CN101341883A - Nano-silver antiseptic solution - Google Patents
Nano-silver antiseptic solution Download PDFInfo
- Publication number
- CN101341883A CN101341883A CNA2008100302203A CN200810030220A CN101341883A CN 101341883 A CN101341883 A CN 101341883A CN A2008100302203 A CNA2008100302203 A CN A2008100302203A CN 200810030220 A CN200810030220 A CN 200810030220A CN 101341883 A CN101341883 A CN 101341883A
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- CN
- China
- Prior art keywords
- nano
- dispersant
- silver
- water
- antiseptic solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 230000002421 anti-septic effect Effects 0.000 title claims description 14
- 239000002270 dispersing agent Substances 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 10
- 239000006185 dispersion Substances 0.000 claims description 9
- AYKOTYRPPUMHMT-UHFFFAOYSA-N silver;hydrate Chemical compound O.[Ag] AYKOTYRPPUMHMT-UHFFFAOYSA-N 0.000 claims description 7
- 238000005516 engineering process Methods 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000009210 therapy by ultrasound Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- 239000000645 desinfectant Substances 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 3
- 229910052709 silver Inorganic materials 0.000 abstract description 2
- 239000004332 silver Substances 0.000 abstract description 2
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- -1 silver ions Chemical class 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 6
- 241000700605 Viruses Species 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 239000010944 silver (metal) Substances 0.000 description 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 3
- 229940033663 thimerosal Drugs 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 239000010946 fine silver Substances 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Manufacture Of Metal Powder And Suspensions Thereof (AREA)
Abstract
The invention discloses nano silver disinfectant liquid which comprises nano silver powder, dispersant and water mixed together; the weight ratio of the silver powder to the water is 15:10<6> to 100:10<6>, and the weight ratio of the dispersant to the water is 1:12000 to 1:8000; because the composition is adopted for the nano silver disinfectant liquid, nano silver particles can keep release disinfectant and bacteriostatic silver ions for a long time, so as to conduct sterilization and bacteriostasis for a long time; the nano silver disinfectant liquid does not produce drugfastness theoretically, and the scope of sterilization and bacteriostasis is wide.
Description
Technical field
The present invention relates to a kind of thimerosal, belong to antibiotic bactericidal agent technical field.
Background technology
At present, AT STATION, crowded public areas such as airport, school, hotel, hotel, large-scale meeting-place, public equipment such as ground, wall, compartment, cabin, table, chair even air all are stained with germ easily, need artificial sterilizing.Just can avoid bacterium to spread unchecked but how to clean and clean from which aspect, in general should set about from domestic hygiene and public health aspect, for example using disinfection solution is a kind of means preferably.Common disinfectant generally adopts organic matter as antibacterial agent and disinfectant, mainly is by carrying out chemical reaction with bacterium and virus, and the structure of destroying bacterium and virus realizes it is killed, and the sterilization duration is short, and bacterium and virus are easy to generate pesticide resistance.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of thimerosal, the antibacterial longer duration of sterilizing, and bacterium and virus can not develop immunity to drugs.
In order to solve the problems of the technologies described above, a kind of nano-silver antiseptic solution of the present invention comprises the nano level silver powder, dispersant and the water that are mixed, and the part by weight of described silver powder and water is 15: 10
6To 100: 10
6, the part by weight of described dispersant and water is 1: 12000 to 1: 8000.
As improvement of the technical scheme, the particle diameter of described silver powder is less than or equal to 30 nanometers.
As further improvement in the technical proposal, described dispersant is a polyvinylpyrrolidone.
The production technology of described nano-silver antiseptic solution may further comprise the steps:
A) with the nano level silver powder of 2～10 grams, 4 premium on currency and 2～8 gram dispersant, stirred 4 hours in agitator then, the rotating speed of agitator is 1000～3000 rev/mins, and power is 60～300 watts;
B) dispersion liquid that step a is handled carries out the ultrasonic processing in ultrasonic unit, and the frequency of this ultrasonic unit is 15kHz～47kHz, and power is 1000 watts～2500 watts, and ultrasonic treatment time is 20 minutes;
C) in the intact dispersion liquid of b step process, add entry and dispersant respectively, make its part by weight that reaches described silver powder and water, dispersant and water, stirred then 2 hours;
D) dispersion liquid that step c is handled left standstill 1～3 day, extracted supernatant liquid then.
The invention has the beneficial effects as follows: this nano-silver antiseptic solution is owing to adopted above-mentioned composition, nano level silver-colored particle can constantly discharge for a long time can bactericidal silver ion, thereby it is antibacterial to sterilize muchly, can not develop immunity to drugs in theory, and the antibacterial scope of sterilizing is wide.
Embodiment
A kind of nano-silver antiseptic solution of the present invention comprises the nano level silver powder, dispersant and the water that are mixed, and the part by weight of described silver powder and water is 15: 10
6To 100: 10
6, the part by weight of described dispersant and water is 1: 12000 to 1: 8000.This nano-silver antiseptic solution since adopted above-mentioned composition, nano level silver-colored particle can constantly discharge for a long time can bactericidal silver ion, thereby it is antibacterial to sterilize muchly, can not develop immunity to drugs in theory, and the antibacterial scope of sterilizing is wide.The silver particle can kill 650 various bacteria in several minutes, nano-Ag particles is with after cell wall/film of pathogen combine, can directly enter thalline, (SH) combine, make enzyme deactivation, block respiratory metabolism it is choked to death with the sulfydryl of oxygen metabolism enzyme rapidly.Unique sterilization mechanism makes nano-Ag particles at low concentration kill pathogenic organisms rapidly just.In addition, because the costing an arm and a leg of fine silver powder, and the content of nano level silver powder and sterilization are antibacterial direct relation arranged, in order to reach the good sterilization fungistatic effect and the unification of should cost, thereby the part by weight of definite silver powder and water is 15: 10
6To 100: 10
6
In order to make nano-Ag particles have better surface-active and permeability, the particle diameter of described silver powder is less than or equal to 30 nanometers.
Described dispersant is a polyvinylpyrrolidone, and polyvinylpyrrolidone has good physiology inertia and biocompatibility, to skin, eyes are non-stimulated or irritated, and are actual nontoxic, guarantee the safety in the thimerosal use.
The production technology of described nano-silver antiseptic solution may further comprise the steps:
A) with the nano level silver powder of 2～10 grams, 4 premium on currency and 2～8 gram dispersant, stirred 4 hours in agitator then, the rotating speed of agitator is 1000～3000 rev/mins, and power is 60～300 watts;
B) dispersion liquid that step a is handled carries out the ultrasonic processing in ultrasonic unit, and the frequency of this ultrasonic unit is 15kHz～47kHz, and power is 1000 watts～2500 watts, and ultrasonic treatment time is 20 minutes;
C) in the intact dispersion liquid of b step process, add entry and dispersant respectively, make its part by weight that reaches described silver powder and water, dispersant and water, stirred then 2 hours;
D) dispersion liquid that step c is handled left standstill 1～3 day, extracted supernatant liquid then.
The supernatant liquid that is extracted in the steps d is nano-silver antiseptic solution of the present invention.
Claims (4)
1. a nano-silver antiseptic solution is characterized in that comprising the nano level silver powder, dispersant and the water that are mixed, and the part by weight of described silver powder and water is 15: 10
6To 100: 10
6, the part by weight of described dispersant and water is 1: 12000 to 1: 8000.
2. nano-silver antiseptic solution according to claim 1 is characterized in that the particle diameter of described silver powder is less than or equal to 30 nanometers.
3. nano-silver antiseptic solution according to claim 1 is characterized in that described dispersant is a polyvinylpyrrolidone.
4. nano-silver antiseptic solution according to claim 1 is characterized in that the production technology of described nano-silver antiseptic solution may further comprise the steps:
A) with the nano level silver powder of 2～10 grams, 4 premium on currency and 2～8 gram dispersant, stirred 4 hours in agitator then, the rotating speed of agitator is 1000～3000 rev/mins, and power is 60～300 watts;
B) dispersion liquid that step a is handled carries out the ultrasonic processing in ultrasonic unit, and the frequency of this ultrasonic unit is 15kHz～47kHz, and power is 1000 watts～2500 watts, and ultrasonic treatment time is 20 minutes;
C) in the intact dispersion liquid of b step process, add entry and dispersant respectively, make its part by weight that reaches described silver powder and water, dispersant and water, stirred then 2 hours;
D) dispersion liquid that step c is handled left standstill 1～3 day, extracted supernatant liquid then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100302203A CN101341883A (en) | 2008-08-13 | 2008-08-13 | Nano-silver antiseptic solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100302203A CN101341883A (en) | 2008-08-13 | 2008-08-13 | Nano-silver antiseptic solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101341883A true CN101341883A (en) | 2009-01-14 |
Family
ID=40244089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100302203A Pending CN101341883A (en) | 2008-08-13 | 2008-08-13 | Nano-silver antiseptic solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101341883A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103200825A (en) * | 2010-11-02 | 2013-07-10 | 印度德里技术研究院 | Blue coloured aqueous dispersion of silver nanoparticles a process for preparation and compositions thereof |
| CN104522050A (en) * | 2015-01-07 | 2015-04-22 | 安徽瀚驰生物科技有限公司 | Composite bactericide of nano-silver and polyhexamethylene guanidine and processing technology of composite bactericide |
| CN107251906A (en) * | 2017-06-02 | 2017-10-17 | 广州市科瑨材料科技有限公司 | Nano silver complex solution and preparation method thereof |
| CN111387207A (en) * | 2020-03-17 | 2020-07-10 | 安徽工大化工科技有限公司 | High-molecular antibacterial and bactericidal composite film spraying agent and preparation method thereof |
| CN111449086A (en) * | 2020-05-11 | 2020-07-28 | 武汉工程大学 | Colloidal silver/polymer mixed disinfectant and preparation method and application thereof |
| CN111466407A (en) * | 2020-03-10 | 2020-07-31 | 董南 | Nano-silver sprays and methods for combating coronavirus |
| CN112704082A (en) * | 2021-02-07 | 2021-04-27 | 贾天法 | Long-acting safe antibacterial disinfectant |
-
2008
- 2008-08-13 CN CNA2008100302203A patent/CN101341883A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103200825A (en) * | 2010-11-02 | 2013-07-10 | 印度德里技术研究院 | Blue coloured aqueous dispersion of silver nanoparticles a process for preparation and compositions thereof |
| CN103200825B (en) * | 2010-11-02 | 2015-08-12 | 印度德里技术研究院 | Blue water-based dispersion, its preparation method and the composition thereof of silver nano-grain |
| CN104522050A (en) * | 2015-01-07 | 2015-04-22 | 安徽瀚驰生物科技有限公司 | Composite bactericide of nano-silver and polyhexamethylene guanidine and processing technology of composite bactericide |
| CN104522050B (en) * | 2015-01-07 | 2018-01-09 | 安徽瀚驰生物科技有限公司 | A kind of compound disinfectant and processing technology of Nano Silver and polyhexamethylene guanide |
| CN107251906A (en) * | 2017-06-02 | 2017-10-17 | 广州市科瑨材料科技有限公司 | Nano silver complex solution and preparation method thereof |
| CN111466407A (en) * | 2020-03-10 | 2020-07-31 | 董南 | Nano-silver sprays and methods for combating coronavirus |
| CN111387207A (en) * | 2020-03-17 | 2020-07-10 | 安徽工大化工科技有限公司 | High-molecular antibacterial and bactericidal composite film spraying agent and preparation method thereof |
| CN111449086A (en) * | 2020-05-11 | 2020-07-28 | 武汉工程大学 | Colloidal silver/polymer mixed disinfectant and preparation method and application thereof |
| CN112704082A (en) * | 2021-02-07 | 2021-04-27 | 贾天法 | Long-acting safe antibacterial disinfectant |
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Legal Events
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: ZHU HAI ZHONGJIN NANO-TECH CO,.LTD. Free format text: FORMER OWNER: SITU JIANQIANG Effective date: 20100705 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 529325 SECTION B6 WEST, KAIPING INDUSTRIAL PARK, SHAGANG DISTRICT, KAIPING CITY, GUANGDONG PROVINCE TO: 519070 5TH FLOOR, NO.109, XINGHUA ROAD, XIANGZHOU DISTRICT, ZHUHAI CITY, GUANGDONG PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20100705 Address after: 5 building, No. 109 Xinghua Road, Guangdong, Zhuhai, Xiangzhou 519070, China Applicant after: Zhuhai Zhongjin Nano Technology Co.,Ltd. Address before: 529325 B6 Industrial Park, Kaiping Industrial Zone, Sha Gang District, Guangdong, Kaiping Applicant before: Situ Jianqiang |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20090114 |