CN1040433C - 唑类化合物及其生产方法和应用 - Google Patents

唑类化合物及其生产方法和应用 Download PDF

Info

Publication number
CN1040433C
CN1040433C CN93105239A CN93105239A CN1040433C CN 1040433 C CN1040433 C CN 1040433C CN 93105239 A CN93105239 A CN 93105239A CN 93105239 A CN93105239 A CN 93105239A CN 1040433 C CN1040433 C CN 1040433C
Authority
CN
China
Prior art keywords
compound
phenyl
salt
difluorophenyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN93105239A
Other languages
English (en)
Chinese (zh)
Other versions
CN1079467A (zh
Inventor
伊藤克己
小此木研二
田村典一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CN1079467A publication Critical patent/CN1079467A/zh
Application granted granted Critical
Publication of CN1040433C publication Critical patent/CN1040433C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
CN93105239A 1992-04-28 1993-04-28 唑类化合物及其生产方法和应用 Expired - Fee Related CN1040433C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP110400/92 1992-04-28
JP11040092 1992-04-28
JP22623/93 1993-02-10
JP2262393 1993-02-10

Publications (2)

Publication Number Publication Date
CN1079467A CN1079467A (zh) 1993-12-15
CN1040433C true CN1040433C (zh) 1998-10-28

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93105239A Expired - Fee Related CN1040433C (zh) 1992-04-28 1993-04-28 唑类化合物及其生产方法和应用

Country Status (18)

Country Link
US (2) US5371101A (enExample)
EP (1) EP0567982B1 (enExample)
JP (1) JP2818097B2 (enExample)
KR (1) KR100257619B1 (enExample)
CN (1) CN1040433C (enExample)
AT (1) ATE167857T1 (enExample)
AU (1) AU655544B2 (enExample)
CA (1) CA2094962A1 (enExample)
DE (1) DE69319380T2 (enExample)
DK (1) DK0567982T3 (enExample)
ES (1) ES2118160T3 (enExample)
FI (1) FI931901L (enExample)
HU (2) HUT64327A (enExample)
NO (1) NO303284B1 (enExample)
NZ (1) NZ247488A (enExample)
PH (1) PH31082A (enExample)
SG (1) SG48939A1 (enExample)
TW (1) TW218017B (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU212458B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
TW297813B (enExample) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
US5814324A (en) * 1994-02-25 1998-09-29 Takeda Chemical Industries, Ltd. Injectable composition and a method of producing the same
CA2150533A1 (en) * 1994-05-31 1995-12-01 Katsumi Itoh Production of optically active triazole compounds and their intermediates
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
TW318841B (enExample) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
AU4675596A (en) * 1995-02-17 1996-09-04 Takeda Chemical Industries Ltd. Azole compounds, their production and use
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
BR9606546A (pt) * 1995-08-02 1998-07-14 Uriach & Cia Sa J Novas carboxamidas com atividade fungicida
PT783501E (pt) * 1995-08-02 2001-04-30 Uriach & Cia Sa J Derivados de pirimidona com actividade antifungica
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU715603B2 (en) * 1996-04-03 2000-02-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU6119798A (en) * 1997-03-05 1998-09-22 Takeda Chemical Industries Ltd. Crystalline form of a bis 1,2,4-triazole compound
CN1251098A (zh) * 1997-03-31 2000-04-19 武田药品工业株式会社 吡咯化合物,其制备及其用途
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
US6583164B1 (en) 1998-09-29 2003-06-24 Takeda Chemical Industries, Ltd. Antimycotic drug composition
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
IN191188B (enExample) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
EP1278755A2 (en) * 2000-03-07 2003-01-29 Ranbaxy Laboratories, Limited Azole compounds as therapeutic agents for fungal infections
CZ20032028A3 (cs) 2000-12-26 2003-11-12 Ranbaxy Laboratories Limited Sloučeniny azolu jako fungicidní činidla
DE60114889T2 (de) * 2001-03-23 2006-07-20 Richter Gedeon Vegyészeti Gyár R.T. Verfahren zur herstellung von fluconazole und kristallmodifikationen davon
IN191819B (enExample) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (enExample) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
MXPA04010066A (es) * 2002-04-12 2004-12-13 Ranbaxy Lab Ltd Derivados de tetrahidrofurano 2,2,4-trisubstituido como agentes antifungicos.
JPWO2003105841A1 (ja) 2002-06-18 2005-10-13 ポーラ化成工業株式会社 抗真菌医薬組成物
WO2004018485A1 (en) * 2002-08-26 2004-03-04 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
KR20140006070A (ko) * 2004-11-18 2014-01-15 신타 파마슈티칼스 코프. Ｈｓｐ90 활성을 조절하는 트리아졸 화합물
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
EP1934185A1 (en) * 2005-08-12 2008-06-25 Synta Pharmaceuticals Corporation Pyrazole compounds that modulate hsp90 activity
CA2618628C (en) * 2005-08-18 2014-11-18 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
CA2653327A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Compounds that modulate hsp90 activity and methods for identifying same
AU2007267860B2 (en) * 2006-05-25 2012-08-09 Synta Pharmaceuticals Corp. Triazole compounds that modulate Hsp90 activity
CA2653222A1 (en) 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
EP2035396B1 (en) * 2006-05-25 2014-05-14 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
JP2010513222A (ja) 2006-08-07 2010-04-30 スティーフェル ラボラトリーズ インコーポレイテッド 結晶抗真菌化合物
AU2007312391B2 (en) * 2006-10-19 2012-06-21 F. Hoffmann-La Roche Ag Imidazolone and imidazolidinone derivatives as 11b-HSD1 inhibitors for diabetes
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
WO2013067162A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
CA2854188A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625036A (en) * 1983-03-08 1986-11-25 Imperial Chemical Industries Plc Antifungal azole compounds
US4925863A (en) * 1984-09-05 1990-05-15 Imperial Chemical Industries Plc Antifugal azole compounds
US5126359A (en) * 1988-11-04 1992-06-30 Bayer Aktiengesellschaft Substituted bisazoles and their use as medicaments

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
DK105189A (da) * 1988-03-04 1989-09-05 Sankyo Co Triazolderivater og fremgangsmaade til fremstilling deraf samt fungicide midler indeholdende derivaterne

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625036A (en) * 1983-03-08 1986-11-25 Imperial Chemical Industries Plc Antifungal azole compounds
US4925863A (en) * 1984-09-05 1990-05-15 Imperial Chemical Industries Plc Antifugal azole compounds
US5126359A (en) * 1988-11-04 1992-06-30 Bayer Aktiengesellschaft Substituted bisazoles and their use as medicaments

Also Published As

Publication number Publication date
PH31082A (en) 1998-02-05
US5466820A (en) 1995-11-14
NO931533L (no) 1993-10-29
DK0567982T3 (da) 1999-04-12
ATE167857T1 (de) 1998-07-15
NO303284B1 (no) 1998-06-22
SG48939A1 (en) 1998-05-18
ES2118160T3 (es) 1998-09-16
HU211474A9 (en) 1995-11-28
TW218017B (enExample) 1993-12-21
FI931901A0 (fi) 1993-04-27
EP0567982B1 (en) 1998-07-01
DE69319380D1 (de) 1998-08-06
AU3822193A (en) 1993-11-04
HU9301226D0 (en) 1993-07-28
JP2818097B2 (ja) 1998-10-30
CN1079467A (zh) 1993-12-15
JPH06293740A (ja) 1994-10-21
FI931901A7 (fi) 1993-10-29
KR100257619B1 (en) 2000-07-01
FI931901L (fi) 1993-10-29
EP0567982A1 (en) 1993-11-03
NZ247488A (en) 1995-02-24
DE69319380T2 (de) 1998-10-29
NO931533D0 (no) 1993-04-27
US5371101A (en) 1994-12-06
HUT64327A (en) 1993-12-28
KR940005616A (ko) 1994-03-21
CA2094962A1 (en) 1993-10-29
AU655544B2 (en) 1994-12-22

Similar Documents

Publication Publication Date Title
CN1040433C (zh) 唑类化合物及其生产方法和应用
CN1185230C (zh) N－取代的氨基甲酰氧基烷基－吡咯鎓衍生物
CN1072680A (zh) 旋光吡咯化合物及其制法和用途
CN1078444C (zh) 含硅的杀真菌化合物、其制备方法及其在农业化学和医药上的应用
CN1178936C (zh) 磺酰基吡咯烷衍生物
CN1036304C (zh) 以苯基三唑衍生物作为活性成份的杀虫剂组合物
CN1106390A (zh) 吡咯化合物，其生产及应用
CN1060841A (zh) 喹唑啉衍生物及其制备方法
CN1575284A (zh) 作为激酶抑制剂的取代的三唑二胺衍生物
CN1073944A (zh) 三取代四氢呋喃抗真菌剂
CN1168670A (zh) 1，2，3，4-四氢喹喔啉二酮衍生物
CN101031555A (zh) 具有vap－1抑制活性的噻唑衍生物
CN1155599C (zh) 三环三唑并苯并氮杂�衍生物、用于制备该衍生物的方法和抗变态反应剂
CN1035817C (zh) 三唑基取代的叔胺化合物及其盐的制备方法
CN1639133A (zh) 新抗菌化合物、其制备方法和含有它们的药物组合物
CN1291979C (zh) 咪唑化合物及其作为腺苷脱氨酶抑制剂的用途
CN1922156A (zh) 作为钠通道阻断剂的取代的三唑
CN1059336A (zh) 抗真菌的三唑衍生物及其制备和用途
CN1087017C (zh) 唑系化合物、其制备及用途
CN1151138C (zh) 三唑抗真菌剂
CN1040366A (zh) 丁烯酸或丙烯酸衍生物
CN1671717A (zh) 作为抗真菌剂的唑类衍生物
CN1522250A (zh) 带有五元环基团的环状二胺化合物
CN1058005C (zh) 三唑衍生物,其制备方法及包含其作有效成分的药物
CN1182739A (zh) N－苄基唑鎓衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee