CN105362740A - Traditional Chinese medicine composition for treatment of stroke and application thereof - Google Patents
Traditional Chinese medicine composition for treatment of stroke and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for the treatment of stroke. The raw materials include by weight: 5-7 parts of muscardine silkworm, 8-10 parts of Tribulus terrestris, 2-4 parts of centipede, 5-7 parts of rhizoma gastrodiae, 2-4 parts of peganum harmala, 5-7 parts of giraldi daphne, 5-7 parts of Hylomecon Japonicum, 19-23 parts of rhizoma polygonati, 10-14 parts of the root of red-rooted salvia, 10-14 parts of lignum acronychiae, 5-7 parts of Artemisia anomala, 2-4 parts of Sophora flavescens, 5-7 parts of bambusae caulis im taeniam, 10-14 parts of lilyturf root, 8-10 parts of Hypericum sampsonii, 10-14 parts of herba taching, and 10-14 parts of couchgrass root. The invention also discloses the application of the traditional Chinese medicine composition for the treatment of stroke in the preparation of drugs for the treatment of cerebral hemorrhage. Based on the etiology and pathogenesis analysis of stroke in traditional Chinese medicine, the composition suits the remedy to the case, has the effects of strengthening stomach, tonifying kidney, cooling blood to stop bleeding, nourishing Yin, promoting blood circulation to remove blood stasis, activating collaterals and inducing resuscitation, has good curative effect for stroke especially cerebral hemorrhage type of stroke, reaches total effective rate of 98%, and is safe to take orally.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, particularly relate to a kind of Chinese medicine composition and the application thereof that are used for the treatment of apoplexy.
Background technology
Apoplexy is so that suddenly dusk falls forward, syncope, with deviation of the eye and mouth, and dysphonia, hemiplegia, or without dusk servant only with the unsuccessful a kind of disease for main symptom of Wai Pi.Because of its morbidity suddenly, change rapidly, seemingly has the feature of " characteristic of wind being apt to move in frequent change ", again " among arrows and stones, if storm wind quickly ", therefore to be called " apoplexy ", to have another name called " apoplexy ", " apoplexy due to endogenous wind " etc.The multiple cerebrovascular disease such as cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral vasospasm, subarachnoid hemorrhage of doctor trained in Western medicine.
The morbidity of apoplexy is unexpected, is that its pathology is formed gradually.The closest with the relation of liver, kidney, the heart, spleen, its cause of disease and void, wind, expectorant, fiery four closely related, pathogeny sieve is complexity, be generally summarized as following some:
1, feelings will is hindered or old renal failure, causes imbalance of YIN and YANG, sends out as primary disease.Or because cruelly exerting impairing the liver, make liver-yang rebellion, cause heart-fire, wind-fire is fanned mutually, gas heat stagnation is inverse, and QI and blood is also walked, and mind dusk emits and falls ill;
2, surfeit delicious food or overstrain impairing the spleen, or liver-yang element is prosperous, and perverse and unreasonable manner violates spleen, dysfunction of the spleen in transportation, life in phlegm-damp, or burns in liver-fire, and the bright liquid that burns becomes expectorant, stagnation of phlegm converting into fire, and the worn-out clear key of illiteracy, flees meridians and soldier so falls ill;
3, venation is hollow, invades in ailment said due to cold or exposure, in the resistance of meridian qi and blood numbness, muscle muscle arteries and veins loses in moistening foster, or shape contains weakness of QI, and phlegm-damp element is contained, exogenous wind priming phlegm-damp, impatency meridians and to cause Wai Pi unsuccessful.
At present, because Western medicine effectively cannot treat apoplexy, and have certain side effect, therefore, there is great demand to the Chinese medicine of effectively treating apoplexy in people.
Summary of the invention
Based on background technology exist technical problem, the present invention proposes a kind of Chinese medicine composition and the application thereof that are used for the treatment of apoplexy, in the traditional Chinese medical science to the pathogenic analysis of apoplexy, suit the remedy to the case, energy good in strengthening stomach and tonifying kidney, cooling blood for hemostasis, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, consciousness and resuscitation restoring, good curative effect is had for apoplexy especially cerebral hemorrhage type apoplexy, total effective rate can reach 98%, and toxicity is low, oral safety.
A kind of Chinese medicine composition being used for the treatment of apoplexy that the present invention proposes, its raw material comprises by weight: Bombyx Batryticatus 5-7 part, Fructus Atriplicis Sibiricae 8-10 part, Scolopendra 2-4 part, Rhizoma Gastrodiae 5-7 part, Herba pegani harmalae 2-4 part, Daphne giraldii Nitsche 5-7 part, Semen Hoveniae (Fructus Hoveniae) seven 5-7 part, Rhizoma Polygonati 19-23 part, Radix Salviae Miltiorrhizae 10-14 part, Lignum Dalbergiae Odoriferae 10-14 part, Herba Artemisiae Anomalae 5-7 part, Radix Sophorae Flavescentis 2-4 part, Caulis Bambusae In Taenia 5-7 part, Radix Ophiopogonis 10-14 part, Herba Hyperici Sampsonii 8-10 part, Folium Isatidis 10-14 part, Rhizoma Imperatae 10-14 part.
Bombyx Batryticatus, the larva for Bombycidae insecticide silkworm 4-5 age infects (or artificial vaccination) muscardine and lethal dry body.Produce more than spring, autumn, the silkworm died of illness by infection muscardine is dry.Dry after eluriating, removing impurity.Salty in the mouth, pungent, property is put down.Return liver, lung, stomach warp.Energy expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, submandibular lymph nodes is scorching, facial paralysis, skin pruritus, the headache that liver-wind stirring up internally causes, dizzy, tic.
Fructus Atriplicis Sibiricae is the fruit of zygophyllaceae plant Fructus Tribuli.After autumn fruit maturation, tap herb, dry, lay fruit, removing impurity.Acrid in the mouth, hardship, slightly warm in nature.Enter Liver Channel.There is suppressing the hyperactive liver, soothing the liver, dispel the wind, effect of improving eyesight.For excessive rising of liver-YANG, dizziness and blurred vision, liver infuses pent-up, the diseases such as the many tear of conjunctival congestion, rubella pruritus.
Scolopendra is the dry body of Scolopendridae animal Scolopendpa Subspinipes Mutilans L. KOCH.Spring, Xia Erji catch, and insert end to end with bamboo chip, exceptionally straight, dry.Prop up bamboo chip, clean, low baking temperature roasting is yellow, the section of cutting.Acrid in the mouth, warm in nature; Poisonous.Return Liver Channel.Energy endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Rhizoma Gastrodiae is the tuber of orchid Rhizoma Gastrodiae.The Second Year winter that winter plants or the 3rd year spring receive.The winter then that spring plants or Second Year spring receive.Sweet in the mouth, slightly warm in nature.Enter Liver Channel.There is suppressing the hyperactive liver to relieve the wind syndrome, effect of removing obstruction in the collateral to relieve pain.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.
Herba pegani harmalae, zygophyllaceae Peganum Three Plants Herba pegani harmalae, is used as medicine with herb and seed.Acrid in the mouth, hardship, property is put down, poisonous.GUIXIN, liver, lung meridian.There is lung qi dispersing gas, relieving cough and asthma, wind-damp dispelling, effect of detumescence poison.Cure mainly cough and asthma, rheumatic arthralgia, innominate toxic swelling, skin pruritus.
Daphne giraldii Nitsche, is thymelaeceae daphne plant Daphne Giraldii Nitsche, is used as medicine with root bark and peel of stem.Autumn uproops, and removes branch and leaf, strips crust, dries for subsequent use respectively.Bitter in the mouth, pungent, warm in nature.Slightly poisonous.Energy dispelling wind and removing obstruction in the collateral, stasis-dispelling and pain-killing.For headache, toothache, rheumatic arthritis, traumatic injury, stomachache, pain in the hepatic region.
Semen Hoveniae (Fructus Hoveniae) seven, is Papaveraceae Radix Hylomeci japonicae platymiscium Radix Hylomeci japonicae, is used as medicine with root.Xia Qiu excavates, and dries in the shade.Bitter in the mouth, property is put down.Energy wind-damp dispelling, relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis for subsidence of swelling, hemostasis, pain relieving.For rheumatic arthritis, traumatic injury.
Rhizoma Polygonati is the rhizome of liliaceous plant Rhizoma Polygonati.Sweet in the mouth, property is put down.Enter spleen, lung meridian.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as to be quenched one's thirst the disease, and very effective in cure for diabetes.
Radix Salviae Miltiorrhizae is the dry root and rhizome of dicotyledon Labiatae Radix Salviae Miltiorrhizae.Bitter in the mouth, cold nature.GUIXIN, Liver Channel.Have promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, effect of nourishing blood to tranquillize the mind.Cure mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Lignum Dalbergiae Odoriferae is the dry duramen of leguminous plant Lignum Dalbergiae Odoriferae wingceltis trunk and root.The whole year all can gather, and removing sapwood, dries in the shade.Acrid in the mouth, warm in nature.Return liver, spleen channel.Energy promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.
Herba Artemisiae Anomalae is the herb of feverfew artemisia anomalas.In time blooming August, uproop, dry, removing root and earth, break into bundle.Bitter in the mouth, warm in nature.Enter the heart, spleen channel.Can stimulate the menstrual flow by removing blood stasis, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
Radix Sophorae Flavescentis is the root of perennial fallen leaves semishrub plant Radix Sophorae Flavescentis.Spring, Qiu Erji excavate.Removing root head and little supporting root, cleaning, drying, or take advantage of fresh slices, dry.Pick clean impurity, remove residual stem, clean earth, be soaked in water, pull out, run through, section, dries; First need to soak one night with the dense water from washing rice juice of Oryza glutinosa, above have raw meat oxious gas and float at the water surface, and must heavyly wash in a pan, namely steaming, go out to Shen from the sixth of the twelve Earthly Branches, dry smooth file and use it.Bitter in the mouth, cold in nature.Return liver, kidney, large intestine, small intestinal, bladder, heart channel.Energy heat clearing and damp drying, wind dispelling insecticide.Cure mainly damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.
Caulis Bambusae In Taenia is the dry intermediate layer of stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.The whole year all can gather and process, and gets fresh stem, and removing crust, spreads to strand by slightly viridant intermediate layer, or chip, tie up bunchy, dry in the shade.The former claims " loose Caulis Bambusae In Taenia ", and the latter claims " neat Caulis Bambusae In Taenia ".Sweet in the mouth, cold nature.Return stomach warp, lung meridian.There is removing heat-phlegm, the function relieved restlessness and prevented vomiting.Expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement is held under the arm for phlegm-heat cough, gallbladder fire.
Radix Ophiopogonis is the dried root of liliaceous plant Radix Ophiopogonis.Summer excavates, and cleans, is repeatedly exposed to the sun, banks up, to doing very likely, and removing fibrous root, dry.Sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.Energy YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.
Herba Hyperici Sampsonii is the herb of Hypericaceae hypericum Herba Hyperici Sampsonii.Xia Qiu gathers, and cleans and dries or using fresh herb.Acrid in the mouth, hardship, cold in nature, return spleen, Liver Channel.There is heat-clearing and toxic substances removing, dredge the meridian passage, the function of cooling blood for hemostasis.For infantile hyperpyrexia, dysentery, enteritis, spits blood, epistaxis, menoxenia, leucorrhea; Traumatic hemorrhage is controlled in external, traumatic injury, mastitis, burn and scald, venom.
Folium Isatidis is leaf or the branch and leaf of Verbenaceae Herba Diclipterae Chinensis, polygonaceae plant polygonum tinctorium ait., cruciferae isatis, careless Folium Isatidis or acanthaceous vegetable acanthaceous indigo etc.Pick decontamination and dead leaf, clean, slightly moisten, cutting, dry.Bitter in the mouth, cold in nature.Enter liver, the heart, stomach warp.Energy heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Cure mainly epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Rhizoma Imperatae, has another name called Rhizoma Imperatae, Rhizoma Imperatae, Rhizoma Imperatae, for grass family Rhizoma Imperatae belongs to herbaceos perennial.Spring, autumn excavate, removing aerial parts and earth, after cleaning, drying, rub fibrous root and film quality sheath.Sweet in the mouth, cold in nature.Enter lung, stomach, small intestine meridian.There is clearing away heat and promoting production of body fluid, effect of cooling blood for hemostasis.For calentura excessive thirst, gastric heat is vomitted the sound of vomiting, cough due to lung-heat, bleeding due to blood-heat, tells the diseases such as nosebleed hematuria.
Preferably, the weight ratio of Bombyx Batryticatus, Fructus Atriplicis Sibiricae and Scolopendra is 5.7-6.3:8.8-9.2:2.8-3.2.
Preferably, the weight ratio of Rhizoma Gastrodiae, Herba pegani harmalae, Daphne giraldii Nitsche and Semen Hoveniae (Fructus Hoveniae) seven is 5.5-6.5:2.2-3.8:5.3-6.7:5.6-6.4.
Preferably, its raw material comprises by weight: Bombyx Batryticatus 5.7-6.3 part, Fructus Atriplicis Sibiricae 8.8-9.2 part, Scolopendra 2.8-3.2 part, Rhizoma Gastrodiae 5.5-6.5 part, Herba pegani harmalae 2.2-3.8 part, Daphne giraldii Nitsche 5.3-6.7 part, Semen Hoveniae (Fructus Hoveniae) seven 5.6-6.4 part, Rhizoma Polygonati 20-22 part, Radix Salviae Miltiorrhizae 11-13 part, Lignum Dalbergiae Odoriferae 11-13 part, Herba Artemisiae Anomalae 5.3-6.7 part, Radix Sophorae Flavescentis 2.2-3.8 part, Caulis Bambusae In Taenia 5.6-6.4 part, Radix Ophiopogonis 11-13 part, Herba Hyperici Sampsonii 8.5-9.5 part, Folium Isatidis 11-13 part, Rhizoma Imperatae 11-13 part.
Preferably, the weight ratio of Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Herba Artemisiae Anomalae and Radix Sophorae Flavescentis is 4:4:2:1.
Preferably, its raw material comprises by weight: Bombyx Batryticatus 6 parts, Fructus Atriplicis Sibiricae 9 parts, Scolopendra 3 parts, 6 parts, Rhizoma Gastrodiae, Herba pegani harmalae 3 parts, Daphne giraldii Nitsche 6 parts, Semen Hoveniae (Fructus Hoveniae) 76 parts, Rhizoma Polygonati 21 parts, Radix Salviae Miltiorrhizae 12 parts, Lignum Dalbergiae Odoriferae 12 parts, Herba Artemisiae Anomalae 6 parts, Radix Sophorae Flavescentis 3 parts, Caulis Bambusae In Taenia 6 parts, Radix Ophiopogonis 12 parts, Herba Hyperici Sampsonii 9 parts, Folium Isatidis 12 parts, Rhizoma Imperatae 12 parts.
Preparation technology of the present invention is as follows: after 6g Bombyx Batryticatus, 9g Fructus Atriplicis Sibiricae, 3g Scolopendra, 6g Rhizoma Gastrodiae, 3g Herba pegani harmalae, 6g Daphne giraldii Nitsche, 6g Semen Hoveniae (Fructus Hoveniae) seven, 21g Rhizoma Polygonati, 12g Radix Salviae Miltiorrhizae, 6g Herba Artemisiae Anomalae, 3g Radix Sophorae Flavescentis, 6g Caulis Bambusae In Taenia, 12g Radix Ophiopogonis, 9g Herba Hyperici Sampsonii, 12g Folium Isatidis and 12g Rhizoma Imperatae being pulverized, mix homogeneously, add the water slow fire boiling 1-2h of 5000mL, add the Lignum Dalbergiae Odoriferae of 12g powdery again, continue to decoct to residue medicine juice 500ml with intense fire, filter and get final product.
The above-mentioned application of Chinese medicine composition in preparation treatment cerebral hemorrhage medicine being used for the treatment of apoplexy that the present invention also proposes.
The present invention is directed to the pathogenic analysis to apoplexy in the traditional Chinese medical science, suit the remedy to the case, adopt Bombyx Batryticatus, Fructus Atriplicis Sibiricae, the mutual compatibility of Scolopendra, soothing the liverly to dispel the wind, spasmolytic is calmed the frightened, dissipating phlegm and resolving masses, removing obstruction in the collateral to relieve pain; Cooperatively interact with Rhizoma Gastrodiae, Herba pegani harmalae, Daphne giraldii Nitsche and Semen Hoveniae (Fructus Hoveniae) seven, suppressing the hyperactive liver to relieve the wind syndrome, relaxing muscles and tendons and activating QI and blood in the collateral, stasis-dispelling and pain-killing; Again with Rhizoma Polygonati boosting qi and nourishing yin, tonifying speen and tonifying kidney; And adopt Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Herba Artemisiae Anomalae, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, promote qi circulation opening warp, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind; With Radix Sophorae Flavescentis, Caulis Bambusae In Taenia, Radix Ophiopogonis, Herba Hyperici Sampsonii, Folium Isatidis and Rhizoma Imperatae, heat clearing and damp drying, YIN nourishing and the production of body fluid promoting, dredge the meridian passage, cooling blood for hemostasis; Above-mentioned all medicines share, and energy good in strengthening stomach and tonifying kidney, cooling blood for hemostasis, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, consciousness and resuscitation restoring, have good curative effect for apoplexy especially cerebral hemorrhage type apoplexy, total effective rate can reach 98%, and toxicity of the present invention is low, oral safety.
Detailed description of the invention
Below, by specific embodiment, technical scheme of the present invention is described in detail.
Embodiment 1
A kind of Chinese medicine composition being used for the treatment of apoplexy that the present invention proposes, its raw material comprises by weight: Bombyx Batryticatus 5 parts, Fructus Atriplicis Sibiricae 10 parts, Scolopendra 2 parts, 7 parts, Rhizoma Gastrodiae, Herba pegani harmalae 2 parts, Daphne giraldii Nitsche 7 parts, Semen Hoveniae (Fructus Hoveniae) 75 parts, Rhizoma Polygonati 23 parts, Radix Salviae Miltiorrhizae 10 parts, Lignum Dalbergiae Odoriferae 14 parts, Herba Artemisiae Anomalae 5 parts, Radix Sophorae Flavescentis 4 parts, Caulis Bambusae In Taenia 5 parts, Radix Ophiopogonis 14 parts, Herba Hyperici Sampsonii 8 parts, Folium Isatidis 14 parts, Rhizoma Imperatae 10 parts.
Embodiment 2
A kind of Chinese medicine composition being used for the treatment of apoplexy that the present invention proposes, its raw material comprises by weight: Bombyx Batryticatus 7 parts, Fructus Atriplicis Sibiricae 8 parts, Scolopendra 4 parts, 5 parts, Rhizoma Gastrodiae, Herba pegani harmalae 4 parts, Daphne giraldii Nitsche 5 parts, Semen Hoveniae (Fructus Hoveniae) 77 parts, Rhizoma Polygonati 19 parts, Radix Salviae Miltiorrhizae 14 parts, Lignum Dalbergiae Odoriferae 10 parts, Herba Artemisiae Anomalae 7 parts, Radix Sophorae Flavescentis 2 parts, Caulis Bambusae In Taenia 7 parts, Radix Ophiopogonis 10 parts, Herba Hyperici Sampsonii 10 parts, Folium Isatidis 10 parts, Rhizoma Imperatae 14 parts.
Embodiment 3
A kind of Chinese medicine composition being used for the treatment of apoplexy that the present invention proposes, its raw material comprises by weight: Bombyx Batryticatus 5.7 parts, Fructus Atriplicis Sibiricae 9.2 parts, Scolopendra 2.8 parts, 6.5 parts, Rhizoma Gastrodiae, Herba pegani harmalae 2.2 parts, Daphne giraldii Nitsche 6.7 parts, Semen Hoveniae (Fructus Hoveniae) 7 5.6 parts, Rhizoma Polygonati 22 parts, Radix Salviae Miltiorrhizae 11 parts, Lignum Dalbergiae Odoriferae 13 parts, Herba Artemisiae Anomalae 5.3 parts, Radix Sophorae Flavescentis 3.8 parts, Caulis Bambusae In Taenia 5.6 parts, Radix Ophiopogonis 13 parts, Herba Hyperici Sampsonii 8.5 parts, Folium Isatidis 13 parts, Rhizoma Imperatae 11 parts.
Embodiment 4
A kind of Chinese medicine composition being used for the treatment of apoplexy that the present invention proposes, its raw material comprises by weight: Bombyx Batryticatus 6.3 parts, Fructus Atriplicis Sibiricae 8.8 parts, Scolopendra 3.2 parts, 5.5 parts, Rhizoma Gastrodiae, Herba pegani harmalae 3.8 parts, Daphne giraldii Nitsche 5.3 parts, Semen Hoveniae (Fructus Hoveniae) 7 6.4 parts, Rhizoma Polygonati 20 parts, Radix Salviae Miltiorrhizae 13 parts, Lignum Dalbergiae Odoriferae 11 parts, Herba Artemisiae Anomalae 6.7 parts, Radix Sophorae Flavescentis 2.2 parts, Caulis Bambusae In Taenia 6.4 parts, Radix Ophiopogonis 11 parts, Herba Hyperici Sampsonii 9.5 parts, Folium Isatidis 11 parts, Rhizoma Imperatae 13 parts.
Embodiment 5
A kind of Chinese medicine composition being used for the treatment of apoplexy that the present invention proposes, its raw material comprises by weight: Bombyx Batryticatus 6 parts, Fructus Atriplicis Sibiricae 9 parts, Scolopendra 3 parts, 6 parts, Rhizoma Gastrodiae, Herba pegani harmalae 3 parts, Daphne giraldii Nitsche 6 parts, Semen Hoveniae (Fructus Hoveniae) 76 parts, Rhizoma Polygonati 21 parts, Radix Salviae Miltiorrhizae 12 parts, Lignum Dalbergiae Odoriferae 12 parts, Herba Artemisiae Anomalae 6 parts, Radix Sophorae Flavescentis 3 parts, Caulis Bambusae In Taenia 6 parts, Radix Ophiopogonis 12 parts, Herba Hyperici Sampsonii 9 parts, Folium Isatidis 12 parts, Rhizoma Imperatae 12 parts.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test and the clinical observation test of medicine of the present invention.
Test example 1 animal toxicity test is reported
Get regular grade NIH mice 20, body weight 20 ± 2g, male and female half and half.Be divided into experimental group and blank group at random, test after fasting 16h, experimental group adopts embodiment 5 gained medicine juice to carry out gavage by the dosage of 0.4ml/10g, gavage twice altogether; Blank group adopts consubstantiality hydrops to carry out gavage, altogether gavage twice.Raise seven days to observation post administration, the reaction of record mouse toxicity and death condition, and observe the change of its main organs and tissue.
After seven days, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirty, and without fainting from fear addicted to saliva, eye, mouth, nose, ear and crissum secretions without exception, without the rotten toe of docking.Put to death mice, dissect, observe the main organs such as its heart, liver, lung, kidney and organize no abnormality seen, showing the oral safety of this medicine.
The clinical effectiveness situation of test example 2 traditional Chinese medicine composition for treating cerebral hemorrhage of the present invention type apoplexy:
Choose paralytic 100 example, wherein man 56 example, female 44 example; Be the patients with cerebral hemorrhage of being in hospital 1-30 days.The oldest person 68 years old, age reckling only has 40 years old.
Adopt the embodiment of the present invention 5 gained medicine juice, every day three times, each oral 100mL.Within one month, be a course for the treatment of, treated for 5 courses for the treatment of altogether.Medication checks head CT after 5 courses for the treatment of, carries out nervous function damage and improves degree scoring, to observe absorption of hematoma situation and efficacy evaluation.
Therapeutic outcome is analyzed:
After 5 courses for the treatment of, in the 100 routine patients with cerebral hemorrhage that pharmaceutical composition of the present invention is treated, cure 88 examples, account for 88%; Effective 7 examples, account for 7%; Effective 3 examples, account for 3%.Total effective rate is 98%.Result shows, Chinese medicine composition of the present invention has extremely significant curative effect to treatment cerebral hemorrhage type paralytic.
Wherein the standard of curative effect evaluation:
Cure: hemiplegic limb recovers 5 grades, language performance is without difficulty, and life can be taken care of oneself;
Effective: language performance is still not exclusively fluent, Myodynamia recovery 3-4 level, life can be taken care of oneself or half self-care;
Effective: vital sign is normal; Hemiplegic limb takes a turn for the better, Myodynamia recovery 2-3 level, and language performance is unfluent, can't take care of oneself;
Invalid: to die from complication, clinical death.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (7)
1. be used for the treatment of a Chinese medicine composition for apoplexy, it is characterized in that, its raw material comprises by weight: Bombyx Batryticatus 5-7 part, Fructus Atriplicis Sibiricae 8-10 part, Scolopendra 2-4 part, Rhizoma Gastrodiae 5-7 part, Herba pegani harmalae 2-4 part, Daphne giraldii Nitsche 5-7 part, Semen Hoveniae (Fructus Hoveniae) seven 5-7 part, Rhizoma Polygonati 19-23 part, Radix Salviae Miltiorrhizae 10-14 part, Lignum Dalbergiae Odoriferae 10-14 part, Herba Artemisiae Anomalae 5-7 part, Radix Sophorae Flavescentis 2-4 part, Caulis Bambusae In Taenia 5-7 part, Radix Ophiopogonis 10-14 part, Herba Hyperici Sampsonii 8-10 part, Folium Isatidis 10-14 part, Rhizoma Imperatae 10-14 part.
2. be used for the treatment of the Chinese medicine composition of apoplexy according to claim 1, it is characterized in that, the weight ratio of Bombyx Batryticatus, Fructus Atriplicis Sibiricae and Scolopendra is 5.7-6.3:8.8-9.2:2.8-3.2.
3. according to claim 1 or 2, be used for the treatment of the Chinese medicine composition of apoplexy, it is characterized in that, the weight ratio of Rhizoma Gastrodiae, Herba pegani harmalae, Daphne giraldii Nitsche and Semen Hoveniae (Fructus Hoveniae) seven is 5.5-6.5:2.2-3.8:5.3-6.7:5.6-6.4.
4. according to any one of claim 1-3, be used for the treatment of the Chinese medicine composition of apoplexy, it is characterized in that, its raw material comprises by weight: Bombyx Batryticatus 5.7-6.3 part, Fructus Atriplicis Sibiricae 8.8-9.2 part, Scolopendra 2.8-3.2 part, Rhizoma Gastrodiae 5.5-6.5 part, Herba pegani harmalae 2.2-3.8 part, Daphne giraldii Nitsche 5.3-6.7 part, Semen Hoveniae (Fructus Hoveniae) seven 5.6-6.4 part, Rhizoma Polygonati 20-22 part, Radix Salviae Miltiorrhizae 11-13 part, Lignum Dalbergiae Odoriferae 11-13 part, Herba Artemisiae Anomalae 5.3-6.7 part, Radix Sophorae Flavescentis 2.2-3.8 part, Caulis Bambusae In Taenia 5.6-6.4 part, Radix Ophiopogonis 11-13 part, Herba Hyperici Sampsonii 8.5-9.5 part, Folium Isatidis 11-13 part, Rhizoma Imperatae 11-13 part.
5. according to any one of claim 1-4, be used for the treatment of the Chinese medicine composition of apoplexy, it is characterized in that, the weight ratio of Radix Salviae Miltiorrhizae, Lignum Dalbergiae Odoriferae, Herba Artemisiae Anomalae and Radix Sophorae Flavescentis is 4:4:2:1.
6. according to any one of claim 1-5, be used for the treatment of the Chinese medicine composition of apoplexy, it is characterized in that, its raw material comprises by weight: Bombyx Batryticatus 6 parts, Fructus Atriplicis Sibiricae 9 parts, Scolopendra 3 parts, 6 parts, Rhizoma Gastrodiae, Herba pegani harmalae 3 parts, Daphne giraldii Nitsche 6 parts, Semen Hoveniae (Fructus Hoveniae) 76 parts, Rhizoma Polygonati 21 parts, Radix Salviae Miltiorrhizae 12 parts, Lignum Dalbergiae Odoriferae 12 parts, Herba Artemisiae Anomalae 6 parts, Radix Sophorae Flavescentis 3 parts, Caulis Bambusae In Taenia 6 parts, Radix Ophiopogonis 12 parts, Herba Hyperici Sampsonii 9 parts, Folium Isatidis 12 parts, Rhizoma Imperatae 12 parts.
7. one kind is used for the treatment of the application of Chinese medicine composition in preparation treatment cerebral hemorrhage medicine of apoplexy as described in any one of claim 1-6.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105832984A (en) * | 2016-06-12 | 2016-08-10 | 全运明 | Traditional Chinese medicine composition for treating apoplexia |
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| CN1081888A (en) * | 1993-01-01 | 1994-02-16 | 河南省中药研究所 | Treatment commonly encountered diseases of internal department, the apoplexy of frequently-occurring disease and the Chinese patent medicine tablet of sequela |
| CN1255336A (en) * | 1998-11-27 | 2000-06-07 | 常德市第一中医院 | Medicine for treating apoplexy and thrombus |
| CN101057940A (en) * | 2007-05-31 | 2007-10-24 | 徐明波 | Apoplexy recover pills |
| CN101675948A (en) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for treating apoplexy |
| CN101991780A (en) * | 2009-08-13 | 2011-03-30 | 萧百川 | Chinese material medical preparation for treating apoplexy |
| CN104523861A (en) * | 2014-12-31 | 2015-04-22 | 田元生 | Traditional Chinese medicine combination used for treating stroke and preparation method thereof |
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| CN1081888A (en) * | 1993-01-01 | 1994-02-16 | 河南省中药研究所 | Treatment commonly encountered diseases of internal department, the apoplexy of frequently-occurring disease and the Chinese patent medicine tablet of sequela |
| CN1255336A (en) * | 1998-11-27 | 2000-06-07 | 常德市第一中医院 | Medicine for treating apoplexy and thrombus |
| CN101057940A (en) * | 2007-05-31 | 2007-10-24 | 徐明波 | Apoplexy recover pills |
| CN101675948A (en) * | 2008-09-18 | 2010-03-24 | 天津市中宝制药有限公司 | Traditional Chinese medicine composition for treating apoplexy |
| CN101991780A (en) * | 2009-08-13 | 2011-03-30 | 萧百川 | Chinese material medical preparation for treating apoplexy |
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| CN105832984A (en) * | 2016-06-12 | 2016-08-10 | 全运明 | Traditional Chinese medicine composition for treating apoplexia |
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