CN104010653B - 用于预防并治疗口腔疾病的组合物和方法 - Google Patents

用于预防并治疗口腔疾病的组合物和方法 Download PDF

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CN104010653B
CN104010653B CN201280063283.3A CN201280063283A CN104010653B CN 104010653 B CN104010653 B CN 104010653B CN 201280063283 A CN201280063283 A CN 201280063283A CN 104010653 B CN104010653 B CN 104010653B
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naedta
sodium
biomembrane
bacterium
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CN104010653A (zh
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卡伦·罗维特
斯里尼瓦桑·马德亚斯塔
南达德瓦·亚坎达瓦拉
伯鲁斯霍塔姆·V·葛文德
戈德·弗勒利希
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Kane Biotech Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51—Chelating agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280063283.3A 2011-10-31 2012-06-27 用于预防并治疗口腔疾病的组合物和方法 Active CN104010653B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161553506P 2011-10-31 2011-10-31
US61/553,506 2011-10-31
US201261641503P 2012-05-02 2012-05-02
US61/641,503 2012-05-02
US201261654490P 2012-06-01 2012-06-01
US61/654,490 2012-06-01
PCT/CA2012/050432 WO2013063695A1 (en) 2011-10-31 2012-06-27 Compositions and methods for preventing and treating oral diseases

Publications (2)

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CN104010653A CN104010653A (zh) 2014-08-27
CN104010653B true CN104010653B (zh) 2019-01-01

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US (2) US11090366B2 (enExample)
EP (1) EP2773369B1 (enExample)
JP (1) JP6038167B2 (enExample)
CN (1) CN104010653B (enExample)
AU (1) AU2012332014B2 (enExample)
CA (1) CA2853857C (enExample)
WO (1) WO2013063695A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (pt) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície
US11723852B2 (en) 2011-10-31 2023-08-15 Kane Biotech Inc. Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products
EP2964235B1 (en) * 2013-03-07 2021-07-28 Kane Biotech Inc. Antimicrobial-antibiofilm compositions comprising disodium edta and sodium citrate
CN103432576B (zh) * 2013-09-09 2014-08-20 华中农业大学 卵黏蛋白液体制剂及其制备方法
PL3049073T3 (pl) * 2013-09-24 2021-10-25 The Regents Of The University Of Michigan Kompozycje i sposoby destabilizowania, modyfikowania i rozpraszania biofilmów
CN105916486B (zh) 2013-12-27 2020-01-14 高露洁-棕榄公司 含有羧酸的益生元口腔护理组合物
JP6440954B2 (ja) * 2014-03-18 2018-12-19 サンスター株式会社 オーラルケア組成物
CN106572662A (zh) * 2014-06-27 2017-04-19 凯恩生物科技有限公司 抗微生物‑抗生物膜组合物及其作为个人护理产品的使用方法
US20170296629A1 (en) * 2014-10-08 2017-10-19 Keio University Inhibitor of extracellular trap formation in leukocyte
KR20180016347A (ko) * 2015-04-13 2018-02-14 파운테인 테크놀로지스 인터내셔널, 엘엘씨 초-소형 지질 구조체의 생산을 위한 단일-단계 방법
CN105169375A (zh) * 2015-08-21 2015-12-23 吕欢 一种防治儿童蛀牙的复方含片
CN108430436A (zh) * 2015-12-17 2018-08-21 高露洁-棕榄公司 包含至少一种磷酸酯/丙烯酸酯共聚物和至少一种阳离子型活性成分的口腔护理组合物
US20170326054A1 (en) * 2016-05-11 2017-11-16 Nestec Sa Compositions and methods for reducing or preventing dental calculus accumulation in companion animals
CN106729649B (zh) * 2016-12-22 2020-11-10 江山 一种治疗口干症的口腔护理组合物及其应用
WO2018201119A1 (en) 2017-04-29 2018-11-01 Nevada Naturals Inc. Biofilm penetrating compositions and methods
FR3071729B1 (fr) * 2017-10-04 2026-01-16 Cementic Ciments dentaires desinfectants comprenant des liposomes
CN108186384A (zh) * 2018-01-24 2018-06-22 深圳市芭格美生物科技有限公司 一种漱口水及其制备方法
JP6580735B2 (ja) * 2018-03-16 2019-09-25 サンスター株式会社 オーラルケア組成物
HUE063939T2 (hu) * 2018-05-08 2024-02-28 Evonik Operations Gmbh Bio-reszorbeálható poliésztert, hidrofil polimert és acilált humán laktoferrin-eredetû peptidet tartalmazó nanorészecske
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN111138524B (zh) * 2018-11-02 2023-07-07 武汉禾元生物科技股份有限公司 一种从基因工程水稻种子中分离纯化低铁饱和度的重组人乳铁蛋白的方法
US12478571B2 (en) * 2018-12-17 2025-11-25 Pontis Biologics, Inc. Enzyme based compositions and methods for removing dental calculi
IT201900004599A1 (it) * 2019-03-27 2020-09-27 Microbo Srl Formulazioni topiche orali e/o orali sistemiche contenenti una miscela a base di lattoferrina, più efficace nella captazione del ferro, per la prevenzione e trattamento di varie patologie
EP4013372A4 (en) 2019-08-13 2023-08-30 McCord, Darlene E. Non-activated, amorphous, ph neutral, two-part bedside-ready clay delivery system that treats pathogen infections in humans and animals
KR102090592B1 (ko) * 2019-11-15 2020-03-18 (주)제노랩 치석 방지용 구강 조성물
US20240041991A1 (en) * 2020-02-25 2024-02-08 Ontario Power Generation Inc. Stable liquid dispersinb compositions
DE202020102037U1 (de) 2020-04-14 2020-04-22 Dot Gmbh Kupferhaltige Wasserlösliche Zusammensetzung
EP4046649A1 (en) * 2021-02-22 2022-08-24 Bioseutica B.V. Ovotransferrins for use in the treatment of iron deficiency anaemia
CN113662699B (zh) * 2021-04-24 2022-04-29 北京航空航天大学 一种基于霍尔效应的牙周袋深度测量装置
WO2023076855A1 (en) 2021-10-25 2023-05-04 Mccord Darlene E Coated medicinal clay compositions, pharmaceutical compositions, and delivery of cation sources and methods of use thereof
CN113975294B (zh) * 2021-11-04 2022-06-28 首都医科大学附属北京口腔医院 根管内消毒药物及其制备方法
KR102838913B1 (ko) * 2022-06-17 2025-07-28 건국대학교 산학협력단 오보뮤코이드를 포함하는 구강질환 예방, 개선 또는 치료용 조성물 내지 이의 용도
CN116270266A (zh) * 2023-03-01 2023-06-23 杭州纳美智康科技有限公司 含锌化合物与过氧化氢结合在去口腔异味产品中的应用
CN116211848B (zh) * 2023-03-15 2025-02-25 河南科技大学 抗坏血酸钠在恢复耐氟苯尼考猪链球菌敏感性中的应用
WO2024226508A1 (en) * 2023-04-24 2024-10-31 Regents Of The University Of Minnesota Artificial calculus
CN117122564B (zh) * 2023-09-26 2024-05-14 海南卓科制药有限公司 一种氟尿嘧啶注射液及其制备方法
CN118384187B (zh) * 2024-06-17 2024-09-17 中山大学附属口腔医院 双向伯克霍尔德氏菌在制备预防和/或治疗龋病的微生态制品中的应用
WO2026142283A1 (ko) * 2024-12-27 2026-07-02 (주)코랩 신규 펩티드 및 이를 포함하는 항균용 조성물
CN120078670B (zh) * 2025-04-25 2025-11-25 四川大学 蔗糖修饰的聚乙二醇纳米四氧化三铁防龋凝胶的制备方法
CN121102267B (zh) * 2025-11-12 2026-04-10 南开大学 一种抗炎的多糖类口腔抑菌组合物及其制备工艺
CN122297464A (zh) * 2026-05-29 2026-06-30 四川大学 L-色氨酸在制备防龋口腔护理产品中的应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060600A (en) 1972-10-26 1977-11-29 National Patent Development Corporation Treating teeth
US3887712A (en) 1973-06-15 1975-06-03 Merck & Co Inc Oral hygiene products
GB1524325A (en) 1976-03-18 1978-09-13 Ferrosan Ab Piperidine derivatives
US4160821A (en) 1978-02-27 1979-07-10 Johnson & Johnson Treatment for gingivitis
US4178363A (en) 1978-05-09 1979-12-11 Miller Taylor C Jr Method for reducing dental plaque and pellicle precursor of plaque
US4999184A (en) 1982-06-22 1991-03-12 The Procter & Gamble Company Oral compositions
US4610871A (en) 1984-12-21 1986-09-09 Ici Americas Inc. Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation
US5304540A (en) * 1988-06-22 1994-04-19 Applied Microbiology, Inc. Pharmaceutical bacteriocin compositions and methods for using the same
US5310546A (en) * 1990-02-07 1994-05-10 7-L Corporation Mouthrinse and method of preparation
US5174990A (en) * 1990-02-07 1992-12-29 7-L Corporation Mouthrinse and method of preparation
US5104644A (en) * 1990-02-07 1992-04-14 7-L Corporation Mouthrinse composition
ZA94438B (en) * 1993-02-19 1994-08-29 Warner Lambert Co Pre-brushing rinse composition
KR20010013377A (ko) 1997-06-04 2001-02-26 데이비드 엠 모이어 마일드한 잔류성 항균 조성물
US5932469A (en) 1997-06-10 1999-08-03 University Of Florida Antimicrobial polypeptide, nucleic acid, and methods of use
US6475771B1 (en) 1997-06-10 2002-11-05 University Of Florida Research Foundation Antimicrobial polypeptides and methods of use
US6218362B1 (en) 1997-09-08 2001-04-17 Universite Laval Lantibiotic from Streptococcus mutans and uses thereof
US6342385B1 (en) 2000-07-28 2002-01-29 The Uab Research Foundation Mutacin I biosynthesis genes and proteins
US6589562B1 (en) 2000-10-25 2003-07-08 Salvona L.L.C. Multicomponent biodegradable bioadhesive controlled release system for oral care products
US7597895B2 (en) 2001-02-20 2009-10-06 The Governing Council Of The University Of Toronto Signal peptides, nucleic acid molecules and methods for treatment of caries
US6696047B2 (en) 2001-09-13 2004-02-24 The Procter & Gamble Company Stable oral care compositions comprising chlorite
US6602490B1 (en) * 2002-03-04 2003-08-05 Richard A. Cloonan Dental cleaning formulation and manufacturing process
JP2005139201A (ja) * 2002-11-19 2005-06-02 Showa Yakuhin Kako Kk 歯石及びウ蝕部溶解剤
ES2214135B1 (es) * 2003-02-21 2005-05-01 Laboratorios Kin S.A. Composicion para el tratamiento de la cavidad bucal y utilizaciones correspondientes.
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
US20050170013A1 (en) 2004-02-04 2005-08-04 Douglas Jerry A. Composition for treating a dermatological inflammatory response and method of preparation thereof
US20060134020A1 (en) * 2004-12-21 2006-06-22 Robinson Richard S Anti-caries oral care composition with a chelating agent
WO2006089139A2 (en) * 2005-02-15 2006-08-24 Lab39, Llc Oral care cleaning compositions and methods
JP2009521932A (ja) 2005-12-29 2009-06-11 カンザス ステート ユニバーシティー リサーチ ファウンデーション 抗菌性カテリシジンペプチド
ITMI20061132A1 (it) * 2006-06-13 2007-12-14 Sinclair Pharmaceuticals Ltd Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali
US9072868B2 (en) 2008-10-27 2015-07-07 Pursuit Vascular, Inc. Device for delivery of antimicrobial agent into trans-dermal catheter
CN101756794A (zh) * 2008-11-18 2010-06-30 陈恩平 一种氯化锌防牙斑和牙龈炎的漱口水

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
含有甘草次酸及其衍生物的口腔疾病治疗剂;无;《国外医药.植物药分册》;19921231;第7卷(第2期);第87页第1栏最后1段 *

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