CN104105966B - 用于检测多特异性结合物的结合搭档的方法 - Google Patents

用于检测多特异性结合物的结合搭档的方法 Download PDF

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Publication number
CN104105966B
CN104105966B CN201380007278.5A CN201380007278A CN104105966B CN 104105966 B CN104105966 B CN 104105966B CN 201380007278 A CN201380007278 A CN 201380007278A CN 104105966 B CN104105966 B CN 104105966B
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antibody
antigen
sample
binding
idiotype
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Chinese (zh)
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CN104105966A (zh
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K-G·施图本拉赫
U·韦塞尔斯
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
CN201380007278.5A 2012-02-01 2013-01-29 用于检测多特异性结合物的结合搭档的方法 Active CN104105966B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610880999.2A CN106443016B (zh) 2012-02-01 2013-01-29 用于检测多特异性结合物的结合搭档的方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12153457.2 2012-02-01
EP12153457 2012-02-01
EP12182505.3 2012-08-31
EP12182505 2012-08-31
PCT/EP2013/051604 WO2013113663A1 (en) 2012-02-01 2013-01-29 Method for the detection of a binding partner of a multispecific binder

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CN104105966A CN104105966A (zh) 2014-10-15
CN104105966B true CN104105966B (zh) 2016-10-26

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US (3) US9945869B2 (https=)
EP (1) EP2810074B1 (https=)
JP (3) JP2015507193A (https=)
KR (1) KR20140128314A (https=)
CN (2) CN104105966B (https=)
BR (1) BR112014017630A8 (https=)
CA (1) CA2859268A1 (https=)
MX (1) MX349661B (https=)
RU (1) RU2620563C2 (https=)
WO (1) WO2013113663A1 (https=)

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JP2015507193A (ja) 2012-02-01 2015-03-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物の結合パートナーを検出するための方法
MX346146B (es) 2012-07-13 2017-03-09 Hoffmann La Roche Metodo para detectar un aglutinante multiespecifico.
JP6446044B2 (ja) * 2013-11-05 2018-12-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 結合分子の存在下で被検体の総量および／または総濃度を決定するための方法、ならびにそれに関係するキット、組成物および使用
CN104109197B (zh) * 2013-11-13 2017-05-10 叶森 一种双识别抗体片段的制备方法及其应用
CN108139394B (zh) * 2015-10-02 2020-10-30 豪夫迈·罗氏有限公司 用于确定同时结合的基于细胞的fret测定法
NZ739090A (en) 2015-10-02 2025-06-27 Hoffmann La Roche Bispecific antibodies specific for pd1 and tim3
WO2018141970A1 (en) * 2017-02-06 2018-08-09 Resiliun B.V. Interaction between c-peptides and elastin receptor, a model for understanding vascular disease
RU2761377C2 (ru) 2017-04-03 2021-12-07 Ф. Хоффманн-Ля Рош Аг Иммуноконъюгаты антитела к pd-1 с мутантом il-2 или с il-15
TWI690538B (zh) 2017-04-05 2020-04-11 瑞士商赫孚孟拉羅股份公司 特異性結合至pd1至lag3的雙特異性抗體
WO2019235420A1 (ja) 2018-06-04 2019-12-12 中外製薬株式会社 複合体を検出する方法
WO2020229378A1 (en) * 2019-05-13 2020-11-19 F. Hoffmann-La Roche Ag Interference-suppressed pharmacokinetic immunoassay
WO2022065052A1 (ja) * 2020-09-24 2022-03-31 株式会社Ｊｖｃケンウッド 捕捉用抗体、固相担体、検出用抗体、固相担体粒子、並びに検出対象物質の測定キット及び測定方法
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

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Also Published As

Publication number Publication date
CN106443016A (zh) 2017-02-22
US20210055304A1 (en) 2021-02-25
EP2810074A1 (en) 2014-12-10
US20140342382A1 (en) 2014-11-20
MX349661B (es) 2017-08-08
RU2620563C2 (ru) 2017-05-26
US20180328942A1 (en) 2018-11-15
WO2013113663A1 (en) 2013-08-08
US9945869B2 (en) 2018-04-17
RU2014133701A (ru) 2016-03-27
MX2014008762A (es) 2014-08-27
JP2017223710A (ja) 2017-12-21
JP2015507193A (ja) 2015-03-05
JP2019113564A (ja) 2019-07-11
EP2810074B1 (en) 2017-08-23
BR112014017630A8 (pt) 2017-07-11
JP6678792B2 (ja) 2020-04-08
KR20140128314A (ko) 2014-11-05
CN106443016B (zh) 2019-08-13
JP6502441B2 (ja) 2019-04-17
CN104105966A (zh) 2014-10-15
CA2859268A1 (en) 2013-08-08
HK1202921A1 (en) 2015-10-09
BR112014017630A2 (https=) 2017-06-20
US10761097B2 (en) 2020-09-01

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