CN104284657A - 用于抑制RORγ活性和治疗疾病的双环砜化合物 - Google Patents

用于抑制RORγ活性和治疗疾病的双环砜化合物 Download PDF

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CN104284657A
CN104284657A CN201380023864.9A CN201380023864A CN104284657A CN 104284657 A CN104284657 A CN 104284657A CN 201380023864 A CN201380023864 A CN 201380023864A CN 104284657 A CN104284657 A CN 104284657A
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alkyl
compound
alkylene
haloalkyl
halogen
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Chinese (zh)
Inventor
T.埃彻尔
K.巴尔
V.西莫夫
W.托马斯
P.图古德
C.范胡伊斯
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Merck Sharp and Dohme LLC
Lycera Corp
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Merck Sharp and Dohme LLC
Lycera Corp
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WO2019063015A1 (zh) * 2017-09-30 2019-04-04 正大天晴药业集团股份有限公司 作为RORγ抑制剂的磺酰基取代的双环化合物
CN112334450A (zh) * 2018-06-18 2021-02-05 詹森药业有限公司 作为RORγt的调节剂的苯基和吡啶基取代的咪唑

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JP2017507950A (ja) 2014-02-27 2017-03-23 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法
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JP6523337B2 (ja) 2014-05-05 2019-05-29 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
DK3207043T6 (da) 2014-10-14 2020-01-20 Vitae Pharmaceuticals Llc Dihydropyrrolopyridin-inhibitorer af ror-gamma
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WO2016130818A1 (en) 2015-02-11 2016-08-18 Merck Sharp & Dohme Corp. SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
US10039727B2 (en) 2015-04-21 2018-08-07 Commissariat A L'energie Atomique Et Aux Energies Alternatives Adamantane or pinene derivatives for use in the treatment of chlamydiales infections
AU2016257997A1 (en) 2015-05-05 2017-11-09 Lycera Corporation Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
UY36673A (es) * 2015-05-07 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Sulfonas tricíclicas como moduladores de ror y composiciones farmacéuticas que las contienen
CN108026045B (zh) 2015-05-15 2021-04-27 奥瑞基尼探索技术有限公司 用作RORγ调节剂的经过取代的四氢喹啉酮化合物
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US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
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EP3368516B1 (en) 2015-10-27 2020-07-15 Merck Sharp & Dohme Corp. SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
EP3368535B1 (en) 2015-10-27 2020-12-02 Merck Sharp & Dohme Corp. Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
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TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
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FR3063079B1 (fr) 2017-02-17 2019-03-22 Galderma Research & Development Derives sulfonamides hydroxyles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t)
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CN108473429A (zh) * 2015-06-05 2018-08-31 领先制药控股公司 RORγ调节剂
CN108473429B (zh) * 2015-06-05 2021-09-10 领先制药控股公司 RORγ调节剂
CN108503584A (zh) * 2017-02-27 2018-09-07 复旦大学 一种1,2,3,4-四氢喹啉磺酰胺类化合物及其应用
CN108503584B (zh) * 2017-02-27 2021-05-04 复旦大学 一种1,2,3,4-四氢喹啉磺酰胺类化合物及其应用
WO2019063015A1 (zh) * 2017-09-30 2019-04-04 正大天晴药业集团股份有限公司 作为RORγ抑制剂的磺酰基取代的双环化合物
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CN112334450A (zh) * 2018-06-18 2021-02-05 詹森药业有限公司 作为RORγt的调节剂的苯基和吡啶基取代的咪唑

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