CN104024233B - 通过fgfr激酶的抑制抗癌的苯并吡嗪类化合物 - Google Patents
通过fgfr激酶的抑制抗癌的苯并吡嗪类化合物 Download PDFInfo
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- CN104024233B CN104024233B CN201280065562.3A CN201280065562A CN104024233B CN 104024233 B CN104024233 B CN 104024233B CN 201280065562 A CN201280065562 A CN 201280065562A CN 104024233 B CN104024233 B CN 104024233B
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- 0 CC(*1)/C(/O)=C(/C)\CCc2c1ccc([Zn+](*)CC1C=N*=CC1)c2 Chemical compound CC(*1)/C(/O)=C(/C)\CCc2c1ccc([Zn+](*)CC1C=N*=CC1)c2 0.000 description 17
- FAFKZPVWOYULMT-UHFFFAOYSA-N CC(C(C)=C)N1CCN(CCO)CC1 Chemical compound CC(C(C)=C)N1CCN(CCO)CC1 FAFKZPVWOYULMT-UHFFFAOYSA-N 0.000 description 1
- WABFKBUTOZWIJF-RDFRSEGOSA-N CCc1cc(OC)cc(N(CC2CC2)c(cc2)cc3c2ncc(N/C=C(/CO[Si+](C)(C)C(C)(C)C)\N=C/C)n3)c1 Chemical compound CCc1cc(OC)cc(N(CC2CC2)c(cc2)cc3c2ncc(N/C=C(/CO[Si+](C)(C)C(C)(C)C)\N=C/C)n3)c1 WABFKBUTOZWIJF-RDFRSEGOSA-N 0.000 description 1
- UPMVIZQNPBCLEQ-UHFFFAOYSA-N COC1=CC(OC)=CC(N(CC2CCC2)C2=CCC3=NCC(N4CCNCC4)=NC3=C2)=CC1 Chemical compound COC1=CC(OC)=CC(N(CC2CCC2)C2=CCC3=NCC(N4CCNCC4)=NC3=C2)=CC1 UPMVIZQNPBCLEQ-UHFFFAOYSA-N 0.000 description 1
- CNRIBNUVSAHYRY-UHFFFAOYSA-N COc1cc(Nc(cc2)cc(N3)c2N=CC3=O)cc(OC)c1 Chemical compound COc1cc(Nc(cc2)cc(N3)c2N=CC3=O)cc(OC)c1 CNRIBNUVSAHYRY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161552873P | 2011-10-28 | 2011-10-28 | |
US61/552873 | 2011-10-28 | ||
GBGB1118654.1A GB201118654D0 (en) | 2011-10-28 | 2011-10-28 | New compounds |
GB1118654.1 | 2011-10-28 | ||
PCT/GB2012/052673 WO2013061081A1 (en) | 2011-10-28 | 2012-10-26 | Anticancer benzopyrazines via the inhibition of fgfr kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104024233A CN104024233A (zh) | 2014-09-03 |
CN104024233B true CN104024233B (zh) | 2017-05-24 |
Family
ID=45373582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280065562.3A Active CN104024233B (zh) | 2011-10-28 | 2012-10-26 | 通过fgfr激酶的抑制抗癌的苯并吡嗪类化合物 |
Country Status (18)
Country | Link |
---|---|
US (2) | US9303029B2 (pt) |
EP (1) | EP2776408B1 (pt) |
JP (1) | JP6054406B2 (pt) |
KR (1) | KR102086871B1 (pt) |
CN (1) | CN104024233B (pt) |
AU (1) | AU2012328171B2 (pt) |
BR (1) | BR112014010183B8 (pt) |
CA (1) | CA2853401C (pt) |
DK (1) | DK2776408T3 (pt) |
ES (1) | ES2765031T3 (pt) |
GB (1) | GB201118654D0 (pt) |
HR (1) | HRP20192102T1 (pt) |
HU (1) | HUE048704T2 (pt) |
IN (1) | IN2014MN00986A (pt) |
MX (1) | MX356205B (pt) |
RU (1) | RU2639863C2 (pt) |
SI (1) | SI2776408T1 (pt) |
WO (1) | WO2013061081A1 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
SI3122358T1 (sl) | 2014-03-26 | 2021-04-30 | Astex Therapeutics Ltd. | Kombinacije FGFR- in CMET-inhibitorjev za zdravljenje raka |
BR112016022062B1 (pt) | 2014-03-26 | 2023-04-11 | Astex Therapeutics Limited | Combinação, composição farmacêutica, uso de uma combinação ou de uma composição farmacêutica, e, produto farmacêutico |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
CA2956270C (en) | 2014-08-18 | 2022-08-09 | Eisai R&D Management Co., Ltd. | Salt of monocyclic pyridine derivative and crystal thereof |
CN104370825B (zh) * | 2014-09-29 | 2017-04-19 | 人福医药集团股份公司 | 作为激酶抑制剂的取代杂环化合物及其制备方法和用途 |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
ES2811845T3 (es) | 2015-09-23 | 2021-03-15 | Janssen Pharmaceutica Nv | Heterociclos tricíclicos para el tratamiento del cáncer |
HUE057090T2 (hu) | 2015-09-23 | 2022-04-28 | Janssen Pharmaceutica Nv | BI-heteroaril-szubsztituált 1,4-benzodiazepinek és alkalmazásuk rák kezelésében |
CN109071444A (zh) | 2016-03-16 | 2018-12-21 | 拜耳作物科学股份公司 | 作为农药和植物保护剂的n-(氰苄基)-6-(环丙基-羰基氨基)-4-(苯基)-吡啶-2-羧酰胺衍生物及相关化合物 |
CA3039919A1 (en) * | 2016-10-10 | 2018-04-19 | Development Center For Biotechnology | Quinoxaline compounds as type iii receptor tyrosine kinase inhibitors |
EP3284739A1 (de) | 2017-07-19 | 2018-02-21 | Bayer CropScience Aktiengesellschaft | Substituierte (het)arylverbindungen als schädlingsbekämpfungsmittel |
JP7168149B2 (ja) * | 2018-02-08 | 2022-11-09 | ▲ザン▼州片仔▲ファン▼薬業股▲フン▼有限公司 | Fgfr阻害剤としてのピラジン-2(1h)-オン系化合物 |
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MX356205B (es) | 2018-05-18 |
EP2776408A1 (en) | 2014-09-17 |
RU2014121389A (ru) | 2015-12-10 |
WO2013061081A1 (en) | 2013-05-02 |
US10052320B2 (en) | 2018-08-21 |
BR112014010183B8 (pt) | 2022-09-13 |
JP6054406B2 (ja) | 2016-12-27 |
BR112014010183B1 (pt) | 2022-03-29 |
CA2853401A1 (en) | 2013-05-02 |
JP2014534212A (ja) | 2014-12-18 |
US20160220564A1 (en) | 2016-08-04 |
GB201118654D0 (en) | 2011-12-07 |
DK2776408T3 (da) | 2019-12-02 |
SI2776408T1 (sl) | 2020-02-28 |
KR20140084063A (ko) | 2014-07-04 |
CN104024233A (zh) | 2014-09-03 |
MX2014004861A (es) | 2014-08-21 |
CA2853401C (en) | 2022-02-15 |
AU2012328171A1 (en) | 2014-03-27 |
KR102086871B1 (ko) | 2020-03-09 |
HRP20192102T1 (hr) | 2020-02-21 |
US20150031669A1 (en) | 2015-01-29 |
US9303029B2 (en) | 2016-04-05 |
RU2639863C2 (ru) | 2017-12-25 |
ES2765031T3 (es) | 2020-06-05 |
BR112014010183A2 (pt) | 2017-05-02 |
HUE048704T2 (hu) | 2020-08-28 |
AU2012328171B2 (en) | 2017-08-17 |
EP2776408B1 (en) | 2019-11-06 |
IN2014MN00986A (pt) | 2015-04-24 |
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