CN113101408A - Antibacterial foam dressing and preparation method thereof - Google Patents
Antibacterial foam dressing and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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Abstract
The invention discloses an antibacterial foam dressing which comprises the following raw materials in parts by weight: 100 parts of raw materials, 100 parts of water, 50 parts of a silver ion antibacterial agent, 50 parts of an alginate agent, 90 parts of a sodium hyaluronate agent, 120 parts of a foam stabilizer, 100 parts of a surfactant, 80 parts of an aromatic and 100 parts of perfluoro methyl acrylate, wherein the surfactant is an ionic surfactant, and the silver ion antibacterial agent is one of antibacterial materials and comprises the following raw materials in parts by weight: the ratio of the silver ion antibacterial agent to the alginate agent is 1:1, the aromatic agent is lemon olein, the raw material is glycolic acid copolymer, the water is deionized water, and the deionized water is nearly pure water obtained by removing ionic impurities in the water through ion exchange resin. The invention can increase the antibacterial property of the dressing, can provide the antibacterial durability of the dressing, avoids the repeated replacement of a user, avoids the defect that the wound is not healed due to excessive replacement times, and is beneficial to the recovery of the wound.
Description
Technical Field
The invention relates to the technical field of dressings, in particular to an antibacterial foam dressing and a preparation method thereof.
Background
The dressing is widely applied in the medical field, and along with the continuous importance of people on healthy life, the dressing also appears in the health care field and is more and more widely used, and in recent years, the antibacterial component of the dressing is also more and more important.
Chinese invention patent CN105536038A discloses a foam-based dressing, which is composed of a base frame made of sheet-shaped foam dressing and gel material filled and attached in pores of the base frame, wherein the foam-based dressing contains copper ions, silver ions or nano silver with antibacterial property, and three types of wet dressings are prepared by a method for controlling water content, so that the novel wet dressing with good usability, better function and lower cost can be prepared.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the dressing, which has the advantages of antibiosis and the like, and solves the problem of bacteriostasis.
(II) technical scheme
In order to achieve the purpose of degerming, the invention provides the following technical scheme:
preferably, the feed comprises the following raw materials in parts by weight: 100-200 parts of raw materials, 100-300 parts of water, 50-150 parts of silver ion antibacterial agent, 50-150 parts of alginate agent, 90-110 parts of sodium hyaluronate agent, 120-140 parts of foam stabilizer, 100-120 parts of surfactant and 80-100 parts of aromatic.
Preferably, the surfactant is an ionic surfactant, and the silver ion antibacterial agent is one of antibacterial materials.
Preferably, the feed comprises the following raw materials in parts by weight: the ratio of the silver ion antibacterial agent to the alginate agent is 1: 1.
Preferably, the aromatic is limonene, and the raw material is glycolic acid copolymer.
Preferably, the water is deionized water, and the deionized water is nearly pure water obtained by removing ionic impurities in the water through ion exchange resin.
The invention also provides a preparation method of the antibacterial foam dressing, which comprises the following steps:
s1: the raw materials with the proportion are prepared, impurities in the raw materials are removed, the raw materials are in a pure state, the quality of prepared dressing can be improved, and the use effect of the dressing is prevented from being influenced;
s2: adding the raw materials into water, wherein the water is hot water with the temperature of 50-70 ℃, and fusing the raw materials and the water in a manual stirring manner for 3-5 minutes, so that the hot water can accelerate the fusing efficiency and is convenient to save the working time;
s3: after water and raw materials are mixed, sequentially adding a silver ion antibacterial agent, an alginate agent, a sodium hyaluronate agent, a foam stabilizer, a surfactant and methyl perfluoroacrylate, carrying out secondary mixing and stirring, heating the raw materials while stirring, and enabling the heating temperature to be uniform, so that a fusion effect is achieved, and a mixed dressing solution is obtained;
s4: when the dressing solution is mixed into paste, stopping stirring the dressing solution, placing the dressing solution in a container, and waiting for cooling in a standing way;
s5: after the dressing solution is cooled to a constant temperature and the cooling time is 20-40 minutes, the prepared aromatic solution is put into the dressing solution, and the aromatic solution and the dressing solution are mixed in a way of manually shaking the container to emit fragrance, so that the functionality of the dressing is enhanced, and a user can be pleased;
s6: pouring the dressing solution into a prepared container, carrying out molding operation on the dressing solution in a high-temperature mode to make the dressing solution into a dressing, and then carrying out compression molding on the dressing in a compression mode, wherein the compression mode is manual compression, and the dressing is molded to prolong the storage time of the dressing;
s7: the formed dressing is cut into the application with uniform size, the length of the application is 4-6cm, and the prepared application can be directly used at the wound of a user or used in an auxiliary way.
Preferably, according to the step S3, a stirring motor is adopted for mixing and stirring, the model is Y100L-2, the stirring time is 30-40 minutes, and the stirring temperature is 50 ℃.
Preferably, in S4, the cooling mode is natural cooling, and the cooling time is 40-60 minutes.
Preferably, according to S6, the drying mode is fan drying, the model of the fan is XG-3, and the drying time is 3-4 hours.
(III) advantageous effects
Compared with the prior art, the invention provides an antibacterial foam dressing and a preparation method thereof, and the antibacterial foam dressing has the following beneficial effects:
the silver ion antibacterial agent has the antibacterial effect of the material, can inhibit the growth, reproduction or kill microorganisms, has the adsorption effect on the microorganisms in the liquid, can lose the effect of the enzymes playing a breathing role after the microorganisms are adsorbed by the silver, can rapidly die, has extremely strong bactericidal capacity of the silver ions, thereby improving the antibacterial effect of the dressing, has the disinfection function through the matching use of the alginate, can stop bleeding and inhibit bacteria, can stop bleeding on wounds, reduces the risk of infection of the wounds to a certain extent, has obvious use effect, and can assist the healing of the wounds by matching the natural hyaluronic acid of human bodies with other medicaments for promoting cell regeneration and removing wrinkles to prepare a gel through the matching use of the sodium hyaluronate, meanwhile, the dressing can repair scars to a certain extent, so that the use functionality of the dressing is improved, the foam stabilizer has fine and uniform air holes, when the system is in a low viscosity stage, the air holes can grow to the thickness suitable for opening the holes, conditions are created for final opening the holes, the production quality of the foam dressing is improved to a certain extent, the surfactant is used in combination, the surfactant is a substance which can obviously reduce the surface tension of a target solution, and has fixed hydrophilic lipophilic groups, so that the use effect of the dressing is effectively improved, the durability of the dressing antibacterial property can be improved by using the perfluoro methyl acrylate in combination, the repeated replacement of a user is avoided, the trouble of the user is reduced to a certain extent, meanwhile, the phenomenon that the replacement times are too many to be not beneficial to wound healing is avoided, and the wound recovery is facilitated, through the cooperation of aromatic, can increase the fragrant smell of dressing, can alleviate user's mood.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows: an antibacterial foam dressing comprises the following raw materials in parts by weight: 100 parts of raw materials, 100 parts of water, 50 parts of a silver ion antibacterial agent, 50 parts of an alginate agent, 90 parts of a sodium hyaluronate agent, 120 parts of a foam stabilizer, 100 parts of a surfactant, 80 parts of an aromatic and 100 parts of perfluoro methyl acrylate, wherein the surfactant is an ionic surfactant, and the silver ion antibacterial agent is one of antibacterial materials and comprises the following raw materials in parts by weight: the ratio of the silver ion antibacterial agent to the alginate agent is 1:1, the aromatic agent is lemon olein, the raw material is glycolic acid copolymer, the water is deionized water, and the deionized water is nearly pure water obtained by removing ionic impurities in the water through ion exchange resin.
A preparation method of an antibacterial foam dressing comprises the following steps:
s1: the raw materials with the proportion are prepared, impurities in the raw materials are removed, the raw materials are in a pure state, the quality of prepared dressing can be improved, and the use effect of the dressing is prevented from being influenced;
s2: adding the raw materials into water, wherein the water is hot water with the temperature of 50-70 ℃, and fusing the raw materials and the water in a manual stirring manner for 3-5 minutes, so that the hot water can accelerate the fusing efficiency and is convenient to save the working time;
s3: after water and raw materials are mixed, sequentially adding a silver ion antibacterial agent, an alginate agent, a sodium hyaluronate agent, a foam stabilizer, a surfactant and methyl perfluoroacrylate, carrying out secondary mixing and stirring, heating the raw materials while stirring, and enabling the heating temperature to be uniform, so that a fusion effect is achieved, and a mixed dressing solution is obtained;
s4: when the dressing solution is mixed into paste, stopping stirring the dressing solution, placing the dressing solution in a container, and waiting for cooling in a standing way;
s5: after the dressing solution is cooled to a constant temperature and the cooling time is 20-40 minutes, the prepared aromatic solution is put into the dressing solution, and the aromatic solution and the dressing solution are mixed in a way of manually shaking the container to emit fragrance, so that the functionality of the dressing is enhanced, and a user can be pleased;
s6: pouring the dressing solution into a prepared container, carrying out molding operation on the dressing solution in a high-temperature mode to make the dressing solution into a dressing, and then carrying out compression molding on the dressing in a compression mode, wherein the compression mode is manual compression, and the dressing is molded to prolong the storage time of the dressing;
s7: the formed dressing is cut into the application with uniform size, the length of the application is 4-6cm, and the prepared application can be directly used at the wound of a user or used in an auxiliary way.
According to S3, a stirring motor is adopted for mixing and stirring, the model is Y100L-2, the stirring time is 30-40 minutes, the stirring temperature is 50 ℃, the cooling mode is natural cooling according to S4, the cooling time is 40-60 minutes, the drying mode is fan drying according to S6, the model of a fan is XG-3, and the drying time is 3-4 hours.
Example two: an antibacterial foam dressing comprises the following raw materials in parts by weight: 150 parts of raw materials, 200 parts of water, 100 parts of a silver ion antibacterial agent, 100 parts of an alginate agent, 100 parts of a sodium hyaluronate agent, 130 parts of a foam stabilizer, 110 parts of a surfactant, 90 parts of an aromatic and 110 parts of methyl perfluoroacrylate, wherein the surfactant is an ionic surfactant, and the silver ion antibacterial agent is one of antibacterial materials and comprises the following raw materials in parts by weight: the ratio of the silver ion antibacterial agent to the alginate agent is 1:1, the aromatic agent is lemon olein, the raw material is glycolic acid copolymer, the water is deionized water, and the deionized water is nearly pure water obtained by removing ionic impurities in the water through ion exchange resin.
A preparation method of an antibacterial foam dressing comprises the following steps:
s1: the raw materials with the proportion are prepared, impurities in the raw materials are removed, the raw materials are in a pure state, the quality of prepared dressing can be improved, and the use effect of the dressing is prevented from being influenced;
s2: adding the raw materials into water, wherein the water is hot water with the temperature of 50-70 ℃, and fusing the raw materials and the water in a manual stirring manner for 3-5 minutes, so that the hot water can accelerate the fusing efficiency and is convenient to save the working time;
s3: after water and raw materials are mixed, sequentially adding a silver ion antibacterial agent, an alginate agent, a sodium hyaluronate agent, a foam stabilizer, a surfactant and methyl perfluoroacrylate, carrying out secondary mixing and stirring, heating the raw materials while stirring, and enabling the heating temperature to be uniform, so that a fusion effect is achieved, and a mixed dressing solution is obtained;
s4: when the dressing solution is mixed into paste, stopping stirring the dressing solution, placing the dressing solution in a container, and waiting for cooling in a standing way;
s5: after the dressing solution is cooled to a constant temperature and the cooling time is 20-40 minutes, the prepared aromatic solution is put into the dressing solution, and the aromatic solution and the dressing solution are mixed in a way of manually shaking the container to emit fragrance, so that the functionality of the dressing is enhanced, and a user can be pleased;
s6: pouring the dressing solution into a prepared container, carrying out molding operation on the dressing solution in a high-temperature mode to make the dressing solution into a dressing, and then carrying out compression molding on the dressing in a compression mode, wherein the compression mode is manual compression, and the dressing is molded to prolong the storage time of the dressing;
s7: the formed dressing is cut into the application with uniform size, the length of the application is 4-6cm, and the prepared application can be directly used at the wound of a user or used in an auxiliary way.
According to S3, a stirring motor is adopted for mixing and stirring, the model is Y100L-2, the stirring time is 30-40 minutes, the stirring temperature is 50 ℃, the cooling mode is natural cooling according to S4, the cooling time is 40-60 minutes, the drying mode is fan drying according to S6, the model of a fan is XG-3, and the drying time is 3-4 hours.
Example three: an antibacterial foam dressing comprises the following raw materials in parts by weight: 200 parts of raw materials, 300 parts of water, 150 parts of a silver ion antibacterial agent, 150 parts of an alginate agent, 110 parts of a sodium hyaluronate agent, 140 parts of a foam stabilizer, 120 parts of a surfactant, 100 parts of an aromatic and 120 parts of methyl perfluoroacrylate, wherein the surfactant is an ionic surfactant, and the silver ion antibacterial agent is one of antibacterial materials and comprises the following raw materials in parts by weight: the ratio of the silver ion antibacterial agent to the alginate agent is 1:1, the aromatic agent is lemon olein, the raw material is glycolic acid copolymer, the water is deionized water, and the deionized water is nearly pure water obtained by removing ionic impurities in the water through ion exchange resin.
A preparation method of an antibacterial foam dressing comprises the following steps:
s1: the raw materials with the proportion are prepared, impurities in the raw materials are removed, the raw materials are in a pure state, the quality of prepared dressing can be improved, and the use effect of the dressing is prevented from being influenced;
s2: adding the raw materials into water, wherein the water is hot water with the temperature of 50-70 ℃, and fusing the raw materials and the water in a manual stirring manner for 3-5 minutes, so that the hot water can accelerate the fusing efficiency and is convenient to save the working time;
s3: after water and raw materials are mixed, sequentially adding a silver ion antibacterial agent, an alginate agent, a sodium hyaluronate agent, a foam stabilizer, a surfactant and methyl perfluoroacrylate, carrying out secondary mixing and stirring, heating the raw materials while stirring, and enabling the heating temperature to be uniform, so that a fusion effect is achieved, and a mixed dressing solution is obtained;
s4: when the dressing solution is mixed into paste, stopping stirring the dressing solution, placing the dressing solution in a container, and waiting for cooling in a standing way;
s5: after the dressing solution is cooled to a constant temperature and the cooling time is 20-40 minutes, the prepared aromatic solution is put into the dressing solution, and the aromatic solution and the dressing solution are mixed in a way of manually shaking the container to emit fragrance, so that the functionality of the dressing is enhanced, and a user can be pleased;
s6: pouring the dressing solution into a prepared container, carrying out molding operation on the dressing solution in a high-temperature mode to make the dressing solution into a dressing, and then carrying out compression molding on the dressing in a compression mode, wherein the compression mode is manual compression, and the dressing is molded to prolong the storage time of the dressing;
s7: the formed dressing is cut into the application with uniform size, the length of the application is 4-6cm, and the prepared application can be directly used at the wound of a user or used in an auxiliary way.
According to S3, a stirring motor is adopted for mixing and stirring, the model is Y100L-2, the stirring time is 30-40 minutes, the stirring temperature is 50 ℃, the cooling mode is natural cooling according to S4, the cooling time is 40-60 minutes, the drying mode is fan drying according to S6, the model of a fan is XG-3, and the drying time is 3-4 hours.
The results of the antimicrobial foam dressing and the method of preparation provided in examples 1-3 were observed as shown in the following table:
and (4) judging the standard: the silver ion antibacterial agent has the antibacterial effect of the material, can inhibit the growth, reproduction or kill microorganisms, has the adsorption effect on the microorganisms in the liquid, can lose the effect of the enzymes playing a breathing role after the microorganisms are adsorbed by the silver, can rapidly die, has extremely strong bactericidal capacity of the silver ions, thereby improving the antibacterial effect of the dressing, has the disinfection function through the matching use of the alginate, can stop bleeding and inhibit bacteria, can stop bleeding on wounds, reduces the risk of infection of the wounds to a certain extent, has obvious use effect, and can assist the healing of the wounds by matching the natural hyaluronic acid of human bodies with other medicaments for promoting cell regeneration and removing wrinkles to prepare a gel through the matching use of the sodium hyaluronate, meanwhile, the dressing can repair scars to a certain extent, so that the use functionality of the dressing is improved, the foam stabilizer has fine and uniform air holes, when the system is in a low viscosity stage, the air holes can grow to the thickness suitable for opening the holes, conditions are created for final opening the holes, the production quality of the foam dressing is improved to a certain extent, the surfactant is used in combination, the surfactant is a substance which can obviously reduce the surface tension of a target solution, and has fixed hydrophilic lipophilic groups, so that the use effect of the dressing is effectively improved, the durability of the dressing antibacterial property can be improved by using the perfluoro methyl acrylate in combination, the repeated replacement of a user is avoided, the trouble of the user is reduced to a certain extent, meanwhile, the phenomenon that the replacement times are too many to be not beneficial to wound healing is avoided, and the wound recovery is facilitated, through the cooperation of aromatic, can increase the fragrant smell of dressing, can alleviate user's mood.
The experimental method comprises the following steps: preparing materials required for preparation according to a ratio for later use, fusing the raw materials and water in a stirring manner, wherein the water required for mixing is hot water and can shorten the mixing time of the raw materials and the water so as to obtain a solvent, then sequentially adding a silver ion antibacterial agent, an alginate agent, a sodium hyaluronate agent, a foam stabilizer, a surfactant and perfluoromethyl acrylate, carrying out secondary mixing and stirring, wherein the stirring and fusing manner is a stirring motor, the model of the used stirring motor is Y100L-2, the stirring time is 30-40 minutes, the stirring temperature is 50 ℃, then carrying out impurity removal treatment on the fused materials, then adding an aromatic, mixing the materials in a manual stirring manner so as to increase the functionality of the dressing, next pressing and molding the mixed materials to obtain a molded dressing, and drying the molded dressing by a fan, the model of the fan is XG-3, the drying time is 3-4 hours, and after the drying is finished, the patch with uniform size is prepared and can be directly used for the wound of a user.
Claims (9)
1. The antibacterial foam dressing is characterized by comprising the following raw materials in parts by weight: 100-200 parts of raw materials, 100-300 parts of water, 50-150 parts of silver ion antibacterial agent, 50-150 parts of alginate agent, 90-110 parts of sodium hyaluronate agent, 120-140 parts of foam stabilizer, 100-120 parts of surfactant, 80-100 parts of aromatic and 100-120 parts of perfluoromethyl acrylate.
2. The antimicrobial foam dressing of claim 1, wherein said surfactant is an ionic surfactant and said silver-ion antimicrobial agent is one of the antimicrobial materials.
3. The antibacterial foam dressing of claim 1, which is characterized by comprising the following raw materials in parts by weight: the ratio of the silver ion antibacterial agent to the alginate agent is 1: 1.
4. The antimicrobial foam dressing of claim 1, wherein said fragrance is limonene and starting material is glycolic acid copolymer.
5. The antimicrobial foam dressing of claim 1, wherein the water is deionized water, and the deionized water is near-pure water obtained by removing ionic impurities from water through an ion exchange resin.
6. A preparation method of an antibacterial foam dressing is characterized by comprising the following steps: the method comprises the following steps:
s1: preparing the raw materials in the proportion, and removing impurities in the raw materials to enable the raw materials to be in a pure state;
s2: adding the raw materials into water, wherein the water is hot water with the temperature of 50-70 ℃, and fusing the raw materials and the water in a manual stirring manner for 3-5 minutes;
s3: after water and raw materials are mixed, sequentially adding a silver ion antibacterial agent, an alginate agent, a sodium hyaluronate agent, a foam stabilizer, a surfactant and methyl perfluoroacrylate, carrying out secondary mixing and stirring, heating the raw materials while stirring, and enabling the heating temperature to be uniform, so that a fusion effect is achieved, and a mixed dressing solution is obtained;
s4: when the dressing solution is mixed into paste, stopping stirring the dressing solution, placing the dressing solution in a container, and waiting for cooling in a standing way;
s5: cooling the dressing solution to constant temperature for 20-40 min, adding prepared aromatic solution, and manually shaking the container to mix the aromatic solution and the dressing solution for emitting fragrance;
s6: pouring the dressing solution into a prepared container, carrying out molding operation on the dressing solution in a high-temperature mode to make the dressing solution into a dressing, and then pressing and molding the dressing in a pressing mode, wherein the pressing mode is manual pressing;
s7: the formed dressing is cut into the application with uniform size, the length of the application is 4-6cm, and the prepared application can be directly used at the wound of a user or used in an auxiliary way.
7. The method for preparing an antibacterial foam dressing according to claim 1, wherein the method comprises the following steps: according to S3, a stirring motor is adopted for mixing and stirring, the model is Y100L-2, the stirring time is 30-40 minutes, and the stirring temperature is 50 ℃.
8. The method for preparing an antibacterial foam dressing according to claim 1, wherein the method comprises the following steps: in the step S4, the cooling mode is natural cooling, and the cooling time is 40-60 minutes.
9. The method for preparing an antibacterial foam dressing according to claim 1, wherein the method comprises the following steps: according to S6, the drying mode is fan drying, the model of the fan is XG-3, and the drying time is 3-4 hours.
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| CN202110465683.8A CN113101408A (en) | 2021-04-28 | 2021-04-28 | Antibacterial foam dressing and preparation method thereof |
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| CN110368514A (en) * | 2019-09-04 | 2019-10-25 | 上海凌仕医疗科技有限公司 | A kind of dressing and preparation method thereof that can discharge silver ion for a long time |
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2021
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| GB8328516D0 (en) * | 1982-11-09 | 1983-11-23 | Asahi Glass Co Ltd | Preparing perfluoroacrylic acid ester |
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| CN106267314A (en) * | 2016-10-09 | 2017-01-04 | 常州亚环环保科技有限公司 | A kind of preparation method of antibacterial corrosion-resistant bearing hydrocolloid dressing |
| CN110368514A (en) * | 2019-09-04 | 2019-10-25 | 上海凌仕医疗科技有限公司 | A kind of dressing and preparation method thereof that can discharge silver ion for a long time |
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