CN104225663B - A kind of antibacterial bearing hydrocolloid dressing and preparation method thereof - Google Patents
A kind of antibacterial bearing hydrocolloid dressing and preparation method thereof Download PDFInfo
- Publication number
- CN104225663B CN104225663B CN201410478994.8A CN201410478994A CN104225663B CN 104225663 B CN104225663 B CN 104225663B CN 201410478994 A CN201410478994 A CN 201410478994A CN 104225663 B CN104225663 B CN 104225663B
- Authority
- CN
- China
- Prior art keywords
- parts
- hydrocolloid
- antibacterial
- dressing
- polyvinyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention provides a kind of antibacterial bearing hydrocolloid dressing and preparation method thereof, belong to medical dressing technical field.The preparation method of antibacterial bearing hydrocolloid dressing of the present invention first adds in banbury by elastomer, tackifying resin, plasticizer, antioxidant, and mixing, prepares hot-fusible pressure-sensitive adhesive; Hydrocolloid particle, polyvinyl alcohol, chitosan derivatives, antibacterial is added again, mixing in hot-fusible pressure-sensitive adhesive; Be placed in vulcanizing press to process, then coat on water-proof polyurethane backing, cover release paper, through irradiation sterilization, prepare finished product.Bearing hydrocolloid dressing prepared by the method has good anti-microbial property, without security risk; The polyvinyl alcohol composition added in preparation process can be cross-linked to form physical gel when irradiation, effectively maintains the integrity of dressing, improves the corrosion resistance of dressing.
Description
Technical field
The invention belongs to medical dressing technical field, be specifically related to a kind of antibacterial bearing hydrocolloid dressing and preparation method thereof.
Background technology
Hydrocolloid medical dressing is the granule of absorbent polymer and the blended rear obtained a kind of medical dressing of hot-fusible pressure-sensitive adhesive.This material combines the cement properties of elastomeric material and the water absorbing properties of absorbent polymer material.Rubber substrate provides viscosity, can make dressing paste on wound surface, and swelling after being dispersed in hydrocolloid particle water suction wherein, provides a moistening closed environment, promote the healing of wound to wound.The healing of moistening environment to wound plays good facilitation, and the nursing for wound brings very large convenience.
But traditional bearing hydrocolloid dressing is without anti-microbial property, when process has the chronic wound of latent infection risk or low-grade infection, often effect is undesirable.With the addition of inorganic antiseptic in some bearing hydrocolloid dressings as the composition such as silver ion, nanometer silver, although product has good bacteriostasis property, such antibacterial has larger cytotoxicity, has potential biological safety hidden danger for human body; Traditional bearing hydrocolloid dressing corrosion resistance is poor simultaneously, and after water absorption and swelling, the integrity of dressing is damaged, and hydrocolloid component is easy to remain in wound surface surface, causes dressing performance to be greatly affected.Such as, Chinese patent CN102218155A discloses a kind of preparation method of nano-silver functional hydrocolloid medical dressing, by nanometer silver is joined in hydrocolloid, impart hydrocolloid antibacterial functions, both the sterilizing ability that nanometer silver continues can have been played, promote the healing of wound surface, after conventional silver ionic oxide formation can be overcome again, easily form the drawback of black speck.But, the negative biological effect produced after the silver-colored particulate migration due to nano-scale enters in human body and untoward reaction still undistinct, should be extremely restricted containing the application clinically of nanometer silver class bearing hydrocolloid dressing.
More existing bearing hydrocolloid dressings are generally for primary raw material with cellulosic derivant sodium carboxymethyl cellulose sodium, recovery from illness as the Mei Pikang of the Urgotul of the Comfeel ulcer dressing of Mentor Corp. of Denmark, French yogurt company, Monick, Sweden company, brightness company of Xerox of the U.S. is appropriate etc., but because cellulosic function ratio is more single, antibacterial, promote that in the effect such as wound healing, performance is not enough, can not meet the requirement of complicated wound surface for wound dressing.And for example, Chinese patent CN102488919A discloses a kind of bearing hydrocolloid dressing and preparation method thereof, and described bearing hydrocolloid dressing comprises one or more hydrocolloids of the styrene isoprene styrene block copolymer (SIS) of 5-40%, the tackifying resin of 10-50% and 20-60%, the plasticizer of 5-30% and the antioxidant of 0-5%.Its preparation method comprises: 1) at the temperature of 130-160 DEG C, soften 5-10 minute in banbury; 2) mix in styrene isoprene styrene block copolymer (SIS) softening for tackifying resin, plasticizer and antioxidant input, obtain pre-composition; 3) in pre-composition, hydrocolloid particle is added; 4) be coated with.Although the bearing hydrocolloid dressing imbibition ability prepared by this invention is better, the antibacterial and bacteriostasis of self is limited, needs to improve further.
To sum up, desirable Morden wound dressing should have following feature: can absorb a large amount of transudates and noxious substance, maintains the humidity that wound is enough, has reasonable resistance bacterium property and bacteriostasis, more change dressings is to wound not damaged, has significantly short more effect.But existing bearing hydrocolloid dressing generally only has the ability keeping wound moist, can not meet the diverse requirements of complicated wound.
Summary of the invention
Technical problem to be solved by this invention is, for the deficiencies in the prior art, provide a kind of antibacterial bearing hydrocolloid dressing and preparation method thereof, the bearing hydrocolloid dressing prepared by the method has good anti-microbial property, without security risk; The polyvinyl alcohol composition added in preparation process can form physical gel when irradiation, effectively maintains the integrity of dressing, improves the corrosion resistance of dressing.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: a kind of antibacterial bearing hydrocolloid dressing, comprise hydrocolloid layer, described hydrocolloid layer is made up of the raw material of following weight: 5 ~ 15 parts, elastomer, tackifying resin 5 ~ 20 parts, plasticizer 1 ~ 10 part, antioxidant 0.5 ~ 3 part, 30 ~ 50 parts, hydrocolloid particle, polyvinyl alcohol 5 ~ 10 parts, chitosan derivatives 1 ~ 5 part, antibacterial 0.05 ~ 0.5 part.
Described elastomer is the one in polyurethane rubber, butyl rubber, styrene block copolymer thermoplastic elastomer (TPE), silicone rubber, natural rubber, polyacrylate, acrylate copolymer; Preferably, described styrene block copolymer is SIS.
Described tackifying resin is disproportionated rosin ester.
Described plasticizer to be molecular weight be 300 ~ 1000 polyisobutylene.
Described antioxidant is the two octadecyl ester of thio-2 acid.
Described hydrocolloid particle is sodium carboxymethyl cellulose.
Described chitosan derivatives is molecular weight is 5000 ~ 1000000 acylation chitosans.
Described antibacterial is polyhexamethylene guanidine, poly (hexamethylene) hydrochloride or hexamethylene.
Prepare the method for described antibacterial bearing hydrocolloid dressing, comprise the following steps:
1. described elastomer, described tackifying resin, described plasticizer, described antioxidant are added in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. described hydrocolloid particle, polyvinyl alcohol, described chitosan derivatives, described antibacterial is added in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper, through 60Coradiation sterilizing, prepare finished product.
Described step 2. in the dosage of 60Coradiation sterilizing be 15 ~ 50kGy.
Antibacterial bearing hydrocolloid dressing prepared by the present invention, compared with prior art has following beneficial effect:
1. in hydrocolloid, be loaded with antipathogenic composition, and described antibacterial is guanidinesalt polyhexamethylene guanidine, poly (hexamethylene) hydrochloride or hexamethylene, this inhibition performance is strong, and safety is good, be a kind of antibacterial material that can be used for infective wound surface of excellence, avoid and use inorganic antibacterial as the potential source biomolecule security risks of silver system antibacterial;
2. in hydrocolloid, polyvinyl alcohol composition is added, this composition can when irradiation sterilization by molecule crosslinked formation physics network gel, the integrity of effective maintenance dressing, the skin caused because of water absorption and swelling in preventing hydrocolloid from using remains, and improves the corrosion resistance of bearing hydrocolloid dressing in life-time service;
3. in hydrocolloid, shellglycan composition is added, this composition is a kind of hydrophilic chitosan derivatives, coordinate Dropless high polymer, as polyurethane material etc., make this bearing hydrocolloid dressing not only waterproof and breathable, and there is excellent absorbent, wound is made to keep a moistening healing environment, it also has the physiologically active of good wound healing simultaneously, effectively can improve the wound healing performance of dressing, accelerates the healing rate of wound surface;
4. bearing hydrocolloid dressing has good elasticity and autohension, can be soft be applied to skin surface, feel more comfortable.
Detailed description of the invention
Below in conjunction with specific embodiment the present invention done and describe in detail further.
Embodiment one
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is release paper or mould release membrance, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 1 part, polyhexamethylene guanidine 0.05 part that the polyisobutylene 1 part that polyurethane rubber 5 parts, disproportionated rosin ester 5 parts, molecular weight are 300, the two octadecyl ester 0.5 part of thio-2 acid, sodium carboxymethyl cellulose 30 parts, polyvinyl alcohol 5 parts, molecular weight are 5000 ~ 8000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the polyurethane rubber 5 parts of described weight portion, disproportionated rosin ester 5 parts, molecular weight be 300 polyisobutylene 1 part, the two octadecyl ester 0.5 part of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 30 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 5 parts, molecular weight be 5000 ~ 8000 acylation chitosan 1 part, polyhexamethylene guanidine 0.05 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper or mould release membrance, after having packed, through the sterilizing of 15kGy 60Coradiation, be finished product.
Embodiment two
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is release paper, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 1.5 parts, polyhexamethylene guanidine 0.1 part that the polyisobutylene 2 parts that butyl rubber 7 parts, disproportionated rosin ester 8 parts, molecular weight are 400, the two octadecyl ester 0.8 part of thio-2 acid, sodium carboxymethyl cellulose 32 parts, polyvinyl alcohol 5.5 parts, molecular weight are 8000 ~ 10000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the butyl rubber 7 parts of described weight portion, disproportionated rosin ester 8 parts, molecular weight be 400 polyisobutylene 2 parts, the two octadecyl ester 0.8 part of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 32 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 5.5 parts, molecular weight be 8000 ~ 10000 acylation chitosan 1.5 parts, polyhexamethylene guanidine 0.1 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper, after having packed, through the sterilizing of 20kGy 60Coradiation, be finished product.
Embodiment three
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is release paper, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 2 parts, poly (hexamethylene) hydrochloride 0.2 part that the polyisobutylene 4 parts that styrene block copolymer thermoplastic elastomer (TPE) 9 parts, disproportionated rosin ester 10 parts, molecular weight are 500, the two octadecyl ester 1 part of thio-2 acid, sodium carboxymethyl cellulose 35 parts, polyvinyl alcohol 7 parts, molecular weight are 10000 ~ 50000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the styrene block copolymer thermoplastic elastomer (TPE) 9 parts of described weight portion, disproportionated rosin ester 10 parts, molecular weight be 500 polyisobutylene 4 parts, the two octadecyl ester 1 part of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 35 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 7 parts, molecular weight be 10000 ~ 50000 acylation chitosan 2 parts, poly (hexamethylene) hydrochloride 0.2 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper, after having packed, through the sterilizing of 25kGy 60Coradiation, be finished product.
Embodiment four
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is release paper, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 3 parts, poly (hexamethylene) hydrochloride 0.3 part that the polyisobutylene 5 parts that 10 parts, silicone rubber, disproportionated rosin ester 12 parts, molecular weight are 600, the two octadecyl ester 1.5 parts of thio-2 acid, sodium carboxymethyl cellulose 40 parts, polyvinyl alcohol 8 parts, molecular weight are 500000 ~ 700000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by 10 parts, the silicone rubber of described weight portion, disproportionated rosin ester 12 parts, molecular weight be 600 polyisobutylene 5 parts, the two octadecyl ester 1.5 parts of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 40 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 8 parts, molecular weight be 500000 ~ 700000 acylation chitosan 3 parts, poly (hexamethylene) hydrochloride 0.3 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper, after having packed, through the sterilizing of 30kGy 60Coradiation, be finished product.
Embodiment five
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is release paper, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 4 parts, hexamethylene 0.4 part that the polyisobutylene 6 parts that natural rubber 12 parts, disproportionated rosin ester 14 parts, molecular weight are 700, the two octadecyl ester 2 parts of thio-2 acid, sodium carboxymethyl cellulose 45 parts, polyvinyl alcohol 9 parts, molecular weight are 50000 ~ 100000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the natural rubber 12 parts of described weight portion, disproportionated rosin ester 14 parts, molecular weight be 700 polyisobutylene 6 parts, the two octadecyl ester 2 parts of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 45 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 9 parts, molecular weight be 50000 ~ 100000 acylation chitosan 4 parts, hexamethylene 0.4 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper, after having packed, through the sterilizing of 35kGy 60Coradiation, be finished product.
Embodiment six
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is mould release membrance, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 4.5 parts, hexamethylene 0.45 part that the polyisobutylene 8 parts that polyacrylate 13 parts, disproportionated rosin ester 16 parts, molecular weight are 800, the two octadecyl ester 2.2 parts of thio-2 acid, sodium carboxymethyl cellulose 48 parts, polyvinyl alcohol 10 parts, molecular weight are 100000 ~ 400000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the polyacrylate 13 parts of described weight portion, disproportionated rosin ester 16 parts, molecular weight be 800 polyisobutylene 8 parts, the two octadecyl ester 2.2 parts of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 48 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 10 parts, molecular weight be 100000 ~ 400000 acylation chitosan 4.5 parts, hexamethylene 0.45 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover mould release membrance, after having packed, through the sterilizing of 40kGy 60Coradiation, be finished product.
Embodiment seven
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is mould release membrance, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 5 parts, hexamethylene 0.5 part that the polyisobutylene 9 parts that acrylate 14 parts, disproportionated rosin ester 18 parts, molecular weight are 900, the two octadecyl ester 2.5 parts of thio-2 acid, sodium carboxymethyl cellulose 50 parts, polyvinyl alcohol 10 parts, molecular weight are 400000 ~ 800000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the acrylate 14 parts of described weight portion, disproportionated rosin ester 18 parts, molecular weight be 900 polyisobutylene 9 parts, the two octadecyl ester 2.5 parts of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 50 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 10 parts, molecular weight be 400000 ~ 800000 acylation chitosan 5 parts, hexamethylene 0.5 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover mould release membrance, after having packed, through the sterilizing of 45kGy 60Coradiation, be finished product.
Embodiment eight
The antibacterial bearing hydrocolloid dressing of the present invention, comprises backing layer, hydrocolloid layer and peel ply, and hydrocolloid layer is located on backing layer, and peel ply is located on hydrocolloid layer; Described backing layer is water-proof polyurethane material; described peel ply is mould release membrance, and described hydrocolloid layer is made up of the raw material of following weight: acylation chitosan 3.5 parts, poly (hexamethylene) hydrochloride 0.25 part that the polyisobutylene 10 parts that SIS 15 parts, disproportionated rosin ester 20 parts, molecular weight are 1000, the two octadecyl ester 3 parts of thio-2 acid, sodium carboxymethyl cellulose 50 parts, polyvinyl alcohol 9 parts, molecular weight are 800000 ~ 1000000.
Prepare the method for described antibacterial bearing hydrocolloid dressing, can carry out according to the following steps:
1. by the SIS 15 parts of described weight portion, disproportionated rosin ester 20 parts, molecular weight be 1000 polyisobutylene 10 parts, the two octadecyl ester 3 parts of thio-2 acid add in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. add the sodium carboxymethyl cellulose 50 parts of described weight portion in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, polyvinyl alcohol 9 parts, molecular weight be 800000 ~ 1000000 acylation chitosan 3.5 parts, poly (hexamethylene) hydrochloride 0.25 part, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover mould release membrance, after having packed, through the sterilizing of 50kGy 60Coradiation, be finished product.
Claims (3)
1. an antibacterial bearing hydrocolloid dressing, comprise hydrocolloid layer, it is characterized in that: described hydrocolloid layer is made up of the raw material of following weight: 5 ~ 15 parts, elastomer, tackifying resin 5 ~ 20 parts, plasticizer 1 ~ 10 part, antioxidant 0.5 ~ 3 part, 30 ~ 50 parts, hydrocolloid particle, polyvinyl alcohol 5 ~ 10 parts, chitosan derivatives 1 ~ 5 part, antibacterial 0.05 ~ 0.5 part;
Described elastomer is the one in polyurethane rubber, butyl rubber, styrene block copolymer thermoplastic elastomer (TPE), silicone rubber, natural rubber, polyacrylate, acrylate copolymer; Described styrene block copolymer is SIS;
Described tackifying resin is disproportionated rosin ester;
Described plasticizer to be molecular weight be 300 ~ 1000 polyisobutylene;
Described antioxidant is the two octadecyl ester of thio-2 acid;
Described hydrocolloid particle is sodium carboxymethyl cellulose;
Described chitosan derivatives to be molecular weight be 5000 ~ 1000000 acylation chitosan;
Described antibacterial is polyhexamethylene guanidine, poly (hexamethylene) hydrochloride or hexamethylene.
2. prepare the method for antibacterial bearing hydrocolloid dressing as claimed in claim 1, it is characterized in that, comprise the following steps:
1. described elastomer, described tackifying resin, described plasticizer, described antioxidant are added in banbury, in 140 DEG C, under the condition of 100r/min, mixing 20min, prepares hot-fusible pressure-sensitive adhesive;
2. described hydrocolloid particle, polyvinyl alcohol, described chitosan derivatives, described antibacterial is added in the hot-fusible pressure-sensitive adhesive 1. prepared in described step, mixing 10min; Be placed in 100 DEG C of vulcanizing presses to process, then coat on water-proof polyurethane backing, cover release paper, after having packed, through 60Coradiation sterilizing, prepare finished product.
3. the method for the antibacterial bearing hydrocolloid dressing of preparation as claimed in claim 2, is characterized in that: described step 2. in the dosage of 60Coradiation sterilizing be 15 ~ 50kGy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410478994.8A CN104225663B (en) | 2014-09-19 | 2014-09-19 | A kind of antibacterial bearing hydrocolloid dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410478994.8A CN104225663B (en) | 2014-09-19 | 2014-09-19 | A kind of antibacterial bearing hydrocolloid dressing and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104225663A CN104225663A (en) | 2014-12-24 |
| CN104225663B true CN104225663B (en) | 2016-01-27 |
Family
ID=52215132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410478994.8A Active CN104225663B (en) | 2014-09-19 | 2014-09-19 | A kind of antibacterial bearing hydrocolloid dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104225663B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822985A (en) * | 2017-03-22 | 2017-06-13 | 嘉好(太仓)新材料股份有限公司 | A kind of medical use hydrocolloid dressing adhesive |
| CN108339145A (en) * | 2017-11-27 | 2018-07-31 | 广州润虹医药科技股份有限公司 | A kind of hydrocolloid and bearing hydrocolloid dressing and preparation method thereof |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833329A (en) * | 2015-12-21 | 2016-08-10 | 马盟 | Hydrocolloid dressing and preparation method thereof |
| CN105662917A (en) * | 2016-03-30 | 2016-06-15 | 上海白衣缘生物工程有限公司 | Minimally invasive beautifying post-operation gel application and preparation method thereof |
| CN106215231A (en) * | 2016-07-29 | 2016-12-14 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of hydrocolloid medical dressing |
| CN106267314A (en) * | 2016-10-09 | 2017-01-04 | 常州亚环环保科技有限公司 | A kind of preparation method of antibacterial corrosion-resistant bearing hydrocolloid dressing |
| CN106362195A (en) * | 2016-11-28 | 2017-02-01 | 河南汇博医疗股份有限公司 | Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof |
| CN106581740A (en) * | 2016-12-09 | 2017-04-26 | 苏州纳贝通环境科技有限公司 | Hemostatic and antibacterial medical dressing and preparation method thereof |
| CN106729961A (en) * | 2016-12-19 | 2017-05-31 | 广东泰宝医疗器械技术研究院有限公司 | A kind of moisture absorption antibacterial bearing hydrocolloid dressing and preparation method thereof |
| CN108030954A (en) * | 2017-12-13 | 2018-05-15 | 义乌市中科院兰州化物所功能材料中心 | One kind includes nanometer polysaccharide medical wound dressing |
| CN107998438A (en) * | 2017-12-18 | 2018-05-08 | 广东泰宝医疗科技股份有限公司 | A kind of sustained anti-microbial bearing hydrocolloid dressing and preparation method thereof |
| CN108790224A (en) * | 2018-04-24 | 2018-11-13 | 上海益好纳米科技有限公司 | A kind of gel mould and the compound composite membrane and preparation method thereof of electrostatic nanometer film |
| CN109054115A (en) * | 2018-06-27 | 2018-12-21 | 滁州环球聚氨酯科技有限公司 | A kind of strong resistant polyurethane rubber |
| CN108926428B (en) * | 2018-07-24 | 2021-07-30 | 河南汇博医疗股份有限公司 | Hydrocolloid dressing core and preparation method thereof, hydrocolloid dressing and application thereof |
| CN109395152A (en) * | 2018-09-21 | 2019-03-01 | 南通强生石墨烯科技有限公司 | A kind of compound hydrocolloid medical dressing of graphene and preparation method thereof |
| CN111643718A (en) * | 2020-06-12 | 2020-09-11 | 扬州百思泰医疗科技有限公司 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
| CN114344547A (en) * | 2022-02-10 | 2022-04-15 | 山东万容生物科技有限公司 | Hydrocolloid medical dressing and preparation method thereof |
| CN114681664A (en) * | 2022-05-07 | 2022-07-01 | 嘉兴林华医用材料有限公司 | Hydrocolloid dressing and preparation process thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579559A (en) * | 2004-05-14 | 2005-02-16 | 中国科学院长春应用化学研究所 | Dressing material containing medicine chitoholosida and its preparation method |
| CN101559236A (en) * | 2009-02-12 | 2009-10-21 | 泰州市三易医疗科技有限公司 | Silver-bearing hydrocolloid dressing and preparation method |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN102488919A (en) * | 2011-12-29 | 2012-06-13 | 湖北大学 | Hydrocolloid dressing and its preparation method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8829053B2 (en) * | 2011-12-07 | 2014-09-09 | Rochal Industries Llp | Biocidal compositions and methods of using the same |
-
2014
- 2014-09-19 CN CN201410478994.8A patent/CN104225663B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1579559A (en) * | 2004-05-14 | 2005-02-16 | 中国科学院长春应用化学研究所 | Dressing material containing medicine chitoholosida and its preparation method |
| CN101559236A (en) * | 2009-02-12 | 2009-10-21 | 泰州市三易医疗科技有限公司 | Silver-bearing hydrocolloid dressing and preparation method |
| CN102335451A (en) * | 2011-09-15 | 2012-02-01 | 德州海利安生物科技股份有限公司 | Medical colloid dressing with functions for inhibiting bacteria and promoting heal and application thereof |
| CN102488919A (en) * | 2011-12-29 | 2012-06-13 | 湖北大学 | Hydrocolloid dressing and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| PVA/PVP/ws-chitosan水凝胶伤口敷料的辐射制备及性能表征;杨小敏等;《核技术》;20070430;第30卷(第4期);第356-360页 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822985A (en) * | 2017-03-22 | 2017-06-13 | 嘉好(太仓)新材料股份有限公司 | A kind of medical use hydrocolloid dressing adhesive |
| CN108339145A (en) * | 2017-11-27 | 2018-07-31 | 广州润虹医药科技股份有限公司 | A kind of hydrocolloid and bearing hydrocolloid dressing and preparation method thereof |
| CN108339145B (en) * | 2017-11-27 | 2019-09-20 | 广州润虹医药科技股份有限公司 | A kind of hydrocolloid and bearing hydrocolloid dressing and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104225663A (en) | 2014-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104225663B (en) | A kind of antibacterial bearing hydrocolloid dressing and preparation method thereof | |
| CN101862470A (en) | Bacteriostatic hydrocolloid dressing and preparation method thereof | |
| CN101249274B (en) | Preparation of bletilla striata polyose water gelatin of promoting wound healing and uses thereof | |
| CN103494668B (en) | Medical hydrogel moisturizing eye care mask and preparation method thereof | |
| CN102850598B (en) | Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof | |
| TW201034693A (en) | Gel sheet for cosmetic patching | |
| CN101559236A (en) | Silver-bearing hydrocolloid dressing and preparation method | |
| CN104371614B (en) | A kind of medical use hydrocolloid pressure sensitive adhesive and preparation method thereof | |
| CN108926428B (en) | Hydrocolloid dressing core and preparation method thereof, hydrocolloid dressing and application thereof | |
| CN107982571A (en) | Strong bearing hydrocolloid dressing of a kind of bacteriostasis and preparation method thereof | |
| CN106310353A (en) | Hydrocolloid adhesive, related application and hydrocolloid dressing | |
| CN208448217U (en) | A kind of anti-bacterial hydrogel dressing | |
| CN103751833A (en) | Medical antibacterial wound dressing and preparation method thereof | |
| CN106139239A (en) | Full-service fluid dressing and preparation method thereof | |
| CN109498834B (en) | Antibacterial hydrocolloid dressing and preparation method thereof | |
| CN103143053A (en) | Novel povidone-iodine antibacterial hydrocolloid dressing and preparation method thereof | |
| CN106459693A (en) | Improved pressure-sensitive adhesives used for medical applications | |
| CN107335089A (en) | A kind of modified hydrophilic polyurethane dressing and preparation method thereof | |
| CN202682163U (en) | Double-layer hydrocolloid medical dressing | |
| CN103480032A (en) | Silver-containing composite gel dressing and preparation method thereof | |
| CN204072475U (en) | A kind of composite aquogel wound dressing | |
| CN108339145B (en) | A kind of hydrocolloid and bearing hydrocolloid dressing and preparation method thereof | |
| CN103041436A (en) | Chitosan gel band-aid | |
| CN103386143A (en) | Chitosan-iodine composite biological medical film and preparation method thereof | |
| CN204050037U (en) | A kind of Compound Water colloid medical dressing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Patentee after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Patentee before: Nanyang Hui Bo Bioisystech Co., Ltd |
|
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: 473000 Nanyang City, Henan Province, the new energy economic and Technological Development Zone, the middle of the road in the middle of the road, ten Patentee after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Patentee before: Henan Huibo Medical Co., Ltd. |