CN109498834A - A kind of bacteriostatic hydrocolloid dressing and preparation method thereof - Google Patents
A kind of bacteriostatic hydrocolloid dressing and preparation method thereof Download PDFInfo
- Publication number
- CN109498834A CN109498834A CN201811536883.2A CN201811536883A CN109498834A CN 109498834 A CN109498834 A CN 109498834A CN 201811536883 A CN201811536883 A CN 201811536883A CN 109498834 A CN109498834 A CN 109498834A
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- CN
- China
- Prior art keywords
- bacteriostatic
- parts
- hydrocolloid dressing
- gelatin
- triclocarban
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000416 hydrocolloid Substances 0.000 title claims abstract description 69
- 230000003385 bacteriostatic effect Effects 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- NCTHNHPAQAVBEB-WGCWOXMQSA-M sodium ferulate Chemical compound [Na+].COC1=CC(\C=C\C([O-])=O)=CC=C1O NCTHNHPAQAVBEB-WGCWOXMQSA-M 0.000 claims abstract description 33
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229960001325 triclocarban Drugs 0.000 claims abstract description 33
- 108010010803 Gelatin Proteins 0.000 claims abstract description 29
- 239000008273 gelatin Substances 0.000 claims abstract description 29
- 229920000159 gelatin Polymers 0.000 claims abstract description 29
- 235000019322 gelatine Nutrition 0.000 claims abstract description 29
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 29
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 23
- 229920001661 Chitosan Polymers 0.000 claims abstract description 21
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 21
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 17
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 17
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000011347 resin Substances 0.000 claims abstract description 10
- 229920005989 resin Polymers 0.000 claims abstract description 10
- 229920002725 thermoplastic elastomer Polymers 0.000 claims abstract description 10
- 230000000844 anti-bacterial effect Effects 0.000 claims description 12
- 239000012943 hotmelt Substances 0.000 claims description 12
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims description 10
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims description 10
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- 229920003225 polyurethane elastomer Polymers 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 2
- 229940114124 ferulic acid Drugs 0.000 claims description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 2
- 235000001785 ferulic acid Nutrition 0.000 claims description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229920006132 styrene block copolymer Polymers 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000001408 fungistatic effect Effects 0.000 abstract description 11
- 230000029663 wound healing Effects 0.000 abstract description 5
- 238000005213 imbibition Methods 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 15
- 208000027418 Wounds and injury Diseases 0.000 description 13
- 206010052428 Wound Diseases 0.000 description 12
- 238000012360 testing method Methods 0.000 description 8
- 239000002250 absorbent Substances 0.000 description 7
- 230000002745 absorbent Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 7
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- NWFNSTOSIVLCJA-UHFFFAOYSA-L copper;diacetate;hydrate Chemical compound O.[Cu+2].CC([O-])=O.CC([O-])=O NWFNSTOSIVLCJA-UHFFFAOYSA-L 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- XDROKJSWHURZGO-UHFFFAOYSA-N isopsoralen Natural products C1=C2OC=CC2=C2OC(=O)C=CC2=C1 XDROKJSWHURZGO-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- MLMVLVJMKDPYBM-UHFFFAOYSA-N pseudoisopsoralene Natural products C1=C2C=COC2=C2OC(=O)C=CC2=C1 MLMVLVJMKDPYBM-UHFFFAOYSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to bearing hydrocolloid dressing technical fields, and in particular to a kind of bacteriostatic hydrocolloid dressing and preparation method thereof.The bacteriostatic hydrocolloid dressing includes that following parts by weight prepare raw material: 25~35 parts of sodium carboxymethylcellulose, 20~30 parts of carboxymethyl chitosan, 5~10 parts of gelatin, 20~30 parts of thermoplastic elastomer, 3~10 parts of tackifying resin and 0.5~1.5 part of bacteriostatic agent.Bearing hydrocolloid dressing of the present invention is using triclocarban and sodium ferulate as bacteriostatic agent, the two is synergistic, and fungistatic effect is significant while reducing the usage amount of triclocarban, and the ability with good imbibition and promotion wound healing, safe without toxic side effect is suitble to promote the use of.
Description
Technical field
The invention belongs to bearing hydrocolloid dressing technical fields, and in particular to a kind of bacteriostatic hydrocolloid dressing and preparation method thereof.
Background technique
Bearing hydrocolloid dressing is a kind of Medical dressing, have many advantages, such as waterproof, it is anti-be adhered, moisturizing and heat preservation, hydrocolloid
Dressing is to be mixed and processed the particle of absorbent polymer with hot-fusible pressure-sensitive adhesive, and this dressing combines the viscous of rubber material
The water absorbing properties of performance and absorbent polymer material are closed, wherein rubber substrate provides viscosity, and it can make dressing patch on the surface of a wound, and
It is swollen after hydrocolloid particle water suction dispersed therein, provides a wet sealed environment to wound, promote the healing of wound,
Wet environment plays important facilitation to the healing of wound, brings very big convenience for the nursing of wound.
Ideal bearing hydrocolloid dressing should have the following characteristics that (1) can absorb a large amount of diffusate and noxious material,
Wet is also to be able to maintain certain form and intensity；(2) it is able to maintain that the enough humidity of wound, there is good resistance bacterium property and antibacterial
Ability；(3) storage stability is good, has degradable performance, and waste does not generate pollution to environment.Current existing hydrocolloid
Dressing is mainly to prepare raw material with sodium carboxymethylcellulose and gelatin etc., is had in terms of imbibition ability and wound healing certain
Advantage, but still there is certain limitation when in face of the complicated surface of a wound, in terms of especially showing anti-microbial property.
On the one hand, the antimicrobial component in traditional bacteriostatic hydrocolloid dressing is inorganic antiseptic such as silver ion and nano silver etc.
Ingredient, although having good bacteriostasis property, such bacteriostatic agent has biggish cytotoxicity.For example, Chinese patent literature
102218155 A of CN discloses a kind of preparation method of nano-silver functional hydrocolloid medical dressing, by by nano silver or receiving
Rice silver dispersions are added in hydrocolloid, assign the function of hydrocolloid antibacterial, but the medical dressing is due to nano silver or nanometer
The addition long-time service of silver dispersions will cause certain cytotoxicity, bring injury to human body.On the other hand, some bacteriostatic agents
If triclocarban is a kind of wide spectrum and efficient antibacterial agent, because there is efficient sterilizing rate, do not stimulate skin, will not cause
Allergy and with skin there is good compatibility to be widely used, studies have shown that long-term a large amount of uses can cause human liver
Injury of kidney and immune system is had an impact.For example, to disclose a kind of bacteriostasis strong by Chinese patent literature CN 107982571A
Bearing hydrocolloid dressing and preparation method thereof, including below prepare raw material: sodium carboxymethylcellulose, carboxymethyl chitosan, poly- ammonia
It is ester thermoplastic elastomer, sodium alginate, tackifying resin, plasticizer, gelatin, alkyl starches ester, polyisobutene, antioxidant, antibacterial
Agent and collaboration bacteriostatic agent, with good anti-microbial property, but complicated component, and main antimicrobial component triclocarban is long-term
Using can cause human body lesions of liver and kidney and be had an impact to immune system, therefore should rationally be controlled while guaranteeing fungistatic effect
Its dosage.
Therefore, antibacterial agent bad in the prevalence of absorbent when facing the complicated surface of a wound based on current bearing hydrocolloid dressing
The problems such as side effect and complicated component for human body is added in ingredient, needs to provide a kind of simple ingredient, imbibition for people and controls
Treat that surface of a wound effect is good, anti-microbial property is good and bearing hydrocolloid dressing and preparation method thereof without side-effects safely.
Summary of the invention
The present invention is directed to overcome the shortcomings of the prior art, a kind of bacteriostatic hydrocolloid dressing and preparation method thereof is provided,
The bearing hydrocolloid dressing has the effect of the good treatment surface of a wound and promotes wound healing, strong antibacterial, and safe and non-toxic pair
Effect is suitble to promote the use of.
To achieve the goals above, technical scheme is as follows:
A kind of bacteriostatic hydrocolloid dressing prepares raw material including following parts by weight: 25~35 parts of sodium carboxymethylcellulose,
20~30 parts of carboxymethyl chitosan, 5~10 parts of gelatin, 20~30 parts of thermoplastic elastomer, 3~10 parts of tackifying resin and bacteriostatic agent
0.5~1.5 part.
Further, the bearing hydrocolloid dressing prepares raw material including following parts by weight: sodium carboxymethylcellulose 30
Part, 28.8 parts of carboxymethyl chitosan, 8 parts of gelatin, 25 parts of thermoplastic elastomer, 7 parts of tackifying resin and 1.2 parts of bacteriostatic agent.
Further, the thermoplastic elastomer is polyurethane rubber or Styrene-Butadiene-Styrene Block Copolymer.
Further, the tackifying resin is rosin glycerides.
Further, the bacteriostatic agent is triclocarban and sodium ferulate, the weight of the triclocarban and sodium ferulate
Than for (0.05~0.3): 1.
Further, the weight ratio of the triclocarban and sodium ferulate is 0.15:1.
The preparation method of above-mentioned bacteriostatic hydrocolloid dressing, comprising the following steps:
S1, according to formula ratio, thermoplastic elastomer and tackifying resin are added in mixer, 100~150 DEG C, 100~
15~20min, preparation hot melt pressure gelatin A are mixed under conditions of 120r/min；
S2, according to formula ratio, hot melt presses gelatin A that sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and antibacterial is added
Agent mixes 8~12min, is placed in 90~110 DEG C of vulcanizing presses and handles, be then coated on waterproof polyurethane backing, cover
Lid release paper, sterilizes through 60Coradiation, and sheet bearing hydrocolloid dressing is made.
Further, the dosage of the 60Coradiation sterilizing is 20~30kGy.
In the inventive solutions, triclocarban is a kind of wide spectrum and efficient antibacterial agent, because having height
The sterilizing rate of effect does not stimulate skin, will not cause allergy and with skin there is good compatibility to be widely used, but grinds
Study carefully and show that long-term a large amount of uses can cause human body lesions of liver and kidney and have an impact to immune system, therefore is guaranteeing fungistatic effect
Its dosage should be rationally controlled simultaneously.Sodium ferulate also known as angelicin are the sodium salts of ferulic acid, freely with anti-oxidant and removing
The effect of base finds that sodium ferulate also has certain fungistatic effect, but its exclusive use is ineffective through retrieval, and
Not yet there is triclocarban and sodium ferulate for antibacterial combination.Therefore, the bacteriostatic agent that the present invention uses for triclocarban and
Sodium ferulate compounding, the two is synergistic, by groping the appropriate proportioning of the two, is on the one hand substantially reducing making for triclocarban
While dosage, another aspect fungistatic effect is also greatly enhanced on the basis of respective be used alone.
Secondly, inventor is found surprisingly that, the sodium ferulate in bacteriostatic agent can not only be compounded with triclocarban and be played very
Good fungistatic effect, but also make bearing hydrocolloid dressing that there is more excellent absorbent, further promote the healing of wound, this
May be since sodium ferulate can also form hydrogen bond between active constituent hydrocolloid particle carboxymethyl chitosan of the invention,
Interaction, to enhance the gelation reaction of carboxymethyl chitosan, enhance the absorbent of bearing hydrocolloid dressing and promote wound
Healing.
Compared with prior art, the invention has the following advantages:
(1) bacteriostatic agent of the present invention is compounded using triclocarban and sodium ferulate, and the two is synergistic, by groping the two
Appropriate proportioning, on the one hand while the usage amount for substantially reducing triclocarban, fungistatic effect is also in the base being respectively used alone
It is greatly enhanced on plinth, safe without toxic side effect, is suitble to promote the use of.
(2) present invention acts synergistically between respectively preparing raw material, the ability with good imbibition and promotion wound healing, simultaneously
It interacts between sodium ferulate and carboxymethyl chitosan in bacteriostatic agent, enhances the gelation reaction of carboxymethyl chitosan,
Further promote absorbent and promotes the healing of wound.
Specific embodiment
The following describes the present invention further through the description of specific embodiments, but it is to limit of the invention that this, which is not,
System, those skilled in the art's basic thought according to the present invention can make various modifications or improvements, but without departing from this
The basic thought of invention, is all within the scope of the present invention.
Sodium ferulate CAS 24276-84-4 of the present invention, it is conventional commercial product that remaining, which prepares raw material and reagent,.
Embodiment 1, bacteriostatic hydrocolloid dressing of the present invention
A kind of bacteriostatic hydrocolloid dressing is made of: sodium carboxymethylcellulose 35kg, carboxymethyl the raw material for preparing of following weight
Chitosan 22kg, gelatin 10kg, Styrene-Butadiene-Styrene Block Copolymer 22.5kg, rosin glycerides 10kg and antibacterial
Agent 0.5kg.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban and sodium ferulate is 0.05:
1。
The preparation method of above-mentioned bacteriostatic hydrocolloid dressing, comprising the following steps:
S1, according to formula ratio, mixer is added in Styrene-Butadiene-Styrene Block Copolymer and rosin glycerides
In, 15min, preparation hot melt pressure gelatin A are mixed under conditions of 130 DEG C and 110r/min；
S2, according to formula ratio, hot melt presses gelatin A that sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and antibacterial is added
Agent mixes 10min, is placed in 100 DEG C of vulcanizing presses and handles, be then coated on waterproof polyurethane backing, covers release
Paper sterilizes through 60Coradiation, dosage 20kGy, and sheet bearing hydrocolloid dressing is made.
Embodiment 2, bacteriostatic hydrocolloid dressing of the present invention
2 bacteriostatic hydrocolloid dressing of the embodiment of the present invention is made of: sodium carboxymethylcellulose the raw material for preparing of following weight
30kg, carboxymethyl chitosan 28.8kg, gelatin 8kg, Styrene-Butadiene-Styrene Block Copolymer 25kg, rosin glycerides
7kg and bacteriostatic agent 1.2kg.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban and sodium ferulate is 0.15:
1。
The preparation method of above-mentioned bacteriostatic hydrocolloid dressing, comprising the following steps:
S1, according to formula ratio, mixer is added in Styrene-Butadiene-Styrene Block Copolymer and rosin glycerides
In, 15min, preparation hot melt pressure gelatin A are mixed under conditions of 130 DEG C and 110r/min；
S2, according to formula ratio, hot melt presses gelatin A that sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and antibacterial is added
Agent mixes 10min, is placed in 100 DEG C of vulcanizing presses and handles, be then coated on waterproof polyurethane backing, covers release
Paper sterilizes through 60Coradiation, dosage 25kGy, and sheet bearing hydrocolloid dressing is made.
Embodiment 3, bacteriostatic hydrocolloid dressing of the present invention
3 bacteriostatic hydrocolloid dressing of the embodiment of the present invention is made of: sodium carboxymethylcellulose the raw material for preparing of following weight
26kg, carboxymethyl chitosan 30kg, gelatin 8.5kg, Styrene-Butadiene-Styrene Block Copolymer 30kg, rosin glycerides
4kg and bacteriostatic agent 1.5kg.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban and sodium ferulate is 0.3:1.
The preparation method of above-mentioned bacteriostatic hydrocolloid dressing, comprising the following steps:
S1, according to formula ratio, mixer is added in Styrene-Butadiene-Styrene Block Copolymer and rosin glycerides
In, 15min, preparation hot melt pressure gelatin A are mixed under conditions of 130 DEG C and 110r/min；
S2, according to formula ratio, hot melt presses gelatin A that sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and antibacterial is added
Agent mixes 10min, is placed in 100 DEG C of vulcanizing presses and handles, be then coated on waterproof polyurethane backing, covers release
Paper sterilizes through 60Coradiation, dosage 30Gy, and sheet bearing hydrocolloid dressing is made.
Embodiment 4, bacteriostatic hydrocolloid dressing of the present invention
4 bacteriostatic hydrocolloid dressing of the embodiment of the present invention is made of: sodium carboxymethylcellulose the raw material for preparing of following weight
30kg, carboxymethyl chitosan 28.8kg, gelatin 8kg, polyurethane rubber 25kg, rosin glycerides 7kg and bacteriostatic agent 1.2kg.
The bacteriostatic agent is triclocarban and sodium ferulate, and the weight ratio of the triclocarban and sodium ferulate is 0.15:
1。
The preparation method of above-mentioned bacteriostatic hydrocolloid dressing, comprising the following steps:
S1, according to formula ratio, polyurethane rubber and rosin glycerides are added in mixer, in 130 DEG C and 110r/min
Under conditions of mix 15min, preparation hot melt pressure gelatin A；
S2, according to formula ratio, hot melt presses gelatin A that sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and antibacterial is added
Agent mixes 10min, is placed in 100 DEG C of vulcanizing presses and handles, be then coated on waterproof polyurethane backing, covers release
Paper sterilizes through 60Coradiation, dosage 25kGy, and sheet bearing hydrocolloid dressing is made.
Comparative example 1
Compared with Example 2, the difference of this comparative example is only that: not being added triclocarban, is accordingly increased sodium ferulate
Additive amount.
Comparative example 2
Compared with Example 2, the difference of this comparative example is only that: not being added sodium ferulate, is accordingly increased triclocarban
Additive amount.
Comparative example 3
Compared with Example 2, the difference of this comparative example is only that: the weight ratio of triclocarban and sodium ferulate is 0.5:1.
Test example one, the test of the antibiotic property of bearing hydrocolloid dressing
1, test material: bacteriostatic hydrocolloid dressing prepared by Examples 1 to 4 and comparative example 1~3；Staphylococcus aureus
ATCC6538, pseudomonas aeruginosa ATCC27853 and Candida albicans 98001；
2, bacteriostatic hydrocolloid dressing prepared by Examples 1 to 4 and comparative example 1~3 uniformly test method: is cut into 1.0*
1.0cm size, is put into conical flask, is then respectively adding the phosphate buffer and three kinds of bacteria suspensions of same volume, and makes
Concentration of the bacteria suspension in PBS is 1 × 104~9 × 104Conical flask is fixed on oscillation shaking table, with 300r/ by CFU/mL
Min shakes 1h, the sample liquid after taking shaking preceding respectively and shaking, after suitably being diluted with PBS, is inoculated with plate with agar tilt-pour process, into
Row bacterium colony counts, and bacteriostasis rate is the ratio of average colony number before being shaken the difference of forward backward averaging clump count by test agent and shaking,
In terms of percentage；
3, test result is as shown in table 1.
1 bearing hydrocolloid dressing antibacterial experiment result of table
(1) as shown in Table 1, the bearing hydrocolloid dressing of Examples 1 to 4 preparation is for staphylococcus aureus, verdigris first list bud
Bacterium and Candida albicans have good inhibiting effect, wherein it is best with the fungistatic effect of embodiment 2, it is best reality of the invention
Apply example；
(2) compared with Example 2, comparative example 1 and comparative example 2 do not add triclocarban and sodium ferulate respectively, preparation
The bacteriostasis property of bearing hydrocolloid dressing is decreased obviously, and illustrates that there are very strong collaborations for both triclocarban and sodium ferulate of the present invention
Effect, fungistatic effect are significant；
(3) compared with Example 2, the component of 3 bacteriostatic agent of comparative example is identical, but match it is different, fungistatic effect under
Drop, illustrates bacteriostatic agent triclocarban and sodium ferulate of the present invention in weight ratio (0.05~0.3): cooperateing under 1, fungistatic effect is aobvious
It writes.
The performance test of test example two, bearing hydrocolloid dressing
1, test material: bacteriostatic hydrocolloid dressing prepared by Examples 1 to 4 and comparative example 1~3；
2, it test method: is tested according to liquid absorption amount of the GB/T 0471.1-2004 standard to bearing hydrocolloid dressing；
3, test result is as shown in table 2.
The performance test results of 2 bearing hydrocolloid dressing of table
(1) as shown in Table 2, the liquid absorption dose-effect fruit of the bearing hydrocolloid dressing of Examples 1 to 4 preparation is fine, wherein with reality
The liquid absorption dose-effect fruit for applying example 2 is best, is highly preferred embodiment of the present invention；
(2) compared with Example 2, comparative example 1 does not add triclocarban, and the liquid absorption amount of the bearing hydrocolloid dressing of preparation has
Declined, fall is unobvious；Comparative example 2 does not add sodium ferulate, the liquid absorption dose-effect fruit of the bearing hydrocolloid dressing of preparation
It is decreased obviously；Comparative example 3 changes the ratio of triclocarban and sodium ferulate, the liquid absorption dose-effect of the bearing hydrocolloid dressing of preparation
Fruit is declined, and fall is unobvious, illustrates that sodium ferulate of the present invention and carboxymethyl chitosan are synergistic, and with other systems
Standby raw material interacts, and the bearing hydrocolloid dressing of preparation has good absorbent.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (8)
1. a kind of bacteriostatic hydrocolloid dressing, which is characterized in that prepare raw material including following parts by weight: sodium carboxymethylcellulose
25~35 parts, 20~30 parts of carboxymethyl chitosan, 5~10 parts of gelatin, 20~30 parts of thermoplastic elastomer, 3~10 parts of tackifying resin
With 0.5~1.5 part of bacteriostatic agent.
2. bacteriostatic hydrocolloid dressing as described in claim 1, which is characterized in that prepare raw material including following parts by weight: carboxylic
30 parts of sodium carboxymethylcellulose pyce, 28.8 parts of carboxymethyl chitosan, 8 parts of gelatin, 25 parts of thermoplastic elastomer, 7 parts of tackifying resin and antibacterial
1.2 parts of agent.
3. bacteriostatic hydrocolloid dressing as described in claim 1, which is characterized in that the thermoplastic elastomer is polyurethane rubber or benzene
Ethylene-butadiene-styrene block copolymer.
4. bacteriostatic hydrocolloid dressing as described in claim 1, which is characterized in that the tackifying resin is rosin glycerides.
5. bacteriostatic hydrocolloid dressing as described in claim 1, which is characterized in that the bacteriostatic agent is triclocarban and ferulic acid
The weight ratio of sodium, the triclocarban and sodium ferulate is (0.05~0.3): 1.
6. bacteriostatic hydrocolloid dressing as claimed in claim 5, which is characterized in that the weight ratio of the triclocarban and sodium ferulate
For 0.15:1.
7. a kind of preparation method of the bacteriostatic hydrocolloid dressing as described in claim 1~6 is any, which is characterized in that including following
Step:
S1, according to formula ratio, thermoplastic elastomer and tackifying resin are added in mixer, in 100~150 DEG C, 100~120r/
15~20min, preparation hot melt pressure gelatin A are mixed under conditions of min；
S2, according to formula ratio, hot melt, which is pressed, is added sodium carboxymethylcellulose, carboxymethyl chitosan, gelatin and antibacterial in gelatin A
Agent mixes 8~12min, is placed in 90~110 DEG C of vulcanizing presses and handles, be then coated on waterproof polyurethane backing, cover
Lid release paper, sterilizes through 60Coradiation, and sheet bacteriostatic hydrocolloid dressing is made.
8. the preparation method of bacteriostatic hydrocolloid dressing as claimed in claim 7, which is characterized in that the agent of the 60Coradiation sterilizing
Amount is 20~30kGy.
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