CN103965128B - 作为显像剂的n‑烷氧基酰胺共轭物 - Google Patents

作为显像剂的n‑烷氧基酰胺共轭物 Download PDF

Info

Publication number
CN103965128B
CN103965128B CN201410136402.4A CN201410136402A CN103965128B CN 103965128 B CN103965128 B CN 103965128B CN 201410136402 A CN201410136402 A CN 201410136402A CN 103965128 B CN103965128 B CN 103965128B
Authority
CN
China
Prior art keywords
alkyl
aryl
hydrogen
substituted
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201410136402.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN103965128A (zh
Inventor
R.R.切萨蒂
T.D.哈里斯
S.P.罗宾逊
R.J.卢比
E.H.基斯曼
P.亚拉曼基利
D.S.凯斯比尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
Lantheus Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging Inc filed Critical Lantheus Medical Imaging Inc
Publication of CN103965128A publication Critical patent/CN103965128A/zh
Application granted granted Critical
Publication of CN103965128B publication Critical patent/CN103965128B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C07C53/18—Halogenated acetic acids containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201410136402.4A 2008-01-08 2009-01-08 作为显像剂的n‑烷氧基酰胺共轭物 Expired - Fee Related CN103965128B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1962708P 2008-01-08 2008-01-08
US61/019627 2008-01-08
US61/019,627 2008-01-08
CN200980108357.9A CN101970015B (zh) 2008-01-08 2009-01-08 作为显像剂的n-烷氧基酰胺共轭物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200980108357.9A Division CN101970015B (zh) 2008-01-08 2009-01-08 作为显像剂的n-烷氧基酰胺共轭物

Publications (2)

Publication Number Publication Date
CN103965128A CN103965128A (zh) 2014-08-06
CN103965128B true CN103965128B (zh) 2018-04-03

Family

ID=40456854

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410136402.4A Expired - Fee Related CN103965128B (zh) 2008-01-08 2009-01-08 作为显像剂的n‑烷氧基酰胺共轭物
CN200980108357.9A Expired - Fee Related CN101970015B (zh) 2008-01-08 2009-01-08 作为显像剂的n-烷氧基酰胺共轭物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN200980108357.9A Expired - Fee Related CN101970015B (zh) 2008-01-08 2009-01-08 作为显像剂的n-烷氧基酰胺共轭物

Country Status (14)

Country Link
US (4) US8361438B2 (enExample)
EP (1) EP2240206B1 (enExample)
JP (2) JP5730581B2 (enExample)
KR (2) KR101595324B1 (enExample)
CN (2) CN103965128B (enExample)
AU (2) AU2009204427B2 (enExample)
BR (1) BRPI0907612A2 (enExample)
CA (1) CA2711426C (enExample)
ES (1) ES2629340T3 (enExample)
IL (1) IL206846A (enExample)
MX (1) MX2010007501A (enExample)
TW (1) TWI465251B (enExample)
WO (1) WO2009089022A1 (enExample)
ZA (1) ZA201005130B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3209821B2 (ja) 1993-03-31 2001-09-17 日立ビアメカニクス株式会社 消耗電極式ガスシールドアーク溶接の出力制御方法およびその溶接装置
BRPI0907612A2 (pt) 2008-01-08 2015-07-21 Lantheus Medical Imaging Inc Conjugados de n-coxiamida como agentes de imageamento
US8877157B2 (en) 2009-07-08 2014-11-04 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
SI3050878T1 (sl) 2013-09-24 2022-01-31 Fujifilm Corporation Nova dušik-vsebujoča spojina ali njena sol ali kovinski kompleks le-te

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874573A (en) * 1995-06-26 1999-02-23 Concat, Inc. Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy
WO2002074981A2 (en) * 2001-03-21 2002-09-26 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
CN1795015A (zh) * 2003-05-23 2006-06-28 埃匹克斯医药品股份有限公司 螯合配位体和造影剂的光学纯和光学富集异构体
US20070142417A1 (en) * 2005-05-11 2007-06-21 Aventis Pharmaceuticals Inc Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5122885A (en) * 1974-08-13 1976-02-23 Sagami Chem Res Ashiru ll aminosan oo chikanhidorokisamidono seizohoho
JPS5910322B2 (ja) 1975-07-30 1984-03-08 三井東圧化学株式会社 殺草剤
HU175152B (hu) 1976-12-30 1980-05-28 Richter Gedeon Vegyeszet Sposob poluchenija peptidov s gastrin-aktivnost'ju, soderzhahhikh amino-oksi-kisloty
US4859777A (en) 1981-07-01 1989-08-22 Eastman Kodak Company Terpyridine chelating agents
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
AU6621586A (en) 1985-11-18 1987-06-02 University Of Texas System, The Polychelating agents for image and spectral enhancement (and spectral shift)
DE3768523D1 (de) * 1986-02-18 1991-04-18 Squibb & Sons Inc ((2,2,2-trichloroethoxy)methoxy)amin.
US5064956A (en) 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
JP2573006B2 (ja) 1987-12-17 1997-01-16 富士薬品工業株式会社 新規なヒドロキサム酸誘導体
IT1224627B (it) 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
US5089043A (en) 1989-11-09 1992-02-18 Shionogi & Co., Ltd. Heterocyclic oxy-phenoxyacetic acid derivatives and their use as herbicides
JPH0491070A (ja) * 1990-08-06 1992-03-24 Kanebo Ltd カリックスアレーン誘導体
US5225173A (en) * 1991-06-12 1993-07-06 Idaho Research Foundation, Inc. Methods and devices for the separation of radioactive rare earth metal isotopes from their alkaline earth metal precursors
US5274129A (en) * 1991-06-12 1993-12-28 Idaho Research Foundation, Inc. Hydroxamic acid crown ethers
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
TW319763B (enExample) 1995-02-01 1997-11-11 Epix Medical Inc
JP3131225B2 (ja) 1995-07-26 2001-01-31 ファイザー・インコーポレーテッド Ｎ−（アロイル）グリシンヒドロキサム酸誘導体および関連化合物
US6461587B1 (en) * 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US6989139B2 (en) 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US20020002152A1 (en) 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
CA2438174A1 (en) 2001-02-23 2002-09-06 Bristol-Myers Squibb Pharma Company Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
JP2007521254A (ja) * 2003-06-25 2007-08-02 ゲルベ 診断画像用化合物
US7662856B2 (en) 2003-08-29 2010-02-16 The University Of Houston System Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine
US20050106100A1 (en) 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
EP2962699A3 (en) 2003-12-01 2016-04-06 Immunomedics Inc. Improved method for preparing conjugates of proteins and chelating agents
CN101252954A (zh) 2005-06-30 2008-08-27 布里斯托尔-迈尔斯斯奎布药品公司 作为显像剂的酰肼偶联物
DE102005033902B3 (de) 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
US7618957B2 (en) * 2005-07-15 2009-11-17 Bayer Schering Pharma Aktiengesellschaft Perfluoroalkyl-containing complexes, process for their production as well as their use
BRPI0907612A2 (pt) 2008-01-08 2015-07-21 Lantheus Medical Imaging Inc Conjugados de n-coxiamida como agentes de imageamento
EP2448917A2 (de) 2009-07-03 2012-05-09 Archimica GmbH Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren
US8877157B2 (en) 2009-07-08 2014-11-04 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874573A (en) * 1995-06-26 1999-02-23 Concat, Inc. Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy
WO2002074981A2 (en) * 2001-03-21 2002-09-26 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
CN1795015A (zh) * 2003-05-23 2006-06-28 埃匹克斯医药品股份有限公司 螯合配位体和造影剂的光学纯和光学富集异构体
US20070142417A1 (en) * 2005-05-11 2007-06-21 Aventis Pharmaceuticals Inc Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor

Also Published As

Publication number Publication date
US20130315822A1 (en) 2013-11-28
AU2014200012B2 (en) 2016-06-23
AU2009204427A1 (en) 2009-07-16
US20150094465A1 (en) 2015-04-02
ES2629340T3 (es) 2017-08-08
KR101595324B1 (ko) 2016-02-18
JP2011509294A (ja) 2011-03-24
US9266846B2 (en) 2016-02-23
US9732047B2 (en) 2017-08-15
US20170029386A9 (en) 2017-02-02
US20160185737A1 (en) 2016-06-30
CA2711426C (en) 2018-05-22
CN101970015A (zh) 2011-02-09
AU2009204427B2 (en) 2013-10-03
HK1200823A1 (en) 2015-08-14
IL206846A0 (en) 2010-12-30
JP5730581B2 (ja) 2015-06-10
WO2009089022A1 (en) 2009-07-16
CA2711426A1 (en) 2009-07-16
ZA201005130B (en) 2014-12-23
MX2010007501A (es) 2010-08-16
EP2240206A1 (en) 2010-10-20
US8852553B2 (en) 2014-10-07
TW200936169A (en) 2009-09-01
BRPI0907612A2 (pt) 2015-07-21
JP6087386B2 (ja) 2017-03-01
JP2015180623A (ja) 2015-10-15
CN103965128A (zh) 2014-08-06
US8361438B2 (en) 2013-01-29
AU2014200012C1 (en) 2016-12-15
EP2240206B1 (en) 2017-03-22
KR20100103672A (ko) 2010-09-27
US20090252676A1 (en) 2009-10-08
TWI465251B (zh) 2014-12-21
KR20160022394A (ko) 2016-02-29
KR101861025B1 (ko) 2018-05-24
CN101970015B (zh) 2014-05-07
IL206846A (en) 2015-05-31

Similar Documents

Publication Publication Date Title
CN102781909B (zh) 作为显像剂的n-烷氧基酰胺共轭物
NO319680B1 (no) Perfluorholdige metallkomplekser, fremgangsmate for fremstilling av dem, farmasoytiske midler som inneholder dem og anvendelse av dem for fremstilling av farmasoytiske midler til anvendelse som kontrastmidler.
CN103965128B (zh) 作为显像剂的n‑烷氧基酰胺共轭物
US20070014721A1 (en) Hydrazide conjugates as imaging agents
EP4244216A1 (en) Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks
HK1200823B (en) N-alkoxyamide conjugates as imaging agents
WO2025044924A1 (zh) 靶向碳酸酐酶放射性药物
HK1148941B (en) N-alkoxyamide conjugates as imaging agents
HK1148941A (en) N-alkoxyamide conjugates as imaging agents
HK1178511B (en) N-alkoxyamide conjugates as imaging agents

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1200823

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180403