CN104292283B - 尼莫克汀的纯化方法 - Google Patents
尼莫克汀的纯化方法 Download PDFInfo
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- CN104292283B CN104292283B CN201310298096.XA CN201310298096A CN104292283B CN 104292283 B CN104292283 B CN 104292283B CN 201310298096 A CN201310298096 A CN 201310298096A CN 104292283 B CN104292283 B CN 104292283B
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- nimoctin
- crude product
- organic salt
- organic solvent
- liquid organic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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CN201310298096.XA CN104292283B (zh) | 2013-07-16 | 2013-07-16 | 尼莫克汀的纯化方法 |
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CN201310298096.XA CN104292283B (zh) | 2013-07-16 | 2013-07-16 | 尼莫克汀的纯化方法 |
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CN104292283A CN104292283A (zh) | 2015-01-21 |
CN104292283B true CN104292283B (zh) | 2017-08-01 |
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CN201310298096.XA Active CN104292283B (zh) | 2013-07-16 | 2013-07-16 | 尼莫克汀的纯化方法 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106831811B (zh) * | 2015-08-12 | 2018-10-26 | 内蒙古佳瑞米精细化工有限公司 | 一种制备高含量尼莫克汀的方法 |
CN106046020B (zh) * | 2016-07-26 | 2019-02-19 | 江苏海阔生物医药有限公司 | 一种通过结晶作用纯化尼莫克汀的方法 |
CN111187276A (zh) * | 2018-11-15 | 2020-05-22 | 山西卓联锐科科技有限公司 | 一种尼莫克汀的提纯方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4869901A (en) * | 1984-06-05 | 1989-09-26 | American Cyanamid Company | Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents |
CN1587240A (zh) * | 2004-07-16 | 2005-03-02 | 中国科学院过程工程研究所 | 离子液体双水相中抗生素类药物制备分离一体化的新方法 |
WO2008005381A2 (en) * | 2006-07-06 | 2008-01-10 | Wyeth | Process for the preparation of moxidectin comprising a step of microbiologically mediated oxidation of 23 -hydroxy- ll- f28249 -alpha to 23-keto-ll-f28249-alpha |
CN101372492A (zh) * | 2007-06-29 | 2009-02-25 | 浙江海正药业股份有限公司 | 一种制备高纯度莫西克汀的方法 |
CN101502722A (zh) * | 2008-12-29 | 2009-08-12 | 嘉兴学院 | 萃取食品中残留抗生素的离子液体双水相体系及其应用 |
CN101813685A (zh) * | 2010-04-20 | 2010-08-25 | 长安大学 | 疏水性离子液体测定环境中残留红霉素的方法 |
CN102336796A (zh) * | 2010-07-27 | 2012-02-01 | 北大方正集团有限公司 | 一种尼莫克汀的制备方法 |
CN102952832A (zh) * | 2011-08-23 | 2013-03-06 | 北大方正集团有限公司 | 一种发酵生产尼莫克汀的方法 |
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2013
- 2013-07-16 CN CN201310298096.XA patent/CN104292283B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4869901A (en) * | 1984-06-05 | 1989-09-26 | American Cyanamid Company | Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents |
CN1587240A (zh) * | 2004-07-16 | 2005-03-02 | 中国科学院过程工程研究所 | 离子液体双水相中抗生素类药物制备分离一体化的新方法 |
WO2008005381A2 (en) * | 2006-07-06 | 2008-01-10 | Wyeth | Process for the preparation of moxidectin comprising a step of microbiologically mediated oxidation of 23 -hydroxy- ll- f28249 -alpha to 23-keto-ll-f28249-alpha |
CN101372492A (zh) * | 2007-06-29 | 2009-02-25 | 浙江海正药业股份有限公司 | 一种制备高纯度莫西克汀的方法 |
CN101502722A (zh) * | 2008-12-29 | 2009-08-12 | 嘉兴学院 | 萃取食品中残留抗生素的离子液体双水相体系及其应用 |
CN101813685A (zh) * | 2010-04-20 | 2010-08-25 | 长安大学 | 疏水性离子液体测定环境中残留红霉素的方法 |
CN102336796A (zh) * | 2010-07-27 | 2012-02-01 | 北大方正集团有限公司 | 一种尼莫克汀的制备方法 |
CN102952832A (zh) * | 2011-08-23 | 2013-03-06 | 北大方正集团有限公司 | 一种发酵生产尼莫克汀的方法 |
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CN104292283A (zh) | 2015-01-21 |
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Address after: 100871, Beijing, Haidian District Cheng Fu Road 298, founder building, 9 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: Peking University International Hospital Group Chongqing Daxin Pharmaceutical Co.,Ltd. Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
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Effective date of registration: 20221026 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District Cheng Fu Road 298, founder building, 9 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: CHONGQING DAXIN PHARMACEUTICAL Co.,Ltd. Patentee before: PKU HEALTHCARE INDUSTRY Group |
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