CN103143053A - Novel povidone-iodine antibacterial hydrocolloid dressing and preparation method thereof - Google Patents
Novel povidone-iodine antibacterial hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN103143053A CN103143053A CN2013100944687A CN201310094468A CN103143053A CN 103143053 A CN103143053 A CN 103143053A CN 2013100944687 A CN2013100944687 A CN 2013100944687A CN 201310094468 A CN201310094468 A CN 201310094468A CN 103143053 A CN103143053 A CN 103143053A
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Abstract
The invention provides a novel povidone-iodine antibacterial hydrocolloid dressing and a preparation method thereof. The preparation method comprises the following steps of: (a) adding styrene-isoprene segmented copolymer and mineral oil (medical-grade white oil) into an internal mixer at a temperature of between 120 and 170 DEG C, and softening for 5 to 10 minutes; (b) dosing tackifying resin and an antioxidant into the softened styrene-isoprene segmented copolymer, and mixing to obtain premix; (c) adding hydrocolloid particles, sodium carboxymethylcellulose and carboxymethyl chitosan into the premix; (d) uniformly spraying povidone-iodine into the mixture obtained in step (c) by using a povidone-iodine complex device; and (e) applying to a copolymer film or non-woven fabric, namely coating the hydrocolloid layer to a back-lining layer. The copolymer film or glassine paper is coated on the prepared hydrocolloid layer, which means that a release layer is coated on the hydrocolloid layer to obtain the povidone-iodine antibacterial hydrocolloid dressing. The povidone-iodine antibacterial hydrocolloid dressing has the advantages of reducing the side effect of antibiosis and improving the effect of constant antibiosis.
Description
Technical field
the present invention relates to composition of a kind of new bio medical macromolecular materials and preparation method thereof, particularly relate to and a kind ofly have antibioticly, accelerate novel povidone-iodine antibacterial bearing hydrocolloid dressing of wound healing function and preparation method thereof.
Background technology
since the eighties in last century, wound dressing has had large development.Alternative dressing on market now, except traditional dressing (comprising gauze and artificial synthetic fiber), various modern dressing and active dressing have also occurred.Wherein mainly to take aerogel dressing, alginate dressing, bearing hydrocolloid dressing and the dressing of foam class be representative in modern dressing, and that active dressing mainly relates to is antibiotic and containing the dressing of somatomedin.Have statistical data to show, end 2012, the utilization rate of Foreign Modern dressing reaches 35%; And the utilization rate of modern domestic dressing only has 10%, the market space is wide.Bearing hydrocolloid dressing in modern dressing has can absorb wound fluid, keeps wound surface clean moistening, reduces cicatrix shape, and the characteristics that promote wound healing, mainly be applicable to all kinds of low, the exudative wounds of moderate, venous leg ulcers, various shallow wounds and shaping and beauty wound etc.Comprise the polyamino Ethyl formate layer (being backing layer) of outer field softness and tool water proofing property and being mixed with hydrophobic polymer by hydrophilic granules of internal layer by functional stratification, the hydrocolloid layer that hydrophilic particle is surrounded by hydrophobic polymer and be located at the peel ply on the hydrocolloid layer.It is to dry and the moist equal Pasting of wound.In addition, in bearing hydrocolloid dressing, modal gel is hydroxy methocel, and this gel can be pasted on wound edge skin securely, but 12 times of swelling after absorbing sepage.Along with the industrialization conversion of technology, the demand of active medical antiseptic dressing on market is increasing.And mostly adopt the active medical antiseptic dressing all with the method for adding metal ion (as silver ion), to reach antibiotic purpose, dressing as active as silver-ion antibiotic, in this silver dressings or surface scribble silver ion, argent or silver compound.Its advantage is to discharge silver ion for sterilization, infection control; Promote the granulation tissue growth; Dissolve slough etc.But argyrosis (Argyria) is to use the common side effect of silver dressings product.After using the argentiferous medical dressing on wound, with anion, from dressing, be discharged into wound, form black Argentous sulfide. precipitation under illumination.This class Argentous sulfide. granule (diameter 30 ~ 100nm) the most easily is gathered in around sweat gland and hair follicle, and the human body such as nail matrix, forms melanin.External, use silver dressings time period of greater than two months also to need to re-start assessment, and can not use on the good granulation wound of producing.
Summary of the invention
the purpose of this invention is to provide the antibiotic side effect of a kind of minimizing, increase novel povidone-iodine antibacterial bearing hydrocolloid dressing that continues antibacterial effect and preparation method thereof.
for achieving the above object, the technical solution adopted in the present invention is:
a kind of novel povidone-iodine antibacterial bearing hydrocolloid dressing and preparation method thereof, its characteristics are: comprising: styrene-isoprene block copolymer 15 ~ 30%, mineral oil (medical grade white oil) 5 ~ 15%, 10 ~ 15% tackifying resin and 20 ~ 45% one or more hydrocolloid particles, sodium carboxymethyl cellulose 15 ~ 35%, carboxymethyl chitosan 2 ~ 5% and 0 ~ 5% antioxidant, 5 ~ 15% povidone iodine, wherein the available iodine content of povidone iodine is 5 ~ 10%.
a kind of preparation method of novel povidone-iodine antibacterial bearing hydrocolloid dressing:
a) add styrene-isoprene block copolymer, mineral oil (medical grade white oil) at banbury at the temperature of 120 ~ 170 ℃, softening 5-10 minute;
b) tackifying resin, antioxidant are dropped in softening styrene isoprene styrene block copolymer (SIS) and mix, obtain pre-composition;
c) add hydrocolloid particle, sodium carboxymethyl cellulose and carboxymethyl chitosan in pre-composition;
d) with povidone iodine complexation device, povidone iodine is evenly sprayed to c) in;
e) coating, on polymeric film or non-woven fabrics, the hydrocolloid layer is coated on backing layer.Again on the hydrocolloid layer of preparation coated with polymeric film or Ge Laxin paper, on the hydrocolloid layer, cover peel ply, obtain the povidone-iodine antibacterial bearing hydrocolloid dressing.
advantage of the present invention is:
1, can absorb wound surface exudate and some noxious substances
2, chelated iodine: in this product, hydrocolloid and povidone iodine complexation form unique lasting antibacterial effect, thereby have avoided the side effect brought because metal ion is antibiotic.
3, keep wound surface moistening, for the healing of focus wound surface provides outside the microenvironment an of the best.
4, can slowly discharge free-iodine, maintain the effect of lasting kill bacteria, fungus, virus, effectively prevent the infection of wound.
5, there is autohension, easy to use, during replacing not with wound surface adhesion, no pain.
6, good biocompatibility, it is comfortable that user is felt, and outward appearance is hidden.
7, stronger pliability is arranged, can effectively intercept the intrusion of extraneous graininess foreign body as dust and antibacterial, resist involving and mechanical stimulus of wound.
The specific embodiment
below with specific embodiment, the present invention is described further:
a kind of novel povidone-iodine antibacterial bearing hydrocolloid dressing and preparation method thereof: novel povidone-iodine antibacterial bearing hydrocolloid dressing has can absorb wound fluid, keep wound surface clean moistening, reduce cicatrization, stop antibacterial to be invaded, protect from infection, and the characteristics that promote wound healing, skin is the polyamino Ethyl formate layer of softness and tool water proofing property; Internal layer is to be mixed with hydrophobic polymer by hydrophilic granules, the hydrocolloid layer that hydrophilic particle is surrounded by hydrophobic polymer.The composition quality percentage ratio of hydrocolloid layer is: styrene-isoprene block copolymer 15 ~ 30%, mineral oil (medical grade white oil) 5 ~ 15%, 10 ~ 15% tackifying resin and 20 ~ 45% one or more hydrocolloid particles, sodium carboxymethyl cellulose 15 ~ 35%, the thickness of carboxymethyl chitosan 2 ~ 5% and 0 ~ 5% antioxidant, 5 ~ 15% povidone iodine (available iodine content is 5 ~ 10%) hydrocolloid layer is 2 ~ 4mm.
the preparation process of povidone-iodine antibacterial bearing hydrocolloid dressing is: at first, get styrene-isoprene block copolymer by composition proportion and mineral oil is dissolved in reactor at the temperature of 120 ~ 170 ℃; Be cooled to 50 ℃, add tackifying resin, antioxidant, stir 15min, fetch water colloidal particle, sodium carboxymethyl cellulose and carboxymethyl chitosan, by after three kinds of material mix homogeneously, slowly join in reactor again, stir while adding, after complete mix homogeneously forms homogeneous solution, under agitation, evenly spray betagen solution; Mixture by obtaining, be uniformly coated on after cooling on polymeric film or non-woven fabrics, and the hydrocolloid layer is coated on backing layer, then cooling; Coated with polymeric film or Ge Laxin paper, on the hydrocolloid layer, cover peel ply on the hydrocolloid layer of preparation, obtain active bearing hydrocolloid dressing, packing.
embodiment 1
get 2.0kg styrene-isoprene block copolymer and 1.5kg medical grade white oil is dissolved in reactor, temperature is controlled at 120 ~ 170 ℃; After styrene-isoprene block copolymer dissolves fully, add the 1.5kg isoprene rubber in reactor, insulation a period of time; Get 1.6kg hydrocolloid particle, 3.8kg sodium carboxymethyl cellulose and 0.2kg carboxymethyl chitosan mix homogeneously; Then slowly join in reactor, constantly stir, after complete mix homogeneously, evenly spray betagen solution, the cooling deaeration; Then the mixture obtained is uniformly coated on thin polymeric film, and the hydrocolloid layer is coated on backing layer, and the thickness of hydrocolloid layer is 3.5mm, cooling; Finally on the hydrocolloid layer coated with Ge Laxin paper, on the hydrocolloid layer, cover peel ply, then the packing.
embodiment 2
get 1.5kg styrene-isoprene block copolymer and 1.2kg medical grade white oil is dissolved in reactor, temperature is controlled at 120 ~ 170 ℃; After styrene-isoprene block copolymer dissolves fully, add 1.8kg Colophonium in reactor, insulation a period of time; Get 2.0kg hydrocolloid particle, 2.8 kg sodium carboxymethyl cellulose and 0.27kg carboxymethyl chitosan mix homogeneously, then slowly join in reactor, constantly stir, after complete mix homogeneously, evenly spray povidone iodine, the cooling deaeration; Then the mixture obtained is uniformly coated on thin polymeric film, and the hydrocolloid layer is coated on backing layer, and the thickness of hydrocolloid layer is 2.5mm, cooling; Finally on the hydrocolloid layer coated with Ge Laxin paper, then the packing.
the invention has the beneficial effects as follows:
it is the formed complex of iodine and polyvinylpyrrolidine that the present invention utilizes povidone iodine, for antibacterial, fungus, virus, protozoon etc. have efficiently, the broad-spectrum bactericidal action of good, low toxicity, and to burn and scald, skin ulcer, gynaecopathia, prevention and auxiliary treatment sexually transmitted disease (STD) effect outstanding feature, employing evenly is sprayed at by previously prepared betagen solution the mode that forms complex in the hydrocolloid premixed liquid and prepares the povidone-iodine antibacterial bearing hydrocolloid dressing, adhere to focus, directly act on affected part and its close contact, be conducive to slow and lasting being released on focus of free-iodine in povidone iodine, focus is had to the covering protection effect, non-stimulated, curative effect improves and few side effects, promoting wound healing, play certain bacteriostasis when reducing cicatrix.
embodiment recited above is described the preferred embodiment of the present invention; not design of the present invention and protection domain are limited; under the prerequisite that does not break away from design concept of the present invention; various modification and improvement that in this area, common engineers and technicians make technical scheme of the present invention, all should fall into protection scope of the present invention.
Claims (2)
1. a novel povidone-iodine antibacterial bearing hydrocolloid dressing, its characteristics are: comprising: styrene-isoprene block copolymer 15 ~ 30%, mineral oil (medical grade white oil) 5 ~ 15%, 10 ~ 15% tackifying resin and 20 ~ 45% one or more hydrocolloid particles, sodium carboxymethyl cellulose 15 ~ 35%, carboxymethyl chitosan 2 ~ 5% and 0 ~ 5% antioxidant, 5 ~ 15% povidone iodine, wherein the available iodine content of povidone iodine is 5 ~ 10%.
2. the preparation method of a novel povidone-iodine antibacterial bearing hydrocolloid dressing comprises that following step is poly-:
a) add styrene-isoprene block copolymer, mineral oil (medical grade white oil) at banbury at the temperature of 120 ~ 170 ℃, softening 5-10 minute;
b) tackifying resin, antioxidant are dropped in softening styrene isoprene styrene block copolymer (SIS) and mix, obtain pre-composition;
C) add hydrocolloid particle, sodium carboxymethyl cellulose and carboxymethyl chitosan in pre-composition;
d) with povidone iodine complexation device, povidone iodine is evenly sprayed to c) in;
E) coating, on polymeric film or non-woven fabrics, the hydrocolloid layer is coated on backing layer;
Again on the hydrocolloid layer of preparation coated with polymeric film or Ge Laxin paper, on the hydrocolloid layer, cover peel ply, obtain the povidone-iodine antibacterial bearing hydrocolloid dressing.
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| CN2013100944687A CN103143053A (en) | 2013-03-24 | 2013-03-24 | Novel povidone-iodine antibacterial hydrocolloid dressing and preparation method thereof |
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| CN2013100944687A CN103143053A (en) | 2013-03-24 | 2013-03-24 | Novel povidone-iodine antibacterial hydrocolloid dressing and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520765A (en) * | 2013-11-06 | 2014-01-22 | 中国科学院长春应用化学研究所 | Method for preparing wound hemostasis dressing |
| CN104208744A (en) * | 2014-09-17 | 2014-12-17 | 云南白药集团股份有限公司 | Antibacterial adhesive bandage containing povidone iodine |
| CN104474570A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Medical povidone-iodine dressing and preparation method thereof |
| CN106729961A (en) * | 2016-12-19 | 2017-05-31 | 广东泰宝医疗器械技术研究院有限公司 | A kind of moisture absorption antibacterial bearing hydrocolloid dressing and preparation method thereof |
| CN106821769A (en) * | 2015-12-07 | 2017-06-13 | 北京乳凝创智生物技术研发中心（有限合伙） | New parents' gel membrane material and preparation method thereof |
| WO2020226575A3 (en) * | 2019-04-23 | 2021-01-21 | Singhalak Sirisut | The method of invention of a drug for treatment of diabetic ulcer and rare healing ulcers |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352551A (en) * | 1999-05-27 | 2002-06-05 | 尤罗塞尔蒂克股份有限公司 | Preparations for the application of anti-inflammatory agents |
| CN101130105A (en) * | 2007-09-13 | 2008-02-27 | 郑州大学 | Wound dressing of povidone iodine hydrogel and radiation preparation method of the same |
| CN102078325A (en) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | Nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid |
| CN102379773A (en) * | 2011-08-18 | 2012-03-21 | 苏州美迪斯医疗运动用品有限公司 | Self-adhesive elastic bandage capable of being directly used on wound |
| CN102716509A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid |
-
2013
- 2013-03-24 CN CN2013100944687A patent/CN103143053A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352551A (en) * | 1999-05-27 | 2002-06-05 | 尤罗塞尔蒂克股份有限公司 | Preparations for the application of anti-inflammatory agents |
| CN101130105A (en) * | 2007-09-13 | 2008-02-27 | 郑州大学 | Wound dressing of povidone iodine hydrogel and radiation preparation method of the same |
| CN102078325A (en) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | Nasal composition containing povidone iodine and cyclodextrin inclusion of glucocorticoid |
| CN102379773A (en) * | 2011-08-18 | 2012-03-21 | 苏州美迪斯医疗运动用品有限公司 | Self-adhesive elastic bandage capable of being directly used on wound |
| CN102716509A (en) * | 2012-06-25 | 2012-10-10 | 武汉纺织大学 | Antibacterial hydrocolloid and preparation method of antibacterial hydrocolloid |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520765A (en) * | 2013-11-06 | 2014-01-22 | 中国科学院长春应用化学研究所 | Method for preparing wound hemostasis dressing |
| CN104208744A (en) * | 2014-09-17 | 2014-12-17 | 云南白药集团股份有限公司 | Antibacterial adhesive bandage containing povidone iodine |
| CN104474570A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Medical povidone-iodine dressing and preparation method thereof |
| CN106821769A (en) * | 2015-12-07 | 2017-06-13 | 北京乳凝创智生物技术研发中心（有限合伙） | New parents' gel membrane material and preparation method thereof |
| CN106729961A (en) * | 2016-12-19 | 2017-05-31 | 广东泰宝医疗器械技术研究院有限公司 | A kind of moisture absorption antibacterial bearing hydrocolloid dressing and preparation method thereof |
| WO2020226575A3 (en) * | 2019-04-23 | 2021-01-21 | Singhalak Sirisut | The method of invention of a drug for treatment of diabetic ulcer and rare healing ulcers |
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Application publication date: 20130612 |