CN110368514A - A kind of dressing and preparation method thereof that can discharge silver ion for a long time - Google Patents
A kind of dressing and preparation method thereof that can discharge silver ion for a long time Download PDFInfo
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- CN110368514A CN110368514A CN201910830060.9A CN201910830060A CN110368514A CN 110368514 A CN110368514 A CN 110368514A CN 201910830060 A CN201910830060 A CN 201910830060A CN 110368514 A CN110368514 A CN 110368514A
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- dressing
- silver ion
- silver
- long time
- wound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/64—Use of materials characterised by their function or physical properties specially adapted to be resorbable inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
Abstract
The invention discloses a kind of dressing and preparation method thereof that can discharge silver ion for a long time, it is to solve existing silver ion material release and absorbs silver ion and uneven caused problem.The present invention includes dressing ontology, the dressing body surface is provided with one layer containing silver coating, it include silver ion and absorbable polymer containing silver coating, the degradation that silver ion passes through absorbable polymer, slowly and uniformly releases silver ion and be quickly absorbed by tissue, realization plays wound continual and steady antibacterial effect, further solves pain brought by long term frequent dressing and high financial burden for patient.The sustainable long-term performance of product of the invention discharges silver ion, provides continual and steady silver ion for wound, it is ensured that long-term antibacterial effect reduces dressing change frequency, and greatly reduces the pain and financial burden of patient, and use scope is wide.
Description
Technical field
The present invention relates to burn medical dressing field, specifically a kind of dressing that can discharge silver ion for a long time.
Background technique
Chronic and comprehensive wound is the maximum challenge of world health system.These wounds are difficult to cure, and time-consuming
It include limbs excision and death with may cause serious complication.Old man, diabetes, immunosupress and mobile inconvenient group increase
Skin illness rate caused by chronic wounds and other bad as blood circulation, mobile inconvenience is added, for example, bedsore is (decubital to burst
Ulcer), venous stasis ulcers and diabetes.These chronic disease problems can all greatly increase nursing expense and reduce the life of patient
Bioplasm amount.
Wound substantially may be defined as any complete skin injury.Wound is generally divided into acute and chronic.Acute wound
Mouth follows normal healing process, and healing time is generally lower than 8 weeks.Chronic wounds are one not by the wound normally to heal.And
Healing time is much larger than 8 weeks.Wound healing is a complicated process, and be non-fully understood that.But, agglutination point
For the three phases of overlapping: 1, inflammatory phase, blood clot are formed, and the attack of bacterium, key cells enter wound.2, cell increases
The phase is grown, in the continuous hyperplasia of wound histocyte that needs are closed, forms new tissue and capillary (part " granulation " group
It knits).3, the phase is remolded, after wound healing, preliminary cicatricial tissue is formed.After damage 1 year, tensile strength is improved, although healing
Skin strength be not so good as the skin that is not wound, but their intensity can be restored to the 70~80% of green strength.Although most of
Wound healing without unnecessary complication, any interference under situation can lead to a kind of chronic, non-healing of wound.It is any
Be not improved in surrounding, in eight weeks cannot the wound of the moon completely be regarded as chronic, refractory wound.
Wound care is the main project in health care market.Wound care mainly includes two parts: in dry environments
Traditional dressing and the advanced dressing used in moist environment.It has been shown that aerial compared with wound exposure
Way, this healing that can more effectively accelerate wound in moist environment dressing.Traditional dressing is gauze mostly, and this material allows
Wound climate is easy to become very dry, and promotes healthy cell dead, can also damage wound when replacing gauze, because
It causes the adhesion of tissue.In contrast, dampness dressing does not need often to replace, and can be reduced pain when replacement.Although
In this way, tradition dry dressing still occupies more than half of global wound dressing market at present.It is here main that there are two reasons: the
One, traditional dressing compares shallower wound effect or good.Second, it is because it is cheaper than advanced dampness dressing
Much.In addition the advanced dressing of dampness, is lacking in terms of scientific and technical innovation, so that overall technology fails to keep up in time.
In advanced wound care art, there are more and more new pattern compress, specifically includes that hydrogel, hydrocolloid,
Alginates, foam and transparent membrane.And recent years, as the innovation of technology has developed a series of new dressing again: including
Antimicrobial component, growth factor, other drugs or biological component, to reinforce protecting the main purpose of wound ability.These are new
Kind can be segmented are as follows: provide the antibiotic property dressing of antibacterial material, such as silver: the biological dressing containing growth factor, skin to wound
Skin substitute and tissue engineering product etc..
" silver " is a kind of material for being used to treat wound tissue gradually popularized in recent years.Methicillin-resistant Staphylococcus color staphylococcus
The health of patient has not only been threatened, but also has aggravated the financial burden of medical care mechanism." silver " then can solve this problem.It
With antibiotic property and hypotoxicity.Nanocrystal silver in dressing becomes the great advantage in this field.Nano silver resists naturally
Raw effect is more significant, because the smallest Argent grain is easier to react with bodily tissue.Just because of its nanoscale crystallization silver
Particle size very little is easy release, is easy to be absorbed by tissue and work, but the release and absorption of silver ion and uneven, entirety
Early period (in 1~2 day) quick release and absorption reach peak value, be gradually reduced later, this generates pole to the therapeutic effect in later period
Big influence.People are also in the research for carrying out related fields.
Summary of the invention
The embodiment of the present invention is designed to provide a kind of dressing that can discharge silver ion for a long time, to solve above-mentioned background skill
The problem of being proposed in art.
To achieve the above object, the embodiment of the present invention provides the following technical solutions:
A kind of dressing that can discharge silver ion for a long time, including dressing ontology, the dressing body surface are provided with one layer of argentiferous and apply
Layer includes silver ion and absorbable polymer containing silver coating, and silver ion is slowly and uniform by the degradation of absorbable polymer
It releases silver ion and is quickly absorbed by tissue, realization plays wound continual and steady antibacterial effect, is further trouble
Person solves pain brought by long term frequent dressing and high financial burden.
As further embodiment of the embodiment of the present invention: dressing ontology includes the dressing of hydrophily class, the dressing of argentiferous class, foam
Any one material production in dressing, alginic acid salt dressing etc..
As further embodiment of the embodiment of the present invention: dressing ontology includes PVP(polyvinylpyrrolidone), PEO(polyoxy
Change ethylene), PEG(polyethylene glycol) material, alginate fiber, polyurethane foam, PVA(polyvinyl alcohol) foam, sheet high score
The production of at least one of sub- hydrogel and hydrocolloid material.
As further embodiment of the embodiment of the present invention: silver ion is replaced with to the chelate or silver ion of silver ion
Complex compound, further using sodium zirconium phosphate silver, flamazine, silver carbonate and silver sulfate etc..
As further embodiment of the embodiment of the present invention: absorbable polymer is mainly used for making the carrier of silver ion, simultaneously
It can also be compounded in dressing body surface, so that the slow release silver ion in dressing ontology use process, is used for absorbing polymer
The compound of object include lactide, glycolide and caprolactone homopolymer perhaps one of copolymer or its polymer or
Several blend of person.
As further embodiment of the embodiment of the present invention: content of the silver ion in dressing ontology be 0.01-100 microgram/
Square centimeter.
The preparation method of the dressing that silver ion can be discharged for a long time is as follows；Silver ion and absorbable polymer is completely molten
Solution in organic solvent, forms the compound of silver ion, and the compound of silver ion is evenly applied to dressing body surface,
After organic solvent volatilization, uniform coating can be formed in dressing body surface to get finished product is arrived.
As further embodiment of the embodiment of the present invention: organic solvent is polar organic solvent, including methylene chloride, third
At least one of ketone, chloroform, water, dioxane, dimethyl sulfoxide or dimethylformamide.
Compared with prior art, the beneficial effect of the embodiment of the present invention is:
The sustainable long-term performance of product of the invention discharges silver ion, provides continual and steady silver ion for wound, it is ensured that long-term
Antibacterial effect reduces dressing change frequency, and greatly reduces the pain and financial burden of patient, and use scope is wide.
Detailed description of the invention
Fig. 1 is the change curve that can discharge embodiment 1-6 and comparison 1-2 silver content in the dressing of silver ion for a long time.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
By 5 microgram sodium zirconium phosphate silver and 1 gram of PLLA polymer, it is dissolved in dichloromethane solvent, dissolution completely, obtains
Ag-containing solution composition.The composition is uniformly applied to by syringe has the aerogel dressing table having a size of 10 × 10cm
On face.8 hours are stood in room temperature, obtains sheet argentiferous aerogel dressing.Silver ion content is 0.5 micro- gram/cm.
Embodiment 2
It is to be dissolved complete in chloroform solvent by 500 microgram flamazines and 1 gram of PDLLA polymer, obtain argentiferous
Liquid composite.The composition is uniformly applied to by syringe has the bearing hydrocolloid dressing surface having a size of 10 × 10cm
On.10 hours are stood in room temperature, obtains sheet silver-bearing hydrocolloid dressing.Silver content is 50 micro- grams/cm.
Embodiment 3
It is to be dissolved complete in acetone solvent by 250 microgram silver carbonates and 1 gram of PLGA polymer, obtain Ag-containing solution
Composition.The composition is uniformly applied to by syringe to be had on the bearing hydrocolloid dressing surface having a size of 10 × 10cm.In
6 hours are stood in room temperature, obtains sheet argentiferous alginate dressing.Silver content is 25 micro- grams/cm.
Embodiment 4
It is to be dissolved complete in dioxane solvent by 10 microgram flamazines and 10 grams of PCL polymer, contained
Silver-colored liquid composite.The composition is uniformly applied to by syringe has the PVA foam dressing table having a size of 10 × 20cm
On face.10 hours are stood in room temperature, obtains sheet silver-bearing hydrocolloid dressing.Silver content is 0.05 micro- gram/cm.
Embodiment 5
It is to be dissolved complete in dimethyl sulfoxide solvent by 40 microgram silver sulfates and 10 grams of PCLLA polymer, contained
Silver-colored liquid composite.The composition is uniformly applied to by syringe has the Silica hydrogel dressing surface having a size of 6 × 20cm
On.3 hours are stood in room temperature, obtains sheet argentiferous Silica hydrogel dressing.Silver content is 0.33 micro- gram/cm.
Embodiment 6
60 microgram silver are ground into the PGA polymer of fine powder and 10 grams, disperses and is dissolved in solvent dimethylformamide,
After the complete silver powder of object dissolution to be polymerized is uniformly dispersed, the polymeric composition of argentiferous is obtained.The composition is equal by syringe
Even be applied to has on the Silica hydrogel dressing surface having a size of 10 × 10cm.3 hours are stood in room temperature, it is solidifying to obtain sheet argentiferous silicon
Glue dressing.Silver content is 0.6 micro- gram/cm.
Comparative example 1
It is to be dissolved complete in dioxane solvent by 50 microgram flamazines, obtain Ag-containing solution composition.By the group
Closing object and being uniformly applied to by syringe has on the aerogel dressing surface having a size of 6 × 150cm.It is small that 3 are stood in room temperature
When, obtain sheet argentiferous aerogel dressing.Silver content is 0.06 micro- gram/cm.
Comparative example 2
It is to be dissolved complete in dichloromethane solvent by 30 microgram sodium zirconium phosphate silver, obtain Ag-containing solution composition.By the group
Closing object and being uniformly applied to by syringe has on the bearing hydrocolloid dressing surface having a size of 10 × 10cm.It is small that 3 are stood in room temperature
When, obtain sheet silver-bearing hydrocolloid dressing.Silver content is 0.3 micro- gram/cm.
The product of embodiment 1-6 heat-emitting products and comparative example 1-2 are carried out to the result test of silver content and antibiotic rate respectively,
The specific method is as follows:
The product of embodiment 1-6 and comparative example 1-2: being adhered to rabbit's foot surface by the test of silver-colored release profiles respectively, and with stretching tight
Band is fixed.Respectively in 30min, 8h, for 24 hours, 3 days, 7 days, 16 days, 30 days.Take out the wound group of rabbit dressing adhered area range
It knits, is contained with perchloric acid, hydrofluoric acid and nitric acid dissolution process, then respectively with the silver in atomic absorption spectrophotometer measurement tissue
Amount, the results are shown in Table 1.
1 rabbit surface texture silver content of table
From table 1 it follows that product of the product of embodiment 1-6 relative to comparative example 1-2: silver is bright in the release of animal tissue
Powerful and influential mitigation and uniform more, it is often more important that, it is to reach release time 30 days, and content is also relatively high, and comparative example
The product of 1-2 has been almost then 0 at 16 days.As it can be seen that be solved by this invention ask is fully achieved in the product of embodiment 1-6
The purpose of topic.
The working principle of the embodiment of the present invention is: dressing ontology absorption speed is fast, has good biocompatibility, is able to maintain
The suitable humidity of wound forms a kind of microenvironment for being conducive to wound healing, creates a good environment for tissue is newborn.
This product is primarily used for burn, wound, acute and chronic skin tissue wounds debridement and keeps moist
The dressing of Curing circumstance, wound debriding agent, corium debridement agent etc. should be also included wherein.
Silver ion is mainly elemental silver or the relevant compound of silver ion, elemental silver or silver ion relevantization in this product
The advantages that closing object is generally acknowledged because it is with good antibacterial spectrum, and germicidal efficiency is high, is not likely to produce drug resistance, extensively at present
It is used for antibiotic and sterilizing class product.Its major antibacterial effect have it is following several, 1) Electrostatic Absorption sterilization；2) metal dissolving is sterilized；
3) photo-catalyst；4) compound action is sterilized.The relevant compound of silver ion is mainly combined in the form of secondary or physical bond with dressing ontology,
Such as hydrogen bond, Van der Waals force, intermolecular force.
Superfines can be made by mechanical in elemental silver, then is having with hydrophilic high molecular material or absorbable polymer
It dissolves and is uniformly dispersed in solvent, composition silver composition is applied on dressing body surface, and organic solvent volatilization obtains
Finished product.Wound tissue's continuous sepage of meeting in agglutination early period, dressing ontology will absorb sepage constantly to keep hurting at this time
Mouthful wet environment, while dressing body surface containing silver coating due to hydrophilic high molecular material contact tissue sepage
Cheng Zhong can slowly dissolve high molecular material, the slow release elemental silver in course of dissolution, to persistently resist for organizational environment performance
The effect of bacterium.In addition, the relevant compound of silver ion can be directly with hydrophilic high molecular material or absorbable polymer organic
It is dissolved completely in solvent, composed Ag-containing solution composition is directly applied on dressing ontology, and organic solvent volatilization obtains
Finished product.In use, with the degradation of absorbable polymer, slowly from containing releasing silver ion in silver coating, due to can
The degradation of absorbing polymeric be it is slow, stablize and lasting process, therefore silver ion release also with the drop of absorbable polymer
Solution is consistent, to provide lasting, stable a, process for slow release silver ion to wound, and in silver ion
Entire release process be all it is gentle, there is no violent release point, because of violent release meeting so that tissue local silver content within certain a period of time
The problem of instantaneously increasing so as to cause histocyte " silver " poisoning, eventually leading to patient body function various aspects, seriously affects trouble
The health of person.Therefore, gentle, stable, lasting silver-colored release process is ideal delivery mode and the present invention to solve
The key point of present problems.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.No
It should treat any reference in the claims as limiting the claims involved.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (7)
1. one kind can discharge the dressing of silver ion, including dressing ontology for a long time, the dressing body surface is provided with one layer of argentiferous
Coating, which is characterized in that containing silver coating include silver ion and absorbable polymer.
2. the dressing according to claim 1 that silver ion can be discharged for a long time, which is characterized in that the dressing ontology is using parent
Any one in aqueous class dressing, the dressing of argentiferous class, foam dressing and alginic acid salt dressing.
3. the dressing according to claim 1 that silver ion can be discharged for a long time, which is characterized in that the silver ion replaces with silver
The chelate of ion or the complex compound of silver ion.
4. the dressing according to claim 1 or 2 that silver ion can be discharged for a long time, which is characterized in that the absorbable polymerization
Object includes at least one of homopolymer and copolymer of lactide, glycolide and caprolactone.
5. the dressing according to claim 1 that silver ion can be discharged for a long time, which is characterized in that the silver ion is in dressing sheet
Content in body is micro- gram/cm of 0.01-100.
6. a kind of preparation method of the dressing a method as claimed in any one of claims 1 to 5 that can discharge silver ion for a long time, which is characterized in that
Specific step is as follows: silver ion and absorbable polymer are completely dissolved to the compound for forming silver ion in organic solvent,
The compound of silver ion is evenly applied to dressing body surface can be in dressing body surface shape after organic solvent volatilization
At uniform coating to get arrive finished product.
7. the preparation method of the dressing according to claim 6 that silver ion can be discharged for a long time, which is characterized in that described organic
Solvent includes at least one in methylene chloride, acetone, chloroform, water, dioxane, dimethyl sulfoxide or dimethylformamide
Kind.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910830060.9A CN110368514A (en) | 2019-09-04 | 2019-09-04 | A kind of dressing and preparation method thereof that can discharge silver ion for a long time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910830060.9A CN110368514A (en) | 2019-09-04 | 2019-09-04 | A kind of dressing and preparation method thereof that can discharge silver ion for a long time |
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| Publication Number | Publication Date |
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| CN110368514A true CN110368514A (en) | 2019-10-25 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111731671A (en) * | 2020-06-28 | 2020-10-02 | 四川汇利实业有限公司 | Composite material for liquid medicine packaging bag |
| CN113101408A (en) * | 2021-04-28 | 2021-07-13 | 南昌智产科技有限公司 | Antibacterial foam dressing and preparation method thereof |
| CN114515225A (en) * | 2020-11-18 | 2022-05-20 | 正美企业股份有限公司 | Wound dressing |
-
2019
- 2019-09-04 CN CN201910830060.9A patent/CN110368514A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111731671A (en) * | 2020-06-28 | 2020-10-02 | 四川汇利实业有限公司 | Composite material for liquid medicine packaging bag |
| CN114515225A (en) * | 2020-11-18 | 2022-05-20 | 正美企业股份有限公司 | Wound dressing |
| CN114515225B (en) * | 2020-11-18 | 2022-11-15 | 正美企业股份有限公司 | Wound dressing |
| CN113101408A (en) * | 2021-04-28 | 2021-07-13 | 南昌智产科技有限公司 | Antibacterial foam dressing and preparation method thereof |
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Application publication date: 20191025 |