CN101862470A - Bacteriostatic hydrocolloid dressing and preparation method thereof - Google Patents
Bacteriostatic hydrocolloid dressing and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a bacteriostatic hydrocolloid dressing and a preparation method thereof. The dressing comprises a polyurethane film, a hydrophilic colloid layer and a peeling layer which are adhered in turn. The preparation method comprises the following steps of: mixing a medical grade rubber substrate, gelatin, mineral oil, an antioxidant, sodium carboxymethyl cellulose, calcium alginate, a tackifier, O-carboxymethyl chitosan and dried nano-silver powder uniformly to obtain a blend; uniformly coating the obtained blend on the polyurethane film to form the hydrophilic colloid layer; covering the peeling layer on the hydrophilic colloid layer; and stamping to obtain the bacteriostatic hydrocolloid dressing. The bacteriostatic hydrocolloid dressing of the invention has high bacteriostasis, and simultaneously has the characteristics of high capacity of absorbing transudate, waterproofness, air permeability, firm adhesion, high compliance, capability of meeting diversified requirements on complicated wound, and simple and easily-implemented preparation method.
Description
Technical field
The present invention relates to a kind of bacteriostatic hydrocolloid dressing and preparation method thereof, belong to field of medical products, also belong to technical field of biological material.
Background technology
Bearing hydrocolloid dressing is a kind of novel medical dressing, is mainly used in clinical healing property of difficulty wound.Bearing hydrocolloid dressing since can create moist healing environment with and the character of semipermeable membrane, therefore be subjected to numerous medical personnel's welcome.Bearing hydrocolloid dressing is compared with traditional dressing has following advantage: healing is very fast, adhesion wound when changing dressings, be convenient to nurse operation, antibacterial can not see through, alleviates wound pain, reduce dressing change frequency.
More existing bearing hydrocolloid dressings generally are to be primary raw material with cellulosic derivant sodium carboxymethyl cellulose, as the Kang Huier ulcer of Denmark Mentor Corp. paste, the recovery from illness of the Mei Pikang of the Urgotul of French yogurt company, Monick, Sweden company, brightness company of U.S. Xerox is appropriate etc., but because cellulosic function ratio is more single, antibacterial, promote that performance is not enough aspect the effect such as wound healing, can not satisfy of the requirement of complicated wound surface for wound dressing.Ideal modern wound dressing should have following characteristics: can absorb a large amount of transudates and noxious substance, keep the enough humidity of wound, reasonable resistance bacterium property and bacteriostasis are arranged, more change dressings has significantly short more effect to the wound not damaged.But existing bearing hydrocolloid dressing generally only has the moistening ability of the wound of maintenance, can not satisfy various demand of complicated wound.
Chitosan is the unique alkaline polysaccharide in the natural polysaccharide, has many special physicochemical character and physiological function.Chitosan is biodegradable in human body, have no side effect, wide material sources, the biological activity height, and have antibacterial, transfer blood fat, regulate immunity, multiple biological function such as activation intestinal bifidobacteria etc., simultaneously different molecular weight ranges chitosan the activity of blood is had different character (anticoagulant property is arranged during low-molecular-weight, the coagulant courage and uprightness are arranged during high molecular).Therefore the hydrocolloid that with the chitosan is raw material has good biologic activity and medical performance, and this hydrocolloid is used to prepare dressing, can improve the speed of wound healing.The O-carboxymethyl chitosan is the derivant of chitosan, have and the chitosan similar biological, and contain a large amount of hydrophilic radicals in the molecule, compare with chitosan, water solublity strengthens greatly, kept free amine group as much as possible simultaneously, promptly guaranteed good biocidal property, made its application have great potential at biomedical sector.
Nanometer silver has that broad-spectrum antiseptic, potent sterilization, permeability are strong, reparative regeneration, antibiotic lasting, safety non-toxic and characteristics such as have no drug resistance, and makes its application potential in casting product huge.
There are some producers to utilize the chitosan or derivatives thereof for the feedstock production hydrocolloid and then come production dressing both at home and abroad,, are difficult to form moistening healing environment at wound with its dressing of making though the hydrocolloid that obtains like this can partly keep the activity of chitosan; Though perhaps can form moist environment, can not give full play to the biological activity of chitosan, make its biocidal property poor, function singleness can not improve the healing quality of wound.
Summary of the invention
The objective of the invention is to remedy the deficiency of above-mentioned existing bearing hydrocolloid dressing, provide a kind of and have good bacteriostasis property and absorb the sepage ability, bearing hydrocolloid dressing of good healing environment and preparation method thereof is provided for wound surface.
The objective of the invention is to be achieved by the following technical programs:
A kind of bacteriostatic hydrocolloid dressing, it comprises polyurethane film, the hydrophilic colloid layer of fitting with the one side of polyurethane film and the peel ply of fitting with hydrophilic colloid layer; Hydrophilic colloid layer contains medical grade rubber substrate, viscosifier, mineral oil, gelatin, antioxidant, sodium carboxymethyl cellulose, calcium alginate, O-carboxymethyl chitosan and nanometer silver dry powder, medical grade rubber substrate: viscosifier: mineral oil: gelatin: antioxidant: sodium carboxymethyl cellulose: calcium alginate: the O-carboxymethyl chitosan: the weight ratio of nanometer silver dry powder is 10～30: 10～20: 5～20: 5～15: 1～5: 20～60: 10～20: 5～15: 1～5.
The present invention also provides the preparation method of above-mentioned bacteriostatic hydrocolloid dressing, may further comprise the steps:
(1) with medical grade rubber substrate, viscosifier, mineral oil, gelatin, antioxidant, sodium carboxymethyl cellulose, calcium alginate, O-carboxymethyl chitosan and nanometer silver dry powder, according to 10～30: 10～20: 5～20: 5～15: 1～5: 20～60: 10～20: 5～15: 1～5 weight ratio mix homogeneously obtains blend;
(2) above-mentioned blend evenly is applied on the polyurethane film, obtains hydrophilic colloid layer, on hydrophilic colloid layer, cover peel ply again, strike out the required shape of wound size then, promptly obtain bacteriostatic hydrocolloid dressing.
Described polyurethane film is fine porous structure, and its aperture is 0.2 μ m～10 μ m, and thickness is 0.01mm～0.02mm, and peel ply is a Ge Laxin paper.
Described medical grade rubber substrate is the medical grade ethylene propylene rubber, and viscosifier are the medical grade tackifying resin, and mineral oil is medical grade mineral oil, and antioxidant is a phytic acid.
The molecular weight of described O-carboxymethyl chitosan is 1000～2,000,000, and deacetylation is 70%～90%, and the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is 0.5～1.0; The molecular weight of sodium carboxymethyl cellulose is 20,000～300,000, and deacetylation is 65%～95%.
The particle diameter of described nanometer silver dry powder is 100nm～10000nm.
Compared with prior art, the present invention has the following advantages:
1. bacteriostatic hydrocolloid dressing of the present invention has adopted the O-carboxymethyl chitosan, it has and the chitosan similar biological, and contain a large amount of hydrophilic radicals in the molecule, compare with chitosan, water solublity strengthens greatly, so just make dressing when being applied to wound surface, can give full play to the biological activity of O-carboxymethyl chitosan; The O-carboxymethyl chitosan has kept free amine group as much as possible simultaneously, has guaranteed good biocidal property, makes this dressing have bacteriostasis property preferably.
2. added the extremely strong nanometer silver microgranule of biocidal property in the bacteriostatic hydrocolloid dressing of the present invention, made the bacteriostasis property of this dressing that bigger lifting arranged, good bacteriostasis property will make dressing be applicable to difficult more property such as pressure ulcer, diabetic foot, burn easy infection wound surface.
3. when bacteriostatic hydrocolloid dressing of the present invention has good biocidal property, also have the ability of remarkable absorption transudate, make this kind of dressing can easily tackle more wound surface such as burn transudate such as grade.Add that its surface recombination has fine porous polyurethane film, make this dressing waterproof and breathable, can keep the moist environment of wound surface well, for wound surface provides good healing environment.
4. bacteriostatic hydrocolloid dressing of the present invention is thick middle, thin flanging structure all around, makes stickup more firm, and compliance is better, is applicable to the treatment of out-of-flatness position wound surface.
The specific embodiment
In order to understand the present invention better, further illustrate content of the present invention below in conjunction with embodiment, but protection content of the present invention not only is confined to the following examples.
Embodiment 1:
Getting medical grade ethylene propylene rubber 1.5kg, gelatin 1.0kg, mineral oil 1kg and phytic acid 0.2kg mixes, through the abundant mixing of banbury, add sodium carboxymethyl cellulose 3.0kg, calcium alginate 1.0kg, tackifying resin 1.0kg, O-carboxymethyl chitosan 1.2kg, nanometer silver dry powder 0.1kg again, form blend behind the mix homogeneously.Wherein, mineral oil and tackifying resin are medical grade; O-carboxymethyl chitosan molecular weight is 100,000～500,000, and deacetylation is 70%, and the carboxy methylation degree is the substitution value 0.9 of 0.5～0.7,6 hydroxyls; The particle diameter of nanometer silver dry powder is 100～1000nm; The molecular weight of sodium carboxymethyl cellulose is 20,000～50,000, deacetylation is 70%.It is that 0.2 μ m～10 μ m, thickness are to form hydrophilic colloid layer on the one side of fine porous polyurethane film of 0.01mm～0.02mm that above-mentioned blend evenly is applied to the aperture, on hydrophilic colloid layer, cover Ge Laxin paper then again as peel ply, at last the gained finished product is struck out the required shape of wound size, promptly obtain bacteriostatic hydrocolloid dressing.
The dressing of present embodiment gained is thick middle, thin flanging structure all around, hydrophilic colloid layer that comprises polyurethane film, fits with the one side of polyurethane film and the peel ply of fitting with hydrophilic colloid layer, contained medical grade ethylene propylene rubber in the hydrophilic colloid layer: tackifying resin: mineral oil: gelatin: phytic acid: sodium carboxymethyl cellulose: calcium alginate: O-carboxymethyl chitosan: the weight ratio of nanometer silver dry powder is 15: 10: 10: 10: 2: 30: 10: 12: 1.
Embodiment 2:
Getting medical grade ethylene propylene rubber 2.0kg, gelatin 1.0kg, mineral oil 1kg and phytic acid 0.2kg mixes, through the abundant mixing of banbury, add sodium carboxymethyl cellulose 2.5kg, calcium alginate 1.0kg, tackifying resin 1.0kg, O-carboxymethyl chitosan 1.2kg, nanometer silver dry powder 0.1kg again, form blend behind the mix homogeneously.Wherein, mineral oil and tackifying resin are medical grade; O-carboxymethyl chitosan molecular weight is 500,000～1,000,000, and deacetylation is 75%, and the carboxy methylation degree is that the substitution value of 0.7～0.9,6 hydroxyls is 0.7; The molecular weight of sodium carboxymethyl cellulose is 80,000～150,000, deacetylation is 75%; The particle diameter of nanometer silver dry powder is 1000～3000nm.It is that 0.2 μ m～10 μ m, thickness are to form hydrophilic colloid layer on the one side of fine porous polyurethane film of 0.01mm～0.02mm that above-mentioned blend evenly is applied to the aperture, on hydrophilic colloid layer, cover Ge Laxin paper then again as peel ply, at last the gained finished product is struck out the required shape of wound size, promptly obtain bacteriostatic hydrocolloid dressing.
The dressing of present embodiment gained is thick middle, thin flanging structure all around, hydrophilic colloid layer that comprises polyurethane film, fits with the one side of polyurethane film and the peel ply of fitting with hydrophilic colloid layer, contained medical grade ethylene propylene rubber in the hydrophilic colloid layer: tackifying resin: mineral oil: gelatin: phytic acid: sodium carboxymethyl cellulose: calcium alginate: O-carboxymethyl chitosan: the weight ratio of nanometer silver dry powder is 20: 10: 10: 10: 2: 25: 10: 12: 1.
Embodiment 3:
Getting medical grade ethylene propylene rubber 1.5kg, gelatin 0.8kg, mineral oil 1kg and phytic acid 0.2kg mixes, through the abundant mixing of banbury, add sodium carboxymethyl cellulose 3.0kg, calcium alginate 1.2kg, tackifying resin 1.0kg, O-carboxymethyl chitosan 1.2kg, nanometer silver dry powder 0.1kg again, form blend behind the mix homogeneously.Wherein, mineral oil and tackifying resin are medical grade; O-carboxymethyl chitosan molecular weight is 1,000,000～1,500,000, and deacetylation is 80%, the carboxy methylation degree is that the substitution value of 0.9～1.2,6 hydroxyls is 0.8; The molecular weight of sodium carboxymethyl cellulose is 200,000～300,000, deacetylation is 85%; The particle diameter of nanometer silver dry powder is 3000～6000nm.It is that 0.2 μ m～10 μ m, thickness are to form hydrophilic colloid layer on the one side of fine porous polyurethane film of 0.01mm～0.02mm that above-mentioned blend evenly is applied to the aperture, on hydrophilic colloid layer, cover Ge Laxin paper then again as peel ply, at last the gained finished product is struck out the required shape of wound size, promptly obtain bacteriostatic hydrocolloid dressing.
The dressing of present embodiment gained is thick middle, thin flanging structure all around, hydrophilic colloid layer that comprises polyurethane film, fits with the one side of polyurethane film and the peel ply of fitting with hydrophilic colloid layer, contained medical grade ethylene propylene rubber in the hydrophilic colloid layer: tackifying resin: mineral oil: gelatin: phytic acid: sodium carboxymethyl cellulose: calcium alginate: O-carboxymethyl chitosan: the weight ratio of nanometer silver dry powder is 15: 10: 10: 8: 2: 30: 12: 12: 1.
Embodiment 4:
Getting medical grade ethylene propylene rubber 1.5kg, gelatin 1.0kg, mineral oil 1kg and phytic acid 0.2kg mixes, through the abundant mixing of banbury, add sodium carboxymethyl cellulose 2.5kg, calcium alginate 1.0kg, tackifying resin 1.0kg, O-carboxymethyl chitosan 1.6kg, nanometer silver dry powder 0.2kg again, form blend behind the mix homogeneously.Wherein, mineral oil and tackifying resin are medical grade; O-carboxymethyl chitosan molecular weight is 1,500,000～2,000,000, and deacetylation is 85%, the carboxy methylation degree is that the substitution value of 1.2～1.5,6 hydroxyls is 0.6; The molecular weight of sodium carboxymethyl cellulose is 250,000～300,000, deacetylation is 82%; The particle diameter of nanometer silver dry powder is 6000～9000nm.It is that 0.2 μ m～10 μ m, thickness are to form hydrophilic colloid layer on the one side of fine porous polyurethane film of 0.01mm～0.02mm that above-mentioned blend evenly is applied to the aperture, on hydrophilic colloid layer, cover Ge Laxin paper then again as peel ply, at last the gained finished product is struck out the required shape of wound size, promptly obtain bacteriostatic hydrocolloid dressing.
The dressing of present embodiment gained is thick middle, thin flanging structure all around, hydrophilic colloid layer that comprises polyurethane film, fits with the one side of polyurethane film and the peel ply of fitting with hydrophilic colloid layer, contained medical grade ethylene propylene rubber in the hydrophilic colloid layer: tackifying resin: mineral oil: gelatin: phytic acid: sodium carboxymethyl cellulose: calcium alginate: O-carboxymethyl chitosan: the weight ratio of nanometer silver dry powder is 15: 10: 10: 10: 2: 25: 10: 16: 2.
Bacteriostatic hydrocolloid dressing of the present invention is carried out bacteriostatic experiment, observes the growing state of bacterium colony in dressing behind 16～20h, the results are shown in Table 1:
The bacteriostatic experiment result of table 1. biocidal property bearing hydrocolloid dressing
Annotate :+expression has colony growth, the aseptic length of being born of-expression.
Bacteriostatic hydrocolloid dressing of the present invention is absorbed sepage aptitude tests experiments, and method is as follows: the bearing hydrocolloid dressing that takes by weighing quality and be 10.0g adds the experimental liquid that is preheated to 37 ℃ ± 1 ℃ and (wherein contains 142mol/L Na
+, 2.5mmol/LCa
2+), the quality of experimental liquid is 400.0g ± 0.5g.In the immigration drying baker, keep 30min down at 37 ℃ ± 1 ℃.With one jiao of a tweezers clamped sample or an end, the 30s that dangles, weighing.Adopt above-mentioned steps to test to other 9 samples.Percent with absorbtivity and sample quality ratio serves as to absorb liquid ability, the results are shown in Table 2:
The absorption sepage ability experimental result of table 2. biocidal property bearing hydrocolloid dressing
| Sample number | ??1 | ??2 | ??3 | ??4 | ??5 | ??6 | ??7 | ??8 | ??9 | ??10 | Meansigma methods |
| Sample quality (g) | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 | ??10.0 |
| Sample number | ??1 | ??2 | ??3 | ??4 | ??5 | ??6 | ??7 | ??8 | ??9 | ??10 | Meansigma methods |
| Absorbtivity (g) | ??20.8 | ??22.8 | ??22.3 | ??21.7 | ??22.0 | ??22.1 | ??21.9 | ??22.5 | ??21.5 | ??22.0 | ??22.0 |
| Absorbability (%) (absorbtivity/sample quality) | ??208 | ??228 | ??223 | ??217 | ??220 | ??221 | ??219 | ??225 | ??215 | ??220 | ??220 |
Claims (10)
1. bacteriostatic hydrocolloid dressing is characterized in that: it comprises polyurethane film, the hydrophilic colloid layer of fitting with the one side of polyurethane film and the peel ply of fitting with hydrophilic colloid layer; Hydrophilic colloid layer contains medical grade rubber substrate, viscosifier, mineral oil, gelatin, antioxidant, sodium carboxymethyl cellulose, calcium alginate, O-carboxymethyl chitosan and nanometer silver dry powder, medical grade rubber substrate: viscosifier: mineral oil: gelatin: antioxidant: sodium carboxymethyl cellulose: calcium alginate: the O-carboxymethyl chitosan: the weight ratio of nanometer silver dry powder is 10～30: 10～20: 5～20: 5～15: 1～5: 20～60: 10～20: 5～15: 1～5.
2. bacteriostatic hydrocolloid dressing according to claim 1 is characterized in that: described polyurethane film is fine porous structure, and its aperture is 0.2 μ m～10 μ m, and thickness is 0.01mm～0.02mm, and peel ply is a Ge Laxin paper.
3. bacteriostatic hydrocolloid dressing according to claim 1 is characterized in that: described medical grade rubber substrate is the medical grade ethylene propylene rubber, and viscosifier are the medical grade tackifying resin, and mineral oil is medical grade mineral oil, and antioxidant is a phytic acid.
4. bacteriostatic hydrocolloid dressing according to claim 1 is characterized in that: the molecular weight of described O-carboxymethyl chitosan is 1000～2,000,000, deacetylation is 70%～90%, and the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is 0.5～1.0; The molecular weight of sodium carboxymethyl cellulose is 20,000～300,000, and deacetylation is 65%～95%.
5. bacteriostatic hydrocolloid dressing according to claim 1 is characterized in that: the particle diameter of described nanometer silver dry powder is 100nm～10000nm.
6. the preparation method of the described bacteriostatic hydrocolloid dressing of claim 1 is characterized in that may further comprise the steps:
(1) with medical grade rubber substrate, viscosifier, mineral oil, gelatin, antioxidant, sodium carboxymethyl cellulose, calcium alginate, O-carboxymethyl chitosan and nanometer silver dry powder, according to 10～30: 10～20: 5～20: 5～15: 1～5: 20～60: 10～20: 5～15: 1～5 weight ratio mix homogeneously obtains blend;
(2) above-mentioned blend evenly is applied on the polyurethane film, obtains hydrophilic colloid layer, on hydrophilic colloid layer, cover peel ply again, strike out the required shape of wound size then, promptly obtain bacteriostatic hydrocolloid dressing.
7. the preparation method of bacteriostatic hydrocolloid dressing according to claim 6, it is characterized in that: described polyurethane film is fine porous structure, and its aperture is 0.2 μ m～10 μ m, and thickness is 0.01～0.02mm, and peel ply is a Ge Laxin paper.
8. the preparation method of bacteriostatic hydrocolloid dressing according to claim 6, it is characterized in that: described medical grade rubber substrate is the medical grade ethylene propylene rubber, and viscosifier are the medical grade tackifying resin, and mineral oil is medical grade mineral oil, and antioxidant is a phytic acid.
9. the preparation method of bacteriostatic hydrocolloid dressing according to claim 6, it is characterized in that: the molecular weight of described O-carboxymethyl chitosan is 1000～2,000,000, deacetylation is 70%～90%, and the carboxy methylation degree is that the substitution value of 0.5～1.5,6 hydroxyls is 0.5～1.0; The molecular weight of sodium carboxymethyl cellulose is 20,000～300,000, and deacetylation is 65%～95%.
10. the preparation method of bacteriostatic hydrocolloid dressing according to claim 6, it is characterized in that: the particle diameter of described nanometer silver dry powder is 100～10000nm.
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Application publication date: 20101020 |