CN104225110A - Traditional Chinese medicine composition for curing microcytic hypochromic anemia and preparation method and application method thereof - Google Patents
Traditional Chinese medicine composition for curing microcytic hypochromic anemia and preparation method and application method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for curing microcytic hypochromic anemia. The traditional Chinese medicine composition for curing microcytic hypochromic anemia is prepared by raw materials of, by weight, 16 parts of lysimachia hypericoides hemsl, 14 parts of blumea, 12 parts of root or leaf of redback christmashush, 10 parts of delavay falsepanax herb, 15 parts of root and rhizome of bloodred iris, 13 parts of plantain, 10 parts of chicken claw wind, 12 parts of dicranostigma leptopodum, 14 parts of walking spleenwort, 18 parts of herb of rednerve ainsliaea, 12 parts of drymoglossum piloselloides presl, 16 parts of root of eggplant, 12 parts of red bartsia, 13 parts of conyza blinii, 11 parts of genista, 13 parts of Scutellaria hypericifolia, 17 parts of ageratum conyzoides, 12 parts of rubus lambertianus, 15 parts of herb of manybranch meadowrue and 13 parts of begonia fimbristipula hance. The traditional Chinese medicine composition for curing microcytic hypochromic anemia can be used for curing the microcytic hypochromic anemia.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that treat microcytic hypochromic anemia.
Background technology
Anemia is classified by erythrocytic morphology, usually can be divided into: macrocytic anemia, normocytic anemia, simple small cell anemia, microcytic hypochromic anemia are that the peritoneum caused by tubercule bacillus is chronic, diffuse inflammation.Microcytic hypochromic anemia mainly comprises: (1) iron deficiency anemia: refer to that a variety of causes makes storage ferrum in body consume idle most, the affected anemia of erythrocytic maturation.Be characterized in lacking the ferrum that can dye in bone marrow, liver, spleen and other tissue.Serum ferritin, serum levels of iron and Transferrin turation reduce.(2) thalassemia: mainly β thalassemia major, light-duty beta Thalassemia, HbH disease.They often have visible most target erythrocyte in family history, blood sheet, and visible fetal hemoglobin (HbF) or HbA2 (HbA2) or HbH increase.The serum levels of iron of patient, Transferrin turation, bone marrow can contaminate ferrum all to be increased.(3) sideroblastic anemia: comprise the hypochrosis that many reasons causes.Haemachrome dyssynthesis and ferrum utilize bad, are the common mechanisms that this type of anemia occurs with the invalid generation of erythrocyte.Its hematological common feature is that in bone marrow, sideroblast significantly increases, ferrum granule wherein in a lot of cell is arranged in ring-type around core, erythrocyte in peripheral blood is obvious low pigment feature, and serum iron significantly increases, and in monokaryon-macrophage, hemosiderin significantly increases.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat microcytic hypochromic anemia.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for microcytic hypochromic anemia, it is prepared by the raw material of following parts by weight: Herba Lysimachiae hypercodis 16 parts, Herba Blumeae Lacerae 14 parts, Radix seu Folium Alchorneae trewioidis 12 parts, Herba seu Radix Nothopanacis delavayi 10 parts, Radix et Rhizoma Iridis Sanguineae 15 parts, 13 parts, Musa basjoo Sieb. Et Zucc. head, curled paralysis 10 parts, Herba Dicranostigmatis Leptopodi 12 parts, determine grass roots 14 parts, Herba Ainsliaeae Rubrinervis 18 parts, Drymoglossum Herba Drymoglossi 12 parts, Fructus Solani melongenae root 16 parts, Herba Odontitis serotinae 12 parts, conyza blinii 13 parts, Flos Caraganae Sinicae 11 parts, meadow Radix Scutellariae 13 parts, Herba Agerati Conyzoidis 17 parts, Rubus lambertianus 12 parts, Herba Thalictri Ramosi 15 parts, Radix Semiaquilegiae 13 parts.
The application of Chinese medicine composition in preparation treatment microcytic hypochromic anemia medicine of described treatment microcytic hypochromic anemia.
Herba Lysimachiae hypercodis in the present invention, Classification system Lysimachia hypericoides Hemsl. is Primulaceae, and storage of gathering summer of gathering dries or using fresh herb, heat-clearing and toxic substances removing, cooling blood for hemostasis.For carbuncle pyogenic infections from tumour or sore, gastrointestinal hemorrhage, metrorrhagia.The present invention is with all herbal medicine.
Herba Blumeae Lacerae is the herb that Compositae Herba Blumeae Balsamiferae platymiscium is shown in white yellow Blumea lacera DC..Spring and summer is gathered, and clean chopping is dried, or fresh leaf.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For tonsillitis, stomatitis, gingival abscess, mumps, infantile pneumonia; Carbuncle pyogenic infections from tumour or sore is controlled in external, skin pruritus.
Radix seu Folium Alchorneae trewioidis is Euphorbiaceae Cortex Alchorneae Davidii platymiscium red back of the body Cortex Alchorneae Davidii Alchornea trewioides (Benth.) Muell.-Arg., is used as medicine with root, leaf.The root four seasons can adopt, and the picking leaves of autumn in summer, dries.Clearing away heat-damp and promoting diuresis, dissipating blood stasis stops blooding.For dysentery, dysuria, hematuria, lithangiuria, redly collapses, leucorrhea, lumbago and skelalgia, treating swelling and pain by traumatic injury; Traumatic hemorrhage is controlled in external, urticaria, eczema.The present invention is used as medicine with root.
Herba seu Radix Nothopanacis delavayi is Herb or the root of Araliaceae Nothopanax, and spring, summer gather, and cleans using fresh herb or dries use.Heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.For acute pharyngitis, acute conjunctivitis, dyspepsia, lumbago, skelalgia of rheumatism; Fracture is controlled in external, traumatic injury.The present invention is used as medicine with Herb.
Radix et Rhizoma Iridis Sanguineae is phytolith limit fragrant Valeriana hardwickii Wall., with root or all herbal medicine.Xia Qiucai, cleans and dries.Acrid, sweet, warm.Promoting blood flow to regulate menstruation, eliminating stasis to stop pain, spleen invigorating removing food stagnancy.For menoxenia, dysmenorrhea, amenorrhea, thromboangiitis obliterans, treating swelling and pain by traumatic injury, lumbago, rheumatic ostalgia, infantile malnutrition, neurasthenia; External training the body is itched.The present invention is with all herbal medicine.
Musa basjoo Sieb. Et Zucc. head is Musaceae banana Musa basjoo Sieb. Et Zucc. Musa basjoo Sieb et Zucc., is used as medicine with root, stem and flower.Root and the stem four seasons can adopt, and clean using fresh herb or dry; Xia Qiu picks flowers flower bud, many using fresh herbs.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, removing heat from blood, pain relieving.For cold cough, headache, hypertension, stomachache, stomachache, hepatitis, dysentery, metrorrhagia, frequent fetal movement, urinary tract infection, edema; Otitis media is controlled in external, wound hemorrhage, carbuncle furuncle and phyma poison.The present invention is used as medicine with root.
Curled paralysis is annonaceae Desmos Lour Desmos chinensis Desmos cochinchinensis Lour., is used as medicine with root and Herb.The whole year can adopt, and clean chopping is dried.Expelling wind and removing dampness, spleen invigorating is regulated the flow of vital energy, stasis-dispelling and pain-killing.For rheumatic arthritis, puerperal exposure to wind pain, puerperal abdonimal pain, bleed more than, dysmenorrhea, stomachache, stomachache, abdominal distention, dyspepsia, diarrhoea, oedema due to nephritis, traumatic injury.The present invention is used as medicine with Herb.
Herba Dicranostigmatis Leptopodi is Papaveraceae convex combination algorithm plant Herba Dicranostigmatis Leptopodi Dicranostigma leptopodum, is generally perennial herb, high 25-80 centimetre, all containing faint yellow juice, by pubescence, rare without hair.Main root is cylindrical.Stem is many, green, tool powder, the most contour branch of top tool.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, parasite killing.For tonsillitis, toothache, tuberculous lymphadenitis; Tinea capitis is controlled in external, tinea corporis.The present invention is with all herbal medicine.
Determining grass roots is that fern Aspleniaceae spleen wort comes into leaves Asplenium trchomanes L. (Asplenium prolongatum Hook)., with all herbal medicine.Spring gathers to Qiu Junke, cleans and dries.Acrid in the mouth, sweet, flat.Removing damp-heat, blood circulation promoting and blood stasis dispelling, relieving cough and resolving phlegm, diuresis lactogenesis.For rheumatalgia, enteritis, dysentery, urinary tract infection, cough with copious phlegm, traumatic injury, spits blood, metrorrhagia, galactostasis; Fracture is controlled in external, traumatic hemorrhage.
Herba Ainsliaeae Rubrinervis is the herb of the red arteries and veins Ainsliaea fragrans Champ. of feverfew.Call pellet of galloping along on horseback, Herba Polygalae Telephioidis, purple back of the body grass, Rhizoma Ardisiae Gigantifoliae, native Ainsliaea fragrans Champ., blood muscle is careless, arhat is careless.Perennial herb, height about 20 ~ 60 centimetres.Rhizome is crawled, and fibrous root is many, longer.Classification system is Herba Ainsliaeae Rubrinervis, expelling wind and cold, cough-relieving, pain relieving.For cough due to wind and cold, headache, rheumatalgia, traumatic injury; Tuberculous lymphadenitis is controlled in external, venom.
Drymoglossum Herba Drymoglossi is that Polypodiaceae Drymoglossum Herba Drymoglossi belongs to small-sized Epiphyte, the antipyretic antiinflammatory of energy, wind dispelling cold expelling, clearing away lung-heat to relieve cough and hemostasis.Classification system is Drymoglossum piloselloides (L.) C.Presl, heat-clearing and toxic substances removing, hemostasia and detumescence.For jaundice, tuberculous lymphadenitis, parotitis, hemoptysis of pulmonary tuberculosis, metrorrhagia, breast carcinoma, traumatic injury.The present invention is with all herbal medicine.
Fructus Solani melongenae root is the root of Solanaceae nightshade white eggplant Solanum melongena L..Autumn uproots, and removing fibrous root and impurity, section is dried.Clearing away heat-damp and promoting diuresis, dispelling wind stopping cough, astringing to arrest bleeding.For rheumatic arthritis, senile chronic tracheitis, edema, chronic cough, chronic dysentery, leucorrhea, seminal emission, hematuria, has blood in stool; External treating chilblain.
Herba Odontitis serotinae, Latin is called Odontites vulgaris Moench, Scrophulariaceae Bartsia annual herb, high 20-70cm.Herb is lied prostrate by towel and the raw thin bristle of white.Stem top branch, four prismatics.Leaf to life, the alternate on top sometimes; Stockless; Blade lanceolar is to strip lanceolar, and it is raw that fringe closes inflorescence top; The florescence 7-8 month.Heat clearing and damp drying, cooling blood and relieving pain.For hot infectious disease, liver and gall stagnant heat, blood stasis is had a pain.The present invention is with all herbal medicine.
Conyza blinii is the false fluffy platymiscium of Compositae little Herba Acroptili repentis Conyza blinii Levl., with all herbal medicine.Autumn gathers, decontamination, using fresh herb or dry in the shade.Heat clearing and inflammation relieving, eliminating fire and detoxication.For acute icterohepatitis, toothache, chronic tracheitis, stomatitis, pharyngolaryngitis, tonsillitis, nephritis, malaria; Eye conjunctivitis is controlled in external, otitis media, skin infection, eczema, traumatic hemorrhage.
Flos Caraganae Sinicae, Latin literary fame: Parochetus communis), for pulse family, purple passeris montani saturati Pittosporum crawl draft, high 10-20 centimetre, by sparse pubescence.Rhizome is thread, and joint is taken root, and has root nodule.Lobe end is slightly sharp, other point two lobes, and gesture passeris montani saturati like flying, coloured gold is yellow, therefore named " Flos Caraganae Sinicae ".Be born in border meadow, hillside, wasteland, roadside, height above sea level 2000-3000 rice.Produce Sichuan, Yunnan, Tibet.India, Nepal, Bhutan, Sri Lanka, Burma, Thailand, Malaysia and eastern Africa also have distribution.Kidney invigorating and YANG supporting, synthetism is stopped blooding.For impotence due to deficiency of the kidney; Wound hemorrhage is controlled in external, injury and bone fracture.The present invention is with all herbal medicine.
Meadow Radix Scutellariae, Latin is called Scutellaria hypericifolia H.L é v., is labiate species.Perennial herb, blade herbaceous stem, most of oval is Long Circle sometimes, and the full edge in edge or idol have wavy, the total shape of inflorescence, white, the green Bai Zhizi of corolla, hyacinthine, upper lip helmet shape, sliver triangular shape oval in lower lip, pyrene ovoid, black.This product originates from Chuan Xi, is used as medicine with root, property bitter cold.Clearing and antitussive, eliminating damp, detoxifying.For cough due to pathogenic wind-heat, jaundice due to damp-heat, high heat headache, conjunctival congestion and swelling pain, dysentery is suffered from abdominal pain, urinary tract infection, frequent fetal movement, carbuncle furuncle furuncle.The present invention is with all herbal medicine.
Herba Agerati Conyzoidis is Compositae Ageratum plant Ageratum conyzoides Ageratum conyzoides L., is used as medicine with herb or leaf and tender stem.Xia Qiu gathers, and cleans, using fresh herb or dry.Pungent, micro-hardship, cool.Expelling wind and clearing away heat, pain relieving, hemostasis, calculus.For upper respiratory tract infection, tonsillitis, pharyngolaryngitis, acute gastroenteritis, stomachache, stomachache, metrorrhagia, renal calculus, vesical calculus; Eczema is controlled in external, thrush, carbuncle pyogenic infections from tumour or sore, cellulitis, ulcer of the lower limb, otitis media, traumatic hemorrhage.The present invention is with all herbal medicine.
Rubus lambertianus is Rosaceae rubus lambert raspberry root, leaf is used as medicine.Autumn excavates, and root cleans section, by vegetable oil, equal amounts of wine and water fried dry.Leaf using fresh herb.Promoting blood flow to regulate menstruation, subduing swelling and detoxicating.For puerperal abdonimal pain, metrorrhagia, lochiopyra, dysmenorrhea, sciatica, rheumatic arthritis, hemiplegia; Wound hemorrhage is controlled in leaf external.The present invention is used as medicine with root.
Herba Thalictri Ramosi is that Ranunculaceae thalictrum spp racemosus Thalictrum aquilegifolium L. var. sibiricum Regel Thalictrum ramosum Boivin is with all herbal medicine.Summer gathers, and cleans and dries.Hardship, cold.Clearing away heat-damp and promoting diuresis, removing toxic substances.For conjunctival congestion and swelling pain, dysentery, hepatitis; Fracture is controlled in external, carbuncle furuncle and phyma poison.Wild Herba Ixeritis Denticulatae: heat-clearing and toxic substances removing, eliminating stasis to stop pain, hemostasis, leukorrhagia stopping.For cervical erosion, leukorrhagia, metrorrhagia, lower lower limb lymphangitis, traumatic injury, innominate toxic swelling, acute mastitis furuncle and phyma, burn and scald, trichomonal vaginitis.
Radix Semiaquilegiae, Latin is called Begonia fimbristipula Hance, belongs to Parietales, the perennial acaulescence draft of Begoniaceae.Root stock is spherical, and Ye Junji is raw, and pollen is red, in May at florescence, really starts June phase.Clearing away heat and cooling blood, relieving cough and resolving phlegm, dissipating blood stasis for subsidence of swelling.For heatstroke fever, cough due to lung-heat, spitting of blood, tuberculous lymphadenitis, abdominal pain due to blood stasis; Bruise is controlled in external, fracture, burn and scald.The present invention is with all herbal medicine.
Beneficial effect: the medicine that the present invention obtains can safe and effective treatment microcytic hypochromic anemia.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, specific embodiment 1: take Herba Lysimachiae hypercodis 16g, Herba Blumeae Lacerae 14g, Radix seu Folium Alchorneae trewioidis 12g, Herba seu Radix Nothopanacis delavayi 10g, Radix et Rhizoma Iridis Sanguineae 15g, Musa basjoo Sieb. Et Zucc. head 13g, curled paralysis 10g, Herba Dicranostigmatis Leptopodi 12g, determine grass roots 14g, Herba Ainsliaeae Rubrinervis 18g, Drymoglossum Herba Drymoglossi 12g, Fructus Solani melongenae root 16g, Herba Odontitis serotinae 12g, conyza blinii 13g, Flos Caraganae Sinicae 11g, meadow Radix Scutellariae 13g, Herba Agerati Conyzoidis 17g, Rubus lambertianus 12g, Herba Thalictri Ramosi 15g, Radix Semiaquilegiae 13g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, fill, be prepared into hard capsule, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of microcytic hypochromic anemia.Oral, every bu is taken for twice sooner or later.
2, specific embodiment 2: take Herba Lysimachiae hypercodis 16g, Herba Blumeae Lacerae 14g, Radix seu Folium Alchorneae trewioidis 12g, Herba seu Radix Nothopanacis delavayi 10g, Radix et Rhizoma Iridis Sanguineae 15g, Musa basjoo Sieb. Et Zucc. head 13g, curled paralysis 10g, Herba Dicranostigmatis Leptopodi 12g, determine grass roots 14g, Herba Ainsliaeae Rubrinervis 18g, Drymoglossum Herba Drymoglossi 12g, Fructus Solani melongenae root 16g, Herba Odontitis serotinae 12g, conyza blinii 13g, Flos Caraganae Sinicae 11g, meadow Radix Scutellariae 13g, Herba Agerati Conyzoidis 17g, Rubus lambertianus 12g, Herba Thalictri Ramosi 15g, Radix Semiaquilegiae 13g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, be prepared into granule, the granule of adult normal's 1 day consumption must be met.Be used for the treatment of microcytic hypochromic anemia.Oral, every bu is taken for twice sooner or later.
3, specific embodiment 3: take Herba Lysimachiae hypercodis 16g, Herba Blumeae Lacerae 14g, Radix seu Folium Alchorneae trewioidis 12g, Herba seu Radix Nothopanacis delavayi 10g, Radix et Rhizoma Iridis Sanguineae 15g, Musa basjoo Sieb. Et Zucc. head 13g, curled paralysis 10g, Herba Dicranostigmatis Leptopodi 12g, determine grass roots 14g, Herba Ainsliaeae Rubrinervis 18g, Drymoglossum Herba Drymoglossi 12g, Fructus Solani melongenae root 16g, Herba Odontitis serotinae 12g, conyza blinii 13g, Flos Caraganae Sinicae 11g, meadow Radix Scutellariae 13g, Herba Agerati Conyzoidis 17g, Rubus lambertianus 12g, Herba Thalictri Ramosi 15g, Radix Semiaquilegiae 13g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, tabletting, the tablet of adult normal's 1 day consumption must be met.Be used for the treatment of microcytic hypochromic anemia.Oral, every bu is taken for twice sooner or later.
4, the present invention is to the clinical research of microcytic hypochromic anemia
4.1, physical data: inventor collects the out-patient of 50 routine microcytic hypochromic anemias altogether between in June ,-2013 in January, 2012, age 16-38 year, course of disease 1-2.Be divided at random: treatment group 30 example, blank group 20 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
Diagnostic criteria: the detected value of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin (MCHC), all lower than below normal value, can be diagnosed as " microcytic hypochromic anemia ".I.e. MCV<80fl, MCH<28pg, MCHC<32%.
4.2, test method
4.2.1 the oral the present invention for the treatment of group is according to the obtained hard capsule of specific embodiment 1, sooner or later each once.15 days courses for the treatment of.
4.2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
4.3, criterion of therapeutical effect and therapeutic outcome
4.3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.3.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 30 | 10 | 13 | 7 | 76.7 |
| Blank group | 20 | 1 | 2 | 17 | 10 |
Visible, the medicine that the present invention obtains can safe and effective treatment microcytic hypochromic anemia.
Claims (2)
1. treat the Chinese medicine composition of microcytic hypochromic anemia for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: Herba Lysimachiae hypercodis 16 parts, Herba Blumeae Lacerae 14 parts, Radix seu Folium Alchorneae trewioidis 12 parts, Herba seu Radix Nothopanacis delavayi 10 parts, Radix et Rhizoma Iridis Sanguineae 15 parts, 13 parts, Musa basjoo Sieb. Et Zucc. head, curled paralysis 10 parts, Herba Dicranostigmatis Leptopodi 12 parts, determine grass roots 14 parts, Herba Ainsliaeae Rubrinervis 18 parts, Drymoglossum Herba Drymoglossi 12 parts, Fructus Solani melongenae root 16 parts, Herba Odontitis serotinae 12 parts, conyza blinii 13 parts, Flos Caraganae Sinicae 11 parts, meadow Radix Scutellariae 13 parts, Herba Agerati Conyzoidis 17 parts, Rubus lambertianus 12 parts, Herba Thalictri Ramosi 15 parts, Radix Semiaquilegiae 13 parts.
2. treat the application of Chinese medicine composition in treatment microcytic hypochromic anemia medicine of microcytic hypochromic anemia as claimed in claim 1.
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| CN101279044A (en) * | 2008-05-04 | 2008-10-08 | 北京中科仁和科技有限公司 | Chinese medicinal composition for curing aplastic anemia and preparation method thereof |
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