CN104258081A - Traditional Chinese medicine composition for treating thrombocytopenia as well as preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating thrombocytopenia as well as preparation method and application thereof Download PDF

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CN104258081A
CN104258081A CN201410552976.XA CN201410552976A CN104258081A CN 104258081 A CN104258081 A CN 104258081A CN 201410552976 A CN201410552976 A CN 201410552976A CN 104258081 A CN104258081 A CN 104258081A
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herba
thrombocytopenia
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卞毓平
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Abstract

The invention provides a traditional Chinese medicine composition for treating thrombocytopenia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 17 parts of lindernia ruellioides, 14 parts of frog orchid tuber, 12 parts of maesa japonica, 13 parts of rowan, 15 parts of great willowherb herb, 12 parts of umbilicaria hypococcina, 14 parts of spatholirion longifolium, 12 parts of parthenocissus heterophyllus, 15 parts of ilex pernyi root, 12 parts of physalis angulata, 16 parts of flueggea virosa, 12 parts of bacopa monnieri, 14 parts of pothos chinensis, 15 parts of phellandrium, 12 parts of schizocapsa plantaginea, 15 parts of polygala sibirica, 12 parts of mosla dianthera, 14 parts of vallisneria gigantea, 13 parts of kadsura heteroclita, 11 parts of radix pandani tectorii, 15 parts of fruticose breyniae leaves and 8 parts of begonia pedatifida. The traditional Chinese medicine composition can be used for treating the thrombocytopenia.

Description

A kind of Chinese medicine composition and preparation method and application treating thrombocytopenia
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and the preparation method and application that treat thrombocytopenia.
Background technology
Thrombocytopenia reduces (thrombocytopenia) due to platelet counts or hypofunction (Thromboasthenia) causes tampon to be formed bad and hemorrhage and causes.Platelet count is lower than 140,000 ~ 400,000/μ l normal range.Thrombocytopenia may come from platelet and produce not enough, spleen to hematoblastic detention, platelet destruction or utilize and increase and diluted, the serious thrombocytopenia no matter caused by which kind of reason, all can cause typically hemorrhage: multiple ecchymosis, is most commonly in shank; Or there is little being dispersed in property ecchymosis at the position by microtrauma; Mucosal bleeding (epistaxis, gastrointestinal tract and urogenital tract and vaginal hemorrhage); Bleed profusely with Post operation.Gastrointestinal tract is bled profusely and central nervous system's internal hemorrhage can threat to life.But thrombocytopenia can not as being secondary to disorders of blood coagulation.Lack effective medicine at present.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine composition and the preparation method and application that treat thrombocytopenia.
Technical scheme: the object of the invention is by following scheme realize:
Treat a Chinese medicine composition for thrombocytopenia, it is prepared by the raw material of following parts by weight: Lindernia ruellioides (Colsm.) Pennell 17 parts, Radix Habenariae Delavayi 14 parts, Radix Maesae Japonicae 12 parts, flower seize 13 parts, Herba Epilobii Angustifoii 15 parts, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 12 parts, Folium Bambusae Herba Reineckeae Carneae 14 parts, hang rock wind 12 parts, Radix Ilicis Pernyi 15 parts, Physalis minima L. 12 parts, plain rice set 16 parts, spend the female dish 12 parts of pig in vain, 14 parts, Herba Pothi Chinensis, Herba Limnophilae rugosae 15 parts, Rhizoma Schizocapsae Plantagineae 12 parts, little Lan flower Herba Violae 15 parts, Mosla dianthera 12 parts, large Herba vallisneriae Spiralis 14 parts, Caulis Piperis Kadsurae 13 parts, Pandanus tectorius (L.) Parkins. 11 parts, Folium et cacumen Breyniae Fruticosae 15 parts, the palm split Flos Begoniae Evansianae 8 parts.
The application of Chinese medicine composition in preparation treatment thrombocytopenia disease drug of described treatment thrombocytopenia.
Lindernia ruellioides (Colsm.) Pennell in the present invention, Latin is called Lindernia ruellioides (Colsm) Pennell., Scrophulariaceae Vandellia annual herb, high 10-15cm.Stem is weak, few upright, multi-branched and long climing, and joint is taken root, near without hair.Leaf is to life; The long 3-20mm of handle, base portion how many armfuls of stems; Blade Long Circle, ellipticity tables, ovum shape Long Circle or circle, long 1-4cm, wide 0.6-2cm, tip circle is blunt or anxious sharp, the wide wedge shape of base portion, and edge is anxious tapering sawtooth significantly, and without prickle, two sides is by rough undercoat.Raceme top is raw, flower 2-10 piece; Bract drapes over one's shoulders needle-like bar shaped; Bennet is short, is gradually slightly connected in calyx, without hair to top; Calyx 5 drastic crack, sliver wire lanceolar, without hair; Corolla aubergine, corolla pipe is cylindric, and upper lip upright 2 splits, and lower lip is expanded, and 3 split, and sliver is several equal; Stamen 4,2 pieces, front is sterile, and 2 pieces, rear can be educated, without appurtenance; Style has wide and flat stigma.Capsule is cylindrical, long 1.5-2cm, is about 2 times than Constellation calyx.Seed is oval, brown.Florescence 6-9, the fruit phase 7-11 month.Vital energy regualting and blood circulation-promoting, reducing swelling and alleviating pain.For amenorrhea, dysmenorrhea, stomachache, mastitis, lymphoid tuberculosis; Traumatic injury is controlled in external, carbuncle pain, venom, lyssodexis.The present invention is with all herbal medicine.
Radix Habenariae Delavayi is the orchid family beautiful phoenix flower plant Radix Habenariae Delavayi Habenaria delavayi Finet, is used as medicine with tuber.Autumn gathers, and cleans, using fresh herb or dry.Tonify Qi of the kidney.For lumbago due to renal deficiency, nephritis, hernia, function of nervous system's disease.
Radix Maesae Japonicae is Myrsinacea Maesa plant Radix Maesae Japonicae Maesa japonica (Thunb.) Moritzi, is used as medicine with root, leaf.The whole year can adopt, and cleans and dries.To dispel the wind diuresis, hemostasis, detumescence.Root: headache, lumbago, edema, ascites; Leaf: wound hemorrhage is controlled in external.The present invention is used as medicine with root.
Flower is seized as flower seizes tree, and machaka or dungarunga tree, Classification system is Sorbus pohuashanensis (Hance) Hedl, fruit stomach invigorating tonify deficiency.For gastritis, Vitamin A, the third deficiency disease.Stem, peel of stem clearing away lung-heat to relieve cough.For pulmonary tuberculosis, asthma, cough.The present invention adopts peel of stem to be used as medicine.
Herba Epilobii Angustifoii is Oenotheraceae willow herb platymiscium willow herb Chamaenerion angustifolium (L.) Scop., with root stock or all herbal medicine.Autumn adopts, and cleans and dries or using fresh herb.Restore menstrual flow and invigorate blood circulation, reducing swelling and alleviating pain.For menoxenia; Fracture is controlled in external, articular sprain.The present invention is with all herbal medicine.
Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) is lichens Umbilicariaceae Umbilcaria plant red abdomen Umbillcaria esculenta Gyrophora hypocrocina Jatta, is used as medicine with thallus.Gather in after summer rain or drizzle sky, removing foreign material, dry.Invigorating the stomach and promoting digestion, regulating QI to relieve pain.For dyspepsia, infantile malnutrition, abdominal distention, stomachache, dysentery.
Folium Bambusae Herba Reineckeae Carneae is Commelianaceae, and Folium Bambusae Herba Reineckeae Carneae platymiscium Folium Bambusae Herba Reineckeae Carneae Spatholirion longifolium (Gagnep.) Dunn, is used as medicine with inflorescence.Summer gathers, and dries.Regulating menstruation, pain relieving.For menoxenia, nervous headache.The present invention is with all herbal medicine.
Hanging rock wind is Vitaceae Parthenocissus plant different leaf parthenocissus Parthenocissus heterophyllus (Blume) Merr., is used as medicine with root, stem.Autumn adopts, and cleans section, dries.Dispelling, collateral-activating, promoting blood circulation and stopping pain.For bones and muscles pain due to rheumatism, leucorrhea with red and white discharge, puerperal abdonimal pain; Fracture is controlled in external, treating swelling and pain by traumatic injury, furuncle.The present invention is used as medicine with root.
Radix Ilicis Pernyi is Aquifoliaceae Holly Ilex pernyi Ilex pernyi Franch., is used as medicine with root.The whole year can adopt, and cleans section, dries.Heat-clearing and toxic substances removing, nourishing the lung to arrest cough.For cough due to lung-heat, spitting of blood, laryngopharynx swelling and pain, corneal nebula.
Physalis minima L. is Solanaceae monkey flower Fructus Seu Herba Pubescentis Physalis minima L., with all herbal medicine.Xia Qiu gathers, and cleans and dries, or using fresh herb, clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, hard masses softening and resolving.For icterohepatitis, cholecystitis, cold, fever, laryngopharynx swelling and pain, bronchitis, lung abscess, parotitis, orchitis, cystitis, hematuria, the tuberculosis of cervical lymph nodes; Impetigo is controlled in external, eczema, furuncle and phyma.
Plain rice tree is Euphorbiaceae, and plain rice Pterostyrax plant plain rice tree Fluggea virosa (Roxb.ex Willd.) Baill. [F.microcarpa Bl.], is used as medicine with Herb.With with adopting, many using fresh herbs.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, antipruritic hemostasis.Eczema is controlled in external, impetigo, allergic dermatitis, furuncle, burn and scald.
Spend the female dish of pig in vain, Classification system Bacopa monnieri (L.) Wettst. (Herpestis monniera H.B.K.), spend the female dish of pig in vain for Scrophulariaceae belongs to Bacopa kind: clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling.For dysentery, conjunctival congestion and swelling pain, erysipelas, swelling and pain of hemorrhoid; Elephatiasis is controlled in external.The present invention is with all herbal medicine.
Herba Pothi Chinensis is Araeceae Herba Pothi Chinensis platymiscium stone Pu rattan Pothos chinensis (Raf.) Merr., with all herbal medicine.The whole year can adopt, using fresh herb or dry.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis, removing food stagnancy, cough-relieving.For traumatic injury, advanced schistosomiasis hepatosplenomegaly, rheumatic arthritis, infantile malnutrition, cough; Fracture is controlled in external, otitis media, sinusitis.
Herba Limnophilae rugosae is Scrophulariaceae pomegranate garden plant Limnophila rugosa Limnophila rugosa (Roth) Merr. [Limnophila roxburghii G.Don], with all herbal medicine.Autumn gathers, and cleans, using fresh herb or dry.Clearing away heat and expelling pathogen in the exterior, expelling wind and removing dampness, cough-relieving pain relieving.For flu, laryngopharynx swelling and pain, cough due to lung-heat, bronchitis, stomachache.Pemphigus is controlled in external.
Rhizoma Schizocapsae Plantagineae is Rhizoma amorphophalli potato section (spider's thread grass section, Tacca chantrieri section) dehiscent fruit potato platymiscium dehiscent fruit potato Schizocapsa plantaginea Hance Tacca plantaginea (Hance) Drenth., is used as medicine with tuber.The four seasons can adopt, and clean, remove fibrous root, using fresh herb or dry.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, regulating QI to relieve pain, preventing the attack (or recurrence) of malaria.For laryngopharynx swelling and pain, acute gastroenteritis, urinary tract infection, toothache, chronic gastritis, taste-blindness rate, rheumatic arthritis, menoxenia, malaria, traumatic injury; Sore swollen toxin is controlled in external, traumatic hemorrhage.
Little Lan flower Herba Violae is Polygalaceae polygala little Radix Polygalae Polygala sibirica L.var.megalopha Franch., is used as medicine with Herb.The whole year can adopt, and chopping is dried.Antiinflammatory, pain relieving, draws out pus by applying a plaster to the affected part, granulation promoting.For parotitis, infantile pneumonia, gastroenteritis, stomachache, furuncle, toothache, bones and muscles pain due to rheumatism; Skin ulcer, furuncle are controlled in external, stremma, traumatic injury impairment caused by overstrain.
Mosla dianthera, Classification system is Mosla dianthera (Buch.-Ham.ex Roxb.) Maxim., is that Labiatae stone shepherd's purse rather belongs to annual herb plant.Stems to 1 m tall, into four prism shape.Leaf egg shape lanceolar or Pedicellus et Pericarpium Trapae volt lanceolar, raceme is born in the top of stem and branch, pyrene taupe, subsphaeroidal.Flower, fruit phase are in the 5-11 month.With all herbal medicine, Xia Qiu gathers, and cleans, using fresh herb or dry, has multiple pharmaceutical value.Dispel the wind and deliver, dampness removing is antipruritic.For headache due to common cold, tonsillitis, heatstroke, Peptic Ulcers, dysentery; Eczema is controlled in external, miliaria, skin pruritus, furuncle, centipete bite.Get the herb burning cigarette partly dried in the shade and can smoke mosquito.The present invention is with all herbal medicine.
Large Herba vallisneriae Spiralis is Gentianaceae Swertia plant two point Herba Swertiae bimaculatae Swertia bimaculata (Sieb.et Zucc.) Hook.f.et Thoms., with all herbal medicine.Xia Qiucai herb, dries.Heat-clearing and toxic substances removing, 'Shugan Lidan '.For acute, chronic hepatitis, cholecystitis, urinary tract infection, gastroenteritis, cold, fever, influenza, pharyngolaryngitis, toothache.
Caulis Piperis Kadsurae is Magnoliaceae Kadsura abnormity Fructus Schisandrae Sphenantherae Kadsura heteroclita (Roxb.) Craib.Be used as medicine with root, old rattan, fruit.Root, rattan can be adopted the whole year, and the fruit autumn in summer gathers, and removing cork, cleans, and section, dries.Expelling wind and removing dampness, regulating QI to relieve pain, promoting blood circulation to remove blood stasis.For rheumatism bones and muscles pain, lumbar muscle strain, sciatica, acute gastroenteritis, chronic gastritis, taste-blindness rate, dysmenorrhea, puerperal abdonimal pain, traumatic injury.The present invention is used as medicine with root.
Pandanus tectorius (L.) Parkins. is Pandanaceae screw pine Pandanus tectorius (L.) Parkins. Pandanus tectorius (L.) Parkins., is used as medicine with root, fruit and pit.Root can be adopted the whole year, and fruit is adopted winter, using fresh herb or dry.Relieving the exterior syndrome by diaphoresis, heat-clearing and toxic substances removing, diuretic reduces phlegm.Root: cold, fever, oedema due to nephritis, urinary system infection, lithangiuria, hepatitis, cirrhotic ascites, Infantile Summer Fever, eye keratitis.Really: dysentery, cough.Pit: orchitis, hemorrhoid.The present invention is used as medicine with root.
Folium et cacumen Breyniae Fruticosae is the browse of euphorbia plant Folium et cacumen Breyniae Fruticosae.Upright shrub, high 2 ~ 3 meters.Bark taupe brown, branch is cylindric, multi-fork sigmoid, the tiny hole skin of surperficial adularescent.Heat-clearing and toxic substances removing, dissipating blood stasis, pain relieving, antipruritic.Root: acute gastroenteritis, tonsillitis, bronchitis, lithangiuria, puerperal uterine contraction pain, rheumatic arthritis.Leaf: burn and scald is controlled in external, eczema, allergic dermatitis, skin itching, vaginitis.
It is that the Begoniaceae Begonia plant palm splits Flos Begoniae Evansianae Begonia pedatifida Levl. and is used as medicine with root stock that the palm splits Flos Begoniae Evansianae.Autumn and winter excavate, and clean section is dried.Dissipating blood stasis, hemostasia and detumescence, pain relieving.For spitting blood, metrorrhagia, stomachache, rheumatic arthritis; External is controlled traumatic injury and is swollen and ache, venom.
Beneficial effect:
The medicine that the present invention obtains can safe and effective treatment thrombocytopenia.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, specific embodiment 1: take Lindernia ruellioides (Colsm.) Pennell 17g, Radix Habenariae Delavayi 14g, Radix Maesae Japonicae 12g, flower seized 13g, Herba Epilobii Angustifoii 15g, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 12g, Folium Bambusae Herba Reineckeae Carneae 14g, hung rock wind 12g, Radix Ilicis Pernyi 15g, Physalis minima L. 12g, plain rice tree 16g, spend the female dish 12g of pig in vain, Herba Pothi Chinensis 14g, Herba Limnophilae rugosae 15g, Rhizoma Schizocapsae Plantagineae 12g, little Lan flower Herba Violae 15g, Mosla dianthera 12g, large Herba vallisneriae Spiralis 14g, Caulis Piperis Kadsurae 13g, Pandanus tectorius (L.) Parkins. 11g, Folium et cacumen Breyniae Fruticosae 15g, the palm split Flos Begoniae Evansianae 8g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, fill, be prepared into hard capsule, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of thrombocytopenia.Oral, every bu is taken for twice sooner or later.
2, specific embodiment 2: take Lindernia ruellioides (Colsm.) Pennell 17g, Radix Habenariae Delavayi 14g, Radix Maesae Japonicae 12g, flower seized 13g, Herba Epilobii Angustifoii 15g, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 12g, Folium Bambusae Herba Reineckeae Carneae 14g, hung rock wind 12g, Radix Ilicis Pernyi 15g, Physalis minima L. 12g, plain rice tree 16g, spend the female dish 12g of pig in vain, Herba Pothi Chinensis 14g, Herba Limnophilae rugosae 15g, Rhizoma Schizocapsae Plantagineae 12g, little Lan flower Herba Violae 15g, Mosla dianthera 12g, large Herba vallisneriae Spiralis 14g, Caulis Piperis Kadsurae 13g, Pandanus tectorius (L.) Parkins. 11g, Folium et cacumen Breyniae Fruticosae 15g, the palm split Flos Begoniae Evansianae 8g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, be prepared into granule, the granule of adult normal's 1 day consumption must be met.Be used for the treatment of thrombocytopenia.Oral, every bu is taken for twice sooner or later.
3, specific embodiment 3: take Lindernia ruellioides (Colsm.) Pennell 17g, Radix Habenariae Delavayi 14g, Radix Maesae Japonicae 12g, flower seized 13g, Herba Epilobii Angustifoii 15g, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 12g, Folium Bambusae Herba Reineckeae Carneae 14g, hung rock wind 12g, Radix Ilicis Pernyi 15g, Physalis minima L. 12g, plain rice tree 16g, spend the female dish 12g of pig in vain, Herba Pothi Chinensis 14g, Herba Limnophilae rugosae 15g, Rhizoma Schizocapsae Plantagineae 12g, little Lan flower Herba Violae 15g, Mosla dianthera 12g, large Herba vallisneriae Spiralis 14g, Caulis Piperis Kadsurae 13g, Pandanus tectorius (L.) Parkins. 11g, Folium et cacumen Breyniae Fruticosae 15g, the palm split Flos Begoniae Evansianae 8g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add starch, granulate according to a conventional method, tabletting, the tablet of adult normal's 1 day consumption must be met.Be used for the treatment of thrombocytopenia.Oral, every bu is taken for twice sooner or later.
4, the present invention is to the clinical research of thrombocytopenia
4.1, physical data: inventor collects the out-patient of 70 routine thrombocytopenia altogether between in August ,-2013 in May, 2012, age 25-45 year, course of disease 1-4.Be divided at random: treatment group 50 example, blank group 20 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.
Diagnostic criteria: (1) platelet count <100 × 10^9/L.(2) bone marrow megakaryocyte increases or normally, has dysmaturity.Dysmaturity main manifestations is that the megalokaryocyte ratio of infantilism and (or) the release of adult form platelet-free increases, and megalokaryocyte granule lacks, and kytoplasm is few.(3) clinical manifestations such as dermatorrhagia point, ecchymosis and (or) mucosal bleeding are had.(4) spleen is without enlargement.(5) there is any one in following five: 1. adrenocortical hormones in treating is effective; 2. splenectomy is effective; 3. platelet-associated antibody (PAlg, PAC3) or the specificity antiplatelet antibody positive; 4. platelet life span shortens.5. get rid of other and can cause thrombocytopenic disease, as aplastic anemia, leukemia, myelodysplastic syndrome (MDS), other immune diseases and Drug factor etc.
4.2, test method
4.2.1 the oral the present invention for the treatment of group is according to the obtained hard capsule of specific embodiment 1, sooner or later each once.15 days courses for the treatment of.
4.2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
4.3, criterion of therapeutical effect and therapeutic outcome
4.3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, lab testing improvement or normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
4.3.2 statistical result is treated in table 1.
Table 1 liang group comparitive study
Group n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Treatment group 50 23 15 12 76
Blank group 20 1 2 17 15
Visible, the medicine that the present invention obtains can safe and effective treatment thrombocytopenia.

Claims (2)

1. treat the Chinese medicine composition of thrombocytopenia for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: Lindernia ruellioides (Colsm.) Pennell 17 parts, Radix Habenariae Delavayi 14 parts, Radix Maesae Japonicae 12 parts, flower seizes 13 parts, Herba Epilobii Angustifoii 15 parts, Umbilicaria hypococcina (Jatta) Llano. (Gyrophora tornata Ach．,Dermatocarpon miniatum(L.) Mann.) 12 parts, Folium Bambusae Herba Reineckeae Carneae 14 parts, hang rock wind 12 parts, Radix Ilicis Pernyi 15 parts, Physalis minima L. 12 parts, plain rice sets 16 parts, spend the female dish 12 parts of pig in vain, 14 parts, Herba Pothi Chinensis, Herba Limnophilae rugosae 15 parts, Rhizoma Schizocapsae Plantagineae 12 parts, little Lan flower Herba Violae 15 parts, Mosla dianthera 12 parts, large Herba vallisneriae Spiralis 14 parts, Caulis Piperis Kadsurae 13 parts, Pandanus tectorius (L.) Parkins. 11 parts, Folium et cacumen Breyniae Fruticosae 15 parts, the palm splits Flos Begoniae Evansianae 8 parts.
2. treat the application of Chinese medicine composition in treatment thrombocytopenia disease drug of thrombocytopenia as claimed in claim 1.
CN201410552976.XA 2014-10-17 2014-10-17 Traditional Chinese medicine composition for treating thrombocytopenia as well as preparation method and application thereof Pending CN104258081A (en)

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Application publication date: 20150107