CN104114558B - 呋喃并吡啶衍生物 - Google Patents

呋喃并吡啶衍生物 Download PDF

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Publication number
CN104114558B
CN104114558B CN201380010420.1A CN201380010420A CN104114558B CN 104114558 B CN104114558 B CN 104114558B CN 201380010420 A CN201380010420 A CN 201380010420A CN 104114558 B CN104114558 B CN 104114558B
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China
Prior art keywords
furo
pyridin
base
pyridine
trimethoxv
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Expired - Fee Related
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CN201380010420.1A
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English (en)
Chinese (zh)
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CN104114558A (zh
Inventor
L.布格多夫
T.罗斯
C.多伊奇
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Merck Patent GmbH
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
CN201380010420.1A 2012-02-21 2013-01-22 呋喃并吡啶衍生物 Expired - Fee Related CN104114558B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001154.9 2012-02-21
EP12001154 2012-02-21
PCT/EP2013/000188 WO2013124025A1 (en) 2012-02-21 2013-01-22 Furopyridine derivatives

Publications (2)

Publication Number Publication Date
CN104114558A CN104114558A (zh) 2014-10-22
CN104114558B true CN104114558B (zh) 2016-10-26

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US (1) US20150038527A1 (https=)
EP (1) EP2817313B1 (https=)
JP (1) JP6097770B2 (https=)
CN (1) CN104114558B (https=)
AR (1) AR090105A1 (https=)
AU (1) AU2013224420B2 (https=)
CA (1) CA2863717C (https=)
ES (1) ES2606638T3 (https=)
TW (1) TW201336850A (https=)
WO (1) WO2013124025A1 (https=)

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CZ305472B6 (cs) * 2014-04-30 2015-10-14 Masarykova Univerzita Substituované furo[3,2-b]pyridiny pro použití jako léčiva
MX2017015357A (es) 2015-06-29 2018-03-16 Merck Patent Gmbh Compuestos inhibidores de serina/treonina-proteina cinasa (tbk)/inhibidor de cinasa de factor nuclear kappa-b subunidad epsilon (ikk-epsilon) y usos de los mismos.
BR112020015396A2 (pt) 2018-01-29 2020-12-08 Merck Patent Gmbh Inididores de gcn2 e usos dos mesmos
JP7229257B2 (ja) * 2018-01-29 2023-02-28 メルク パテント ゲーエムベーハー Ｇｃｎ２阻害剤およびその使用
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
EP3965888B1 (en) 2019-05-09 2024-08-21 Bristol-Myers Squibb Company Substituted benzimidazolone compounds
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
US20260001889A1 (en) * 2022-05-12 2026-01-01 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
JP2025531008A (ja) 2022-08-09 2025-09-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング フロピリミジン誘導体
WO2024033280A1 (en) 2022-08-09 2024-02-15 Merck Patent Gmbh Furopyridin and furopyrimidin, inhibitors of pi4k, for use in the treatment of parasite infection and malaria

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CN1413213A (zh) * 1999-12-24 2003-04-23 阿文蒂斯药物有限公司 氮杂吲哚类化合物
US20020004511A1 (en) * 2000-06-28 2002-01-10 Luzzio Michael Joseph Thiophene derivatives useful as anticancer agents

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CN104114558A (zh) 2014-10-22
EP2817313B1 (en) 2016-09-07
AU2013224420B2 (en) 2016-12-15
ES2606638T3 (es) 2017-03-24
JP2015508085A (ja) 2015-03-16
WO2013124025A1 (en) 2013-08-29
EP2817313A1 (en) 2014-12-31
AU2013224420A1 (en) 2014-10-02
JP6097770B2 (ja) 2017-03-15
AR090105A1 (es) 2014-10-22
TW201336850A (zh) 2013-09-16
CA2863717C (en) 2021-09-28
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CA2863717A1 (en) 2013-08-29

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