CN104023744A - 用于针对金黄色葡萄球菌免疫的稳定组合物 - Google Patents
用于针对金黄色葡萄球菌免疫的稳定组合物 Download PDFInfo
- Publication number
- CN104023744A CN104023744A CN201280063615.8A CN201280063615A CN104023744A CN 104023744 A CN104023744 A CN 104023744A CN 201280063615 A CN201280063615 A CN 201280063615A CN 104023744 A CN104023744 A CN 104023744A
- Authority
- CN
- China
- Prior art keywords
- antigen
- seq
- sta006
- polypeptide
- esxab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161580191P | 2011-12-23 | 2011-12-23 | |
| US61/580,191 | 2011-12-23 | ||
| PCT/EP2012/076609 WO2013092985A1 (en) | 2011-12-23 | 2012-12-21 | Stable compositions for immunising against staphylococcus aureus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104023744A true CN104023744A (zh) | 2014-09-03 |
Family
ID=47520086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280063615.8A Pending CN104023744A (zh) | 2011-12-23 | 2012-12-21 | 用于针对金黄色葡萄球菌免疫的稳定组合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150044251A1 (https=) |
| EP (1) | EP2793939A1 (https=) |
| JP (1) | JP2015500864A (https=) |
| CN (1) | CN104023744A (https=) |
| WO (1) | WO2013092985A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113893340A (zh) * | 2021-09-30 | 2022-01-07 | 中牧实业股份有限公司 | 双相油佐剂口蹄疫疫苗的稳定剂及其应用 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012214677B2 (en) * | 2011-02-08 | 2016-11-10 | Abvacc, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| JP6670106B2 (ja) | 2012-04-26 | 2020-03-18 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌コアグラーゼ抗原およびその使用方法 |
| HUE044211T2 (hu) | 2012-08-31 | 2019-10-28 | Glaxosmithkline Biologicals Sa | Staphylococcus aureus elleni immunizálásra szolgáló, stabilizált fehérjék |
| EP3077820B1 (en) * | 2013-12-03 | 2025-02-26 | Evaxion Biotech A/S | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
| CN106103469B (zh) | 2014-03-26 | 2020-11-27 | 葛兰素史密丝克莱恩生物有限公司 | 突变型葡萄球菌抗原 |
| CN104147599B (zh) * | 2014-06-24 | 2017-03-01 | 华中科技大学 | 一种疫苗佐剂、其制备方法及应用 |
| WO2016095832A1 (en) * | 2014-12-18 | 2016-06-23 | The University Of Hong Kong | Immunotherapeutic targets against staphylococcus aureus |
| EP3419654B1 (en) * | 2016-02-22 | 2022-04-27 | Evaxion Biotech A/S | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
| WO2023213393A1 (en) * | 2022-05-04 | 2023-11-09 | Evaxion Biotech A/S | Staphylococcal protein variants and truncates |
Citations (6)
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|---|---|---|---|---|
| EP0252059A2 (fr) * | 1986-06-30 | 1988-01-07 | Smithkline Biologicals S.A. | Stabilisants améliorés pour vaccins atténués, procédé pour leur préparation et vaccins les contenant |
| WO2007007344A1 (en) * | 2004-08-27 | 2007-01-18 | Panacea Biotec Ltd. | Inactivated poliomyelitis vaccine derived from sabin strain of polio virus |
| WO2007027076A1 (es) * | 2005-09-01 | 2007-03-08 | Nuno Ayala Jose Luis | Formula estabilizadora de vacunas con antígenos vivos para su uso en sistemas de vacunación masiva |
| CN1927394A (zh) * | 2006-09-05 | 2007-03-14 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| WO2010119343A2 (en) * | 2009-04-14 | 2010-10-21 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| CN102258537A (zh) * | 2011-07-15 | 2011-11-30 | 骆延波 | 鸡传染性法氏囊病特异性转移因子的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| DE69530196T2 (de) * | 1994-06-02 | 2003-11-20 | Elan Drug Delivery Ltd | Methode zum verhindern der aggregation von proteinen/peptiden bei rehydratation oder auftauen |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| NZ508013A (en) | 1998-05-07 | 2003-08-29 | Corixa Corp | Adjuvant composition for use with an antigen in a vaccine composition |
| KR100629028B1 (ko) | 1998-10-16 | 2006-09-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 애쥬번트 시스템 및 백신 |
| WO2000046147A2 (en) | 1999-02-03 | 2000-08-10 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
| WO2000076476A1 (en) * | 1999-06-11 | 2000-12-21 | Endorex Corporation | Adjuvant-containing polymerized liposomes for oral, mucosal or intranasal vaccination |
| DE60039450D1 (de) * | 1999-12-02 | 2008-08-21 | Novartis Vaccines & Diagnostic | Zusammensetzungen und methoden zur stabilisierung von biologischen molekülen nach lyophilisierung |
| JP5118798B2 (ja) * | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
| WO2003087327A2 (en) * | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by freeze dried foam |
| EP2481819A1 (en) * | 2003-02-25 | 2012-08-01 | MedImmune Vaccines, Inc. | Cross flow filtration in the production of stabilized influenza vaccine compositions |
| CA2542777C (en) * | 2003-10-23 | 2016-02-02 | Chiron Corporation | Stabilised compositions |
| KR20110132416A (ko) | 2004-04-05 | 2011-12-07 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
| EP2848692B1 (en) * | 2004-05-21 | 2017-08-16 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus vectors for influenza virus vaccines |
| US20060228369A1 (en) | 2005-04-11 | 2006-10-12 | Program For Appropriate Technology In Health | Stabilization and preservation of temperature-sensitive vaccines |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| US8097584B2 (en) * | 2005-05-25 | 2012-01-17 | Novo Nordisk A/S | Stabilized formulations of insulin that comprise ethylenediamine |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| EP1954308B1 (en) * | 2005-09-16 | 2011-09-07 | Merial Ltd. | Stabilizers for freeze-dried vaccines |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| AU2007281934B2 (en) | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| US20080131457A1 (en) | 2006-06-12 | 2008-06-05 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
| EA015817B1 (ru) | 2006-10-12 | 2011-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Иммуногенная композиция, содержащая адъювант в виде эмульсии "масло в воде" |
| JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| GB0821806D0 (en) * | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
-
2012
- 2012-12-21 CN CN201280063615.8A patent/CN104023744A/zh active Pending
- 2012-12-21 US US14/366,362 patent/US20150044251A1/en not_active Abandoned
- 2012-12-21 JP JP2014548063A patent/JP2015500864A/ja active Pending
- 2012-12-21 EP EP12812257.9A patent/EP2793939A1/en not_active Withdrawn
- 2012-12-21 WO PCT/EP2012/076609 patent/WO2013092985A1/en not_active Ceased
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0252059A2 (fr) * | 1986-06-30 | 1988-01-07 | Smithkline Biologicals S.A. | Stabilisants améliorés pour vaccins atténués, procédé pour leur préparation et vaccins les contenant |
| WO2007007344A1 (en) * | 2004-08-27 | 2007-01-18 | Panacea Biotec Ltd. | Inactivated poliomyelitis vaccine derived from sabin strain of polio virus |
| WO2007027076A1 (es) * | 2005-09-01 | 2007-03-08 | Nuno Ayala Jose Luis | Formula estabilizadora de vacunas con antígenos vivos para su uso en sistemas de vacunación masiva |
| CN1927394A (zh) * | 2006-09-05 | 2007-03-14 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| WO2010119343A2 (en) * | 2009-04-14 | 2010-10-21 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| CN102258537A (zh) * | 2011-07-15 | 2011-11-30 | 骆延波 | 鸡传染性法氏囊病特异性转移因子的制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| CAVALLIN A ET AL: "The spectral and thermodynamic properties of staphylococcal enterotoxin A,E,and variants suggest that structural modification are improtant to control their function", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》, vol. 275, no. 3, 21 January 2000 (2000-01-21), pages 1665 - 1672 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113893340A (zh) * | 2021-09-30 | 2022-01-07 | 中牧实业股份有限公司 | 双相油佐剂口蹄疫疫苗的稳定剂及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015500864A (ja) | 2015-01-08 |
| WO2013092985A1 (en) | 2013-06-27 |
| EP2793939A1 (en) | 2014-10-29 |
| US20150044251A1 (en) | 2015-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140903 |