KR100310592B1 - (s)-1-(2(s)-(1,3-디히드로-1,3-디옥소-이소인도-2-일)-1-옥소-3-페닐프로필)-1,2,3,4-테트라히드로-2-피리딘-카르복실산메틸에스테르및그의중간체의신규제조방법 - Google Patents

(s)-1-(2(s)-(1,3-디히드로-1,3-디옥소-이소인도-2-일)-1-옥소-3-페닐프로필)-1,2,3,4-테트라히드로-2-피리딘-카르복실산메틸에스테르및그의중간체의신규제조방법 Download PDF

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Publication number
KR100310592B1
KR100310592B1 KR1019960702648A KR19960702648A KR100310592B1 KR 100310592 B1 KR100310592 B1 KR 100310592B1 KR 1019960702648 A KR1019960702648 A KR 1019960702648A KR 19960702648 A KR19960702648 A KR 19960702648A KR 100310592 B1 KR100310592 B1 KR 100310592B1
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KR
South Korea
Prior art keywords
chloro
oxo
cyclohex
dioxo
dihydro
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Expired - Fee Related
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KR1019960702648A
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English (en)
Korean (ko)
Inventor
개리 에이. 플라인
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메렐 파마슈티칼스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/14—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019960702648A 1993-11-19 1994-10-20 (s)-1-(2(s)-(1,3-디히드로-1,3-디옥소-이소인도-2-일)-1-옥소-3-페닐프로필)-1,2,3,4-테트라히드로-2-피리딘-카르복실산메틸에스테르및그의중간체의신규제조방법 Expired - Fee Related KR100310592B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15597293A 1993-11-19 1993-11-19
US08/155972 1993-11-19
PCT/US1994/011941 WO1995014663A2 (en) 1993-11-19 1994-10-20 Novel process for preparing (s)-1-[2(s)-(1,3-dihydro-1,3-dioxo-isoindo-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof

Publications (1)

Publication Number Publication Date
KR100310592B1 true KR100310592B1 (ko) 2002-05-13

Family

ID=22557529

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960702648A Expired - Fee Related KR100310592B1 (ko) 1993-11-19 1994-10-20 (s)-1-(2(s)-(1,3-디히드로-1,3-디옥소-이소인도-2-일)-1-옥소-3-페닐프로필)-1,2,3,4-테트라히드로-2-피리딘-카르복실산메틸에스테르및그의중간체의신규제조방법

Country Status (20)

Country Link
US (2) US5502253A (enExample)
EP (1) EP0729456B1 (enExample)
JP (1) JP3547749B2 (enExample)
KR (1) KR100310592B1 (enExample)
CN (1) CN1041627C (enExample)
AT (1) ATE161251T1 (enExample)
AU (1) AU683956B2 (enExample)
CA (1) CA2177044C (enExample)
DE (1) DE69407430T2 (enExample)
DK (1) DK0729456T3 (enExample)
ES (1) ES2112034T3 (enExample)
FI (1) FI962045A0 (enExample)
GR (1) GR3025899T3 (enExample)
HU (1) HU220895B1 (enExample)
IL (1) IL111656A (enExample)
NO (1) NO309269B1 (enExample)
NZ (1) NZ275939A (enExample)
TW (1) TW321638B (enExample)
WO (1) WO1995014663A2 (enExample)
ZA (1) ZA949030B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8049732B2 (en) * 2007-01-03 2011-11-01 Apple Inc. Front-end signal compensation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4608082A (en) * 1985-02-19 1986-08-26 Union Carbide Corporation Herbicidal cycloalkenyl acetamides
ZA874107B (enExample) * 1986-06-13 1987-12-09
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Also Published As

Publication number Publication date
HUT74326A (en) 1996-12-30
CN1135217A (zh) 1996-11-06
IL111656A0 (en) 1995-01-24
IL111656A (en) 1999-06-20
ATE161251T1 (de) 1998-01-15
NO961999L (no) 1996-05-15
EP0729456A1 (en) 1996-09-04
EP0729456B1 (en) 1997-12-17
HU9601335D0 (en) 1996-07-29
NZ275939A (en) 1997-04-24
WO1995014663A2 (en) 1995-06-01
ES2112034T3 (es) 1998-03-16
GR3025899T3 (en) 1998-04-30
DK0729456T3 (da) 1998-03-30
JPH09505583A (ja) 1997-06-03
AU683956B2 (en) 1997-11-27
CA2177044A1 (en) 1995-06-01
NO309269B1 (no) 2001-01-08
US5502253A (en) 1996-03-26
DE69407430D1 (de) 1998-01-29
WO1995014663A3 (en) 1995-08-17
AU8122594A (en) 1995-06-13
ZA949030B (en) 1995-07-18
JP3547749B2 (ja) 2004-07-28
FI962045A7 (fi) 1996-05-14
CA2177044C (en) 1999-06-01
US5508411A (en) 1996-04-16
FI962045L (fi) 1996-05-14
HU220895B1 (en) 2002-06-29
NO961999D0 (no) 1996-05-15
DE69407430T2 (de) 1998-04-09
FI962045A0 (fi) 1996-05-14
TW321638B (enExample) 1997-12-01
CN1041627C (zh) 1999-01-13

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