KR20180081972A - Hydrocolloid Composition of Gluing Agent for Plaster Pad - Google Patents

Abstract

The present invention relates to a hydrocolloid adhesive composition used as adhesive agent for a medicated pad, which has excellent antimicrobial action by suppressing the growth of pathogenic bacteria through containing a natural mugwort extract which is non-irritating and non-toxic and has no side effects, and which contains negative ions effective for fatigue recovery by releasing far infrared rays. The hydrocolloid composition contains: 5 to 55 parts by weight of a hydrophilic polymer; 10 to 90 parts by weight of a hydrophobic polymer; and 0.1 to 20 parts by weight of a mugwort extract.

Description

Hydrocolloid Composition of Gluing Agent for Plaster Pad As a health pad adhesive,

The present invention relates to a hydrocolloid pressure-sensitive adhesive composition as a pressure-sensitive adhesive for a health pad in order to prevent the allergic skin disease by harmlessly mixing with the herbal concentrate, and more particularly, to a hydrocolloid pressure-sensitive adhesive composition which is free from irritation and non- The present invention relates to a hydrocolloid composition comprising a mugwort extract and a mineral powder which emits a far infrared ray and an anion to inhibit the growth of a pathogenic bacterium so that the herbal medicine concentrate is easily mixed with the antimicrobial function.

Generally, a padding agent and a paste are widely known as a pad for attaching to the affected part for the purpose of treatment of muscular pain or neuralgia of the body. Such a padding agent and a paste are most commonly used on adhesive non- The mixed pressure-sensitive adhesive is applied, and then a release paper is attached on the nonwoven fabric and the pressure-sensitive adhesive.

Conventionally, a conventional pace is a mixture of a medicine having an anti-inflammatory analgesic effect containing an effective ingredient and a sticky substance, while a herbal pad in which a herbal medicine is mixed with a sticky substance and attached to the affected part of the body is widely known.

Most of these conventional health pads use an organic solvent-based pressure-sensitive adhesive. Therefore, when they come into contact with the human skin for a long time, there are adverse effects that cause allergic skin diseases such as rash, itching and dermatitis. On the other hand, There was no side effect, but there was a problem that the adhesive force was somewhat high and the moisture contained in the adhesive agent appeared on the skin.

On the other hand, a hydrocolloid preparation that enhances wound restorative ability is composed of a hydrophilic polymer having a hydrophilic functional group and absorbing water while not dissolving in water, and a hydrophobic polymer having elasticity while giving adhesive force to the skin, wherein the hydrophilic polymer has moisture It has a three-dimensional network structure. It does not induce skin disease than conventional adhesive pads and has excellent adhesion. Furthermore, hydrocolloid formulations also have the advantage of reacting with exudates upon adherence of wound sites to provide a moist, gel-like environment to promote epithelialization when wounded.

On the other hand, it is known that mugwort is known to have the ability to inhibit the proliferation of pathogenic bacteria that cause infectious diseases and skin infections, though various drugs are known. Among the mugworts, it is known that the mugwort is effective in inhibiting the growth of pathogenic bacteria and smooth bile secretion, thus inhibiting the development of gallstones and thus also affecting the gallbladder, kidney stones, hepatitis and kidney.

In recent years, there has been an explosion in the demand for far-infrared radiation products, which are known to promote blood circulation and metabolism of the human body, as the interest in health increases. Such far-infrared rays are 100 μm deep from the skin surface of the human body It is believed that there is an effect of accelerating blood circulation, promoting metabolism, and resuscitation of cell tissue by expanding the capillary blood vessels as the temperature of subcutaneous tissues rises due to heat reaction in the body.

In addition, the anion, which is attracting public attention with the far-infrared rays, is a fine particle with negative electricity. It is known that anion stabilizes the breathing and blood pressure by changing the body into a weak alkaline constitution, thereby promoting fatigue recovery.

The present invention has developed a hydrocolloid adhesive composition comprising an anion which is excellent in antimicrobial activity and exhibits an excellent antimicrobial activity and exhibits an ability to inhibit the growth of pathogenic bacteria by containing the mugwort, preferably a mugwort extract.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems of the related art, and has the following objectives.

It is an object of the present invention to provide a hydrocolloid composition which does not induce skin diseases and is excellent in adhesive force, compared with a sticky substance of a conventional pad.

It is an object of the present invention to provide a hydrocolloid composition containing an anion which promotes fatigue recovery, including an extract of mugwort, which inhibits the growth of pathogenic bacteria and has excellent antimicrobial activity.

It is an object of the present invention to provide a hydrocolloid composition containing a mugwort extract derived from a natural product with no irritation and non-toxic side effects.

In order to achieve the above object, the present invention is implemented by the following means.

The hydrocolloid adhesive composition as a pressure-sensitive adhesive for a health pad of the present invention comprises 5 to 55 parts by weight of a hydrophilic polymer; 10 to 90 parts by weight of a hydrophobic polymer; And 0.1 to 20 parts by weight of the mugwort extract.

In the present invention, the hydrophilic polymer may be at least one selected from the group consisting of polyacrylic acid, polyvinylpyrrolidone, hydroxyalkylcellulose, carbomer, polyvinyl alcohol, chitosan, quinine, alginates, carboxymethylcellulose, polyhexamethylenebiguanide, But are not limited to, polyvinylpyrrolidone, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, ≪ RTI ID = 0.0 > and / or < / RTI >

In the present invention, the hydrophobic polymer is one or two or more selected from the group consisting of a pressure-sensitive adhesive material, a thermoplastic elastomer, and a tackifier.

The present invention may further comprise 0.1 to 20 parts by weight of menthol as a penetration promoting agent.

The present invention has the following effects with the above-described configuration.

The present invention relates to a mugwort extract which does not induce skin diseases and which is superior in adhesive strength to existing adhesive pads and which has an excellent antimicrobial action by inhibiting the growth of pathogenic bacteria and contains an anion which promotes fatigue recovery. The present invention provides a hydrocolloid pressure-sensitive adhesive composition.

The Applicant hereunder explains in detail the means for solving the foregoing problem. The detailed description of known technology, which is considered to be unnecessarily obscured by the gist of the present invention, will be omitted.

The hydrocolloid adhesive composition as a pressure sensitive adhesive for a health pad of the present invention comprises 5 to 55 parts by weight of a hydrophilic polymer; 10 to 90 parts by weight of a hydrophobic polymer; And 0.1 to 20 parts by weight of the mugwort extract.

The hydrophilic polymer plays a role of absorbing exudate exudates to form a wet environment, and is contained in an amount of 5 to 55 parts by weight. If the amount of the exudate is less than 5 parts by weight, absorption of the exudates is not smoothly performed. If the amount of the exudate is more than 50 parts by weight, excessive collapse of the structure due to hydrocolloids may occur.

Wherein the hydrophilic polymer is selected from the group consisting of polyacrylic acid, polyvinylpyrrolidone, hydroxyalkylcellulose, carbomer, polyvinyl alcohol, chitosan, quinine, alginates, carboxymethylcellulose, polyhexamethylenebiguanide, A group consisting of saccharide, collagen, gelatin, hyaluronic acid, xanthan gum, acacia gum, guar gum, arginic acid, agar, gelatin, gum arabic, tragacanth, karaya gum, pectin, dextran and starch, And may be one or more, but is not limited thereto. Preferably, pectin, alginates or sodium carboxymethylcellulose can be selected.

The present invention also includes 10 to 90 parts by weight of the hydrophobic polymer. When the amount of the hydrophobic polymer is less than 10 parts by weight, the hydrocolloid adhesion function is deteriorated. When the amount is more than 90 parts by weight, the exudation of the immersion polymer is not smoothly absorbed. The hydrophobic polymer may be selected from one or more of the group consisting of a pressure-sensitive adhesive material, a thermoplastic elastomer, a tackifier, and the like.

Suitable pressure-sensitive adhesive materials include one or more than one selected from the group consisting of various natural or synthetic viscous or elastomeric materials such as natural rubber, silicone rubber, acrylonitrile rubber, polyurethane rubber, polyisobutylene, polyisoprene, And is not limited thereto. Preferably, polyisoprene and polyisobutylene can be selected.

The thermoplastic elastomer may be at least one selected from the group consisting of polyisoprene, polyisobutylene, isobutylene rubber, polyethylene-propylene rubber, polyethylene-propylene diene-modified rubber, styrene-butadiene-styrene, styrene-isoprene- -Ethylene-butylene-styrene copolymer polymer, and the like, but is not limited thereto. Preferably, polyisobutylene, styrene-butadiene-styrene and styrene-isoprene-styrene can be selected.

The tackifier according to the present invention is a thermoplastic material having a molecular weight in the range of 300 to 3000. The petroleum resin system is mainly composed of aliphatic C5, aromatic C9, C5 / C9, and hydrogenated DCPD (Dicyclopentadiene) Resin can be selected.

The hydrocolloid composition according to the present invention may further include hydrocolloids commonly used oils, antioxidants, and the like. The oil plays a role in imparting flexibility and processability in the hydrocolloid matrix. The antioxidant plays a role of preventing the oxidation of the pressure-sensitive adhesive at a high temperature and can be used in a variety of applications such as BHT (Butylated hydroxytoluene), Vulkanox BKF, Lanxess, Irganox 1076, 1010, 565 (Irganox 1076, 565), Ciba Specialty Chemicals, and the like.

In the present invention, 0.1 to 20 parts by weight of the mugwort extract is included. Extraction solvents for extracting active ingredients from mugwort can be non-polar and polar solvents. Non-polar solvents are hexane (n-hexane), polar solvents such as alcohol (usually methyl alcohol or ethyl alcohol) Is ethyl acetate. When extracting physiologically active substances with hot water, since pure water is used as an extraction medium, there is no problem caused by the toxicity of the organic solvent used in the extraction. In some cases, hot water extraction may be performed for a long period of time , It may be necessary to extract a short time within 30 minutes. Therefore, it is important to set the extraction conditions through review of the literature prior to extraction. The extracts extracted with hot water are usually centrifuged, supernatant only, and lyophilized to produce powders and verify their physiological activity or commercialize them.

In the present invention, the mugwort extract is obtained by hot water extraction of mugwort, and the hot water extraction is conducted at 75 to 85 ° C for 1 day to 3 days. Preferably, the mugwort is extracted with hot water at 80 DEG C for 30 hours to obtain mugwort extract.

In the present invention, a mineral powder that emits far-infrared rays and anions, a herbal concentrate,

Etc. can be used. Preferably 1 to 20 parts by weight, of one or more selected from the group consisting of tourmaline, chitosan, loess, and elvan, and may be selectively applied according to the therapeutic purpose of the lesion. Mineral powders that emit far infrared rays and anions are mineral powders such as tourmaline, chitosan, loess, and quartz. Especially tourmaline has a characteristic of generating electric current by fine heat to flow weak current, Is a ceramic material.

As it is already known, wichitosan has the same structure as the sugar in the human body, so it has high fitness for the human body, has the function of enhancing the antibacterial and immunity of the human body and has no toxicity and harmless substance. Chitosan is easy to dissolve in weak acid, Is easily absorbed from the digestive organs and skin as well as absorbed by all kinds of cells, activating it and giving vitality to the immune cells, thereby enhancing natural healing power. Chitosan having such properties has recently been found to have excellent efficacy as a functional food when it is mixed with new materials of pharmaceutical materials, and many researches on it have been conducted. Hereinafter, loess and crushed stone are already well known substances, It will be omitted.

The permeation enhancer is contained in an amount of 0.1 to 20 parts by weight, preferably 0.2 to 15 parts by weight, more preferably 0.3 to 10 parts by weight, most preferably 0.5 to 8 parts by weight. Penetration accelerators, also referred to as skin penetration accelerators, are commonly used to promote penetration of functional ingredients into the skin. In the present invention, natural menthol is used.

The present invention can be easily used by mixing yellowish white soft X-ray, Sanchija soft X-ray, Sancho soft X-ray and the like having an effect of back pain, neck pain, and shoulder pain with analgesic, .

Hereinafter, the present invention will be described in detail with reference to specific examples and comparative examples. The following examples illustrate the invention in more detail but do not limit the scope of the invention.

25 parts by weight of SIS (Styrene-isoprenestyrene block copolymer, D1107, Kraton polymer) which imparts elasticity and cohesion to produce a hydrocolloid adhesive in which hydrophilic hydrocolloid fine particles are dispersed in a hydrophobic polymer matrix having adhesive strength, PIB (polyisobutylene, 15SFN, BASF), 10 parts by weight of tackifier rosin ester (Foral 85-E, Eastman) and 80 parts by weight of mineral oil for imparting flexibility to the matrix were uniformly mixed at 150 ° C using an open kneader 10 parts by weight of pectin, which is a hydrophilic polymer capable of lowering the temperature to 100 占 폚 and capable of imparting water absorption, 20 parts by weight of CMC, 10 parts by weight of mugwort extract, 2 parts by weight of menthol, and other wetting agents and antioxidants, A hydrocolloid pressure-sensitive adhesive was prepared. The hydrocolloid adhesive was pressed to form a uniform thickness (0.5 mm), and then a polyurethane film (thickness: 25 μm) was laminated to produce a hydrocolloid dressing material.

Example 2 was prepared so as to have the same composition as in Example 1 except that 15 parts by weight of pectin as a hydrophilic polymer, 25 parts by weight of CMC and 15 parts by weight of mugwort extract were prepared.

≪ Comparative Example 1 &

The products of commercially available hydrocolloid pressure-sensitive adhesive composition, Duoderm CGF [ConvaTec Co.] and Dermaplast [Hartmann] were compared with Example 1 above.

<Test Example>

The above Examples 1 to 2 and Comparative Example 1 were measured for water absorption and tackiness by the following methods, and the results are shown in Table 1 below.

 1) Absorption rate (%): The sample was dried in a dryer at a temperature of 60 캜 for 24 hours, and the weight (A) was measured. The sample was immersed in an aqueous 0.9% sodium chloride solution at 25 캜 for 24 hours, The weight (B) was measured, and the water absorption rate was measured according to the following water absorption rate equation.

Absorption rate = [(B-A) / A] x 100

2) Adhesive force (g / 12mm): The sample was prepared with a width of 12mm and a length of 250mm, and then the adhesion of each sample was measured by a 180-degree peel adhesion test method of a Texture Analyzer [CNS Farnell Co.] Respectively.

division Example 1 Example 2 Comparative Example 1 Absorption Rate (%) 3325 3420 3250 Adhesion (g / 12mm) 380.3 369.1 450

It can be seen from Table 1 that the hydrocolloid pressure-sensitive adhesive compositions prepared in Examples 1 and 2 according to the present invention had the same or superior water absorption rates as those of Comparative Example 1. Although the comparative example 1 is somewhat higher than those of the examples 1 and 2 in terms of the adhesive strength, it was confirmed that the examples 1 and 2 have the adhesive force required of the actual hydrocolloid. This difference in adhesion is presumed to be the effect of the mugwort extract added to the examples. In conclusion, since the present invention includes mugwort extract derived from a natural product, it has no side effect with no irritation and non-toxicity, and it has been confirmed that it has an excellent water absorption rate and adhesive force while suppressing the growth of pathogenic bacteria and antimicrobial action. In the present invention, 1 to 20 parts by weight of one or more selected from the group consisting of tourmaline, chitosan, loess, and elvan can be further selectively applied according to the therapeutic purpose of the lesion.

Claims (5)

In the hydrocolloid composition,
5 to 55 parts by weight of a hydrophilic polymer;
10 to 90 parts by weight of a hydrophobic polymer; And
And 0.1 to 20 parts by weight of an extract of mugwort. The method according to claim 1,
Wherein the hydrocolloid composition further comprises 1 to 20 parts by weight of one or more selected from the group consisting of tourmaline, chitosan, loess, and elvan. The method according to claim 1,
0.1 to 20 parts by weight of menthol. The method according to claim 1,
The hydrophilic polymer may be,
Polyacrylic acid, polyvinylpyrrolidone, hydroxyalkylcellulose, carbomer, polyvinyl alcohol, chitosan, quinine, alginates, carboxymethyl cellulose, polyhexamethylene beguuanide, carraquinone, polyethylene oxide, polysaccharide, collagen 1, selected from the group consisting of gelatin, hyaluronic acid, xanthan gum, acacia gum, guar gum, arginic acid, agar, gelatin, gum arabic, tragacanth, karaya gum, pectin, dextran and starch, Or at least two hydrocolloids. The method according to claim 1,
The hydrophobic polymer may include,
Wherein the hydrocolloid composition is one or more selected from the group consisting of a pressure-sensitive adhesive material, a thermoplastic elastomer, and a tackifier.