CN103356886A - Traditional Chinese medicine for treating primary biliary cirrhosis - Google Patents
Traditional Chinese medicine for treating primary biliary cirrhosis Download PDFInfo
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- CN103356886A CN103356886A CN2013102539888A CN201310253988A CN103356886A CN 103356886 A CN103356886 A CN 103356886A CN 2013102539888 A CN2013102539888 A CN 2013102539888A CN 201310253988 A CN201310253988 A CN 201310253988A CN 103356886 A CN103356886 A CN 103356886A
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Abstract
The invention relates to a traditional Chinese medicine for treating primary biliary cirrhosis, which is prepared from the following medicinal materials in parts by weight: 12 parts of fructus rosae laevigatae, 14 parts of radix scrophulariae, 6 parts of euphorbia jolkinii, 10 parts of beggarweed, 12 parts of climbing entada, 14 parts of elsholtzia rugulosa hemsl, 10 parts of michelia champaca, 14 parts of radix bupleuri, 10 parts of semen cassiae, 8 parts of rhizoma cyperi, 14 parts of semiliquidambar cathayensis, 10 parts of abutilon peniculatum flower, 14 parts of dysosma difformis, 12 parts of osbeckia chinensis, 14 parts of penthorum chinense pursh, 10 parts of twisted-stalk, 8 parts of all-grass of winkled marshweed, 10 parts of bryoniifolia root and 10 parts of gynura divaricata. Clinical tests prove that the traditional Chinese medicine disclosed by the invention can safely and effectively treat primary biliary cirrhosis.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine for the treatment of primary biliary cirrhosis.
Background technology
Primary biliary cirrhosis (Primary Biliary Cirrhosis, PBC) be a kind of chronic intrahepatic cholestasis disease, serum anti-mitochondrial antibody (AMA) is the specific index of diagnosis PBC, and ursodesoxycholic acid (UDCA) is safely and effectively medicine of the only treatment PBC that confirms through random contrast clinical trial.Although the pathogenesis of PBC may be relevant with autoimmune, the curative effect of immunosuppressant is not proved yet, and the medicine related reactions is restricted its clinical practice.The state of an illness of PBC is carrying out property, finally causes the cirrhosis, liver nonfunction, and liver transplantation is the only effective Therapeutic Method of whole PBC patient in latter stage.
Still lack at present the effective medicine of generally recognized as safe for primary biliary cirrhosis.
The present Research of the related medical material of Chinese medicine of the present invention is as follows:
[source] Chang Lv Ying shrub is obtained through refining tannic extract without the Rhizoma Imperatae skin to Fructus Rosae Laevigatae; Fruit medicine.[function cures mainly] relieving cough and asthma, spasmolytic has diuresis, kidney tonifying functions; Anti-inflammation, blood fat reducing.Leaf has the removing toxic substances and promoting subsidence of swelling effect; Root is medicinal, can promoting blood circulation to remove blood stasis, the convergence of drawing out pus by applying a plaster to the affected part, dispel the wind that it is wet to drive.
Radix Scrophulariae [source] is the root of goatweed Radix Scrophulariae and Radix Scrophulariae, contains the Radix Scrophulariae element, iridoid glycosides; Also contain volatile oil, alkaloid etc.; It is cold in nature, sweet in the mouth, hardship.[function cures mainly] nourishing YIN to lower pathogenic fire, removing pathogenic heat from blood and toxic substance from the body is applicable to the calentura excessive thirst, sends out speckle, hectic fever due to YIN-deficiency consumptive fever, the diseases such as not peaceful, spontaneous sweating, impairment of body fluid constipation and laryngopharynx swelling and pain of sleeping night.
Radix Euphorbiae Nematocyogae [source] Euphorbiaceae euphorbia Radix Euphorbiae Nematocyogae Euphorbia nematocypha Hand.-Mazz. is used as medicine with root.Autumn and winter uproot, and clean earth, put into washing water of rice and soak taking-up on the 3rd, put into lime water again and soak 3, take out, and clean Calx, put and boil 2 hours in the pot, take out, and section is dried.[function cures mainly] removing water retention by purgation, the external hemostasis, antipruritic.Be used for edema, cirrhotic ascites; Wound hemorrhage is controlled in external, tuberculous lymphadenitis, and traumatic injury congestion swells and ache, skin itching, tinea scabies.
Beggarweed [source] pulse family Desmodium genus plant beggarweed Desmodium racemosum (Thunb.) DC. is with root and all herbal medicine.Xia Qiucai cleans and dries.[function cures mainly] dispelling, collateral-activating, removing toxic substances and promoting subsidence of swelling.Be used for traumatic injury, rheumatic arthritis, lumbago, mastitis, venom.
Caulis Bauhihiae Championii [source] is Dou Ke Semen Entadae Shu Zhi Wu Semen Entadae Entada phaseoloides (L.) Merr., is used as medicine with rattan and kernel.Rattan can be adopted the whole year, and section is dried after the steaming; Adopt the seed Winter-Spring, and decapsidate boils or fries and dries the stone roller powder.[function cures mainly] rattan: expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Be used for rheumatic arthritis, traumatic injury, numb limbs and tense tendons.Kernel: inducing diuresis and reducing edema.Be used for jaundice, beriberi, edema.
The herb of the wild embankment Elsholtzia of fragrant Soviet Union's grass [source] Labiatae Elsholtzia species rugulosa Hemsl..Autumn and winter gather, and decontamination dries.[function cures mainly] dispelling wind to relieve the exterior syndrome, dampness removing.Be used for flu, headache, dyspepsia, acute gastroenteritis, dysentery.
The yellow blue Michelia champaca L. of Radix micheliae champacae [source] Magnoliaceae Michelia plant is with root and fruit medicine.Root can be adopted the whole year, and section is dried; The fruit autumn in summer gathers, and levigation is dried in peeling.[function cures mainly] wind-damp dispelling, throat.Be used for rheumatic ostalgia, bony spur stalk larynx.Really: benefiting stomach and stopping pain.Be used for dyspepsia, stomachache.
Radix Bupleuri [source] another name: Asia puecon recklessly, smoke clearind deficient heat Chinese medicine.[function cures mainly] expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.
Semen Cassiae [source] is the dry mature seed of pulse family annual herb plant Semen Cassiae or little Semen Cassiae.[function cures mainly] clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, constipation.
The dry rhizome of Rhizoma Cyperi [source] sedge dried tuber Cyperus rotundus L..[function cures mainly] resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; The belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.
Pterospermi Heterophylli [source] is Sterculiaceae Pterospermum plant pterospermum heterophyllum Hance, is used as medicine with root or stem branch.Can adopt the whole year, dries respectively.[function cures mainly] expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Be used for rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic lambago and skelalgia, hemiplegia, traumatic injury, bruise; External is controlled on the cutter hemorrhage.
Ba Bahua [source] is the Herb of Malvaceae plant circular cone Herba Abutili.Gather autumn, cleans cutting, using fresh herb or dry.[function cures mainly] heat-clearing and toxic substances removing.Main cold, fever; Parotitis; Thyromegaly; The neurasthenia; Dysuria; Furuncle; Tinea pedis and tinnitus.
Burden seven [source] is root and the rhizome of Berberidaceae vegetation water Radix et Rhizoma Dysosmatis.The 4-10 month gathers, and cleans, and dries or using fresh herb.[function cures mainly] heat-clearing and toxic substances removing; Dissipating phlegm and resolving masses; Stasis-dispelling and pain-killing.Main laryngopharynx swelling and pain; Carbuncle; Furuncle; Pneumonia; Parotitis; Venom; Scrofula; Traumatic injury.
Radix Osbeckiae Crinitae [source] Melastomataceae Radix Osbeckiae Crinitae platymiscium Radix Osbeckiae Crinitae Osbeckia chinensis L. is with all herbal medicine.The Xia Qiu herb of gathering is cleaned and is dried.[function cures mainly] clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, relieving cough and resolving phlegm.Be used for acute bacillary dysentery, amebic dysentery, ameba liver abscess, enteritis, cold cough, laryngopharynx swelling and pain, bronchial asthma of child, hemoptysis of pulmonary tuberculosis, appendicitis, venom, furuncle furuncle and phyma.
Penthorum chinense [source] Crassulaceae penthorum plant Penthorum chinense Penthorum chinense Pursh is with all herbal medicine.Adopt after autumn, clean and dry or using fresh herb.The dehumidifying of [function cures mainly] diuretic, stasis-dispelling and pain-killing.Be used for jaundice, edema; Traumatic injury is controlled in external.
Streptopus simplex D. Don [source] is the root of liliaceous plant Streptopus simplex.The 8-9 month excavates, and removes stem and leaf. and clean, tie into wisp, dry.[function cures mainly] clearing away lung-heat to relieve cough; Invigorating the spleen and regulating the stomach.Main cough due to lung-heat; Deficiency of YIN chronic cough; Few food of incoordination between the spleen and stomach.
Herba Limnophilae rugosae [source] Scrophulariaceae Herba Limnophilae sessiliflorae platymiscium Limnophila rugosa is with all herbal medicine.Gather autumn, cleans using fresh herb or dry.[function cures mainly] clearing away heat and expelling pathogen in the exterior, expelling wind and removing dampness, cough-relieving pain relieving.Be used for flu, laryngopharynx swelling and pain, cough due to lung-heat, bronchitis, stomachache.Pemphigus is controlled in external.
Radix vitis thunbergii (Radix Vitis Adstrictae) [source] is the root of the Zhi Wu of Pu grape section Caulis et folium vitis thunbergii, and can adopt the whole year.[function cures mainly] clearing away damp-heat, the detumescence poison.The subcutaneous ulcer of harnessing the Yellow River, arthralgia chiefly caused by damp pathogen, pyretic stranguria, dysentery, toxic swelling, scrofula, traumatic injury.It is vexed to control the inferior burnt burning pain pouring, the detumescence poison.Treat for stomachache, treat hemorrhoid, the diuresis of stimulating the menstrual flow.
Gynura divaricata [source] Compositae Herba Senecionis Chrysanthemoidis platymiscium Gynura divaricata Gynura divaricata is with all herbal medicine.Xia Qiu gathers, and cleans section, using fresh herb or dry.[function cures mainly] heat-clearing and toxic substances removing, relieving rigidity of muscles and knitting bone, cooling blood for hemostasis.Be used for bronchopneumonia, infantile hyperpyrexia, pertussis, conjunctival congestion and swelling pain, rheumatic arthritis, metrorrhagia; Traumatic injury is controlled in external, fracture, and traumatic hemorrhage, mastitis, the skin infection furuncle is swollen, burn and scald.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine for the treatment of primary biliary cirrhosis, by selecting suitable medical material and proportioning thereof, reaches the purpose of safe and effective healing primary biliary cirrhosis.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese medicine for the treatment of primary biliary cirrhosis, it is characterized in that, be prepared from by the medical material of following weight proportion: 12 parts of Fructus Rosae Laevigatae, 14 parts of Radix Scrophulariaes, 6 parts of Radix Euphorbiae Nematocyogae, 10 parts of beggarweeds, 12 parts of Caulis Bauhihiae Championiis, 14 parts of fragrant Soviet Union grass, 10 parts of Radix micheliae champacae, 14 parts of Radix Bupleuri, 10 parts of Semen Cassiaes, 8 parts of Rhizoma Cyperis, 14 parts of Pterospermi Heterophyllis, bar bar are spent 10 parts, 7 14 parts of burdens, 12 parts of Radix Osbeckiae Crinitae, 14 parts of Penthorum chinense, 10 parts of Streptopus simplex D. Don, Herba Limnophilae rugosae 8 10 parts of Fen, Radix vitis thunbergii (Radix Vitis Adstrictae), 10 parts of Gynura divaricatas.
Below in conjunction with clinical experiment data declaration beneficial effect of the present invention:
1, physical data
The inventor in February, 2008-2012 collects the out-patient of 160 routine primary biliary cirrhosiss, age 19-65 year altogether between year November.Be divided at random: treatment group 130 examples, blank group 30 examples.The data there was no significant differences such as two groups of ages, the state of an illness have comparability.
2, test method
2.1 the capsule that the oral the present invention for the treatment of group makes according to specific embodiment 1, sooner or later respectively once.15 days courses for the treatment of.
2.2 blank group oral placebo capsule, sooner or later respectively once.15 days courses for the treatment of.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Recovery from illness: clinical symptoms all disappears, and the test chamber inspection is normal.Take a turn for the better: clinical symptom relief, the state of an illness is controlled, and lab testing improves or is normal.Invalid: clinical symptoms is without being clearly better or increasing the weight of.
3.2 treatment statistical result sees Table 1.
Table 1 liang group curative effect relatively
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 130 | 20(28.6％) | 39(55.7％) | 11(15.7％) | 84.3％ |
| Blank group | 30 | 0 | 4(13.3％) | 14(86.7％) | 13.3％ |
As seen, the medicine that makes of the present invention can safe and effectively be controlled primary biliary cirrhosis.
The specific embodiment
In order to understand better and to implement the present invention, further specify the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take by weighing: Fructus Rosae Laevigatae 12 grams, Radix Scrophulariae 14 grams, Radix Euphorbiae Nematocyogae 6 grams, beggarweed 10 grams, Caulis Bauhihiae Championii 12 grams, fragrant Soviet Union grass 14 grams, Radix micheliae champacae 10 grams, Radix Bupleuri 14 grams, Semen Cassiae 10 grams, Rhizoma Cyperi 8 grams, Pterospermi Heterophylli 14 grams, bar bar are spent 10 grams, burden 7 14 grams, Radix Osbeckiae Crinitae 12 grams, Penthorum chinense 14 grams, Streptopus simplex D. Don 10 grams, Herba Limnophilae rugosae 8 Ke, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 grams, Gynura divaricata 10 grams, add 8 times of water gagings, decocted 1.5 hours, and filtered; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, drying incapsulates shell, namely gets the capsule that meets 1 day consumption of normal adult.
Be used for the treatment of primary biliary cirrhosis.Oral, every bu is taken for twice sooner or later.
Specific embodiment 2
Take by weighing: Fructus Rosae Laevigatae 12 grams, Radix Scrophulariae 14 grams, Radix Euphorbiae Nematocyogae 6 grams, beggarweed 10 grams, Caulis Bauhihiae Championii 12 grams, fragrant Soviet Union grass 14 grams, Radix micheliae champacae 10 grams, Radix Bupleuri 14 grams, Semen Cassiae 10 grams, Rhizoma Cyperi 8 grams, Pterospermi Heterophylli 14 grams, bar bar are spent 10 grams, burden 7 14 grams, Radix Osbeckiae Crinitae 12 grams, Penthorum chinense 14 grams, Streptopus simplex D. Don 10 grams, Herba Limnophilae rugosae 8 Ke, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 grams, Gynura divaricata 10 grams, add 8 times of water gagings, decocted 1.5 hours, and filtered; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, drying is pulverized, and namely gets the powder that meets 1 day consumption of normal adult.
Be used for the treatment of primary biliary cirrhosis.Oral, every bu is taken for twice sooner or later.
Specific embodiment 3
Take by weighing: Fructus Rosae Laevigatae 12 grams, Radix Scrophulariae 14 grams, Radix Euphorbiae Nematocyogae 6 grams, beggarweed 10 grams, Caulis Bauhihiae Championii 12 grams, fragrant Soviet Union grass 14 grams, Radix micheliae champacae 10 grams, Radix Bupleuri 14 grams, Semen Cassiae 10 grams, Rhizoma Cyperi 8 grams, Pterospermi Heterophylli 14 grams, bar bar are spent 10 grams, burden 7 14 grams, Radix Osbeckiae Crinitae 12 grams, Penthorum chinense 14 grams, Streptopus simplex D. Don 10 grams, Herba Limnophilae rugosae 8 Ke, Radix vitis thunbergii (Radix Vitis Adstrictae) 10 grams, Gynura divaricata 10 grams, add 8 times of water gagings, decocted 1.5 hours, and filtered; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, drying adds an amount of dextrin and correctives again, granulates according to this area common process, and packing can make the granule that meets 1 day consumption of normal adult.
Be used for the treatment of primary biliary cirrhosis.Oral, every bu is taken for twice sooner or later.
Claims (1)
1. Chinese medicine for the treatment of primary biliary cirrhosis, it is characterized in that, be prepared from by the medical material of following weight proportion: 12 parts of Fructus Rosae Laevigatae, 14 parts of Radix Scrophulariaes, 6 parts of Radix Euphorbiae Nematocyogae, 10 parts of beggarweeds, 12 parts of Caulis Bauhihiae Championiis, 14 parts of fragrant Soviet Union grass, 10 parts of Radix micheliae champacae, 14 parts of Radix Bupleuri, 10 parts of Semen Cassiaes, 8 parts of Rhizoma Cyperis, 14 parts of Pterospermi Heterophyllis, bar bar are spent 10 parts, 7 14 parts of burdens, 12 parts of Radix Osbeckiae Crinitae, 14 parts of Penthorum chinense, 10 parts of Streptopus simplex D. Don, Herba Limnophilae rugosae 8 10 parts of Fen, Radix vitis thunbergii (Radix Vitis Adstrictae), 10 parts of Gynura divaricatas.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056060A (en) * | 2014-05-29 | 2014-09-24 | 卞永兴 | Traditional Chinese medicine for treating primary biliary cirrhosis |
| CN105998558A (en) * | 2016-07-29 | 2016-10-12 | 河南中医学院 | Traditional Chinese medicinal composition for treating primary biliary cirrhosis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146903A (en) * | 1995-07-12 | 1997-04-09 | 陈瑛 | Prescription of Chinese medicine for treating cholecystitis, cholelithiasis, hepatitis and cholehepatocirrhosis |
| CN1167636A (en) * | 1997-05-10 | 1997-12-17 | 谢永明 | Powder medicine for strengthening spleen and softening liver |
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2013
- 2013-06-24 CN CN2013102539888A patent/CN103356886A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146903A (en) * | 1995-07-12 | 1997-04-09 | 陈瑛 | Prescription of Chinese medicine for treating cholecystitis, cholelithiasis, hepatitis and cholehepatocirrhosis |
| CN1167636A (en) * | 1997-05-10 | 1997-12-17 | 谢永明 | Powder medicine for strengthening spleen and softening liver |
Non-Patent Citations (2)
| Title |
|---|
| 卢殿强等: "原发性胆汁性肝硬化中医辨治思路", 《辽宁中医药大学学报》 * |
| 高丽英: "原发性胆汁性肝硬化中医药研究近况", 《湖南中医杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056060A (en) * | 2014-05-29 | 2014-09-24 | 卞永兴 | Traditional Chinese medicine for treating primary biliary cirrhosis |
| CN105998558A (en) * | 2016-07-29 | 2016-10-12 | 河南中医学院 | Traditional Chinese medicinal composition for treating primary biliary cirrhosis and preparation method thereof |
| CN105998558B (en) * | 2016-07-29 | 2019-08-20 | 河南中医学院 | A kind of Chinese medicine composition and preparation method thereof for treating primary biliary cirrhosis |
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Application publication date: 20131023 |