CN108030954A - One kind includes nanometer polysaccharide medical wound dressing - Google Patents
One kind includes nanometer polysaccharide medical wound dressing Download PDFInfo
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- CN108030954A CN108030954A CN201711326397.3A CN201711326397A CN108030954A CN 108030954 A CN108030954 A CN 108030954A CN 201711326397 A CN201711326397 A CN 201711326397A CN 108030954 A CN108030954 A CN 108030954A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Abstract
One kind includes nanometer polysaccharide medical wound dressing, belongs to medical wound dressing technical field.Including moist dressing, the moist dressing is bearing hydrocolloid dressing or aerogel dressing or Silica hydrogel dressing or seaweed salt dressing, it is characterised in that：The moist dressing is additionally added nanometer polysaccharide compound or derivative, and the nanometer polysaccharide compound or derivative of addition are the one or more in cellulose, starch, chitin, chitosan or derivative；Saccharide compound or derivative particle diameter are the nm of 200 nm of nanoscale~1000；Saccharide compound or derivative and moist dressing mass fraction are respectively 0.1~20 part and 70~115 parts.It mixes nanosizing polysaccharide with moist dressing to the present invention, enables the quick absorbing wound exudate of wound dressing, has good performance of keeping humidity；Enhancing dressing mechanical performance can be aided at the same time.
Description
Technical field
The invention belongs to medical wound dressing technical field, and in particular to one kind is applied comprising nanometer polysaccharide medical wound
Material.
Background technology
Medical wound dressing is because it is widely used in terms of people's wound is cured, so " wound is applied there has been proposed many
The technical solution of material ", such as notification number：102088937 A of CN " wound dressing ", notification number：" wound applies CN102784411A
Material ", notification number：CN 103861144A " medical dressing and preparation method thereof ", notification number：CN 102625686B are " antimicrobial
Medical dressing and protection to wound and conduit position " etc..The existing technical solution in relation to " wound dressing " respectively has advantage,
But " golden standard " handled according to chronic wounds, i.e. " healing of wound mouth moist environment " are theoretical, utilize nanometer polysaccharide material
Bibulous feature, exploitation make medical wound dressing have wound moist environment " wound dressing " it is actually rare.
The content of the invention
In view of the deficiencies of the prior art, the present invention provides one kind includes nanometer polysaccharide medical wound dressing, it is by nanometer
Change polysaccharide to mix with moist dressing, enable the quick absorbing wound exudate of wound dressing, there is good performance of keeping humidity；At the same time
It can aid in enhancing dressing mechanical performance.
Above-mentioned goal of the invention is achieved through the following technical solutions, and one kind is applied comprising nanometer polysaccharide medical wound
Material, including moist dressing, the moist dressing are that bearing hydrocolloid dressing or aerogel dressing or Silica hydrogel dressing or seaweed salt apply
Material, it is characterized by：The moist dressing is additionally added the nanometer polysaccharide that nanometer polysaccharide compound or derivative add
Compound or derivative are the one or more in cellulose, starch, chitin, chitosan or derivative；Saccharide compound spreads out
Biological particle diameter is the nm of 200 nm of nanoscale~1000；Saccharide compound or derivative and moist dressing mass fraction are respectively 0.5
~20 parts and 100~80 parts.
Preferably, the moist dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing includes 10 by mass fraction
~20 parts of linear SIS（Styrene-isoprene）Block copolymer, 10~14 parts of olefin copolymers, 18~22 parts of C5 oil trees
Fat, 8~12 parts of naphthenic oils, 4010,23~30 parts of sodium carboxymethylcelluloses, 2~7 parts of pectin；The polysaccharide compound that is additionally added or
Derivative is by 0.1~8 part of nano-cellulose of mass fraction, and nano-cellulose average grain diameter is 200~700 nm；It is additionally added 1
~3 parts of antioxidant 1010s.
Preferably, the moist dressing is Silica hydrogel dressing, the Silica hydrogel dressing includes 55 by mass fraction
~65 parts of dimethyl silicone polymers, the poly- silicon oxide compound of carbon alkyl more than 17~19 parts, 19~21 parts of dimethyl silicone polymer crosslinkings
Polymer；The nanometer polysaccharide compound or derivative being additionally added are by 0.1~3 portion of nanometer amylose of mass fraction, nanometer
Amylose average grain diameter is 250~700nm.
Preferably, the moist dressing is alginate dressing, mass fraction bag is pressed in the alginate dressing
Include 80~90 parts of water, 4~8 parts of sodium alginates, 2~4 parts of calcium chloride；The nanometer polysaccharide compound or derivative being additionally added be by
0.1~3 part of nanometer sodium carboxymethylcellulose of mass fraction, nanometer sodium carboxymethylcellulose average grain diameter are 200~700 nm.
Preferably, the moist dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing includes 36 by mass fraction
~40 parts of linear SIS（Styrene-isoprene）Block copolymer, 10~14 parts of acrylate copolymers, 13~17 parts of C5
Petropols, 13~17 parts of naphthenic oils, 4010,12~16 parts of sodium carboxymethylcelluloses, 1~3 part of gelatin；The nanometer being additionally added is more
Saccharide compound or derivative are put down by 5~17 parts of nanometer sodium carboxymethylcelluloses of mass fraction, nanometer sodium carboxymethylcellulose
Equal particle diameter is 700~900 nm；It has been additionally added by 1~3 part of antioxidant 1010 of mass fraction.
Preferably, the moist dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing includes 13 by mass fraction
~17 parts of linear SIS（Styrene-isoprene）Block copolymer, 12~17 parts of olefin copolymers, 12~17 parts of C5 oil trees
Fat, 11~15 parts of naphthenic oils, 4010,28~32 parts of sodium carboxymethylcelluloses, 3~7 parts of Ac-Di-Sols；It is additionally added
Nanometer polysaccharide compound or derivative be by 0.1~7 part of nano-cellulose of mass fraction, the average grain diameter of nano-cellulose
For 250~350 nm；It has been additionally added by 1~3 part of antioxidant 1010 of mass fraction.
Preferably, the moist dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing includes 6 by mass fraction~
7 parts of polyvinyl alcohol, 70~80 parts of water, 13~17 parts of vinylpyrrolidones, 1~3 part of crosslinking agent polyacrylamide, what is be additionally added receives
Rice polysaccharide compound or derivative are to be by 0.1~1.5 part of Nano chitosan of mass fraction, the average grain diameter of Nano chitosan
200~550 nm.
Preferably, the moist dressing is Silica hydrogel dressing, the Silica hydrogel dressing includes 55 by mass fraction
~65 parts of dimethyl siloxanes, the poly- silicon oxide compound of carbon alkyl more than 16~20 parts, 18~22 parts of dimethyl silicone polymer crosslinkings are poly-
Compound；The nanometer polysaccharide compound or derivative being additionally added are by 0.1~2.5 portion of nanometer amylose of mass fraction, nanometer
Amylose average grain diameter is 200~700nm.
Preferably, the moist dressing is aerogel dressing, the aerogel dressing includes 10 by mass fraction
~14 parts of polyvinyl alcohol, 65~75 parts of water, 10~20 parts of polyvinylpyrrolidones, 1.5~2.5 acrylate copolymers；Also plus
The nanometer polysaccharide compound or derivative entered is by 0.5~2 part of Nano chitosan of mass fraction, Nano chitosan average grain diameter
For 450~550nm.
Preferably, the moist dressing is aerogel dressing, the aerogel dressing includes 30 by mass fraction
~40 parts of glycerine, 35~45 parts of water, 6~10 parts part neutralize Sodium Polyacrylates, 3~7 parts of polyacrylic acid, 3~7 parts of ripple nurses,
0.5~1.5 part of disodium ethylene diamine tetraacetate；The nanometer polysaccharide compound or derivative being additionally added are by 3~7 parts of mass fraction
Nano double aldocellulose, nano double aldocellulose average grain diameter are 800~1000 nm；It has been additionally added by mass fraction
0.05~0.15 part of pH adjusting agent tartaric acid.
Beneficial effects of the present invention：It can quick absorbing wound exudate, and there is good performance of keeping humidity；Energy at the same time
Enough auxiliary enhancing dressing mechanical performances；Moist dressing can not only provide the environment of wound healing, and replacement frequency is few, during replacement
The pain of wound can be mitigated.Because the present invention moist dressing include bearing hydrocolloid dressing, aerogel dressing, Silica hydrogel dressing,
Seaweed salt dressing, the moist dressing are additionally added nanometer polysaccharide compound or derivative, it forms gel after absorbing water, and keep
Wound healing environment, and viscosity weakens significantly after formation gel, not only can quickly absorb a large amount of wound fluids, keeps wound
Healing environment, and the tension stress intensity of enhancing water suction dressing can be aided in prevent from causing wound second of destruction；Nanometer polysaccharide
Class compound or derivative are because be nano material, since nano material has dimensional effect, quantum effect, skin effect etc.,
Different physical and chemical performances can be embodied, i.e., not only remains original chemical reactivity, and the orderly knot with height
Structure, larger specific surface area, the hydroxyl that bigger serface and surface exposure enrich enable nanosizing polysaccharide to have necessarily
Hydrophily and water-retaining property；In addition, according to notification number：CN 101974172B, the patent No.：201010522109.3 " a kind of nanometer is micro-
The conclusion of the preparation method of crystalline cellulose and its Carbon Black/Rubber Composites "：A small amount of nano-cellulose（NCC）With reference to dioxy
The molecular action between natural rubber can be greatly enhanced in SiClx, improve the mechanical strength of rubber." can here it is above-mentioned
The scientific basis of auxiliary enhancing dressing mechanical performance ".
Brief description of the drawings
Fig. 1：1 different component nano-cellulose of case study on implementation（Average grain diameter is 200 nm）Ratio prepares dressing and carries out dressing
24 h water imbibition measurement result tables.
Fig. 2：Case study on implementation 11 is identical with composition that the moist dressing of case study on implementation 1 is bearing hydrocolloid dressing, mass fraction, adds
Enter that 2 parts of antioxidant 1010s are identical, the only not preparation of the embodiment of the prior art of plus nano polysaccharide compound or derivative
Dressing carries out 24 h water imbibition measurement result tables of dressing.
Can be seen that a small amount of nano-cellulose addition from Fig. 1, Fig. 2 result can be greatly improved bearing hydrocolloid dressing water imbibition.
Embodiment
The present invention is described further below by 1-11 instantiations.
Bearing hydrocolloid dressings of the case study on implementation 1- containing nano-cellulose
It is identical in the moist dressing composition to prove that nano-cellulose influences bearing hydrocolloid dressing water imbibition, add antioxygen
Agent number is identical, and it is by mass fraction only to change the polysaccharide compound of addition or derivative, devises following three kinds for this
Component：
Component one：The moist dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 18 parts linearly by mass fraction
SIS（Styrene-isoprene）Block copolymer, 13 parts of olefin copolymers, 22 parts of C5 Petropols, 10 parts of naphthenic oils 4010,
28.2 parts of water wetted material sodium carboxymethylcelluloses, 6.6 parts of pectin, are additionally added 2 parts of antioxidant 1010s；The polysaccharide being additionally added
Compound or derivative are by 0.4 part of nano-cellulose of mass fraction, and nano-cellulose average grain diameter is 200 nm.Its water imbibition is shown in
Fig. 1.
Component two：The moist dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 18 parts by mass fraction
Linear SIS（Styrene-isoprene）Block copolymer, 13 parts of olefin copolymers, 22 parts of C5 Petropols, 10 parts of naphthenic oils
4010th, 28.2 parts of water wetted material sodium carboxymethylcelluloses, 6.6 parts of pectin, are additionally added 2 parts of antioxidant 1010s；What is be additionally added is more
Saccharide compound or derivative are by 0.6 part of nano-cellulose of mass fraction, and nano-cellulose average grain diameter is 200 nm.It is inhaled
It is water-based to see Fig. 1.
Component three：The moist dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 18 parts by mass fraction
Linear SIS（Styrene-isoprene）Block copolymer, 13 parts of olefin copolymers, 22 parts of C5 Petropols, 10 parts of naphthenic oils
4010th, 28.2 parts of water wetted material sodium carboxymethylcelluloses, 6.6 parts of pectin, are additionally added 2 parts of antioxidant 1010s；What is be additionally added is more
Saccharide compound or derivative are by 0.8 part of nano-cellulose of mass fraction, and nano-cellulose average grain diameter is 200 nm.It is inhaled
It is water-based to see Fig. 1.
The Silica hydrogel dressing of case study on implementation 2-amylose containing nanometer
The moist dressing is Silica hydrogel dressing, and the Silica hydrogel dressing includes 60 parts of polydimethylsiloxanes by mass fraction
Alkane, the poly- silicon oxide compound of carbon alkyl more than 18 parts, 20 parts of Dimethicone Crosspolymers；The nanometer polysaccharide being additionally added
Compound or derivative are by 2 portions of nanometer amyloses of mass fraction, and nanometer amylose average grain diameter is 300nm.
The alginate dressing of case study on implementation 3-sodium carboxymethylcellulose containing nanometer
The moist dressing is alginate dressing, and the alginate dressing includes 85 parts of water, 6 parts of seas by mass fraction
Mosanom, 3 parts of calcium chloride；The nanometer polysaccharide compound or derivative being additionally added are fine by 2 parts of nanometer carboxymethyls of mass fraction
The plain sodium of dimension, nanometer sodium carboxymethylcellulose average grain diameter is 350 nm.
Case study on implementation 4-the bearing hydrocolloid dressing containing nano-starch
The moist dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 38 parts of linear SIS by mass fraction（Benzene second
Alkene-isoprene）Block copolymer, 12 parts of acrylate copolymers, 15 parts of C5 Petropols, 15 parts of naphthenic oils 4010,14
Part sodium carboxymethylcellulose, 2 parts of gelatin；The nanometer polysaccharide compound or derivative being additionally added are by 16 parts of nanometers of mass fraction
Sodium carboxymethylcellulose, nanometer sodium carboxymethylcellulose average grain diameter are 800 nm；It has been additionally added anti-oxidant by 3 parts of mass fraction
Agent 1010.
The bearing hydrocolloid dressing of case study on implementation 5-amylopectin containing nanometer
The moist dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 15 parts of linear SIS by mass fraction（Benzene second
Alkene-isoprene）Block copolymer, 15 parts of olefin copolymers, 14 parts of C5 Petropols, 13 parts of naphthenic oils, 4010,30 parts of carboxylic first
Base sodium cellulosate, 5 parts of Ac-Di-Sols；The nanometer polysaccharide compound or derivative being additionally added are by mass fraction
5 parts of nanometer amylopectin, the average grain diameter of nanometer amylopectin is 220 nm；It has been additionally added by 1 part of antioxidant of mass fraction
1010。
Case study on implementation 6-the aerogel dressing containing Nano chitosan
The moist dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing by mass fraction include 7 parts of polyvinyl alcohol, 75 parts
Water, 15 parts of vinylpyrrolidones, 2 parts of crosslinking agents；The nanometer polysaccharide compound or derivative being additionally added are by mass fraction 0.5
Part Nano chitosan, the average grain diameter of Nano chitosan is 500 nm.
Case study on implementation 7-Silica hydrogel the dressing containing nano-chitosan
The moist dressing is Silica hydrogel dressing, and the Silica hydrogel dressing includes 60 parts of dimethyl silicas by mass fraction
Alkane, the poly- silicon oxide compound of carbon alkyl more than 18 parts, 20 parts of Dimethicone Crosspolymers；The nanometer polysaccharide being additionally added
Compound or derivative are by 2 parts of nano-chitosans of mass fraction, and nano-chitosan average grain diameter is 300nm.
Case study on implementation 8-the aerogel dressing containing Nano chitosan
The moist dressing is aerogel dressing, and the bearing hydrocolloid dressing includes 12 parts of polyvinyl alcohol, 70 by mass fraction
Part water, 15 parts of polyvinylpyrrolidones, 2 parts of acrylate copolymers；The nanometer polysaccharide compound or derivative being additionally added be
By 0.5 part of Nano chitosan of mass fraction, Nano chitosan average grain diameter is 500nm；It has been additionally added by 1 part of pH tune of mass fraction
Save agent tartaric acid.
The aerogel dressing of case study on implementation 9-aldocellulose containing nano double
The moist dressing is aerogel dressing, the aerogel dressing by mass fraction include 35 parts of glycerine, 40 parts of water,
Sodium Polyacrylate, 5 parts of polyacrylic acid, 5 parts of ripple nurses, the 1 part of disodium ethylene diamine tetraacetate that 8 parts of parts neutralize；The nanometer being additionally added
Polysaccharide compound or derivative are by 5 parts of nano double aldocelluloses of mass fraction, nano double aldocellulose average grain diameter
For 900 nm；It has been additionally added by 0.1 part of pH adjusting agent tartaric acid of mass fraction.
Case study on implementation 10-alginate the combine dressing containing nano-chitosan
The moist dressing is seaweed salt dressing, and the seaweed salt dressing includes 88 parts of water, 5 parts of alginic acids by mass fraction
Sodium, 3 parts of calcium chloride；The nanometer polysaccharide compound or derivative being additionally added are by 5 parts of nano-chitosans of mass fraction, nanometer first
Shell element average grain diameter is 1000 nm.
Case study on implementation 11 is identical with composition that the moist dressing of case study on implementation 1 is bearing hydrocolloid dressing, mass fraction, adds 2
Part antioxidant 1010 is identical, only the not embodiment of the prior art of plus nano polysaccharide compound or derivative
The moist dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 18 parts of linear SIS by mass fraction（Benzene second
Alkene-isoprene）Block copolymer, 13 parts of olefin copolymers, 22 parts of C5 Petropols, 10 parts of naphthenic oils, 4010,28.2 parts of parents
Water material sodium carboxymethylcellulose, 6.6 parts of pectin, are additionally added 2 parts of antioxidant 1010s.Its water imbibition is shown in Fig. 2.
Claims (10)
1. one kind includes nanometer polysaccharide medical wound dressing, including moist dressing, the moist dressing are bearing hydrocolloid dressings
Or aerogel dressing or Silica hydrogel dressing or seaweed salt dressing, it is characterised in that：The moist dressing is additionally added a nanometer polysaccharide
Class compound or derivative, the nanometer polysaccharide compound or derivative of addition be cellulose, starch, chitin, chitosan or
One or more in derivative；Saccharide compound or derivative particle diameter are the nm of 200 nm of nanoscale~1000；Saccharide compound
Or derivative and moist dressing mass fraction are respectively 0.1~20 part and 70~115 parts.
2. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 10~20 parts of linear SIS by mass fraction（Styrene-isoamyl two
Alkene）Block copolymer, 10~14 parts of olefin copolymers, 18~22 parts of C5 Petropols, 8~12 parts of naphthenic oils 4010,23~30
Part sodium carboxymethylcellulose, 2~7 parts of pectin；The polysaccharide compound or derivative being additionally added are by 0.1~8 part of mass fraction
Nano-cellulose, nano-cellulose average grain diameter are 200~700 nm；It is additionally added 1~3 part of antioxidant 1010.
3. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is Silica hydrogel dressing, and the Silica hydrogel dressing includes 55~65 parts of dimethyl silicone polymers, 17~19 by mass fraction
The poly- silicon oxide compound of the more carbon alkyl of part, 19~21 parts of Dimethicone Crosspolymers；The nanometer polysaccharide being additionally added
Compound or derivative be by 0.1~3 portion of nanometer amylose of mass fraction, nanometer amylose average grain diameter for 250~
700nm。
4. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is alginate dressing, the alginate dressing by mass fraction include 80~90 parts of water, 4~8 parts of sodium alginates,
2~4 parts of calcium chloride；The nanometer polysaccharide compound or derivative being additionally added are fine by 0.1~3 part of nanometer carboxymethyl of mass fraction
The plain sodium of dimension, nanometer sodium carboxymethylcellulose average grain diameter is 200~700nm.
5. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 36~40 parts of linear SIS by mass fraction（Styrene-isoamyl two
Alkene）Block copolymer, 10~14 parts of acrylate copolymers, 13~17 parts of C5 Petropols, 13~17 parts of naphthenic oils 4010,
12~16 parts of sodium carboxymethylcelluloses, 1~3 part of gelatin；The nanometer polysaccharide compound or derivative being additionally added are by mass parts
5~17 parts of nanometer sodium carboxymethylcelluloses of number, nanometer sodium carboxymethylcellulose average grain diameter are 700~900 nm；It has been additionally added
By 1~3 part of antioxidant 1010 of mass fraction.
6. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is bearing hydrocolloid dressing, and the bearing hydrocolloid dressing includes 13~17 parts of linear SIS by mass fraction（Styrene-isoamyl two
Alkene）Block copolymer, 12~17 parts of olefin copolymers, 12~17 parts of C5 Petropols, 11~15 parts of naphthenic oils 4010,28~
32 parts of sodium carboxymethylcelluloses, 3~7 parts of Ac-Di-Sols；The nanometer polysaccharide compound or derivative being additionally added
It is that the average grain diameter of nano-cellulose is 250~350 nm by 0.1~7 part of nano-cellulose of mass fraction；It has been additionally added by matter
Measure 1~3 part of antioxidant 1010 of number.
7. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is bearing hydrocolloid dressing, the bearing hydrocolloid dressing by mass fraction include 6~7 parts of polyvinyl alcohol, 70~80 parts of water, 13~
17 parts of vinylpyrrolidones, 1~3 part of crosslinking agent polyacrylamide；The nanometer polysaccharide compound or derivative being additionally added be by
0.1~1.5 part of Nano chitosan of mass fraction, the average grain diameter of Nano chitosan is 200~550 nm.
8. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is Silica hydrogel dressing, the Silica hydrogel dressing by mass fraction include 55~65 parts of dimethyl siloxanes, 16~20 parts
The poly- silicon oxide compound of more carbon alkyl, 18~22 parts of Dimethicone Crosspolymers；The nanometer polysaccharide chemical combination being additionally added
Thing or derivative be by 0.1~2.5 portion of nanometer amylose of mass fraction, nanometer amylose average grain diameter for 200~
700nm。
9. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is moist
Dressing is aerogel dressing, and the aerogel dressing includes 10~14 parts of polyvinyl alcohol, 65~75 parts of water, 10 by mass fraction
~20 parts of polyvinylpyrrolidones, 1.5~2.5 parts of acrylate copolymers；The nanometer polysaccharide compound or derivative being additionally added
Thing is by 0.5~2 part of Nano chitosan of mass fraction, and Nano chitosan average grain diameter is 450~550nm.
10. one kind according to claim 1 includes nanometer polysaccharide medical wound dressing, it is characterised in that described is wet
Property dressing be aerogel dressing, the aerogel dressing by mass fraction include 30~40 parts of glycerine, 35~45 parts of water, 6~
Sodium Polyacrylate, 3~7 parts of polyacrylic acid, 3~7 parts of ripple nurses, 0.5~1.5 part of ethylenediamine tetra-acetic acid two that 10 parts of parts neutralize
Sodium；The nanometer polysaccharide compound or derivative being additionally added are by 3~7 parts of nano double aldocelluloses of mass fraction, nano double
Aldocellulose average grain diameter is 800~1000 nm；It has been additionally added by 0.05~0.15 part of pH adjusting agent winestone of mass fraction
Acid.
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