CN106267314A - A kind of preparation method of antibacterial corrosion-resistant bearing hydrocolloid dressing - Google Patents
A kind of preparation method of antibacterial corrosion-resistant bearing hydrocolloid dressing Download PDFInfo
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- CN106267314A CN106267314A CN201610879941.6A CN201610879941A CN106267314A CN 106267314 A CN106267314 A CN 106267314A CN 201610879941 A CN201610879941 A CN 201610879941A CN 106267314 A CN106267314 A CN 106267314A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The present invention relates to the preparation method of a kind of antibacterial corrosion-resistant bearing hydrocolloid dressing, belong to dressing preparing technical field.After first the material such as Rhizoma Curcumae, gardenia florida is dried, mills by the present invention, add hydrochloric acid solution, carry out adding hot mixing, collect supernatant, after again supernatant and tapioca, chitin being carried out Hybrid Heating, and add methylbarbituric acid, continue stirring, and add the material such as polyglycolic acid, phosphoric acid solution and carry out reacting by heating, filter, collect filtering residue, finally by itself and perfume (or spice) pine glyceride, the materials such as dibutyl phthalate are stirred sulfuration, and coat mylar backing.Antibacterial corrosion-resistant bearing hydrocolloid dressing good anti-bacterial effect prepared by the present invention, its antibiotic rate reaches more than 95%；Corrosion resistance and good, its integrity reaches more than 92%；Water absorption reaches 5426g/m2Above, surrounding skin will not be caused damage.
Description
Technical field
The present invention relates to the preparation method of a kind of antibacterial corrosion-resistant bearing hydrocolloid dressing, belong to dressing preparing technical field.
Background technology
Hydrocolloid medical dressing is medical with the one that hot-fusible pressure-sensitive adhesive prepares after blended for the granule of absorbent polymer
Dressing.This material combines cement properties and the water absorbing properties of absorbent polymer material of elastomeric material.Rubber substrate carries
For viscosity, can make dressing paste on wound surface, and swelling after the hydrocolloid particle water suction being dispersed therein, to wound provide one wet
The closed environment of profit, promotes the healing of wound.Moistening environment plays good facilitation to the healing of wound, for wound
Nursing brings the biggest convenience.Therefore medical field it is widely used in.Can be used as adhesive tape, binder, operative membrane, also fit
Close intestinal, urethra colostomy patient is used as neostomy aspect, also has good effect at the aspect such as burn, scald, decubital ulcer, ulcer.
Traditional bearing hydrocolloid dressing fundamentally cannot be used the wound that sepage is relatively more, because tradition bearing hydrocolloid dressing is to sepage
Absorption efficiency be not quickly so that having little time when tackling the many wound of sepage to absorb completely, make sepage spill and leakage, to periphery
Skin causes damage, and this is the drawback of cross conduction.And, traditional bearing hydrocolloid dressing does not has an antibiotic property the most yet, therefore when
It, when chronic wound, usually causes agglutination partially or completely to stop due to reasons such as infection.Some bearing hydrocolloid dressings
In with the addition of the inorganic antiseptic such as composition such as silver ion, nanometer silver, although product has good bacteriostasis property, but such is antibacterial
Agent has bigger cytotoxicity, has potential biological safety hidden danger for human body；Tradition bearing hydrocolloid dressing corrosion resistant simultaneously
Erosion property is poor, and after water absorption and swelling, the integrity of dressing is destroyed, and hydrocolloid component is prone to remain in wound surface surface, causes
Dressing performance is greatly affected.
Summary of the invention
The technical problem to be solved: do not have anti-microbial property for existing bearing hydrocolloid dressing so that itself because
The reasons such as infection, slow down the healing of wound, and its decay resistance is poor simultaneously, cause the integrity of its dressing to be destroyed
Problem, after first the material such as Rhizoma Curcumae, gardenia florida is dried, mills by the present invention, adds hydrochloric acid solution, carries out adding hot mixing, collect
Supernatant, then after supernatant and tapioca, chitin are carried out Hybrid Heating, and add methylbarbituric acid, continue stirring,
And add the material such as polyglycolic acid, phosphoric acid solution and carry out reacting by heating, filter, collect filtering residue, finally by itself and perfume (or spice) pine glyceride,
The materials such as dibutyl phthalate are stirred sulfuration, and coat mylar backing.Prepared by the present invention antibacterial
Corrosion-resistant bearing hydrocolloid dressing has the anti-microbial property of excellence, and decay resistance is relatively strong, maintains the integrity of dressing.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
(1) count by weight, take 40～45 parts of mass fraction 5% hydrochloric acid solutions, 26～29 portions of Rhizoma Curcumae, 16～19 portions of Fructus Gardeniaes
Core, 8～11 portions of Fructus Lyciis and 5～7 parts of Rhizoma Polygonatis, first put in baking oven by Rhizoma Curcumae, gardenia florida, Fructus Lycii and Rhizoma Polygonati, and design temperature is
45～50 DEG C, it is dried 1～2h, places into and herb roller mills 30～35min, collect thing of milling, will mill subsequently thing and quality
Mark 5% hydrochloric acid solution mix homogeneously, puts in decoction vessel；
(2) above-mentioned decoction vessel is heated, be heated to 35～40 DEG C, be incubated 30～40min, then raise temperature to 100～105
DEG C, it is incubated 30～40min, adds above-mentioned mass fraction 5% hydrochloric acid solution volume 40～the distilled water of 45%, continue insulation 40
～after 50min, naturally cool to room temperature, the mixture in decoction vessel is put in centrifuge, with 1500r/min be centrifuged 10～
15min, collects supernatant；
(3) count by weight, take 50～55 parts of above-mentioned supernatant, 23～26 portions of tapiocas and 11～17 parts of chitins and put into
In container, stirring, using mass fraction is 25% sodium hydroxide solution regulation pH to 7.5～8.0, and container is heated to 80
～85 DEG C, stir 20～25min with 120r/min, be subsequently added tapioca quality 2.3～3.4% methylbarbituric acid, continue
Continuous stirring 2～4h；
(4) after above-mentioned stirring terminates, the mixture in said vesse is put into reactor with its quality 1～2 times of polyglycolic acids
In, more respectively in reactor add polyglycolic acid quality 30～35%1.3mol/L phosphoric acid solution, polyglycolic acid quality 4～
7% disodium hydrogen phosphate and polyglycolic acid quality 0.9～1.5% titanium dioxide, stir, and uses nitrogen protection, design temperature
Being 75～85 DEG C, with 150r/min stirring reaction 3～6h, naturally cool to room temperature subsequently, discharging is also filtered, and collects filtering residue；
(5) count by weight, take 12～16 parts of fragrant pine glyceride, 36～39 parts of styrene-isoprene block copolymer rubbers
Glue, 14～17 parts of above-mentioned filtering residues, 3～5 parts of dibutyl phthalates, 9～14 parts of Carboxymethyl cellulose sodium, 11～13 parts of epoxies
Kneader put into by soybean oil, and design temperature is 115～120 DEG C, stirs 15～20min with 120r/min, is subsequently placed at flat board sulfur
Processing 25～30min in change machine, design temperature is 100～105 DEG C, and the mixture after processing coats mylar backing
On, control thickness be 1～2mm, cover release paper, antibacterial corrosion-resistant bearing hydrocolloid dressing.
The application process of the present invention: first clean up the skin at patient's pressurized with warm water, then clean with normal saline
Pressurized area skin, the antibacterial corrosion-resistant bearing hydrocolloid dressing the protection sheet then present invention prepared is torn, and will have dressing, toughness
One side cover on wound, more contactless film protecting film is torn, that changed prepared by present invention every 1～3 day is antibacterial
Corrosion-resistant bearing hydrocolloid dressing.After testing, the antibacterial corrosion-resistant bearing hydrocolloid dressing water absorption that prepared by the present invention reaches 5426g/
m2Above, breathability reaches 0.62kg(24h m2More than), corrosion resistance and good, its integrity reaches more than 92%, antibacterial effect
The best, antibiotic rate reaches more than 95%.
The present invention is compared with additive method, and Advantageous Effects is:
(1) antibacterial corrosion-resistant bearing hydrocolloid dressing good anti-bacterial effect prepared by the present invention, its antibiotic rate reaches more than 95%；
(2) antibacterial corrosion-resistant bearing hydrocolloid dressing corrosion resistance and good prepared by the present invention, its integrity reaches more than 92%；
(3) the antibacterial corrosion-resistant bearing hydrocolloid dressing water absorption that prepared by the present invention is high, and water absorption reaches 5426g/m2Above, will not be right
Surrounding skin causes damage.
Detailed description of the invention
Count the most by weight, take 40～45 parts of mass fraction 5% hydrochloric acid solutions, 26～29 parts of Rhizoma Curcumae, 16～19 parts
Gardenia florida, 8～11 portions of Fructus Lyciis and 5～7 parts of Rhizoma Polygonatis, first put in baking oven by Rhizoma Curcumae, gardenia florida, Fructus Lycii and Rhizoma Polygonati, sets temperature
Degree is 45～50 DEG C, is dried 1～2h, places into and mills 30～35min in herb roller, collects thing of milling, will mill subsequently thing and
Mass fraction 5% hydrochloric acid solution mix homogeneously, puts in decoction vessel；Above-mentioned decoction vessel is heated, is heated to 35～40 DEG C,
Insulation 30～40min, then raises temperature to 100～105 DEG C, is incubated 30～40min, adds above-mentioned mass fraction 5% hydrochloric acid molten
Liquid amasss the distilled water of 40～45%, after continuing insulation 40～50min, naturally cools to room temperature, by the mixture in decoction vessel
Put in centrifuge, be centrifuged 10～15min with 1500r/min, collect supernatant；Count the most by weight, take on 50～55 parts
Stating supernatant, 23～26 portions of tapiocas and 11～17 parts of chitins and put in container, stir, use mass fraction is
25% sodium hydroxide solution regulation pH to 7.5～8.0, container is heated to 80～85 DEG C, with 120r/min stirring 20～
25min, is subsequently added tapioca quality 2.3～3.4% methylbarbituric acid, continues stirring 2～4h；Terminate in above-mentioned stirring
After, the mixture in said vesse is put in reactor with its quality 1～2 times of polyglycolic acids, then adds in reactor respectively
Enter polyglycolic acid quality 30～35%1.3mol/L phosphoric acid solution, polyglycolic acid quality 4～7% disodium hydrogen phosphate and polyglycolic acid
Quality 0.9～1.5% titanium dioxide, stir, and uses nitrogen protection, and design temperature is 75～85 DEG C, stirs with 150r/min
Mixing reaction 3～6h, naturally cool to room temperature subsequently, discharging is also filtered, and collects filtering residue；Count by weight, take 12～16 parts of perfume (or spice)
Pine glyceride, 36～39 parts of styrene-isoprene block copolymer rubber, 14～17 parts of above-mentioned filtering residues, 3～5 parts of adjacent benzene two
Formic acid dibutyl ester, 9～14 parts of Carboxymethyl cellulose sodium, 11～13 parts of epoxy soybean oils put into kneader, design temperature be 115～
120 DEG C, stirring 15～20min with 120r/min, be subsequently placed in vulcanizing press process 25～30min, design temperature is 100
～105 DEG C, the mixture after processing is coated on mylar backing, and controlling thickness is 1～2mm, covers release paper,
Obtain antibacterial corrosion-resistant bearing hydrocolloid dressing.
Example 1
Count the most by weight, take 45 parts of mass fraction 5% hydrochloric acid solutions, 29 parts of Rhizoma Curcumae, 19 parts of gardenia floridas, 11 portions of Fructus Lyciis and
7 parts of Rhizoma Polygonatis, first put in baking oven by Rhizoma Curcumae, gardenia florida, Fructus Lycii and Rhizoma Polygonati, and design temperature is 50 DEG C, are dried 2h, place into medicine
Mill in roller 35min, collects thing of milling, and thing of milling subsequently is mixed homogeneously with mass fraction 5% hydrochloric acid solution, puts into and boils medicine
In device；Above-mentioned decoction vessel is heated, is heated to 40 DEG C, be incubated 40min, then raise temperature to 105 DEG C, be incubated 40min, then add
Enter the distilled water of above-mentioned mass fraction 5% hydrochloric acid solution volume 45%, after continuing insulation 50min, naturally cool to room temperature, will decoct
Mixture in medicine device is put in centrifuge, is centrifuged 15min with 1500r/min, collects supernatant；Count the most by weight, take
55 parts of above-mentioned supernatant, 26 portions of tapiocas and 17 parts of chitins are put in container, stir, and using mass fraction is 25%
Sodium hydroxide solution regulation pH to 8.0, is heated to 85 DEG C, stirs 25min with 120r/min, be subsequently added tapioca container
Quality 3.4% methylbarbituric acid, continues stirring 4h；After above-mentioned stirring terminates, by the mixture in said vesse and its matter
Measure 2 times of polyglycolic acids to put in reactor, then it is molten to add polyglycolic acid quality 35%1.3mol/L phosphoric acid respectively in reactor
Liquid, polyglycolic acid quality 7% disodium hydrogen phosphate and polyglycolic acid quality 1.5% titanium dioxide, stir, and uses nitrogen to protect
Protecting, design temperature is 85 DEG C, with 150r/min stirring reaction 6h, naturally cools to room temperature subsequently, and discharging is also filtered, and collects filter
Slag；Count by weight, take 16 parts of fragrant pine glyceride, 39 parts of styrene-isoprene block copolymer rubber, 17 parts above-mentioned
Filtering residue, 5 parts of dibutyl phthalates, 14 parts of Carboxymethyl cellulose sodium, 13 parts of epoxy soybean oils put into kneader, design temperature
Being 120 DEG C, stir 20min with 120r/min, be subsequently placed in vulcanizing press process 30min, design temperature is 105 DEG C, will
Mixture after process is coated on mylar backing, and control thickness is 2mm, cover release paper, antibacterial corrosion-resistant
Bearing hydrocolloid dressing.
First clean up the skin at patient's pressurized with warm water, then clean pressurized area skin with normal saline, then
The antibacterial corrosion-resistant bearing hydrocolloid dressing protection sheet present invention prepared is torn, and dressing, sticking one side will be had to cover at wound
On, more contactless film protecting film is torn, the antibacterial corrosion-resistant bearing hydrocolloid dressing prepared every present invention of replacing in 3 days is
Can.After testing, the antibacterial corrosion-resistant bearing hydrocolloid dressing water absorption that prepared by the present invention reaches more than 6213 g/m2, breathability reaches
0.65kg(24h m2), corrosion resistance and good, its integrity reaches 93%, and good anti-bacterial effect, antibiotic rate reaches 96%.
Example 2
Count the most by weight, take 40 parts of mass fraction 5% hydrochloric acid solutions, 26 portions of Rhizoma Curcumae, 16 portions of gardenia floridas, 8 portions of Fructus Lyciis and 5
Part Rhizoma Polygonati, first puts in baking oven by Rhizoma Curcumae, gardenia florida, Fructus Lycii and Rhizoma Polygonati, and design temperature is 45 DEG C, is dried 1h, places into medicine
Mill in roller 30min, collects thing of milling, and thing of milling subsequently is mixed homogeneously with mass fraction 5% hydrochloric acid solution, puts into and boils medicine
In device；Above-mentioned decoction vessel is heated, is heated to 35 DEG C, be incubated 30min, then raise temperature to 100 DEG C, be incubated 30min, then add
Enter the distilled water of above-mentioned mass fraction 5% hydrochloric acid solution volume 40%, after continuing insulation 40min, naturally cool to room temperature, will decoct
Mixture in medicine device is put in centrifuge, is centrifuged 10min with 1500r/min, collects supernatant；Count the most by weight, take
50 parts of above-mentioned supernatant, 23 portions of tapiocas and 11 parts of chitins are put in container, stir, and using mass fraction is 25%
Sodium hydroxide solution regulation pH to 7.5, is heated to 80 DEG C, stirs 20min with 120r/min, be subsequently added tapioca container
Quality 2.3% methylbarbituric acid, continues stirring 2h；After above-mentioned stirring terminates, by the mixture in said vesse and its matter
Measure 1 times of polyglycolic acid to put in reactor, then it is molten to add polyglycolic acid quality 30%1.3mol/L phosphoric acid respectively in reactor
Liquid, polyglycolic acid quality 4% disodium hydrogen phosphate and polyglycolic acid quality 0.9% titanium dioxide, stir, and uses nitrogen to protect
Protecting, design temperature is 75 DEG C, with 150r/min stirring reaction 3h, naturally cools to room temperature subsequently, and discharging is also filtered, and collects filter
Slag；Count by weight, take 12 parts of fragrant pine glyceride, 36 parts of styrene-isoprene block copolymer rubber, 14 parts above-mentioned
Filtering residue, 3 parts of dibutyl phthalates, 9 parts of Carboxymethyl cellulose sodium, 11 parts of epoxy soybean oils put into kneader, design temperature
Being 115 DEG C, stir 15min with 120r/min, be subsequently placed in vulcanizing press process 25min, design temperature is 100 DEG C, will
Mixture after process is coated on mylar backing, and control thickness is 1mm, cover release paper, antibacterial corrosion-resistant
Bearing hydrocolloid dressing.
First clean up the skin at patient's pressurized with warm water, then clean pressurized area skin with normal saline, then
The antibacterial corrosion-resistant bearing hydrocolloid dressing protection sheet present invention prepared is torn, and dressing, sticking one side will be had to cover at wound
On, more contactless film protecting film is torn, the antibacterial corrosion-resistant bearing hydrocolloid dressing prepared every present invention of replacing in 1 day is
Can.After testing, the antibacterial corrosion-resistant bearing hydrocolloid dressing water absorption that prepared by the present invention reaches 5897g/m2Above, breathability reaches
0.66kg(24h m2), corrosion resistance and good, its integrity reaches 96%, and good anti-bacterial effect, antibiotic rate reaches 97%.
Example 3
Count the most by weight, take 42 parts of mass fraction 5% hydrochloric acid solutions, 27 parts of Rhizoma Curcumae, 17 parts of gardenia floridas, 10 portions of Fructus Lyciis and
6 parts of Rhizoma Polygonatis, first put in baking oven by Rhizoma Curcumae, gardenia florida, Fructus Lycii and Rhizoma Polygonati, and design temperature is 47 DEG C, are dried 2h, place into medicine
Mill in roller 32min, collects thing of milling, and thing of milling subsequently is mixed homogeneously with mass fraction 5% hydrochloric acid solution, puts into and boils medicine
In device；Above-mentioned decoction vessel is heated, is heated to 37 DEG C, be incubated 35min, then raise temperature to 100 DEG C, be incubated 35min, then add
Enter the distilled water of above-mentioned mass fraction 5% hydrochloric acid solution volume 42%, after continuing insulation 45min, naturally cool to room temperature, will decoct
Mixture in medicine device is put in centrifuge, is centrifuged 12min with 1500r/min, collects supernatant；Count the most by weight, take
52 parts of above-mentioned supernatant, 24 portions of tapiocas and 16 parts of chitins are put in container, stir, and using mass fraction is 25%
Sodium hydroxide solution regulation pH to 7.7, is heated to 82 DEG C, stirs 22min with 120r/min, be subsequently added tapioca container
Quality 3.1% methylbarbituric acid, continues stirring 3h；After above-mentioned stirring terminates, by the mixture in said vesse and its matter
Measure 2 times of polyglycolic acids to put in reactor, then it is molten to add polyglycolic acid quality 32%1.3mol/L phosphoric acid respectively in reactor
Liquid, polyglycolic acid quality 6% disodium hydrogen phosphate and polyglycolic acid quality 1.2% titanium dioxide, stir, and uses nitrogen to protect
Protecting, design temperature is 780 DEG C, with 150r/min stirring reaction 5h, naturally cools to room temperature subsequently, and discharging is also filtered, and collects filter
Slag；Count by weight, take 13 parts of fragrant pine glyceride, 37 parts of styrene-isoprene block copolymer rubber, 16 parts above-mentioned
Filtering residue, 4 parts of dibutyl phthalates, 10 parts of Carboxymethyl cellulose sodium, 12 parts of epoxy soybean oils put into kneader, design temperature
Being 117 DEG C, stir 17min with 120r/min, be subsequently placed in vulcanizing press process 27min, design temperature is 102 DEG C, will
Mixture after process is coated on mylar backing, and control thickness is 2mm, cover release paper, antibacterial corrosion-resistant
Bearing hydrocolloid dressing.
First clean up the skin at patient's pressurized with warm water, then clean pressurized area skin with normal saline, then
The antibacterial corrosion-resistant bearing hydrocolloid dressing protection sheet present invention prepared is torn, and dressing, sticking one side will be had to cover at wound
On, more contactless film protecting film is torn, the antibacterial corrosion-resistant bearing hydrocolloid dressing prepared every present invention of replacing in 2 days is
Can.After testing, the antibacterial corrosion-resistant bearing hydrocolloid dressing water absorption that prepared by the present invention reaches 7025g/m2, breathability reaches 0.67kg
(24h m2), corrosion resistance and good, its integrity reaches 94%, and good anti-bacterial effect, antibiotic rate reaches 98%.
Claims (1)
1. the preparation method of an antibacterial corrosion-resistant bearing hydrocolloid dressing, it is characterised in that concrete preparation process is:
(1) count by weight, take 40～45 parts of mass fraction 5% hydrochloric acid solutions, 26～29 portions of Rhizoma Curcumae, 16～19 portions of Fructus Gardeniaes
Core, 8～11 portions of Fructus Lyciis and 5～7 parts of Rhizoma Polygonatis, first put in baking oven by Rhizoma Curcumae, gardenia florida, Fructus Lycii and Rhizoma Polygonati, and design temperature is
45～50 DEG C, it is dried 1～2h, places into and herb roller mills 30～35min, collect thing of milling, will mill subsequently thing and quality
Mark 5% hydrochloric acid solution mix homogeneously, puts in decoction vessel；
(2) above-mentioned decoction vessel is heated, be heated to 35～40 DEG C, be incubated 30～40min, then raise temperature to 100～105
DEG C, it is incubated 30～40min, adds above-mentioned mass fraction 5% hydrochloric acid solution volume 40～the distilled water of 45%, continue insulation 40
～after 50min, naturally cool to room temperature, the mixture in decoction vessel is put in centrifuge, with 1500r/min be centrifuged 10～
15min, collects supernatant；
(3) count by weight, take 50～55 parts of above-mentioned supernatant, 23～26 portions of tapiocas and 11～17 parts of chitins and put into
In container, stirring, using mass fraction is 25% sodium hydroxide solution regulation pH to 7.5～8.0, and container is heated to 80
～85 DEG C, stir 20～25min with 120r/min, be subsequently added tapioca quality 2.3～3.4% methylbarbituric acid, continue
Continuous stirring 2～4h；
(4) after above-mentioned stirring terminates, the mixture in said vesse is put into reactor with its quality 1～2 times of polyglycolic acids
In, more respectively in reactor add polyglycolic acid quality 30～35%1.3mol/L phosphoric acid solution, polyglycolic acid quality 4～
7% disodium hydrogen phosphate and polyglycolic acid quality 0.9～1.5% titanium dioxide, stir, and uses nitrogen protection, design temperature
Being 75～85 DEG C, with 150r/min stirring reaction 3～6h, naturally cool to room temperature subsequently, discharging is also filtered, and collects filtering residue；
(5) count by weight, take 12～16 parts of fragrant pine glyceride, 36～39 parts of styrene-isoprene block copolymer rubbers
Glue, 14～17 parts of above-mentioned filtering residues, 3～5 parts of dibutyl phthalates, 9～14 parts of Carboxymethyl cellulose sodium, 11～13 parts of epoxies
Kneader put into by soybean oil, and design temperature is 115～120 DEG C, stirs 15～20min with 120r/min, is subsequently placed at flat board sulfur
Processing 25～30min in change machine, design temperature is 100～105 DEG C, and the mixture after processing coats mylar backing
On, control thickness be 1～2mm, cover release paper, antibacterial corrosion-resistant bearing hydrocolloid dressing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113101408A (en) * | 2021-04-28 | 2021-07-13 | 南昌智产科技有限公司 | Antibacterial foam dressing and preparation method thereof |
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