CN107184982A - A kind of nano photo-catalytic thimerosal and preparation method thereof - Google Patents
A kind of nano photo-catalytic thimerosal and preparation method thereof Download PDFInfo
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- CN107184982A CN107184982A CN201710482676.2A CN201710482676A CN107184982A CN 107184982 A CN107184982 A CN 107184982A CN 201710482676 A CN201710482676 A CN 201710482676A CN 107184982 A CN107184982 A CN 107184982A
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- thimerosal
- titania photocatalyst
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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Abstract
A kind of nano photo-catalytic thimerosal, its component is by percentage to the quality：Nano-titania photocatalyst powder 1~10；Ethanol 1~20；Water 70~98.The processing step for preparing nano photo-catalytic thimerosal is：1. nano-titania photocatalyst powder is added to the water by with part, is thoroughly mixed into uniform nano-titania photocatalyst suspension；2. ethanol is added in nano-titania photocatalyst suspension, stirs, nano photocatalyst coal thimerosal is made.Active ingredient in the nano photo-catalytic thimerosal can adhere sufficiently to patient skin surface and persistently disinfection, with it is nontoxic, have no drug resistance, long-acting, wide spectrum the features such as, and the thimerosal color is transparent, is easy to observation, it is easy to use.For fungi, bacterial skin disease, such as tinea pedis, underarm odor, dermatophytosis have obvious curative effects, also there is obvious promotion healing effect for wound disinfection.
Description
Technical field
The present invention relates to thimerosal technical field, more particularly to a kind of nano photo-catalytic thimerosal and preparation method thereof.
Background technology
Sterilize, sterilization be unable to do without sterilization, the medicine of sterilization, medically, all killing pathogenic microorganisms rapid in vitro
Chemical substance is referred to as disinfectant.Traditional chemosterilant is used for medical environment, skin, wound disinfection, and they and antibiotic are not
Together, to pathogen and tissue without obvious selectively acting, so also there is strong toxicity to human body.Use traditional change
It must be selected when learning disinfectant sterilization, sterilization according to the action character and needs of all kinds of chemical substances, in the presence of certain
Toxicity and drug resistance problems, and without continuation.
The content of the invention
It is an object of the invention to provide a kind of nano photo-catalytic thimerosal and preparation method thereof, nano photo-catalytic sterilization
Active ingredient in liquid can adhere sufficiently to patient skin surface and persistently disinfection, with it is nontoxic, have no drug resistance, it is long
The features such as effect, wide spectrum, and the thimerosal color is transparent, is easy to observation, it is easy to use.
Technical solution proposed by the invention is such：
A kind of nano photo-catalytic thimerosal, the component of the nano photo-catalytic thimerosal is by percentage to the quality：
Nano-titania photocatalyst powder 1~10%；
Ethanol 1~20%；
Water 70~98%；
Wherein, nano-titania photocatalyst powder particle size is 1~100nm.
Preferably, the nano-titania photocatalyst powder particle size is 1~20nm.
The nano-titania photocatalyst powder can be visible light type nano-titania photocatalyst powder, following
Worked under visible light conditions：Light or natural light or sunlight.
The nano-titania photocatalyst powder can be ultraviolet light type nano-titania photocatalyst powder.
The method for preparing nano photo-catalytic thimerosal, the processing step of this method is：
（1）By with part, nano-titania photocatalyst powder is added to the water, uniform nanometer titanium dioxide is thoroughly mixed into
Titanium photocatalyst suspension；
（2）By with part, ethanol is added in nano-titania photocatalyst suspension, stirs, nano photocatalyst is made
Coal thimerosal.
Compared with the prior art, the present invention has following remarkable result：
（One）The action principle of nano-titania photocatalyst is：Nano titanium oxide is a kind of semiconductor particle, contains energy
Band structure, is made up of a low energy valence band and an empty higher energy conduction band full of electronics under normal circumstances, between them by
Forbidden band is separated, and the semiconductor particle of nano titanium oxide is by after the light irradiation more than energy gap energy, and electronics is from valence band
Conduction band is transitted to, electronics is generated --- water molecule reaction generation oxidisability in hole pair, hole and air very high OH-from
By base, active OH-free radical can be the inorganic matters such as carbon dioxide and water the oxidation operation of many difficult degradations, active
OH-free radical equally can also react with the organic matter in bacterium, be allowed to lose activity, so as to reach the effect of antivirus sterilization.
The effect of nano-titania photocatalyst and main feature：
1. high-efficiency broad spectrum is acted on：The light-catalyzed reaction activity of nano-titania photocatalyst has high reaction energy, higher than having
All kinds of valence bonds of machine thing, make it have very strong redox ability, and other disinfectant ratios, and its action effect is more rapid；
In nano-titania photocatalyst course of reaction, biotic factor can not only be destroyed, various organic chemicals can be also destroyed, receive
Rice photocatalyst of titanium dioxide can kill the almost bacterium of all, virus, fungi, gemma etc..
2. persistent：In nano photo-catalytic mechanism, nano-titania photocatalyst is not involved in reaction, only rises
The effect of medium is catalyzed, itself is not consumed with time lengthening, and service life is lasting；Meanwhile, nano titanium oxide light is touched
The light-catalyzed reaction of matchmaker while bacterium is killed, can in oxidation Decomposition air and dielectric surface organic matter, cut off micro- life
Thing growth and the organic nutrition source required for breeding, play suppression bacterial action, its disinfective action duration is long.
3. it is innoxious：Nano-titania photocatalyst does not discharge harmful substance and is not involved in reaction in itself, and it is by institute
The material of effect is completely oxidized to the innocuous substances such as carbon dioxide and water, and nano-titania photocatalyst is only attached to its surface.
Therefore, nano-titania photocatalyst can be on the basis of safety kills bacterium, oxidation Decomposition noxious material, and does not produce secondary
Pollution.
（Two）Nano-titania photocatalyst powder is mixed using water by with part, it is mixed into uniform nano-silica
Change titanium photocatalyst suspension, be easy to carry out patient skin and wound uniform, effectively sprinkling, operation is simple, and drug effect is uniform, uses
Patient skin and wound are not also stimulated and damaged afterwards, easily receives patient.
（Three）Nano-titania photocatalyst is set to play its effect for a long time, it is necessary to which place need to be sterilized by sticking to it
, but skin surface can secrete grease always on surface, and this can cause nano-titania photocatalyst composition effectively to adhere to
In patient skin surface.Ethanol is added in nano-titania photocatalyst suspension, ethanol is synchronously contacted patient skin simultaneously
The grease produced by patient skin is removed, and is quickly volatilized, nano-titania photocatalyst powder is effectively adhered to
Remove grease patient skin surface, formed one layer of nano-titania photocatalyst film layer so that persistently, longer play disappear
Poison, the effect of sterilization.
This nano-titania photocatalyst thimerosal is for fungi, bacterial skin disease, such as tinea pedis, underarm odor, skin
Tinea disease etc. has obvious curative effects, also has obvious disinfection for wound and promotes healing effect.
Embodiment
The present invention is further elaborated by example below.
Embodiment 1：
A kind of nano photo-catalytic thimerosal, its component is by percentage to the quality：
Nano-titania photocatalyst powder 1~10%；
Ethanol 1~20%；
Water 70~98%；
Wherein, nano-titania photocatalyst powder particle size is 1~100nm, preferably 1~20nm.
The nano-titania photocatalyst powder can be visible light type nano-titania photocatalyst powder, following
Worked under visible light conditions：Light or natural light or sunlight；The nano-titania photocatalyst powder can also be ultraviolet light
Type nano-titania photocatalyst powder, works under ultraviolet light irradiation.
In the present embodiment, ultraviolet light type nano-titania photocatalyst powder is chosen by mass percentage（Particle size
For 1nm）1%；Ethanol 1%；Water 98%.
It is by the above-mentioned method that nano photo-catalytic thimerosal is prepared with part：
1. ultraviolet light type nano-titania photocatalyst powder is added to the water, is thoroughly mixed into uniform ultraviolet light type and receives
Rice photocatalyst of titanium dioxide suspension.
2. ethanol is added in ultraviolet light type nano-titania photocatalyst suspension, stirred, as nanometer
Light touches coal thimerosal.
Embodiment 2：
Visible light type nano-titania photocatalyst powder is chosen by mass percentage（Particle size is 7nm）5%；Ethanol
10%；Water 85%.
It is by the above-mentioned method that nano photo-catalytic thimerosal is prepared with part：
1. it will be seen that light type nano-titania photocatalyst powder is added to the water, it is thoroughly mixed into uniform visible light type and receives
Rice photocatalyst of titanium dioxide suspension.
2. ethanol is added in visible light type nano-titania photocatalyst suspension, stirred, as nanometer
Light touches coal thimerosal.
Embodiment 3：
Visible light type nano-titania photocatalyst powder is chosen by mass percentage（Particle size is 20nm）8%；Ethanol
15%；Water 77%.
The preparation method of nano photo-catalytic thimerosal is same as Example 2.
Embodiment 4：
Visible light type nano-titania photocatalyst powder (particle size is 100nm) 10% is chosen by mass percentage；Ethanol
20%；Water 70%.
The preparation method of nano photo-catalytic thimerosal is same as Example 2.
Claims (5)
1. a kind of nano photo-catalytic thimerosal, it is characterised in that：The component of the nano photo-catalytic thimerosal is with mass percent
It is calculated as：
--- nano-titania photocatalyst powder 1~10%；
--- ethanol 1~20%；
--- water 70~98%；
Wherein, nano-titania photocatalyst powder particle size is 1~100nm.
2. nano photo-catalytic thimerosal according to claim 1, it is characterised in that：The nano-titania photocatalyst powder
Last particle size is 1~20nm.
3. nano photo-catalytic thimerosal according to claim 1, it is characterised in that：The nano-titania photocatalyst powder
End is visible light type nano-titania photocatalyst powder, is worked under following visible light conditions：Light or natural light or sunlight.
4. nano photo-catalytic thimerosal according to claim 1, it is characterised in that：The nano-titania photocatalyst powder
End is ultraviolet light type nano-titania photocatalyst powder.
5. prepare the method according to the nano photo-catalytic thimerosal described in claim 1, it is characterised in that：The processing step of this method
For：
（1）By with part, nano-titania photocatalyst powder is added to the water, uniform nanometer titanium dioxide is thoroughly mixed into
Titanium photocatalyst suspension；
（2）By with part, ethanol is added in nano-titania photocatalyst suspension, stirs, nano photocatalyst is made
Coal thimerosal.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710482676.2A CN107184982A (en) | 2017-06-22 | 2017-06-22 | A kind of nano photo-catalytic thimerosal and preparation method thereof |
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| CN201710482676.2A CN107184982A (en) | 2017-06-22 | 2017-06-22 | A kind of nano photo-catalytic thimerosal and preparation method thereof |
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| CN107184982A true CN107184982A (en) | 2017-09-22 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999209A (en) * | 2019-05-10 | 2019-07-12 | 东营市浩瀚生化科技有限公司 | A kind of photocatalyst antiseptic liquid activity activator bottle |
| CN111493071A (en) * | 2020-06-05 | 2020-08-07 | 江苏中新瑞光学材料有限公司 | Nano hydrophobic isolation type photocatalyst disinfectant and preparation method thereof |
| CN111602673A (en) * | 2020-06-05 | 2020-09-01 | 江苏中新瑞光学材料有限公司 | Nano photocatalyst and silver ion composite hydrophobic disinfectant |
| CN111672357A (en) * | 2020-06-10 | 2020-09-18 | 浙江圆融科技有限公司 | Preparation equipment and process of efficient nano photocatalyst disinfectant |
| CN112515988A (en) * | 2020-12-07 | 2021-03-19 | 深圳市哈深智材科技有限公司 | Nano photocatalyst disinfectant and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103190442A (en) * | 2013-02-28 | 2013-07-10 | 陈自金 | Composite antibacterial anion air cleanser and preparation method thereof |
-
2017
- 2017-06-22 CN CN201710482676.2A patent/CN107184982A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103190442A (en) * | 2013-02-28 | 2013-07-10 | 陈自金 | Composite antibacterial anion air cleanser and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109999209A (en) * | 2019-05-10 | 2019-07-12 | 东营市浩瀚生化科技有限公司 | A kind of photocatalyst antiseptic liquid activity activator bottle |
| CN109999209B (en) * | 2019-05-10 | 2024-05-03 | 东营市庄溶生物科技有限公司 | Photocatalyst disinfectant activity activation bottle |
| CN111493071A (en) * | 2020-06-05 | 2020-08-07 | 江苏中新瑞光学材料有限公司 | Nano hydrophobic isolation type photocatalyst disinfectant and preparation method thereof |
| CN111602673A (en) * | 2020-06-05 | 2020-09-01 | 江苏中新瑞光学材料有限公司 | Nano photocatalyst and silver ion composite hydrophobic disinfectant |
| CN111672357A (en) * | 2020-06-10 | 2020-09-18 | 浙江圆融科技有限公司 | Preparation equipment and process of efficient nano photocatalyst disinfectant |
| CN111672357B (en) * | 2020-06-10 | 2021-05-04 | 浙江圆融科技有限公司 | Preparation equipment and process of efficient nano photocatalyst disinfectant |
| CN112515988A (en) * | 2020-12-07 | 2021-03-19 | 深圳市哈深智材科技有限公司 | Nano photocatalyst disinfectant and preparation method thereof |
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