CN1041627C - (s)-2,2,2-三氯-n-(2-氯环己-2-烯基)-乙酰胺和(s)-2-氯环己-2-烯胺 - Google Patents

(s)-2,2,2-三氯-n-(2-氯环己-2-烯基)-乙酰胺和(s)-2-氯环己-2-烯胺 Download PDF

Info

Publication number
CN1041627C
CN1041627C CN94194207A CN94194207A CN1041627C CN 1041627 C CN1041627 C CN 1041627C CN 94194207 A CN94194207 A CN 94194207A CN 94194207 A CN94194207 A CN 94194207A CN 1041627 C CN1041627 C CN 1041627C
Authority
CN
China
Prior art keywords
oxo
acid
dioxo
dihydro
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94194207A
Other languages
English (en)
Chinese (zh)
Other versions
CN1135217A (zh
Inventor
G·A·弗林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of CN1135217A publication Critical patent/CN1135217A/zh
Application granted granted Critical
Publication of CN1041627C publication Critical patent/CN1041627C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/14—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN94194207A 1993-11-19 1994-10-20 (s)-2,2,2-三氯-n-(2-氯环己-2-烯基)-乙酰胺和(s)-2-氯环己-2-烯胺 Expired - Fee Related CN1041627C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15597293A 1993-11-19 1993-11-19
US08/155972 1993-11-19
US08155,972 1993-11-19

Publications (2)

Publication Number Publication Date
CN1135217A CN1135217A (zh) 1996-11-06
CN1041627C true CN1041627C (zh) 1999-01-13

Family

ID=22557529

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94194207A Expired - Fee Related CN1041627C (zh) 1993-11-19 1994-10-20 (s)-2,2,2-三氯-n-(2-氯环己-2-烯基)-乙酰胺和(s)-2-氯环己-2-烯胺

Country Status (20)

Country Link
US (2) US5502253A (enExample)
EP (1) EP0729456B1 (enExample)
JP (1) JP3547749B2 (enExample)
KR (1) KR100310592B1 (enExample)
CN (1) CN1041627C (enExample)
AT (1) ATE161251T1 (enExample)
AU (1) AU683956B2 (enExample)
CA (1) CA2177044C (enExample)
DE (1) DE69407430T2 (enExample)
DK (1) DK0729456T3 (enExample)
ES (1) ES2112034T3 (enExample)
FI (1) FI962045L (enExample)
GR (1) GR3025899T3 (enExample)
HU (1) HU220895B1 (enExample)
IL (1) IL111656A (enExample)
NO (1) NO309269B1 (enExample)
NZ (1) NZ275939A (enExample)
TW (1) TW321638B (enExample)
WO (1) WO1995014663A2 (enExample)
ZA (1) ZA949030B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8049732B2 (en) * 2007-01-03 2011-11-01 Apple Inc. Front-end signal compensation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0249223A2 (en) * 1986-06-13 1987-12-16 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608082A (en) * 1985-02-19 1986-08-26 Union Carbide Corporation Herbicidal cycloalkenyl acetamides
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0249223A2 (en) * 1986-06-13 1987-12-16 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J,AM,CHEM,SUE,109(18) 1987.1.1 E.J.CORY等人,HIGH ENANTISELEEFIVE BORANE REDACFION OF KEFONES CATALGYE EL BES CATALGYEEL B *

Also Published As

Publication number Publication date
CA2177044C (en) 1999-06-01
HU9601335D0 (en) 1996-07-29
TW321638B (enExample) 1997-12-01
NO961999L (no) 1996-05-15
GR3025899T3 (en) 1998-04-30
WO1995014663A3 (en) 1995-08-17
HU220895B1 (en) 2002-06-29
EP0729456A1 (en) 1996-09-04
FI962045A7 (fi) 1996-05-14
DK0729456T3 (da) 1998-03-30
ES2112034T3 (es) 1998-03-16
FI962045A0 (fi) 1996-05-14
CN1135217A (zh) 1996-11-06
IL111656A (en) 1999-06-20
FI962045L (fi) 1996-05-14
CA2177044A1 (en) 1995-06-01
EP0729456B1 (en) 1997-12-17
US5502253A (en) 1996-03-26
JP3547749B2 (ja) 2004-07-28
NO961999D0 (no) 1996-05-15
HUT74326A (en) 1996-12-30
DE69407430T2 (de) 1998-04-09
US5508411A (en) 1996-04-16
DE69407430D1 (de) 1998-01-29
JPH09505583A (ja) 1997-06-03
ATE161251T1 (de) 1998-01-15
AU683956B2 (en) 1997-11-27
KR100310592B1 (ko) 2002-05-13
IL111656A0 (en) 1995-01-24
ZA949030B (en) 1995-07-18
AU8122594A (en) 1995-06-13
WO1995014663A2 (en) 1995-06-01
NZ275939A (en) 1997-04-24
NO309269B1 (no) 2001-01-08

Similar Documents

Publication Publication Date Title
KR100426030B1 (ko) 락톤계 당화합물에서의 키랄성 전환방법
CN1059527A (zh) (6,7-取代-8-烷氧基-1-环丙基-1,4-二氢-4-氧代-3-喹啉羧酸-o3,-o4)二(酰氧基-o)硼酸酯及其盐和他们的制备方法
CN1104409C (zh) 氨基四氢萘酮衍生物及其制备方法
CN1311788A (zh) (1H)-苯并[c]喹嗪-3-酮衍生物的合成方法
CN1385422A (zh) 2-氮杂二羟基二环[2.2.1]庚烷化合物的制备方法
CN86102630A (zh) 制备7-氨基-3-丙烯基头孢素酸及其酯类的方法
CN101407460A (zh) 三羟基-2-酰基苯乙酸酯及其制备方法与应用
CN1135217A (zh) (s)-1[2(s)-(1,3-二氢-1,3-二氧代-异吲哚-2-基)-1-氧代-3-苯基丙基]-1,2,3,4-四氢-2吡啶甲酸甲酯及其中间体的新的制备方法
EP1063232B1 (en) Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives
CN1235607A (zh) 由毒扁豆醚制备毒扁豆碱氨基甲酸酯衍生物的方法
CN112939848B (zh) 一种布比卡因及其中间体(s)-2-哌啶甲酸的制备方法
Mandville et al. A New Stereo-and Enantioselective Approach to the N-Terminal Amino Acid Moiety of Nikkomycins B and BX
CN1121383C (zh) 地尔硫䓬合成的废产物的再利用方法
WO2012098563A2 (en) One-pot preparation of cyclobenzaprine hydrochloride
CN106674330A (zh) 一种34-Dimethyl apratoxin A/E的制备方法
CN116768898B (zh) 长春质碱的不对称全合成方法
WO1994011345A1 (en) Process for optically pure decahydroisoquinolines
CN1300133C (zh) (3r,5r)-3-羟基-5-氨乙基环戊内酯的合成方法
CN1113894C (zh) 制备脑啡呔酶与血管紧张素转化酶抑制剂中间体的新方法及其中间体
CN1723188A (zh) 还原脱卤方法
CN101654426A (zh) 制备伊洛马司他的方法
CN113651715B (zh) 一种一锅法合成香豆酰多巴胺的方法
CN115181055B (zh) 一种中间体消旋混合物的制备方法
CN86106343A (zh) 喹啉酮羧酸衍生物和它们的制备方法
CN101935302A (zh) 一种(-)-石杉碱类关键中间体的不对称合成方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 19990113

Termination date: 20121020