CN113769158A - Bionic dry-wet adhesion self-adjusting dressing and preparation method and application thereof - Google Patents
Bionic dry-wet adhesion self-adjusting dressing and preparation method and application thereof Download PDFInfo
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- CN113769158A CN113769158A CN202111066302.5A CN202111066302A CN113769158A CN 113769158 A CN113769158 A CN 113769158A CN 202111066302 A CN202111066302 A CN 202111066302A CN 113769158 A CN113769158 A CN 113769158A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
Abstract
The invention discloses a bionic dry-wet adhesion self-adjusting dressing which comprises the following components in parts by weight: 7-8 parts of a styrene-isoprene-styrene block copolymer; 5-6 parts of high molecular weight polyisobutylene; 10-12 parts of low molecular weight polyisobutylene; 4-5 parts of tackifying resin; 0.5 to 0.7 portion of age resister; 3-3.5 parts of naphthenic oil; 11-13 parts of sodium carboxymethylcellulose; 3-3.5 parts of chitosan; 3.2-5.5 parts of microcrystalline cellulose; the size of the microcrystalline cellulose is 20-50 mu m. The bionic dry-wet adhesion self-adjusting dressing disclosed by the invention is added with the microcrystalline cellulose, so that the volume and the shape of the bionic dry-wet adhesion self-adjusting dressing are basically kept unchanged after the bionic dry-wet adhesion self-adjusting dressing is contacted with the surface of a wound due to the hydrophobic and water-guiding effects of the microcrystalline cellulose, the hardness of the dressing after moisture absorption is improved, the adhesion of the dressing after moisture absorption is further improved, different adhesion is shown according to different dry humidity of a contact surface, the problems that the dressing is easy to soften and lose adhesion after moisture absorption are solved, and the experience feeling of a patient is improved.
Description
Technical Field
The invention relates to the field of polymer medical materials, in particular to a bionic dry-wet adhesion self-adjusting dressing and a preparation method and application thereof.
Background
In recent years, with the continuous spread of international epidemic infectious diseases, the aging nursing demand of population is increased, the continuous perfection of domestic medical system, the health consciousness and consumption level of residents are improved, and the market scale of Chinese medical dressing shows a rapid growth trend. The medical dressing is a material which can temporarily replace damaged skin and provide an effective barrier and a wound healing environment for organisms, so that the research on the medical dressing is also the key of the wound healing research. With the development of technology, it is recognized that the dressing is not only intended to cover the wound, but also must help heal the wound, control and absorb exudate, block bacteria, provide a good environment for tissue growth, be easy to use, and be easily removed. The demand for multifunctional, new-material and high-added-value medical dressings is pressing day by day. Modern dressing has also got into our field of vision just so, and compared with traditional dressing, modern dressing is the embodiment that the wound healing point of view is from dry healing to humidity therapy, is a high-end medical dressing, can improve wound healing speed, alleviates patient's discomfort, can not cause secondary damage to the wound when taking off or changing, and in the use period, patient's daily activity is not influenced, very big improvement patient's medical experience. Therefore, the demand of modern dressings is increasing, but certain gaps still exist between the modern dressings and developed countries in the aspects of product innovation, technical development and the like, and the research on medical dressings is required to be increased.
At present, the hydrocolloid dressing is widely applied and obtains satisfactory effect clinically as a representative of modern medical dressings. Hydrocolloid dressing is a kind of novel wound dressing that develops under the guidance of moist healing principle, is formed by hydrophilic polymer particle and rubber elastomer mixed processing, and wherein hydrophilic polymer particle is carboxymethyl cellulose usually, as a kind of important novel wound dressing, hydrocolloid dressing has following advantage: the dressing has the capability of absorbing wound seepage, hydrophilic particles in the dressing can form gel-like semisolid substances after the wound seepage is absorbed, the gel-like semisolid substances are attached to the base of a wound, a wet environment which is favorable for wound healing is provided and maintained, and the dressing has viscosity and can form a closed wound. The closed healing environment can promote the proliferation of capillary vessels and the formation of granulation tissues, thereby accelerating the healing of the wound surface. And the wound cleaning function can be achieved. On the one hand, the hydrocolloid contains endogenous enzymes and can promote the dissolution of fibrin; on the other hand, the closed environment provided by the hydrocolloid dressing is beneficial to macrophage to remove necrotic tissues.
However, after the hydrophilic particles absorb the seepage, the hydrophilic particles are easy to swell and deform, so that the dressing becomes soft and is easy to adhere, the original shape is not easy to maintain, and the experience of a patient is easy to reduce. Therefore, to solve this problem to meet the needs of users, it is very challenging to prepare a dressing with controllable dry and wet adhesion and less deformation after imbibing.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a bionic dry-wet adhesion self-adjusting dressing, and a preparation method and application thereof.
The invention provides a bionic dry-wet adhesion self-adjusting dressing which comprises the following components in parts by weight:
7-8 parts of a styrene-isoprene-styrene block copolymer;
5-6 parts of high molecular weight polyisobutylene;
10-12 parts of low molecular weight polyisobutylene;
4-5 parts of tackifying resin;
0.5 to 0.7 portion of age resister
3-3.5 parts of naphthenic oil;
11-13 parts of sodium carboxymethylcellulose;
3-3.5 parts of chitosan;
3.2-5.5 parts of microcrystalline cellulose;
the size of the microcrystalline cellulose is 20-50 mu m.
The microcrystalline cellulose added in the invention is free-flowing superfine short rod-shaped or powdery porous particles which are obtained by hydrolyzing natural cellulose to the limit polymerization degree through dilute acid. Because the main component of the microcrystalline cellulose is a straight-chain polysaccharide substance combined by beta-1, 4-glucoside bonds, an intramolecular and intermolecular hydrogen bond network is easy to form, the rigidity of a molecular chain is enhanced, the microcrystalline cellulose has a closely arranged high-lateral-order crystalline region, has no fiber property and extremely strong fluidity, the volume and the shape of the microcrystalline cellulose are basically kept unchanged after the microcrystalline cellulose contacts the surface of a wound, and the hardness of the dressing after moisture absorption is improved.
Meanwhile, strong hydrogen bond acting force exists between the microcrystalline cellulose and the chitosan, a cross-linked net structure can be formed, and the duration of the lasting adhesion of the dressing and the water absorption performance are improved.
In addition, the size of the added microcrystalline cellulose is 20-50 microns, the microcrystalline cellulose with the size is small in particle size and good in compressibility, the microcrystalline cellulose can be better dispersed in a continuous phase pressure sensitive adhesive matrix, the moisture content is lower, the humidity sensitivity is high, a micron columnar water absorption channel is more favorably constructed, liquid on the surface of the skin is conveyed to the top of the dressing from the bottom of the dressing, and the dressing can perform self-response of dry and wet skin adhesion force when different liquid discharge amounts exist, so that intelligent regulation and control are realized. The microcrystalline cellulose also enhances the toughness of the dressing and improves the deformation of the dressing after moisture absorption.
Furthermore, the molecular weight of the high molecular weight polyisobutylene is 12-20 ten thousand, the cohesion and elasticity of the dressing are improved, and the molecular weight of the low molecular weight polyisobutylene is 4-8.5 ten thousand, so that the prepared dressing is better in viscosity and processability.
Further, the tackifying resin is a C5 petroleum resin; the anti-aging agent is an anti-aging agent 1010.
The invention also discloses a preparation method of the bionic dry-wet adhesion self-adjusting dressing, which comprises the following steps:
the method comprises the following steps: respectively putting the styrene-isoprene-styrene segmented copolymer, the high molecular weight polyisobutylene, the low molecular weight polyisobutylene, the anti-aging agent, the tackifying resin and the naphthenic oil into thermal dispersion equipment, and stirring and mixing uniformly at 100-140 ℃ to obtain the continuous phase pressure sensitive adhesive;
step two: cooling to below 100 deg.C, adding sodium carboxymethylcellulose, chitosan and microcrystalline cellulose into the thermal dispersion equipment, and stirring to obtain hydrocolloid;
step three: and (4) extruding or compression molding the hydrocolloid obtained in the step two to obtain the dry-wet adhesion self-regulating dressing.
The preparation method has the advantages of simple process, easily obtained reaction conditions, short reaction time, easy storage of the prepared dressing and low cost.
Further, the microcrystalline cellulose is pretreated before use, and the pretreatment step comprises the following steps: adding microcrystalline cellulose into deionized water, shearing in a high-speed shearing machine to obtain microcrystalline cellulose with the particle size of 20-50 microns, uniformly dispersing in the hydrocolloid dressing, and better crosslinking with chitosan.
Further, the step of pretreating the microcrystalline cellulose comprises: adding microcrystalline cellulose into deionized water, uniformly mixing under ultrasonic waves, shearing in a high-speed shearing machine for 0.5-1.5h, centrifuging for 10-15min, washing with absolute ethyl alcohol, and naturally drying to obtain the microcrystalline cellulose with the particle size of 20-50 microns.
Further, the heat dispersing equipment of the first step comprises a torque rheometer, an internal mixer or a screw extruder respectively.
Further, in the first step, stirring and mixing for 10-20min at 100-140 ℃ to obtain the continuous phase pressure sensitive adhesive; and in the second step, stirring and mixing for 30-50min to form the hydrocolloid.
Further, the compression molding in the third step is as follows: under a flat vulcanizing machine, hot-pressing at 140-160 ℃ for bubble removal, and then cold-pressing at normal temperature for further bubble removal to obtain the dressing with the thickness of 0.8-1 cm.
The invention also discloses application of the bionic dry-wet adhesion self-adjusting dressing, and the bionic dry-wet adhesion self-adjusting dressing is applied as a medical dressing in dermatosis wounds, infectious ulcer wounds, bedsore wounds and surgical wounds.
The invention has the advantages and beneficial effects that:
1. the microcrystalline cellulose with the size of 20-50 microns is added into the bionic dry-wet adhesion self-adjusting dressing, so that the microcrystalline cellulose and other materials are dispersed more uniformly, the hydrophobic water guiding effect of the microcrystalline cellulose is better exerted, the volume and the shape of the bionic dry-wet adhesion self-adjusting dressing are basically kept unchanged after the bionic dry-wet adhesion self-adjusting dressing is contacted with the surface of a wound, the hardness of the dressing after moisture absorption is improved, the adhesion of the dressing after moisture absorption is further improved, different adhesion is shown according to different dry humidity of a contact surface, the problems that the dressing is easy to soften and lose adhesion after moisture absorption are solved, and the experience of a patient is improved.
2. The bionic dry-wet adhesion self-adjusting dressing prepared by the invention can last for more than 1 hour, and meets the requirements of patients.
3. The preparation method has the advantages of simple process, easily obtained reaction conditions, short reaction time and low cost.
4. The raw materials used in the invention are rich in sources, and chitosan and microcrystalline cellulose have good biocompatibility, and the prepared hydrocolloid dressing is an environment-friendly functional material.
5. The bionic dry-wet adhesion self-adjusting dressing prepared by the invention is inspired by organisms such as insects, geckos and the like, and researches and observes that the organisms can keep moving rapidly in different humidity environments, various solid surfaces and different angles, namely reversible adhesion can be generated on the solid surfaces, the animals realize the action mainly through the reversible adhesion of toes, and fine micro-nano seta or smooth structures on the toes play a decisive role.
Detailed Description
Example 1
Pretreatment method of microcrystalline cellulose
Uniformly mixing 50g of microcrystalline cellulose in 800ml of deionized water under ultrasonic waves, shearing in a high-speed shearing machine for 0.5h (8000r/min), centrifuging for 15min (9800r/min), washing with absolute ethyl alcohol for three times, and naturally drying to obtain the microcrystalline cellulose with the size of 20-50 mu m.
Example 2
Pretreatment method of microcrystalline cellulose
Uniformly mixing 50g of microcrystalline cellulose in 800ml of deionized water under ultrasonic waves, shearing in a high-speed shearing machine for 1.5h (8000r/min), centrifuging for 10min (9800r/min), washing with absolute ethyl alcohol for three times, and naturally drying to obtain the microcrystalline cellulose with the size of 20-50 microns.
Example 3
Pretreatment method of microcrystalline cellulose
Uniformly mixing 50g of microcrystalline cellulose in 800ml of deionized water under ultrasonic waves, shearing in a high-speed shearing machine for 1h (8000r/min), centrifuging for 10min (9800r/min), washing with absolute ethyl alcohol for three times, and naturally drying to obtain the microcrystalline cellulose with the size of 20-50 microns.
Example 4
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) the temperature of a torque rheometer is adjusted to 140 ℃, the torque is set as 100r/min, 7.14g of styrene-isoprene-styrene block copolymer, 5.10g of high molecular weight polyisobutylene (molecular weight is 12 ten thousand), 10.71g of low molecular weight polyisobutylene (molecular weight is 4 thousand), 4.08g of petroleum resin, 0.51g of anti-aging agent and 3.06g of naphthenic oil are sequentially added into the adjusted torque rheometer to be internally mixed for 10 minutes, then the temperature of the torque rheometer is adjusted to 100 ℃, when the temperature of the torque rheometer is reduced to 100 ℃, 3.06g of chitosan, 11.0g of sodium carboxymethyl cellulose and 5.50g of microcrystalline cellulose prepared in the embodiment 1 are sequentially added into the torque rheometer to be internally mixed for 30 minutes and then taken out.
(2) And (2) hot-pressing the hydrocolloid taken out in the step (1) at a high temperature of 150 ℃ under a flat vulcanizing machine, then cold-pressing at a normal temperature, and obtaining the bionic dry-wet adhesion self-adjusting dressing with the thickness of 1cm after cold pressing.
Example 5
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) the temperature of a torque rheometer is adjusted to 140 ℃, the torque is set as 100r/min, 7.29g of styrene-isoprene-styrene block copolymer, 5.21g of high molecular weight polyisobutylene (with the molecular weight of 12 ten thousand), 10g of low molecular weight polyisobutylene (with the molecular weight of 4 ten thousand), 4.17g of petroleum resin, 0.50g of anti-aging agent and 3.13g of naphthenic oil are sequentially added into the adjusted torque rheometer to be internally mixed for 10 minutes, then the temperature of the torque rheometer is adjusted to 100 ℃, when the temperature of the torque rheometer is reduced to 100 ℃, 3.0g of chitosan, 11.46g of sodium carboxymethyl cellulose and 4.17g of microcrystalline cellulose prepared in the embodiment 1 are sequentially added into the torque rheometer to be internally mixed for 30 minutes and then taken out.
(2) Extruding the hydrocolloid taken out in the step (1) at 80 ℃ under an extruder, and then hot-pressing at 150 ℃ to form the bionic dry-wet adhesion self-adjusting dressing with the thickness of 1 cm.
Example 6
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) the temperature of a torque rheometer is adjusted to 140 ℃, the torque is set as 100r/min, 7.45g of styrene-isoprene-styrene block copolymer, 6g of high molecular weight polyisobutylene (with the molecular weight of 15 ten thousand), 11.17g of low molecular weight polyisobutylene (with the molecular weight of 6 ten thousand), 4.26g of petroleum resin, 0.53g of anti-aging agent and 3.19g of naphthenic oil are sequentially added into the adjusted torque rheometer to be subjected to banburying for 10 minutes, then the temperature of the torque rheometer is adjusted to 100 ℃, and when the temperature of the torque rheometer is reduced to 100 ℃, 3.0g of chitosan, 11.7g of sodium carboxymethylcellulose and 3.2g of microcrystalline cellulose prepared in the embodiment 3 are sequentially added into the torque rheometer to be subjected to banburying for 40 minutes, and then the mixture is taken out.
(2) And (2) carrying out high-temperature hot pressing on the hydrocolloid taken out in the step (1) at 140 ℃ under a flat vulcanizing machine, then carrying out cold pressing at normal temperature, and taking out the hydrocolloid after cold pressing to obtain the bionic dry-wet adhesion self-adjusting dressing with the thickness of 0.9 cm.
Example 7
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) the temperature of a torque rheometer is adjusted to 100 ℃, the torque is set to be 100r/min, 7.61g of styrene-isoprene-styrene block copolymer, 5.43g of high molecular weight polyisobutylene (with the molecular weight of 20 ten thousand), 11.41g of low molecular weight polyisobutylene (with the molecular weight of 4 ten thousand), 4g of petroleum resin, 0.54g of anti-aging agent and 3.26g of naphthenic oil are sequentially added into the adjusted torque rheometer to be internally mixed for 20 minutes, then the temperature of the torque rheometer is adjusted to 80 ℃, when the temperature of the torque rheometer is reduced to 80 ℃, 3.26g of chitosan, 11.96g of sodium carboxymethylcellulose and 3.43g of microcrystalline cellulose prepared in the embodiment 2 are sequentially added into the torque rheometer to be internally mixed for 50 minutes and then taken out.
(2) And (2) hot-pressing the hydrocolloid taken out in the step (1) at a high temperature of 160 ℃ under a flat vulcanizing machine, then cold-pressing at a normal temperature, and taking out the hydrocolloid after cold pressing to obtain the bionic dry-wet adhesion self-adjusting dressing with the thickness of 0.8 cm.
Example 8
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) the temperature of a torque rheometer is adjusted to 120 ℃, the torque is set to be 100r/min, 7.78g of styrene-isoprene-styrene block copolymer, 5g of high molecular weight polyisobutylene (molecular weight is 15), 12g of low molecular weight polyisobutylene (molecular weight is 8.5), 5g of petroleum resin, 0.70g of anti-aging agent and 3.5g of naphthenic oil are sequentially added into the adjusted torque rheometer to be internally mixed for 150 minutes, then the temperature of the torque rheometer is adjusted to 100 ℃, when the temperature of the torque rheometer is reduced to 100 ℃, 3.17g of chitosan, 12.22g of sodium carboxymethylcellulose and 3.68g of microcrystalline cellulose prepared in the embodiment 1 are sequentially added into the torque rheometer to be internally mixed for 30 minutes and then taken out.
(2) And (2) hot-pressing the hydrocolloid taken out in the step (1) at a high temperature of 150 ℃ under a flat vulcanizing machine, then cold-pressing at a normal temperature, and obtaining the bionic dry-wet adhesion self-adjusting dressing with the thickness of 1cm after cold pressing.
Example 9
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) the temperature of a torque rheometer is adjusted to 140 ℃, the torque is set as 100r/min, 7.95g of styrene-isoprene-styrene block copolymer, 5.68g of high molecular weight polyisobutylene (with the molecular weight of 18 ten thousand), 11.93g of low molecular weight polyisobutylene (with the molecular weight of 4 ten thousand), 4.55g of petroleum resin, 0.57g of anti-aging agent and 3.5g of naphthenic oil are sequentially added into the adjusted torque rheometer to be internally mixed for 10 minutes, then the temperature of the torque rheometer is adjusted to 90 ℃, and when the temperature of the torque rheometer is reduced to 90 ℃, 3.0g of chitosan, 13.0g of sodium carboxymethylcellulose and 4.3g of microcrystalline cellulose prepared in the embodiment 2 are sequentially added into the torque rheometer to be internally mixed for 40 minutes and then taken out.
(2) And (2) hot-pressing the hydrocolloid taken out in the step (1) at a high temperature of 150 ℃ under a flat vulcanizing machine, then cold-pressing at a normal temperature, and obtaining the bionic dry-wet adhesion self-adjusting dressing with the thickness of 0.8cm after cold pressing.
Comparative example 1 (based on example 6, no microcrystalline cellulose was added)
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) adjusting the temperature of a torque rheometer to 140 ℃, setting the torque as 100r/min, sequentially adding 7.45g of styrene-isoprene-styrene block copolymer, 6g of high molecular weight polyisobutylene (molecular weight is 15 ten thousand), 11.17g of low molecular weight polyisobutylene (molecular weight is 6 thousand), 4.26g of petroleum resin, 0.53g of anti-aging agent and 3.19g of naphthenic oil into the adjusted torque rheometer for banburying for 10 minutes, then adjusting the temperature of the torque rheometer to 100 ℃, and when the temperature of the torque rheometer is reduced to 100 ℃, sequentially adding 3.0g of chitosan and 11.7g of sodium carboxymethylcellulose into the torque rheometer for banburying for 40 minutes and then taking out.
(2) And (2) carrying out high-temperature hot pressing on the hydrocolloid taken out in the step (1) at 140 ℃ under a flat vulcanizing machine, then carrying out cold pressing at normal temperature, and taking out the hydrocolloid after cold pressing to obtain the bionic dry-wet adhesion self-adjusting dressing with the thickness of 0.9 cm.
Comparative example 2 (based on example 6, without microcrystalline cellulose and chitosan)
A preparation method of a bionic dry-wet adhesion self-adjusting dressing comprises the following steps:
(1) adjusting the temperature of a torque rheometer to 140 ℃, setting the torque as 100r/min, sequentially adding 7.45g of styrene-isoprene-styrene block copolymer, 6g of high molecular weight polyisobutylene (molecular weight is 15 ten thousand), 11.17g of low molecular weight polyisobutylene (molecular weight is 6 thousand), 4.26g of petroleum resin, 0.53g of anti-aging agent and 3.19g of naphthenic oil into the adjusted torque rheometer for banburying for 10 minutes, then adjusting the temperature of the torque rheometer to 100 ℃, and adding 11.7g of sodium carboxymethylcellulose into the torque rheometer for banburying for 40 minutes when the temperature of the torque rheometer is reduced to 100 ℃, and then taking out.
(2) And (2) carrying out high-temperature hot pressing on the hydrocolloid taken out in the step (1) at 140 ℃ under a flat vulcanizing machine, then carrying out cold pressing at normal temperature, and taking out the hydrocolloid after cold pressing to obtain the bionic dry-wet adhesion self-adjusting dressing with the thickness of 0.9 cm.
The biomimetic dry-wet adhesion self-regulating dressings prepared in examples 4 to 9 and comparative examples 1 to 2 were subjected to the lasting adhesion time detection, water absorption performance and peel strength test.
Wherein, the permanent adhesion test is carried out on a CZY-GS permanent adhesion tester. The sample was made to be 25X 70mm2After that, it was pressed down to the middle of two 70X 50mm stainless steel plates and rolled back and forth three times with a 2Kg rubber roller. Before testing, the steel plate is required to be kept stand for 20min at room temperature, and then the steel plate is vertically hung on a permanent adhesion tester for permanent adhesion testing, wherein specific detection results are shown in table 1.
Wherein all samples in the liquid absorption test are according to 25X 25mm2Is cut to size. To simulate the wound environment, the hydrocolloid dressing was placed in a closed forced air drying cabinet while in direct contact with the simulated exudate, and the ambient temperature was set at 37 ℃. In addition, the weight of the sample, the liquid absorption of the sample (Ma) at different time periods was determined with the aid of a balance with an accuracy of 0.1mg/) Can be defined as the equation: ma/＝(Mt-Mo)/h2. Wherein M isoIs the initial weight of the sample; mtRepresents the weight of the sample at time t; ma/Is the liquid absorption rate (g/(m) of the sample at different time periods2·h))；h2The sample area is indicated.
Wherein the peel strength test was carried out according to the national standard GB/2792-1998, samples were made at 25X 100mm2180 ° peel strength test was performed. At room temperature, the sample is attached to the middle position of a stainless steel plate and rolled by a 2Kg roller, and then the sample is kept stand for 20min and placed on a clamp for testing. Each sample was tested in triplicate and the peel strength was the average of the three data sets.
According to the detection results in table 1, the time of lasting adhesion of the dressings prepared in examples 4 to 9 of the present invention can be as long as more than 70min, which indicates that the dressings prepared in the present invention have strong ability of lasting adhesion. In contrast, the time for the viscosity retention was 61.48min in comparative example 1 because no microcrystalline cellulose was added, and 48.46min in comparative example 2 because no microcrystalline cellulose and chitosan were added. Thus, it can be seen that the dressing lasts longer with the addition of microcrystalline cellulose; in addition, as the microcrystalline cellulose and the chitosan are not added at the same time in the comparative example 2, the lasting adhesion time of the dressing is 48min, which is obviously lower than that in the examples 4-9, and the fact that the microcrystalline cellulose and the chitosan are added at the same time is shown, and a cross-linking network is formed between the microcrystalline cellulose and the chitosan, so that the cohesive energy of the dressing is improved, and the lasting adhesion time of the dressing is further improved.
As can be seen from the test data of water absorption performance in Table 1, the liquid absorption capacity of the bionic dry-wet adhesion self-adjusting dressing prepared in the embodiments 4-9 of the invention can reach 4696g/m2As above, the patient's needs were satisfied, and the liquid absorption amount of comparative examples 1-2 was low, substantially 1600g/m2Below, the requirement of the patient wound for the amount of adsorption is not sufficiently met. In addition, it was observed that the dressings prepared in examples 4 to 9 were not substantially deformed after absorbing water, and remained viscous for 70min after absorbing water.
According to the test data of the peel strength in the table 1, the peel strength of the bionic dry-wet adhesion self-adjusting dressing prepared in the embodiments 4 to 9 is 15.6 to 19.4N/cm, the requirement of viscosity is met, and the dressing is convenient to peel. If the added microcrystalline cellulose is not sufficiently soaked, the peeling strength can be greatly reduced, and the size of the added microcrystalline cellulose is small and is 20-50 mu m, so that the peeling strength is less influenced on the whole. The dressing has the peel strength of over 15N/cm, and can meet the use requirement of the wound of a patient.
TABLE 1 measurement data of self-regulation of bionic dry and wet adhesion prepared in examples 4-9 and comparative examples 1-2
It should be noted that, although the above embodiments have been described herein, the invention is not limited thereto. Therefore, based on the innovative concepts of the present invention, the technical solutions of the present invention can be directly or indirectly applied to other related technical fields by making changes and modifications to the embodiments described herein or by using equivalent structures or equivalent processes performed in the present specification, and are included in the scope of the present invention.
Claims (10)
1. The bionic dry-wet adhesion self-adjusting dressing is characterized by comprising the following components in parts by weight:
7-8 parts of a styrene-isoprene-styrene block copolymer;
5-6 parts of high molecular weight polyisobutylene;
10-12 parts of low molecular weight polyisobutylene;
4-5 parts of tackifying resin;
0.5 to 0.7 portion of age resister
3-3.5 parts of naphthenic oil;
11-13 parts of sodium carboxymethylcellulose;
3-3.5 parts of chitosan;
3.2-5.5 parts of microcrystalline cellulose;
the size of the microcrystalline cellulose is 20-50 mu m.
2. The biomimetic dry-wet adhesive force self-regulating dressing according to claim 1, wherein the molecular weight of the high molecular weight polyisobutylene is 12-20 ten thousand, and the molecular weight of the low molecular weight polyisobutylene is 4-8.5 ten thousand.
3. The biomimetic dry-wet adhesion self-regulating dressing according to claim 1, wherein the tackifying resin is C5 petroleum resin; the anti-aging agent is an anti-aging agent 1010.
4. A method of making a biomimetic dry-wet adhesion self-regulating dressing according to any of claims 1-3, comprising the steps of:
the method comprises the following steps: respectively putting the styrene-isoprene-styrene segmented copolymer, the high molecular weight polyisobutylene, the low molecular weight polyisobutylene, the anti-aging agent, the tackifying resin and the naphthenic oil into thermal dispersion equipment, and stirring and mixing uniformly at 100-140 ℃ to obtain the continuous phase pressure sensitive adhesive;
step two: cooling to below 100 deg.C, adding sodium carboxymethylcellulose, chitosan and microcrystalline cellulose into the thermal dispersion equipment, and stirring to obtain hydrocolloid;
step three: and (4) extruding or compression molding the hydrocolloid obtained in the step two to obtain the dry-wet adhesion self-regulating dressing.
5. The method for preparing the bionic dry-wet adhesion self-regulating dressing according to claim 4, wherein the microcrystalline cellulose is pretreated before being used, and the pretreatment step comprises the following steps: and adding the microcrystalline cellulose into deionized water, and shearing in a high-speed shearing machine to obtain the microcrystalline cellulose with the particle size of 20-50 microns.
6. The method for preparing the bionic dry-wet adhesion self-regulating dressing according to claim 5, wherein the step of pretreating the microcrystalline cellulose comprises the following steps of: adding microcrystalline cellulose into deionized water, uniformly mixing under ultrasonic waves, shearing in a high-speed shearing machine for 0.5-1.5h, centrifuging for 10-15min, washing with absolute ethyl alcohol, and naturally drying to obtain the microcrystalline cellulose with the particle size of 20-50 microns.
7. The method for preparing the bionic dry-wet adhesion self-regulating dressing according to claim 4, wherein the heat dispersion device in the first step comprises a torque rheometer, an internal mixer or a screw extruder.
8. The preparation method of the bionic dry-wet adhesion self-adjusting dressing according to claim 4, wherein in the first step, the continuous phase pressure sensitive adhesive is obtained by stirring and mixing for 10-20min at 100-140 ℃; and in the second step, stirring and mixing for 30-50min to form the hydrocolloid.
9. The preparation method of the bionic dry-wet adhesion self-adjusting dressing according to claim 4, wherein the compression molding in the third step is as follows: hot pressing at 140-160 deg.C under a flat vulcanizing machine, and cold pressing at normal temperature.
10. Use of a biomimetic dry-wet adhesion self-regulating dressing according to one of claims 1-4, wherein: the bionic dry-wet adhesion self-adjusting dressing is applied as a medical dressing in dermatosis wounds, infectious ulcer wounds, bedsore wounds and surgical wounds.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949354A (en) * | 2022-04-07 | 2022-08-30 | 香港理工大学深圳研究院 | Adhesive artificial periosteum and preparation method and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341207A (en) * | 1979-09-07 | 1982-07-27 | Kingsdown Medical Consultants Limited | Wound dressing |
| US5232702A (en) * | 1991-07-22 | 1993-08-03 | Dow Corning Corporation | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices |
| CN102488919A (en) * | 2011-12-29 | 2012-06-13 | 湖北大学 | Hydrocolloid dressing and its preparation method |
| CN106215231A (en) * | 2016-07-29 | 2016-12-14 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of hydrocolloid medical dressing |
| CN108030954A (en) * | 2017-12-13 | 2018-05-15 | 义乌市中科院兰州化物所功能材料中心 | One kind includes nanometer polysaccharide medical wound dressing |
| KR20180113779A (en) * | 2017-04-07 | 2018-10-17 | 주식회사 엘지화학 | Hydrocolloid adhesive composition and hydrocolloid dressing material comprising thereof |
| WO2020018023A1 (en) * | 2018-07-16 | 2020-01-23 | Thai Polyethylene Co., Ltd. | Method of preparing a microcrystalline cellulose reinforced polymer composite |
| CN111643718A (en) * | 2020-06-12 | 2020-09-11 | 扬州百思泰医疗科技有限公司 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
-
2021
- 2021-09-10 CN CN202111066302.5A patent/CN113769158A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4341207A (en) * | 1979-09-07 | 1982-07-27 | Kingsdown Medical Consultants Limited | Wound dressing |
| US5232702A (en) * | 1991-07-22 | 1993-08-03 | Dow Corning Corporation | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices |
| CN102488919A (en) * | 2011-12-29 | 2012-06-13 | 湖北大学 | Hydrocolloid dressing and its preparation method |
| CN106215231A (en) * | 2016-07-29 | 2016-12-14 | 江苏蓝湾生物科技有限公司 | A kind of preparation method of hydrocolloid medical dressing |
| KR20180113779A (en) * | 2017-04-07 | 2018-10-17 | 주식회사 엘지화학 | Hydrocolloid adhesive composition and hydrocolloid dressing material comprising thereof |
| CN108030954A (en) * | 2017-12-13 | 2018-05-15 | 义乌市中科院兰州化物所功能材料中心 | One kind includes nanometer polysaccharide medical wound dressing |
| WO2020018023A1 (en) * | 2018-07-16 | 2020-01-23 | Thai Polyethylene Co., Ltd. | Method of preparing a microcrystalline cellulose reinforced polymer composite |
| CN111643718A (en) * | 2020-06-12 | 2020-09-11 | 扬州百思泰医疗科技有限公司 | Hydrocolloid dressing glue with self-bacterium-inhibiting effect and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘文 主编: "《药用高分子材料学》", 30 June 2017, 中国中医药出版社 * |
| 姚婧娴 等: "热塑性水胶体压敏胶力学性能与流变性能研究", 《胶体与聚合物》 * |
| 赵洪凯 等: "微晶纤维素／壳聚糖吸水材料的制备与性能研究", 《化工新型材料》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949354A (en) * | 2022-04-07 | 2022-08-30 | 香港理工大学深圳研究院 | Adhesive artificial periosteum and preparation method and application thereof |
| CN114949354B (en) * | 2022-04-07 | 2023-08-18 | 香港理工大学深圳研究院 | Adhesive artificial periosteum and preparation method and application thereof |
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