CN109498834B - Antibacterial hydrocolloid dressing and preparation method thereof - Google Patents
Antibacterial hydrocolloid dressing and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention belongs to the technical field of hydrocolloid dressings, and particularly relates to a bacteriostatic hydrocolloid dressing and a preparation method thereof. The bacteriostatic hydrocolloid dressing comprises the following preparation raw materials in parts by weight: 25-35 parts of sodium carboxymethylcellulose, 20-30 parts of carboxymethyl chitosan, 5-10 parts of gelatin, 20-30 parts of thermoplastic elastomer, 3-10 parts of tackifying resin and 0.5-1.5 parts of bacteriostatic agent. The hydrocolloid dressing disclosed by the invention adopts triclocarban and sodium ferulate as bacteriostatic agents, and the triclocarban and the sodium ferulate are synergistic, so that the bacteriostatic effect is obvious while the using amount of triclocarban is reduced, and the hydrocolloid dressing has good liquid absorption and wound healing promotion capabilities, is safe, has no toxic or side effect, and is suitable for popularization and application.
Description
Technical Field
The invention belongs to the technical field of hydrocolloid dressings, and particularly relates to a bacteriostatic hydrocolloid dressing and a preparation method thereof.
Background
Hydrocolloid dressing is a novel medical dressing, has advantages such as waterproof, prevent sticking, moisturize and keep warm, hydrocolloid dressing is formed with the granule of hydroscopic polymer and hot melt pressure sensitive adhesive mixed processing, this kind of dressing has combined the adhesive property of rubber materials and the water absorption performance of hydroscopic polymer material, wherein rubber substrate provides viscidity, enable dressing to paste on the surface of a wound, and the hydrocolloid granule dispersed wherein swells after absorbing water, provide a moist sealed environment for the wound, promote the healing of wound, moist environment plays important promotion effect to the healing of wound, very big convenience has been brought for the nursing of wound.
An ideal hydrocolloid dressing should have the following characteristics: (1) can absorb a large amount of exudates and toxic substances, and can also keep certain shape and strength when being wetted; (2) can maintain enough humidity of the wound and has good bacteria resistance and bacteriostasis capacity; (3) good storage stability and degradable performance, and the waste does not pollute the environment. The existing hydrocolloid dressing mainly takes sodium carboxymethylcellulose, gelatin and the like as raw materials, has certain advantages in the aspects of liquid absorption capacity and wound healing, but still has certain limitations in the face of complex wound surfaces, and particularly shows antibacterial performance.
On one hand, the antibacterial components in the traditional bacteriostatic hydrocolloid dressing are inorganic antibacterial agents such as silver ions, nano silver and the like, and although the traditional bacteriostatic hydrocolloid dressing has good bacteriostatic performance, the bacteriostatic agents have high cytotoxicity. For example, chinese patent document CN 102218155 a discloses a method for preparing a nano-silver functional hydrocolloid medical dressing, which adds nano-silver or a nano-silver dispersion into a hydrocolloid to provide the hydrocolloid with an antibacterial function, but the medical dressing may cause a certain cytotoxicity and harm to the human body due to the addition of the nano-silver or the nano-silver dispersion after long-term use. On the other hand, some bacteriostatic agents such as triclocarban are novel broad-spectrum and high-efficiency antibacterial agents, which are widely used due to high bactericidal rate, no skin irritation, no allergy and good compatibility with skin, but researches show that a large amount of bacteriostatic agents can cause damage to liver and kidney of human body and influence on immune system after long-term use. For example, chinese patent document CN 107982571a discloses a hydrocolloid dressing with strong bacteriostatic ability and a preparation method thereof, which comprises the following preparation raw materials: the antibacterial agent comprises sodium carboxymethylcellulose, carboxymethyl chitosan, polyurethane thermoplastic elastomer, sodium alginate, tackifying resin, plasticizer, gelatin, alkyl starch ester, polyisobutylene, antioxidant, bacteriostatic agent and synergistic bacteriostatic agent, has good antibacterial performance, but has complex components, and the main antibacterial component triclocarban can cause damage to liver and kidney of a human body and influence on an immune system after being used for a long time, so that the dosage of the antibacterial agent is reasonably controlled while the antibacterial effect is ensured.
Therefore, based on the problems of poor liquid absorption performance, side effects of adding an antibacterial agent component to a human body, complex components and the like commonly existing in the conventional hydrocolloid dressing when the conventional hydrocolloid dressing faces complex wound surfaces, the hydrocolloid dressing which is simple in components, good in liquid absorption and wound surface treatment effects, good in antibacterial performance, safe and free of side effects needs to be provided for people, and the preparation method of the hydrocolloid dressing.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides the bacteriostatic hydrocolloid dressing and the preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows:
the bacteriostatic hydrocolloid dressing comprises the following preparation raw materials in parts by weight: 25-35 parts of sodium carboxymethylcellulose, 20-30 parts of carboxymethyl chitosan, 5-10 parts of gelatin, 20-30 parts of thermoplastic elastomer, 3-10 parts of tackifying resin and 0.5-1.5 parts of bacteriostatic agent.
Further, the hydrocolloid dressing comprises the following preparation raw materials in parts by weight: 30 parts of sodium carboxymethylcellulose, 28.8 parts of carboxymethyl chitosan, 8 parts of gelatin, 25 parts of thermoplastic elastomer, 7 parts of tackifying resin and 1.2 parts of bacteriostatic agent.
Further, the thermoplastic elastomer is a urethane rubber or a styrene-butadiene-styrene block copolymer.
Further, the tackifying resin is rosin glyceride.
Further, the bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban to the sodium ferulate is (0.05-0.3): 1.
further, the weight ratio of triclocarban to sodium ferulate is 0.15: 1.
the preparation method of the antibacterial hydrocolloid dressing comprises the following steps:
s1, adding the thermoplastic elastomer and the tackifying resin into an internal mixer according to the formula amount, and mixing for 15-20 min at 100-150 ℃ and 100-120 r/min to prepare hot melt pressing gelatin A;
s2, adding sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and a bacteriostatic agent into hot melt pressing gelatin A according to the formula amount, mixing for 8-12 min, treating in a flat vulcanizing machine at 90-110 ℃, coating on a waterproof polyurethane backing, covering release paper, and performing irradiation sterilization by cobalt 60 to obtain the sheet hydrocolloid dressing.
Further, the dose of the cobalt 60 irradiation sterilization is 20-30 kGy.
In the technical scheme of the invention, triclocarban is a novel broad-spectrum and high-efficiency antibacterial agent which is widely applied due to high-efficiency sterilization rate, no skin irritation, no allergy and good compatibility with skin, but researches show that a large amount of triclocarban can cause damage to liver and kidney of a human body and influence on an immune system after being used for a long time, so that the dosage of triclocarban is reasonably controlled while the antibacterial effect is ensured. Sodium ferulate, also called angelicin, is sodium salt of ferulic acid, which has the functions of resisting oxidation and removing free radicals, and is found to have a certain bacteriostatic effect through retrieval, but the single use effect is not good, and the combination of triclocarban and sodium ferulate for bacteriostasis does not appear. Therefore, the bacteriostatic agent adopted by the invention is compounded by triclocarban and sodium ferulate, the triclocarban and the sodium ferulate are synergistic, and the bacteriostatic effect is greatly enhanced on the basis of respective independent use by searching the proper proportion of the triclocarban and the sodium ferulate.
Secondly, the inventor surprisingly finds that sodium ferulate in the bacteriostatic agent not only can be compounded with triclocarban to achieve a good bacteriostatic effect, but also enables the hydrocolloid dressing to have more excellent liquid absorption performance and further promotes the healing of wounds, probably because the sodium ferulate and the active ingredient hydrocolloid particle carboxymethyl chitosan of the invention can form hydrogen bonds and interact, the gelation reaction of the carboxymethyl chitosan is enhanced, the liquid absorption performance of the hydrocolloid dressing is enhanced and the healing of the wounds is promoted.
Compared with the prior art, the invention has the following beneficial effects:
(1) the bacteriostatic agent disclosed by the invention is prepared by compounding triclocarban and sodium ferulate, the triclocarban and the sodium ferulate are synergistic, and the proper proportion of the triclocarban and the sodium ferulate is found, so that the bacteriostatic effect is greatly enhanced on the basis of respective independent use while the use amount of the triclocarban is greatly reduced, and the bacteriostatic agent is safe, free of toxic and side effects and suitable for popularization and use.
(2) The synergistic effect of the preparation raw materials has good imbibition and wound healing promotion capability, and the interaction between the sodium ferulate and the carboxymethyl chitosan in the bacteriostatic agent enhances the gelation reaction of the carboxymethyl chitosan, further promotes imbibition performance and promotes wound healing.
Detailed Description
The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.
The sodium ferulate CAS No. 24276-84-4 of the invention, and the other preparation raw materials and reagents are all conventional commercial products.
Example 1 bacteriostatic hydrocolloid dressing according to the invention
The bacteriostatic hydrocolloid dressing is prepared from the following raw materials in parts by weight: 35kg of sodium carboxymethylcellulose, 22kg of carboxymethyl chitosan, 10kg of gelatin, 22.5kg of styrene-butadiene-styrene block copolymer, 10kg of rosin glyceride and 0.5kg of bacteriostatic agent.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban to the sodium ferulate is 0.05: 1.
the preparation method of the antibacterial hydrocolloid dressing comprises the following steps:
s1, adding the styrene-butadiene-styrene block copolymer and the rosin glyceride into an internal mixer according to the formula amount, and mixing for 15min at 130 ℃ and 110r/min to prepare hot-melt-pressed gelatin A;
s2, adding sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and a bacteriostatic agent into hot melt pressing gelatin A according to the formula amount, mixing for 10min, placing in a flat vulcanizing machine at 100 ℃, then coating on a waterproof polyurethane backing, covering release paper, and performing irradiation sterilization by cobalt 60 to obtain the sheet hydrocolloid dressing with the dosage of 20 kGy.
Example 2 bacteriostatic hydrocolloid dressing according to the invention
The bacteriostatic hydrocolloid dressing provided by the embodiment 2 of the invention is prepared from the following raw materials in parts by weight: 30kg of sodium carboxymethylcellulose, 28.8kg of carboxymethyl chitosan, 8kg of gelatin, 25kg of styrene-butadiene-styrene block copolymer, 7kg of rosin glyceride and 1.2kg of bacteriostatic agent.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban to the sodium ferulate is 0.15: 1.
the preparation method of the antibacterial hydrocolloid dressing comprises the following steps:
s1, adding the styrene-butadiene-styrene block copolymer and the rosin glyceride into an internal mixer according to the formula amount, and mixing for 15min at 130 ℃ and 110r/min to prepare hot-melt-pressed gelatin A;
s2, adding sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and a bacteriostatic agent into hot melt pressing gelatin A according to the formula amount, mixing for 10min, placing in a flat vulcanizing machine at 100 ℃, then coating on a waterproof polyurethane backing, covering release paper, and performing irradiation sterilization by cobalt 60 to obtain the sheet hydrocolloid dressing with the dosage of 25 kGy.
Example 3 bacteriostatic hydrocolloid dressing according to the invention
The bacteriostatic hydrocolloid dressing provided by the embodiment 3 of the invention is prepared from the following raw materials in parts by weight: 26kg of sodium carboxymethylcellulose, 30kg of carboxymethyl chitosan, 8.5kg of gelatin, 30kg of styrene-butadiene-styrene block copolymer, 4kg of rosin glyceride and 1.5kg of bacteriostatic agent.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban to the sodium ferulate is 0.3: 1.
the preparation method of the antibacterial hydrocolloid dressing comprises the following steps:
s1, adding the styrene-butadiene-styrene block copolymer and the rosin glyceride into an internal mixer according to the formula amount, mixing for 15min at 130 ℃ and 110r/min, and preparing hot-melt-compression gelatin A;
s2, adding sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and a bacteriostatic agent into hot melt pressing gelatin A according to the formula amount, mixing for 10min, placing in a flat vulcanizing machine at 100 ℃, then coating on a waterproof polyurethane backing, covering release paper, and performing irradiation sterilization by cobalt 60 to obtain the sheet hydrocolloid dressing with the dosage of 30 Gy.
Example 4 bacteriostatic hydrocolloid dressing according to the invention
The bacteriostatic hydrocolloid dressing provided by the embodiment 4 of the invention is prepared from the following raw materials in parts by weight: 30kg of sodium carboxymethylcellulose, 28.8kg of carboxymethyl chitosan, 8kg of gelatin, 25kg of polyurethane rubber, 7kg of rosin glyceride and 1.2kg of bacteriostatic agent.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban to the sodium ferulate is 0.15: 1.
the preparation method of the antibacterial hydrocolloid dressing comprises the following steps:
s1, adding the polyurethane rubber and the rosin glyceride into an internal mixer according to the formula amount, mixing for 15min at 130 ℃ and 110r/min, and preparing hot-melt-pressure gelatin A;
s2, adding sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and a bacteriostatic agent into hot melt pressing gelatin A according to the formula amount, mixing for 10min, placing in a flat vulcanizing machine at 100 ℃, then coating on a waterproof polyurethane backing, covering release paper, and performing irradiation sterilization by cobalt 60 to obtain the sheet hydrocolloid dressing with the dosage of 25 kGy.
Comparative example 1
The comparative example differs from example 2 only in that: the addition amount of sodium ferulate is correspondingly increased without adding triclocarban.
Comparative example 2
The comparative example differs from example 2 only in that: sodium ferulate is not added, and the addition amount of triclocarban is correspondingly increased.
Comparative example 3
The comparative example differs from example 2 only in that: the weight ratio of triclocarban to sodium ferulate is 0.5: 1.
test example one, antimicrobial property test of hydrocolloid dressing
1. Test materials: bacteriostatic hydrocolloid dressings prepared in examples 1-4 and comparative examples 1-3; staphylococcus aureus ATCC6538, pseudomonas aeruginosa ATCC27853, and candida albicans 98001;
2. the test method comprises the following steps: uniformly shearing the bacteriostatic hydrocolloid dressings prepared in examples 1-4 and comparative examples 1-3 into 1.0 x 1.0cm, putting the dressings into a triangular flask, then respectively adding phosphate buffer solution and three bacterial suspensions with the same volume, and enabling the bacterial suspensions to be in PBSThe concentration is 1X 104～9×104CFU/mL, fixing the triangular flask on a shaking table, shaking for 1h at 300r/min, respectively taking sample liquid before and after shaking, properly diluting the sample liquid with PBS, inoculating the sample liquid into a plate by an agar pouring method, and counting bacterial colonies, wherein the bacteriostasis rate is the ratio of the difference of the average bacterial colony number of the sample before and after shaking to the average bacterial colony number of the sample before shaking in percentage;
3. the test results are shown in table 1.
TABLE 1 antiseptic test results of hydrocolloid dressings
(1) As can be seen from table 1, the hydrocolloid dressings prepared in examples 1 to 4 have a good inhibitory effect on staphylococcus aureus, monospora aeruginosa and candida albicans, wherein the most excellent bacteriostatic effect of example 2 is the best example of the present invention;
(2) compared with the example 2, the comparative example 1 and the comparative example 2 are not added with triclocarban and sodium ferulate respectively, and the bacteriostatic performance of the prepared hydrocolloid dressing is obviously reduced, which shows that the triclocarban and the sodium ferulate have strong synergistic effect and remarkable bacteriostatic effect;
(3) compared with the embodiment 2, the bacteriostatic agent of the comparative example 3 has the same components but different proportions, and the bacteriostatic effect is reduced, which shows that the bacteriostatic agent of the invention, namely triclocarban and sodium ferulate, has the following weight ratio (0.05-0.3): 1, the synergistic effect is remarkable.
Test example two, Performance testing of hydrocolloid dressing
1. Test materials: bacteriostatic hydrocolloid dressings prepared in examples 1-4 and comparative examples 1-3;
2. the test method comprises the following steps: testing the liquid absorption capacity of the hydrocolloid dressing according to the GB/T0471.1-2004 standard;
3. the test results are shown in table 2.
Table 2 hydrocolloid dressing performance test results
(1) As can be seen from table 2, the hydrocolloid dressings prepared in examples 1 to 4 have a good effect of liquid absorption amount, and the best liquid absorption amount in example 2 is the best embodiment of the present invention;
(2) compared with the example 2, the comparative example 1 does not add triclocarban, and the liquid absorption amount of the prepared hydrocolloid dressing is reduced to some extent, and the reduction range is not obvious; comparative example 2 sodium ferulate was not added, and the liquid absorption capacity effect of the prepared hydrocolloid dressing was significantly reduced; the comparative example 3 changes the proportion of triclocarban and sodium ferulate, and the liquid absorption effect of the prepared hydrocolloid dressing is reduced, and the reduction range is not obvious, which shows that the sodium ferulate and carboxymethyl chitosan have synergistic effect and interact with other preparation raw materials, and the prepared hydrocolloid dressing has good liquid absorption performance.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (7)
1. The bacteriostatic hydrocolloid dressing is characterized by comprising the following preparation raw materials in parts by weight: 25-35 parts of sodium carboxymethylcellulose, 20-30 parts of carboxymethyl chitosan, 5-10 parts of gelatin, 20-30 parts of thermoplastic elastomer, 3-10 parts of tackifying resin and 0.5-1.5 parts of bacteriostatic agent;
the bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban to the sodium ferulate is (0.05-0.3): 1.
2. the bacteriostatic hydrocolloid dressing of claim 1, which comprises the following raw materials in parts by weight: 30 parts of sodium carboxymethylcellulose, 28.8 parts of carboxymethyl chitosan, 8 parts of gelatin, 25 parts of thermoplastic elastomer, 7 parts of tackifying resin and 1.2 parts of bacteriostatic agent.
3. The bacteriostatic hydrocolloid dressing of claim 1, wherein said thermoplastic elastomer is a polyurethane rubber or a styrene-butadiene-styrene block copolymer.
4. The bacteriostatic hydrocolloid dressing of claim 1, wherein said tackifying resin is rosin glycerol ester.
5. The bacteriostatic hydrocolloid dressing of claim 1, wherein the weight ratio of triclocarban to sodium ferulate is 0.15: 1.
6. a preparation method of the bacteriostatic hydrocolloid dressing as claimed in any one of claims 1 to 5, characterized by comprising the following steps:
s1, adding the thermoplastic elastomer and the tackifying resin into an internal mixer according to the formula amount, and mixing for 15-20 min at 100-150 ℃ under the condition of 100-120 r/min to prepare hot melt pressing gelatin A;
s2, adding sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and a bacteriostatic agent into hot melt pressing gelatin A according to the formula amount, mixing for 8-12 min, treating in a flat vulcanizing machine at 90-110 ℃, coating on a waterproof polyurethane backing, covering release paper, and performing irradiation sterilization by cobalt 60 to obtain the flaky bacteriostatic hydrocolloid dressing.
7. The preparation method of the bacteriostatic hydrocolloid dressing according to claim 6, wherein the dose of the cobalt 60 radiation sterilization is 20-30 kGy.
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| CN112274687B (en) * | 2020-11-25 | 2023-05-30 | 广州润虹医药科技股份有限公司 | Stable hydrocolloid oil yarn and preparation method thereof |
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