庆枝梅化工有限责任公司 | A kind of environmental protection disinfection hand cleanser |
| CN109125102A (en) * | 2018-08-23 | 2019-01-04 | 安庆枝梅化工有限责任公司 | A kind of antibiotic skincare hand cleanser |
| CN109463386A (en) * | 2018-10-25 | 2019-03-15 | 华南农业大学 | Application of the mangostin in prevention and treatment bacterial wilt |
| WO2021143209A1 (en) * | 2020-01-13 | 2021-07-22 | 浙江神英科技股份有限公司 | Method for preparing hand sanitizer suitable for infant skin |
| CN115590846A (en) * | 2022-10-27 | 2023-01-13 | 中国农业科学院兰州畜牧与兽药研究所（Cn） | Application of alpha-mangostin in preparation of preparation for inhibiting formation of escherichia coli biofilm |
| CN117137820A (en) * | 2023-10-27 | 2023-12-01 | 深圳市仙鱼环保科技有限公司 | Long-acting antibacterial hand sanitizer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105686964A (en) * | 2014-11-26 | 2016-06-22 | 天津普范科技开发有限公司 | Moisture-retention bacteriostatic hand sanitizer |
-
2016
- 2016-11-30 CN CN201611084313.5A patent/CN106726662A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105686964A (en) * | 2014-11-26 | 2016-06-22 | 天津普范科技开发有限公司 | Moisture-retention bacteriostatic hand sanitizer |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743423A (en) * | 2018-08-23 | 2018-11-06 | 安庆枝梅化工有限责任公司 | A kind of environmental protection disinfection hand cleanser |
| CN109125102A (en) * | 2018-08-23 | 2019-01-04 | 安庆枝梅化工有限责任公司 | A kind of antibiotic skincare hand cleanser |
| CN109463386A (en) * | 2018-10-25 | 2019-03-15 | 华南农业大学 | Application of the mangostin in prevention and treatment bacterial wilt |
| WO2021143209A1 (en) * | 2020-01-13 | 2021-07-22 | 浙江神英科技股份有限公司 | Method for preparing hand sanitizer suitable for infant skin |
| CN115590846A (en) * | 2022-10-27 | 2023-01-13 | 中国农业科学院兰州畜牧与兽药研究所（Cn） | Application of alpha-mangostin in preparation of preparation for inhibiting formation of escherichia coli biofilm |
| CN117137820A (en) * | 2023-10-27 | 2023-12-01 | 深圳市仙鱼环保科技有限公司 | Long-acting antibacterial hand sanitizer and preparation method thereof |
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Application publication date: 20170531 |