KR20180113779A - Hydrocolloid adhesive composition and hydrocolloid dressing material comprising thereof - Google Patents

Abstract

The present specification relates to a hydrocolloid adhesive composition and a hydrocolloid dressing material comprising the same. The hydrocolloid adhesive composition according to an embodiment of the present invention can provide a hydrocolloid composition with superior exudation powder, absorption power, and fixation power to the skin. The hydrocolloid adhesive composition contains a hydrophobic polymer continuous phase; and a hydrophilic polymer continuous phase.

Description

HYDROCOLLOID ADHESIVE COMPOSITION AND HYDROCOLLOID DRESSING MATERIAL COMPRISING THEREOF BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hydrocolloid pressure-

The present invention relates to a hydrocolloid adhesive composition and a hydrocolloid dressing material containing the same.

Wound healing with dressing should be performed in order to speed up the healing of the wound on the skin and minimize the secondary side effects. Since 1962 Winter was announced that wound healing under humid conditions had an excellent effect, many results have been reported to verify this. The method of wound healing uses the gauze method of the conventional drying environment, but now, the dressing method of the wet environment is in the spotlight.

In general, a dressing material which is attached to and fixed to a wound by a separate adhesive tape is used. However, in this case, since the dressing material is adhered in a dry environment, there is a problem that scratches are generated on the skin, resulting in scarring, and there is a problem that secondary dressing is required because there is no self-adhesive force.

In order to solve the above problems, recently, a dressing material having self-adhesive property has attracted attention, and a representative example thereof is a hydrocolloid dressing material.

Ideal requirements for dressing for wound healing include maintaining a moist environment, preventing infection, preventing adhesion of wound surfaces and dressing materials, thermal effect, protective action, moisture permeability, visibility, non-irritation and ease of use.

It is necessary to study a pressure-sensitive adhesive composition which satisfies the ideal requirements of the dressing material for wound healing and which has high exudate absorption power and excellent skin fixing power.

KR 10-0459494 B1

The present specification intends to provide a hydrocolloid adhesive composition and a hydrocolloid dressing material containing the same.

An embodiment of the present invention relates to a hydrocolloid adhesive composition comprising a hydrophobic polymer continuous phase comprising polyisobutylene and a styrenic block copolymer; And a hydrophilic polymer mobile phase dispersed in the hydrophobic polymer continuous phase and comprising a cellulose derivative and a polypropylene glycol having a weight average molecular weight of 3,000 g / mol to 5,000 g / mol, wherein the content of the polypropylene glycol By weight based on the weight of the colloidal pressure-sensitive adhesive composition, and 1% by weight or more and 5% by weight or less based on the colloidal pressure-sensitive adhesive composition.

According to another embodiment of the present invention, And an adhesive layer laminated on one surface of the substrate layer and including the hydrocolloid adhesive composition.

The hydrocolloid pressure-sensitive adhesive composition according to one embodiment of the present invention can provide a hydrocolloid composition having high triple-power absorption capability and excellent skin-fixing ability.

The hydrocolloid composition according to one embodiment of the present invention has an advantage of solving the problem of elution of absorbed exudates.

The hydrocolloid composition according to one embodiment of the present invention maintains low adhesive property during the process of absorbing moisture on the wound surface by the hydrophilic polymer mobile phase while securing adhesion with the skin when attached to the wound site, Can be suppressed.

The hydrocolloid composition according to one embodiment of the present invention has an advantage that fluidity can be secured by reducing the hardness and at the same time, excessive oil generation can be suppressed when the skin is attached.

When a member is referred to herein as being "on " another member, it includes not only a member in contact with another member but also another member between the two members.

Whenever a component is referred to as "comprising ", it is understood that it may include other components as well, without departing from the other components unless specifically stated otherwise.

Hereinafter, the present invention will be described in more detail.

One embodiment of the present invention provides a hydrocolloid adhesive composition.

One embodiment of the present invention relates to a hydrophobic polymer continuous phase comprising polyisobutylene and a styrenic block copolymer; And a hydrophilic polymer mobile phase dispersed in the hydrophobic polymer continuous phase and comprising a cellulose derivative and a polypropylene glycol having a weight average molecular weight of 3,000 g / mol to 5,000 g / mol, wherein the content of the polypropylene glycol By weight based on the weight of the colloidal pressure-sensitive adhesive composition, and 1% by weight or more and 5% by weight or less based on the colloidal pressure-sensitive adhesive composition.

According to one embodiment of the present invention, the hydrocolloid adhesive composition may be in the form of a dispersion of the hydrophilic polymeric mobile phase in a particulate form in a continuous hydrophobic polymer phase. Specifically, the hydrophilic polymer mobile phase may be in the form of two or more fine particles separated from each other on the continuous hydrophobic polymer phase.

More specifically, according to one embodiment of the present invention, the hydrocolloid pressure-sensitive adhesive composition comprises a hydrophilic polymer mobile phase contained in a colloid, which is a hydrocolloid fine particle and is dispersed in the hydrophobic polymer continuous phase in the form of two or more fine particles, .

According to one embodiment of the present invention, the hydrophobic polymeric continuous phase may be formed by mixing the polyisobutylene and the styrenic block copolymer at a temperature of 140 ° C or higher and 160 ° C or lower.

According to one embodiment of the present invention, the hydrophobic polymer continuous phase can realize the adhesion of the hydrocolloid dressing material including the hydrophobic polymer continuous phase and ensure durability.

According to one embodiment of the present invention, the hydrophilic polymer mobile phase absorbs the exudate generated at the wound area of the skin and can help the wound area to recover.

According to one embodiment of the present invention, the polyisobutylene has a weight average molecular weight of 40,000 g / mol to 60,000 g / mol, specifically 45,000 g / mol to 55,000 g / mol, more specifically 50,000 g / mol Or more and 53,000 g / mol or less. The polyisobutylene has a weight-average molecular weight in the above-described range, thereby providing a hydrocolloid dressing material capable of preventing adherence of a wound surface of a skin and a dressing material while ensuring a sufficient adhesion force to the skin.

According to one embodiment of the present invention, the styrenic block copolymer may be a block copolymer represented by the general formula A-B-A or a block copolymer represented by the general formula A-B. Specifically, in the above formula, A may denote a styrenic block polymer, and B may denote a butadiene and / or an isoprene block polymer.

According to one embodiment of the present invention, the styrenic block copolymer is selected from the group consisting of a styrene-isoprene-styrene block copolymer, a styrene-butadiene-styrene block copolymer, a styrene-butylene-styrene block copolymer, Block copolymers, acrylonitrile-butylene-styrene copolymers, and carboxylic acid derivatives thereof.

According to one embodiment of the present invention, the weight average molecular weight of the styrenic block copolymer may be 150,000 g / mol to 300,000 g / mol, specifically 200,000 g / mol to 240,000 g / mol. It is possible to provide a hydrocolloid dressing material having sufficient durability and adhesion in a weight average molecular weight range within the above range.

According to one embodiment of the present invention, the styrene content of the styrenic block copolymer may be 10 wt% or more and 20 wt% or less, specifically 14 wt% or more and 17 wt% or less. By including styrene in the above content range, it is possible to provide a hydrocolloid dressing material having sufficient durability and adhesive strength.

According to one embodiment of the present invention, the content of the styrenic block copolymer is 25 wt% to 40 wt%, specifically 25 wt% to 35 wt%, more specifically 28 wt% % Or more and 30 wt% or less. By including the styrenic block copolymer in the above content range, the styrenic block copolymer, which is a hard segment of the continuous hydrophobic polymer, can firmly support the hydrophilic polymer mobile phase and can maintain the shape of the hydrocolloid dressing material .

According to one embodiment of the present invention, the cellulose derivative may refer to a compound in which all or a part of the hydroxyl group (-OH) on the cellulose is substituted with a hydrophilic functional group other than a hydroxy group. Specifically, the hydrophilic functional group other than the hydroxy group may mean a carboxyl group (-COOH). The cellulose derivative acts as a hydrophilic polymer mobile phase, thereby providing a hydrocolloid dressing material capable of absorbing moisture.

According to one embodiment of the present invention, the cellulose derivative may be at least one selected from the group consisting of carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, and hydroxypropylmethylcellulose.

According to an embodiment of the present invention, the content of the cellulose derivative may be 8 wt% or more and 20 wt% or less, specifically 10 wt% or more and 15 wt% or less with respect to the hydrocolloid adhesive composition. By including the cellulose derivative in the above-mentioned content range, it can be easily mixed with the hydrocolloid adhesive composition and water absorption of the hydrocolloid adhesive composition can be maintained.

According to one embodiment of the present invention, the weight average molecular weight of the polypropylene glycol may be 3,000 g / mol to 5,000 g / mol, specifically 3,500 g / mol to 4,500 g / mol. When the weight average molecular weight is within the above-mentioned range, it is possible to provide a hydrocolloid dressing material capable of effectively absorbing exudate at the wound site.

According to an embodiment of the present invention, the content of ethylene oxide in the polypropylene glycol may be 10 wt% or more and 30 wt% or less. By containing ethylene oxide in the above range, the polypropylene glycol can secure the water absorption capacity of the hydrocolloid dressing material including the hydrophilic polymer mobile phase and prevent the exudation of exudates from the wound area.

According to one embodiment of the present invention, the content of the polypropylene glycol is 1 wt% or more and 5 wt% or less, specifically 1 wt% or more and 3 wt% or less, more specifically 1.2 wt% or more 2% by weight or less. When the content of the polypropylene glycol is satisfied, the water absorption capacity of the hydrocolloid dressing material can be increased, and the elution of the absorbed water can be prevented.

According to one embodiment of the present invention, the content of the polyisobutylene is 30 wt% or more and 45 wt% or less, specifically 30 wt% or more and 40 wt% or less, more specifically 32 wt% or less, Or more and 36 wt% or less. When the content range of polyisobutylene in the content range is satisfied, it is possible to realize an appropriate adhesive force for producing a hydrocolloid dressing material, and sufficient adhesive force to the skin can be secured while maintaining an appropriate wetting environment.

According to one embodiment of the present invention, the hydrocolloid adhesive composition may further comprise a tackifier. The hydrocolloid adhesive composition includes a tackifier, so that the reaction stability and the initial tack of the tackifier can be improved.

According to one embodiment of the present invention, the tackifier may be at least one kind selected from the group consisting of rosin, terpene, xylene, petroleum and polybutene, and may be specifically rosin-based. More specifically, Rosin, hydrogenated rosin and hydrogenated rosin esters, but is not limited thereto.

According to one embodiment of the present invention, the content of the tackifier is 20 wt% or more and 30 wt% or less, specifically 20 wt% or more and 25 wt% or less, more specifically 22 wt% or more, relative to the hydrocolloid adhesive composition 24% by weight or less. Since the tackifier has a higher glass transition temperature (Tg) than that of polyisobutylene, when the tackifier is included in the above range, adequate adhesion can be ensured and the mechanical properties of the hydrocolloid dressing can be maintained.

According to one embodiment of the present invention, the hydrocolloid adhesive composition may further comprise a softening agent. Specifically, according to one embodiment of the present invention, the softening agent can reduce the hardness of the hydrocolloid adhesive composition and ensure fluidity.

According to one embodiment of the present invention, the softening agent may be at least one selected from the group consisting of mineral oil, vegetable oil, paraffin oil, and polybutene.

According to one embodiment of the present invention, the content of the softening agent is 1 wt% or more and 5 wt% or less, specifically 1 wt% or more and 3 wt% or less, more specifically 1.4 wt% or more and 3 wt% or less based on the hydrocolloid adhesive composition. % ≪ / RTI > When the content of the softening agent is satisfied, the softening agent can be easily mixed with the hydrocolloid adhesive composition, and the discomfort of the user of the hydrocolloid dressing can be prevented.

According to one embodiment of the present invention, the hydrocolloid adhesive composition may further include at least one additive selected from the group consisting of an antioxidant, a wetting agent, a light stabilizer, a surface lubricant, and a curing agent.

According to one embodiment of the present invention, the types of the antioxidant, the wetting agent, the light stabilizer, the surface lubricant and the curing agent are not limited and can be freely selected as long as they are applicable in the art.

According to one embodiment of the present invention, the content of the additive is 0.1 wt% or more and 0.5 wt% or less, specifically 0.12 wt% or more and 0.3 wt% or less, more specifically 0.14 wt% or more and 0.2 wt% or less, Or less.

Another embodiment of the present invention is a method of manufacturing a semiconductor device, comprising: a base layer; And an adhesive layer laminated on one surface of the substrate layer and including the hydrocolloid adhesive composition.

According to one embodiment of the invention, the substrate layer may comprise a thermoplastic polyurethane.

According to one embodiment of the present invention, the thickness of the substrate layer may be 10 μm or more and 50 μm or less.

According to one embodiment of the present invention, the thickness of the adhesive layer may be 200 占 퐉 or more and 600 占 퐉 or less, specifically 250 占 퐉 or more and 400 占 퐉 or less, more specifically 280 占 퐉 or more and 350 占 퐉 or less. In the thickness range of the pressure-sensitive adhesive layer, there is no inconvenience when the hydrocolloid dressing material is used, and the water absorption capacity of the hydrocolloid dressing material can be ensured.

According to one embodiment of the present invention, the pressure-sensitive adhesive layer is formed by coating the hydrocolloid pressure-sensitive adhesive composition to the thickness range, applying pressure to the hydrocolloid pressure-sensitive adhesive composition to have the thickness range, or hydrocolloid And then extruding the pressure-sensitive adhesive composition.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention is not construed as being limited to the embodiments described below. Embodiments of the present disclosure are provided to enable those skilled in the art to more fully understand the present invention.

Example 1

38 g of a styrene-isoprene-styrene block copolymer (D1161, Kraton, weight average molecular weight 200,000 to 240,000 g / mol) and 40 g of an antioxidant (Oppanol 12SFN, BASF, weight average molecular weight 51,000 g / mol) Irganox 1010, BASF) were mixed at 150 占 폚 for 30 minutes, and the mixture was warmed to 100 占 폚.

(SC-2404, KONIX) having a weight average molecular weight of 4000 g / mol, 2 g of a tackifier (Foral 85-E , Eastman) and 0.5 g of mineral oil (LYLY 350, Far East Oil Company) were added and mixed for 30 minutes to prepare a hydrocolloid adhesive composition.

Comparative Example 1

A hydrocolloid adhesive composition was prepared in the same manner as in Example 1, except that 10 g of carboxymethylcellulose was mixed.

Comparative Example 2

A hydrocolloid adhesive composition was prepared in the same manner as in Example 1, except that 15 g of the tackifier was mixed.

Comparative Example 3

A hydrocolloid adhesive composition was prepared in the same manner as in Example 1, except that 2 g of mineral oil was mixed.

Comparative Example 4

A hydrocolloid adhesive composition was prepared in the same manner as in Example 1, except that 10 g of polypropylene glycol was mixed.

Comparative Example 5

A hydrocolloid adhesive composition was prepared in the same manner as in Example 1, except that 60 g of the tackifier was mixed.

The components and their contents of the hydrocolloid according to Example 1 and Comparative Examples 1 to 5 are shown in Table 1 below.

PIB SIS CMC PPG Tackifier Mineral oil Antioxidant Example 1 46 38 16 2 30 0.5 0.2 Comparative Example 1 46 38 10 2 30 0.5 0.2 Comparative Example 2 46 38 16 2 15 0.5 0.2 Comparative Example 3 46 38 16 2 30 2 0.2 Comparative Example 4 46 38 16 10 30 0.5 0.2 Comparative Example 5 46 38 16 2 60 0.5 0.2

* PIB: Polyisobutylene

* SIS: Styrene-Isoprene-Styrene

* CMC: Carboxylmethylcellulose

* PPG: Polypropyleneglycol

* Unit: g

<Experimental Example>

The hydrocolloid compositions of Example 1 and Comparative Examples 1 to 5 were pressed at a temperature of 60 캜 for 15 minutes by hot pressing for 1 minute to prepare a pressure-sensitive adhesive layer.

A thermoplastic polyurethane (TPU) base material having a thickness of 30 占 퐉 was laminated on the adhesive layer to prepare a hydrocolloid dressing material.

Absorption test

The initial weight (W1) of a sample obtained by cutting the hydrocolloid dressing material prepared according to the above Experimental Example into 2 cm x 2 cm (width x length) was measured.

The sample was immersed in 20 ml of distilled water and left for 24 hours at a temperature of 40 ° C and a relative humidity of 20%.

After 5 seconds elapsed from taking out the sample, the late weight (W2) was measured, and the absorption power was measured according to the following formula (1).

[Formula 1]

Absorbency = (W2-W1) / W1

Adhesive force measurement experiment

The sample of the hydrocolloid dressing prepared according to the above Experimental Example was attached to the SUS surface by reciprocating 5 times with a 2 kg roller with a width of 20 mm.

After 1 hour, the sample adhered to the roller was peeled off at an angle of 180 ° at a speed of 300 mm / min to measure its force.

OIL TEST

The hydrocolloid dressing sample prepared according to the above Experimental Example was directly adhered to the skin to judge whether or not there was a slippery feeling.

The results of the absorption test and the adhesion test and the oil test are shown in Table 2 below.

Absorbency (no unit) Adhesion (gf) Whether the oil test passed Example 1 2.53 327 Pass Comparative Example 1 1.81 350 Pass Comparative Example 2 2.50 300 Pass Comparative Example 3 2.50 350 Fail Comparative Example 4 1.20 350 Pass Comparative Example 5 1.8 More than 600 Pass

<Evaluation>

In the case of Comparative Example 1, it was confirmed that the adhesive force was higher than that of Example 1 and the oil absorption test was passed, but the absorption power was lower than that of Example 1. As a result, it was confirmed that hydrocolloid dressing materials having high exudate absorption capacity can be manufactured by containing carboxymethyl cellulose within the content range of the present invention.

In the case of Comparative Example 2, it passed the oiliness test and had an absorption power similar to that of Example 1, but it was confirmed that the adhesive strength was lower than that of Example 1. In the case of Comparative Example 5, it was confirmed that there was a problem that the produced hydrocolloid dressing material was destroyed due to the adhesive force exceeding 600 gf, which had an absorption capacity lower than that of Example 1 though passing the oiliness test. As a result, it was confirmed that a hydrocolloid dressing material having a high adhesive strength could be provided by including a tackifier in the content range of the present invention.

In the case of Comparative Example 3, it was confirmed that it had an absorbing power similar to that of Example 1 and an adhesive strength better than that of Example 1, but it was confirmed that the test did not pass the oiliness test. Thus, it was confirmed that it is possible to provide a hydrocolloid dressing material having an appropriate oiliness in the case of containing mineral oil of the content range of the present invention.

In the case of Comparative Example 4, it passed the oiliness test and had a higher adhesive force than Example 1, but it was confirmed that the absorbency was significantly lower than that of Example 1. As a result, it was confirmed that when the content of polypropylene glycol exceeds the content range of the present invention, the absorbed exudate elutes and the final absorption rate is decreased.

Claims (13)

In the hydrocolloid pressure-sensitive adhesive composition,
A hydrophobic polymer continuous phase comprising polyisobutylene and styrenic block copolymer; And
A hydrophilic polymeric mobile phase dispersed in the hydrophobic polymer continuous phase and comprising a cellulose derivative and polypropylene glycol having a weight average molecular weight of 3,000 g / mol to 5,000 g / mol,
Wherein the content of the polypropylene glycol is 1 wt% or more and 5 wt% or less based on the hydrocolloid pressure-sensitive adhesive composition.
The method according to claim 1,
Wherein the polyisobutylene content is 30 wt% or more and 45 wt% or less based on the hydrocolloid pressure-sensitive adhesive composition.
The method according to claim 1,
Wherein the polyisobutylene has a weight average molecular weight of 40,000 g / mol to 60,000 g / mol.
The method according to claim 1,
Wherein the content of the styrenic block copolymer is 25% by weight or more and 40% by weight or less based on the hydrocolloid pressure-sensitive adhesive composition.
The method according to claim 1,
Wherein the styrenic block copolymer has a weight average molecular weight of 150,000 g / mol to 300,000 g / mol.
The method according to claim 1,
Wherein the styrene content of the styrenic block copolymer is 10 wt% or more and 20 wt% or less.
The method according to claim 1,
Wherein the content of the cellulose derivative is 8 wt% or more and 20 wt% or less based on the hydrocolloid pressure-sensitive adhesive composition.
The method according to claim 1,
Wherein the hydrocolloid adhesive composition further comprises a softening agent,
Wherein the content of the softening agent is 1 wt% or more and 5 wt% or less based on the hydrocolloid adhesive composition.
The method according to claim 1,
Wherein the hydrocolloid adhesive composition further comprises a tackifier,
Wherein the content of the tackifier is 20 wt% or more and 30 wt% or less based on the hydrocolloid adhesive composition.
The method according to claim 1,
Wherein the hydrocolloid adhesive composition further comprises at least one additive selected from the group consisting of an antioxidant, a wetting agent, a light stabilizer, a surface lubricant, and a curing agent,
The content of the additive And the hydrocolloid adhesive composition is 0.1 wt% or more and 0.5 wt% or less based on the hydrocolloid pressure-sensitive adhesive composition.
A base layer; And
And a pressure-sensitive adhesive layer laminated on one surface of the base layer, wherein the pressure-sensitive adhesive layer comprises the hydrocolloid pressure-sensitive adhesive composition according to any one of claims 1 to 10.
12. The method of claim 11,
Wherein the base layer has a thickness of 10 占 퐉 or more and 50 占 퐉 or less.
12. The method of claim 11,
Wherein the thickness of the adhesive layer is 200 占 퐉 or more and 600 占 퐉 or less.