CN103998940B - 芯片装置、操作芯片的制作方法及操作对象成分的方法 - Google Patents

芯片装置、操作芯片的制作方法及操作对象成分的方法 Download PDF

Info

Publication number
CN103998940B
CN103998940B CN201280062684.7A CN201280062684A CN103998940B CN 103998940 B CN103998940 B CN 103998940B CN 201280062684 A CN201280062684 A CN 201280062684A CN 103998940 B CN103998940 B CN 103998940B
Authority
CN
China
Prior art keywords
chip
liquid phase
water system
system liquid
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280062684.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN103998940A (zh
Inventor
片所功
大桥铁雄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Publication of CN103998940A publication Critical patent/CN103998940A/zh
Application granted granted Critical
Publication of CN103998940B publication Critical patent/CN103998940B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G01N33/04—Dairy products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02K—DYNAMO-ELECTRIC MACHINES
    • H02K44/00—Machines in which the dynamo-electric interaction between a plasma or flow of conductive liquid or of fluid-borne conductive or magnetic particles and a coil system or magnetic field converts energy of mass flow into electrical energy or vice versa
    • H02K44/02—Electrodynamic pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Fluid Mechanics (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN201280062684.7A 2011-12-22 2012-11-05 芯片装置、操作芯片的制作方法及操作对象成分的方法 Active CN103998940B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011282185A JP5807542B2 (ja) 2011-12-22 2011-12-22 対象成分を操作するためのチップデバイス及びそれを用いた方法
JP2011-282185 2011-12-22
PCT/JP2012/078587 WO2013094322A1 (ja) 2011-12-22 2012-11-05 対象成分を操作するためのチップデバイス及びそれを用いた方法

Publications (2)

Publication Number Publication Date
CN103998940A CN103998940A (zh) 2014-08-20
CN103998940B true CN103998940B (zh) 2016-07-27

Family

ID=48668222

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280062684.7A Active CN103998940B (zh) 2011-12-22 2012-11-05 芯片装置、操作芯片的制作方法及操作对象成分的方法

Country Status (4)

Country Link
US (1) US9714445B2 (cg-RX-API-DMAC10.html)
JP (1) JP5807542B2 (cg-RX-API-DMAC10.html)
CN (1) CN103998940B (cg-RX-API-DMAC10.html)
WO (1) WO2013094322A1 (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9931632B2 (en) 2014-12-02 2018-04-03 Koninklijke Philips N.V. Dispersion and accumulation of magnetic particles in a microfluidic system
JP6332012B2 (ja) * 2014-12-22 2018-05-30 株式会社島津製作所 磁性体粒子操作用装置
WO2016113883A1 (ja) * 2015-01-15 2016-07-21 株式会社島津製作所 磁性体粒子操作用デバイスおよび磁性体粒子の操作方法
CN107206347B (zh) * 2015-01-30 2019-11-29 株式会社岛津制作所 磁性体粒子操作用器件以及磁性体粒子的操作方法
CN107532990B (zh) * 2015-05-12 2021-11-12 芯片生物技术株式会社 单一粒子解析方法及用于该解析的系统
CN108135581B (zh) * 2015-07-24 2021-11-30 新型微装置有限责任公司（Dba新型装置） 标本提取装置及其使用方法
ES2599056B2 (es) * 2015-07-31 2017-07-07 Pablo ALBERTOS SÁNCHEZ Dispositivo para ensayar una muestra de células
EP3349823B1 (en) * 2015-09-14 2022-01-26 Medisieve Ltd Magnetic filter apparatus
KR101850307B1 (ko) 2016-03-03 2018-04-20 한국과학기술연구원 채널 결합형 스캐폴드의 제조장치 및 제조방법
CN107541462B (zh) * 2017-09-13 2021-02-23 北京理工大学 一种用于核酸纯化，扩增及基因检测的系统及应用方法
US11504712B2 (en) 2017-12-28 2022-11-22 Nikon Corporation Fluid device and fluid control system
CN108801306B (zh) * 2018-06-26 2020-01-24 京东方科技集团股份有限公司 光纤传感器及其制作方法、运动感测装置
TWI688320B (zh) * 2018-10-26 2020-03-11 友達光電股份有限公司 轉置方法及轉置裝置
EP4028167A4 (en) * 2019-09-10 2023-10-11 MGI Holdings Co., Limited OPERATION OF MAGNETIC BEADS ON MICROFLUIDIC SUBSTRATES
CN115747037A (zh) * 2023-01-09 2023-03-07 深圳市科瑞达生物技术有限公司 核酸分析卡及其使用方法
CN117264750B (zh) * 2023-11-23 2024-01-30 中国科学院空天信息创新研究院 检测卡盒及其使用方法
CN118017795B (zh) * 2024-04-08 2024-06-25 浙江大学 感应式电磁泵

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101013128A (zh) * 2007-02-13 2007-08-08 成都夸常医学工业有限公司 包含纳米结构的分析或分离用装置
CN101165486A (zh) * 2006-10-18 2008-04-23 中国科学院上海应用物理研究所 微流控阵列蛋白质芯片及其使用方法
WO2011135881A1 (ja) * 2010-04-28 2011-11-03 株式会社 島津製作所 ゲル状媒体を用いた液滴操作デバイス及び方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313358A (en) 1964-04-01 1967-04-11 Chevron Res Conductor casing for offshore drilling and well completion
US4786600A (en) 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
NL8900725A (nl) 1989-03-23 1990-10-16 Az Univ Amsterdam Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur.
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5354688A (en) 1990-05-11 1994-10-11 Associated Universities, Inc. Anaerobic microbial remobilization of coprecipitated metals
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
ATE362532T1 (de) 1999-03-19 2007-06-15 Takara Bio Inc Verfahren zur amplifizierung einer nukleinsäuresequenz unter verwendung eines chimären primers
US6951722B2 (en) 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
WO2000071999A1 (de) 1999-05-19 2000-11-30 Bilatec Ag Vorrichtung und verfahren zur isolierung von elektrisch geladenen molekülen
US6406604B1 (en) 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US20040018611A1 (en) * 2002-07-23 2004-01-29 Ward Michael Dennis Microfluidic devices for high gradient magnetic separation
US6806543B2 (en) 2002-09-12 2004-10-19 Intel Corporation Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molecule detection
EP1603674B1 (en) 2003-02-05 2016-01-06 Iquum, Inc. Sample processing
JP2004045410A (ja) * 2003-08-06 2004-02-12 Hitachi Ltd 試料分離装置及び化学分析装置
JP2006007146A (ja) * 2004-06-28 2006-01-12 Canon Inc 粒子分離装置
JP2006061031A (ja) 2004-08-25 2006-03-09 Hitachi Maxell Ltd 化学分析装置、分析処理チップ、および化学分析方法
WO2006042838A1 (de) 2004-10-15 2006-04-27 Siemens Aktiengesellschaft Anordnung zur integrierten und automatisierten dna- oder protein-analyse in einer einmal verwendbaren cartridge, herstellungsverfahren für eine solche cartridge und betriebsverfahren der dna- oder protein-analyse unter verwendung einer solchen cartridge
CA2680532C (en) 2006-04-18 2017-03-21 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
JP2007315936A (ja) 2006-05-26 2007-12-06 Toppan Printing Co Ltd 流体制御部を有するマイクロチップ
JP4844263B2 (ja) * 2006-07-07 2011-12-28 株式会社島津製作所 微量化学反応方法及び装置
JP2008039541A (ja) * 2006-08-04 2008-02-21 National Institute For Materials Science マイクロ流路チップ及びそれを用いた生体高分子の処理方法
DE102006050871B4 (de) * 2006-10-27 2011-06-01 Albert-Ludwigs-Universität Freiburg Integriertes mikrofluidisches Bauteil zum Aufreinigen von Analytmolekülen sowie Verfahren zum Aufreinigen
JP2008233002A (ja) 2007-03-23 2008-10-02 Toppan Printing Co Ltd 反応チップ及びそれを用いた反応方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101165486A (zh) * 2006-10-18 2008-04-23 中国科学院上海应用物理研究所 微流控阵列蛋白质芯片及其使用方法
CN101013128A (zh) * 2007-02-13 2007-08-08 成都夸常医学工业有限公司 包含纳米结构的分析或分离用装置
WO2011135881A1 (ja) * 2010-04-28 2011-11-03 株式会社 島津製作所 ゲル状媒体を用いた液滴操作デバイス及び方法

Also Published As

Publication number Publication date
US9714445B2 (en) 2017-07-25
US20140370511A1 (en) 2014-12-18
CN103998940A (zh) 2014-08-20
WO2013094322A1 (ja) 2013-06-27
JP2013130548A (ja) 2013-07-04
JP5807542B2 (ja) 2015-11-10

Similar Documents

Publication Publication Date Title
CN103998940A (zh) 用于操作对象成分的芯片装置及使用其的方法
CN103269787B (zh) 用于在管内操作对象成分的器件和方法
JP5573335B2 (ja) 磁性体粒子操作デバイス及び磁性体粒子操作方法
KR101214780B1 (ko) 미세유동 장치
CN101990516B (zh) 多用试样准备系统及其在集成分析系统中的使用
US10900896B2 (en) Flow cells utilizing surface-attached structures, and related systems and methods
JP2022088380A (ja) コンビナトリアルバーコーディングのための方法および組成物
US7608399B2 (en) Device and method for extraction and analysis of nucleic acids from biological samples
US20220355310A1 (en) Manufacturing method of the operation pipe
US10919036B2 (en) Flow cells utilizing surface-attached structures, and related systems and methods
Parthasarathy et al. Developments in microfluidic integrated lab-on-chip devices for DNA biosensing towards unifying the emergence of nanobiosensor
WO2014065758A1 (en) A method of isolating nucleic acids in an aqueous sample using microfluidic device
AU2012304228B2 (en) Centrifugally-enhanced capture method and device
WO2011135880A1 (ja) 液滴操作によるリアルタイム核酸増幅法
CA2680558A1 (en) Clinical sample preparation on a microfluidic platform
Pahattuge Integrated Modular Microfluidic Systems for the Affinity Selection and Comprehensive Analysis of Rare Liquid Biopsy Biomarkers
CN121160436A (zh) 一种数字微流控芯片、集成测序系统及方法
Zhang et al. Integrated Microfluidic Sample Preparation for Chip-based Molecular Diagnostics

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant