CN104072427B - 盐酸厄洛替尼晶型的制备方法 - Google Patents
盐酸厄洛替尼晶型的制备方法 Download PDFInfo
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- CN104072427B CN104072427B CN201310107856.4A CN201310107856A CN104072427B CN 104072427 B CN104072427 B CN 104072427B CN 201310107856 A CN201310107856 A CN 201310107856A CN 104072427 B CN104072427 B CN 104072427B
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- hydrochloride form
- hydrochloric acid
- preparation
- eriotinib hydrochloride
- eriotinib
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
实施例 | 样品纯度(HPLC) |
实施例1 | 99.82% |
实施例2 | 99.86% |
实施例4 | 99.93% |
实施例6 | 99.89% |
对比例1 | 86.81% |
对比例2 | 86.52% |
Claims (1)
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CN201310107856.4A CN104072427B (zh) | 2013-03-29 | 2013-03-29 | 盐酸厄洛替尼晶型的制备方法 |
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CN201310107856.4A CN104072427B (zh) | 2013-03-29 | 2013-03-29 | 盐酸厄洛替尼晶型的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104072427A CN104072427A (zh) | 2014-10-01 |
CN104072427B true CN104072427B (zh) | 2019-05-28 |
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CN201310107856.4A Active CN104072427B (zh) | 2013-03-29 | 2013-03-29 | 盐酸厄洛替尼晶型的制备方法 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101602734A (zh) * | 2009-04-24 | 2009-12-16 | 浙江九洲药业股份有限公司 | 一种盐酸埃罗替尼晶型a的制备方法 |
CN103124557A (zh) * | 2010-07-23 | 2013-05-29 | 基因里克斯(英国)有限公司 | 纯埃罗替尼 |
CN103360325A (zh) * | 2012-03-26 | 2013-10-23 | 重庆医药工业研究院有限责任公司 | 一种盐酸厄洛替尼晶型a的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2009025875A1 (en) * | 2007-08-23 | 2009-02-26 | Plus Chemicals Sa | Stable formulations of crystalline erlotinib hcl |
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- 2013-03-29 CN CN201310107856.4A patent/CN104072427B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101602734A (zh) * | 2009-04-24 | 2009-12-16 | 浙江九洲药业股份有限公司 | 一种盐酸埃罗替尼晶型a的制备方法 |
CN103124557A (zh) * | 2010-07-23 | 2013-05-29 | 基因里克斯(英国)有限公司 | 纯埃罗替尼 |
CN103360325A (zh) * | 2012-03-26 | 2013-10-23 | 重庆医药工业研究院有限责任公司 | 一种盐酸厄洛替尼晶型a的制备方法 |
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CN104072427A (zh) | 2014-10-01 |
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Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL Co.,Ltd. |
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Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: Jiangsu best Pharmaceutical Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: Jiangsu best Pharmaceutical Co.,Ltd. Applicant after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: JIANGSU HANSOH PHARMACEUTICAL Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
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Effective date of registration: 20160324 Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant after: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Applicant before: JIANGSU HANSOH PHARMACEUTICAL GROUP Co.,Ltd. Applicant before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd. |
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