CN105833329A - Hydrocolloid dressing and preparation method thereof - Google Patents
Hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN105833329A CN105833329A CN201510971424.7A CN201510971424A CN105833329A CN 105833329 A CN105833329 A CN 105833329A CN 201510971424 A CN201510971424 A CN 201510971424A CN 105833329 A CN105833329 A CN 105833329A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/30—Rubbers or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention relates to the field of medical treatment and provides hydrocolloid dressing. The hydrocolloid dressing comprises a base and hydrocolloid. The base comprises petroleum resin, an oil-based liquid, synthetic rubber and distilled water. The hydrocolloid is Karaya gum. Compared with the traditional hydrocolloid dressing, the hydrocolloid dressing is conducive to wound rapid healing, effectively prevents wound infection and has a wide application range. The preparation method slightly improves the traditional hydrocolloid dressing manufacture process before production and saves an early stage investment cost.
Description
Technical field
The present invention relates to medical field, specifically, particularly to a kind of bearing hydrocolloid dressing.
Background technology
Skin is the organ that human body is maximum, be also simultaneously human body resist external microbe invasion and
Keep the barrier that human internal environment is stable.When skin is by wound, this road barrier is destroyed,
Cause the loss of internal body fluid and outside antibacterial and the invasion of virus.Although human body skin has
Good self-regeneration function, but in this road barrier destroyed period, easily cause tissue sense
Contaminate and expand tissue damaged position.Microorganism simultaneously invade human recycle system's meeting further
Cause the infection at other positions of health.
Tradition wound healing mode is all based on dryness mode of healing mostly, keeps being dried of wound surface
Circulation with air.Under dryness environment, wound surface easily forms incrustation, is so healing
Cheng Zhong, epidermis cell migrates to be needed to walk around these incrustations, thus extends healing time.Therefore,
Present most of wound healings use the mode that bearing hydrocolloid dressing is applied ointment or plaster.The basic work of Wound dressing
With being exactly destroyed until during self-regeneration is complete, playing temporary barrier from this road barrier
Effect.
Bearing hydrocolloid dressing is to be mixed and processed with rubber elastomer by hydrophilic macromolecule granule.
Wherein, the hydrophilic colloid of contact skin wound is the part playing and protecting wound moisture-keeping function at all.
First generation bearing hydrocolloid dressing the most frequently with main hydrophilic colloidal materials be carboxymethyl cellulose
Sodium, cross-linking sodium carboxymethyl cellulose or both mixture.It addition, portioned product also has
With gelatin and pectin or its mixture as main hydrophilic colloid.First generation hydrocolloid applies
Expect because it has seal, absorbs wound exudate, has debridement function, is beneficial to the advantages such as movable,
It is widely applied.Therefore, to have the second filial generation bearing hydrocolloid dressing of more preferable performance existing in exploitation
Good social benefit, has again the wide market space.
Summary of the invention
Present invention solves the technical problem that and be to provide novel bearing hydrocolloid dressing, to improve hydrocolloid
The sides such as the dressing antibacterial, acceleration wound healing, reduction body cell necrosis rate in clinical practice
The effect in face.
In order to solve the problems referred to above, present invention employs following technical scheme:
A kind of bearing hydrocolloid dressing, including polymer film layer and invest described polymer film layer
On hydrophilic colloid gel layer, described polymer film layer use polyester family macromolecule material system
Becoming, as the basic unit of described hydrophilic colloid gel layer, described hydrophilic colloid gel layer is by base
And the flexible semi-solid gel that hydrocolloid mixtures is formulated, described hydrocolloid mixtures
In comprise POLY-karaya.
Described polymer film layer is placed in outside skin in use, plays transparent beauty function.
Further, by mass percentage, the composition of described hydrophilic colloid gel layer comprises:
Base:
The thermoplastic elastomer of 5%～20%, relatively conventional is chosen as SIS1105；
The polyisobutylene PIB of 5%～15%；
The tackifying resin of 4.5%～22%；
The naphthenic oil of 7%～13%；
0.4%～0.9% antioxidant；
Hydrocolloid mixtures:
The sodium carboxymethyl cellulose of 15%～25%；
The gelatin of 10%～15%；
The pectin of 5%～12%；
The starch of 12%～16%；
And
The POLY-karaya of 5%～12% i.e. sterculia nobilis natural gum.
Further, the natural gum that described POLY-karaya extracts in deriving from sterculia nobilis tree.
Further, described POLY-karaya is the compound of polysaccharide of partial acetylation, clean through refining
After change, molecular weight is more than 9,000,000.
Further, described POLY-karaya has faintly acid.
Further, described POLY-karaya includes at least three kinds of different types of chains, wherein,
One chain constitutes the 45～55% of total polysaccharides, containing β-D-galactose branches and comprise a L-
The repetitive of reducing end under neutral 4 galacturonic acid residues of rhamnose residue units；Second chain
Constitute the 12～22% of total polysaccharides, the branch containing D-galacturonic acid residues and D-galactose
The galacturonic acid that residue is interrupted once in a while；3rd chain constitutes the 28～38% of total polysaccharides, contains
D-Glucose aldehydic acid residue.
Present invention also offers the preparation method of a kind of bearing hydrocolloid dressing as above, it is hydrophilic
In colloidal gel layer, the preparation of hydrophilic gel mixture comprises the steps:
A. base is made, by styrene-isoprene-phenylethene thermoplastic copolymer, poly-isobutyl
Alkene, rosin glyceride, naphthenic oil and antioxidant are rotated under vacuum by said ratio to be pinched
Close 90～150 minutes；
B. hydrocolloid mixtures powder is made, by POLY-karaya, pectin, gelatin, starch
Mix by said ratio with sodium carboxymethyl cellulose powder；
C. mix under molten condition, powder is slowly added gradually in the base of premix, when
Rotate after all adding and mediate 20～40 minutes, obtain hydrophilic colloid gel.
Preferably, in step a, rotating rotating speed when mediating is 80-120r/min.
Preferably, in step a, rotating temperature when mediating is 100～150 DEG C.
Preferably, in step c, rotating rotating speed when mediating is 90-150r/min.
Further, also include tabletting heat seal step, take out the product of mix homogeneously in step c,
Being placed in tabletting in 100 degree of vulcanizing presses, thickness 0.5～4mm (specifically applies institute depending on dressing
Need), afterwards by tabletting heat seal on polymer film layer.
The bearing hydrocolloid dressing of the present invention, its main component POLY-karaya mixes with water and has viscosity,
Can be in close contact with wound, and the capacity of higher absorption secretions can be provided.Non-toxic and safe,
Also there is good bacteriostasis.Simultaneously because POLY-karaya has faintly acid (isodermic pH
Value 5.5), it is possible to reacting with zest aqueous slkali, therefore POLY-karaya can maintain the weak of skin
Sour environment.These characteristics make antibacterial ooze out the moist of body fluid formation at POLY-karaya and wound
Environment is very difficult to existence procreation, greatly reduces the probability of traumatic infection.
The hydrocolloid using the bearing hydrocolloid dressing of the present invention to make is applied ointment or plaster, and uses the spy of POLY-karaya
Point, improves antibacterial anti-infection ability during wet union on the original basis, accelerates wound
Healing.In addition to all advantages having first generation hydrocolloid, also have some the most excellent
Point: one, more preferable antibiotic anti-infection function；The skin ulcer that two, radiodermatitis caused,
Fibrotic healing has significant curative effect；Three, the healing to shallow two degree of deep second degree burn wound surface
Time substantially reduces, and pain reduces；Four, diabetes patient's foot gangrenosum acne wound surface is had more
Good healing defencive function.
The bearing hydrocolloid dressing preparation method of the present invention can be in the manufacturing process of tradition bearing hydrocolloid dressing
On make slightly amendment and can put into production, save early investment cost.
Detailed description of the invention
The invention provides a kind of bearing hydrocolloid dressing, including polymer film layer and invest polymerization
Hydrophilic colloid gel layer on thing thin layer, polymer film layer uses polyester family macromolecule material
Material is made, and as the basic unit of hydrophilic colloid gel layer, hydrophilic colloid gel layer is by base and parent
The flexible semi-solid gel that hydrocolloid mixture is formulated, wherein, in hydrocolloid mixtures
Comprise POLY-karaya.
In order to be further appreciated by the present invention, below in conjunction with embodiment to the preferred embodiment of the invention
It is described, but it is to be understood that these describe simply as further illustrating inventive feature
With advantage rather than limiting to the claimed invention.
Embodiment one
Bearing hydrocolloid dressing, by mass percentage, the composition of its hydrophilic colloid gel layer comprises:
Base:
Hydrocolloid mixtures:
Its preparation method is:
A makes base, by styrene-isoprene-phenylethene thermoplastic copolymer, poly-isobutyl
Alkene, rosin glyceride, naphthenic oil, antioxidant is rotated under vacuum by above-mentioned percentage ratio
Mediate 90 minutes, wherein, rotating speed 100r/min, temperature 120 DEG C；
B mixing water hydrocolloid powder, by POLY-karaya, pectin, gelatin, starch, carboxymethyl is fine
Dimension element sodium is mixed in above-mentioned gel mixture ratio；
Mix under c molten condition, powder is joined in the base of premix, with rotating speed 100r/min
Rotate and mediate 20 minutes, obtain bearing hydrocolloid dressing；
D tabletting heat seal step, takes out the product of mix homogeneously in above-mentioned steps, is placed in 100 degree
Tabletting in vulcanizing press, thickness takes different value depending on different application, afterwards by tabletting heat seal in poly-
On urethane thin film.
Embodiment two
Bearing hydrocolloid dressing, by mass percentage, the composition of its hydrophilic colloid gel layer comprises:
Base:
Hydrocolloid mixtures:
Its preparation flow is identical with embodiment one, but process conditions change into: when mediating in step a
Between 150 minutes, temperature 100 DEG C, rotating speed 80 turns；Kneading time 30 minutes in step c,
Rotating speed 90 turns.
Embodiment three
Bearing hydrocolloid dressing, by mass percentage, the composition of its hydrophilic colloid gel layer comprises:
Base:
Hydrocolloid mixtures:
Its preparation flow is identical with embodiment one, but process conditions change into: when mediating in step a
Between 120 minutes, temperature 150 DEG C, rotating speed 120 turns；Kneading time 40 minutes in step c,
Rotating speed 120 turns.
Embodiment four
Bearing hydrocolloid dressing, by mass percentage, the composition of its hydrophilic colloid gel layer comprises:
Base:
Hydrocolloid mixtures:
Its preparation flow is identical with embodiment one, but process conditions change into: when mediating in step a
Between 140 minutes, temperature 140 DEG C, rotating speed 110 turns；Kneading time 35 minutes in step c,
Rotating speed 150 turns.
Embodiment five
Bearing hydrocolloid dressing, by mass percentage, the composition of its hydrophilic colloid gel layer comprises:
Base:
Hydrocolloid mixtures:
Its preparation flow is identical with embodiment one, but process conditions change into: when mediating in step a
Between 130 minutes, temperature 130 DEG C, rotating speed 90 turns；Kneading time 25 minutes in step c,
Rotating speed 140 turns.
Embodiment six
Bearing hydrocolloid dressing, by mass percentage, the composition of its hydrophilic colloid gel layer comprises:
Base:
Hydrocolloid mixtures:
Its preparation flow is identical with embodiment one, but process conditions change into: when mediating in step a
Between 120 minutes, temperature 135 DEG C, rotating speed 100 turns；Kneading time 30 minutes in step c,
Rotating speed 120 turns.
Prepared by the bearing hydrocolloid dressing in employing above-described embodiment applies ointment or plaster, and its Clinical practice effect is shown in
Following case:
Table 1 burn case contrast
Table 2 pressure wound case contrast
Table 3 is non-chemically burnt and the burn case of electric burn
Table 4 diabetics ulcer case
It can be seen that the bearing hydrocolloid dressing of the present invention has good clinic makes from above-mentioned case
Use effect.
The explanation of above example is only intended to help to understand that the method for the present invention and core thereof are thought
Think.It should be pointed out that, for those skilled in the art, without departing from this
On the premise of bright principle, it is also possible to the present invention is carried out some improvement and modification, these improve and
Modify in the protection domain also falling into the claims in the present invention.
Claims (10)
1. a bearing hydrocolloid dressing, including polymer film layer and invest the parent on described polymer film layer
Hydrocolloid gel layer, described polymer film layer uses polyester family macromolecule material to make, as described parent
The basic unit of hydrocolloid gel layer, described hydrophilic colloid gel layer is for by base and hydrocolloid mixtures preparation
The flexible semi-solid gel become, it is characterised in that: described hydrocolloid mixtures comprises POLY-karaya.
2. bearing hydrocolloid dressing as claimed in claim 1, it is characterised in that by mass percentage, described
The composition of hydrophilic colloid gel layer comprises:
Base:
The thermoplastic elastomer of 5%～20%；
The polyisobutylene of 5%～15%；
The tackifying resin of 4.5%～22%；
The naphthenic oil of 7%～13%；
0.4%～0.9% antioxidant；
Hydrocolloid mixtures:
The sodium carboxymethyl cellulose of 15%～25%
The gelatin of 10%～15%；
The pectin of 5%～12%；
The starch of 12%～16%；
And
The POLY-karaya of 5%～12%.
3. bearing hydrocolloid dressing as claimed in claim 1, it is characterised in that: described POLY-karaya derives from Herba Marsileae Quadrifoliae
The natural gum extracted in mother-in-law tree.
4. bearing hydrocolloid dressing as claimed in claim 3, it is characterised in that: described POLY-karaya is part second
Acylated compound of polysaccharide, after refining and purifying, molecular weight is more than 9,000,000.
5. bearing hydrocolloid dressing as claimed in claim 1, it is characterised in that: described POLY-karaya has weak acid
Property.
6. the bearing hydrocolloid dressing as described in any one of claim 1-5, it is characterised in that: described POLY-karaya
Including at least three kinds of different types of chains, wherein, the first chain constitutes the 45～55% of total polysaccharides, containing β-D-
Galactose branches and comprise the weight of reducing end under neutral 4 galacturonic acid residues of a L-rhamnose residue units
Multiple unit；Second chain constitutes the 12～22% of total polysaccharides, the branch containing D-galacturonic acid residues and D-
The galacturonic acid that galactose residue is interrupted once in a while；3rd chain constitutes the 28～38% of total polysaccharides, containing D-Portugal
Grape uronic acid residue.
7. the preparation method of the bearing hydrocolloid dressing as described in any one of claim 1-6, it is characterised in that
In described hydrophilic colloid gel layer, the preparation of hydrophilic colloid gel comprises the steps:
A. base is made, by sweet to styrene-isoprene-phenylethene thermoplastic copolymer, polyisobutylene, Colophonium
Grease, naphthenic oil and antioxidant in ratio described in claim 2 at a temperature of 100～150 DEG C, in vacuum
Condition rotates and mediates 90～150 minutes；
B. hydrocolloid mixtures is made, by POLY-karaya, pectin, gelatin, starch and carboxymethyl cellulose
Sodium powder is mixed in ratio described in claim 2；
C. mix under molten condition, the powder that step b prepares gradually be slowly added in the base of premix,
Rotate after all adding and mediate 20～40 minutes, obtain hydrophilic colloid gel.
8. the preparation method of bearing hydrocolloid dressing as claimed in claim 7, it is characterised in that: in step a,
Rotating rotating speed when mediating is 80-120r/min.
9. the preparation method of bearing hydrocolloid dressing as claimed in claim 7, it is characterised in that: in step c,
Rotating rotating speed when mediating is 90-150r/min.
10. the preparation method of the bearing hydrocolloid dressing as described in any one of claim 7-9, it is characterised in that: also
Including tabletting heat seal step, take out the product of mix homogeneously in step c, be placed in 90～120 degree of compression moldings
Tabletting in machine, thickness 0.5～4mm, afterwards by tabletting heat seal on polymer film layer.
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| CN201510971424.7A CN105833329A (en) | 2015-12-21 | 2015-12-21 | Hydrocolloid dressing and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030954A (en) * | 2017-12-13 | 2018-05-15 | 义乌市中科院兰州化物所功能材料中心 | One kind includes nanometer polysaccharide medical wound dressing |
| CN108384510A (en) * | 2017-02-03 | 2018-08-10 | 贝朗医疗公司 | Adhesive composition and element for adhering to application on human skin |
| CN108478854A (en) * | 2018-04-28 | 2018-09-04 | 蒋春霞 | A kind of bearing hydrocolloid dressing and preparation method thereof |
| CN109700601A (en) * | 2019-02-02 | 2019-05-03 | 天津嘉氏堂科技有限公司 | A kind of hydrocolloid silicon dressing patch |
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| CN108384510B (en) * | 2017-02-03 | 2021-11-30 | 贝朗医疗公司 | Adhesive composition and element for attaching human skin |
| CN108030954A (en) * | 2017-12-13 | 2018-05-15 | 义乌市中科院兰州化物所功能材料中心 | One kind includes nanometer polysaccharide medical wound dressing |
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